{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:12:09Z","timestamp":1790471529386,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jri.2019.103076","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T16:43:27Z","timestamp":1577205807000},"page":"103076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Effect of seminal plasma on dendritic cell differentiation in vitro depends on the serum source in the culture medium"],"prefix":"10.1016","volume":"137","author":[{"given":"M.H.C.","family":"Craenmehr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"van der Keur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.H.","family":"Anholts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Kapsenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"van der Westerlaken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"van Kooten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.H.J.","family":"Claas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Heidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Eikmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jri.2019.103076_bib0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0897.1986.tb00030.x","article-title":"The relationship between the immunosuppressive and cytotoxic effects of human seminal plasma","volume":"11","author":"Allen","year":"1986","journal-title":"Am. J. Reprod. Immunol. Microbiol."},{"issue":"1","key":"10.1016\/j.jri.2019.103076_bib0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2047-1440-1-14","article-title":"Human tolerogenic DC-10: perspectives for clinical applications","volume":"1","author":"Amodio","year":"2012","journal-title":"Transplant. Res."},{"issue":"2","key":"10.1016\/j.jri.2019.103076_bib0015","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1046\/j.1365-3083.1998.00284.x","article-title":"Generation of dendritic cells from peripheral blood adherent cells in medium with human serum","volume":"47","author":"Anton","year":"1998","journal-title":"Scand. J. Immunol."},{"issue":"11","key":"10.1016\/j.jri.2019.103076_bib0020","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1161\/CIRCULATIONAHA.110.985523","article-title":"S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation","volume":"123","author":"Averill","year":"2011","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jri.2019.103076_bib0025","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jlb.50.3.252","article-title":"Determination of the number and distribution of macrophages, lymphocytes, and granulocytes in the mouse uterus from mating through implantation","volume":"50","author":"De","year":"1991","journal-title":"J. Leukoc. Biol."},{"issue":"1-2","key":"10.1016\/j.jri.2019.103076_bib0030","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-1759(00)00147-2","article-title":"Distinct subsets of dendritic cells resembling dermal DCs can be generated in vitro from monocytes, in the presence of different serum supplements","volume":"238","author":"Duperrier","year":"2000","journal-title":"J. Immunol. Methods"},{"issue":"2","key":"10.1016\/j.jri.2019.103076_bib0035","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1021\/pr200724e","article-title":"Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells","volume":"11","author":"Ferreira","year":"2012","journal-title":"J. Proteome Res."},{"issue":"6","key":"10.1016\/j.jri.2019.103076_bib0040","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1182\/blood-2009-07-234872","article-title":"Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4\/HLA-G pathway","volume":"116","author":"Gregori","year":"2010","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jri.2019.103076_bib0045","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1095\/biolreprod.110.088591","article-title":"Seminal fluid regulates accumulation of FOXP3+ regulatory T cells in the preimplantation mouse uterus through expanding the FOXP3+ cell pool and CCL19-mediated recruitment","volume":"85","author":"Guerin","year":"2011","journal-title":"Biol. Reprod."},{"issue":"6","key":"10.1016\/j.jri.2019.103076_bib0050","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1095\/biolreprod.103.024794","article-title":"Diversity in phenotype and steroid hormone dependence in dendritic cells and macrophages in the mouse uterus","volume":"70","author":"Keenihan","year":"2004","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.jri.2019.103076_bib0055","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000073263","article-title":"Interleukin-10 influences the expression of MRP8 and MRP14 in human dendritic cells","volume":"132","author":"Kumar","year":"2003","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"1","key":"10.1016\/j.jri.2019.103076_bib0060","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-2249.1991.tb05700.x","article-title":"Regulation of human B cell proliferation and differentiation by seminal plasma","volume":"85","author":"Lee","year":"1991","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2019.103076_bib0065","doi-asserted-by":"crossref","first-page":"15087","DOI":"10.1038\/s41598-017-15569-1","article-title":"Tolerogenic dendritic cells are efficiently generated using minocycline and dexamethasone","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.jri.2019.103076_bib0070","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.4049\/jimmunol.1202089","article-title":"Semen promotes the differentiation of tolerogenic dendritic cells","volume":"189","author":"Lenicov","year":"2012","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.jri.2019.103076_bib0075","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.4049\/jimmunol.118.5.1704","article-title":"Immunosuppressive activity of human seminal plasma. I. Inhibition of in vitro lymphocyte activation","volume":"118","author":"Lord","year":"1977","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.jri.2019.103076_bib0080","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.4049\/jimmunol.148.6.1699","article-title":"Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation period","volume":"148","author":"McMaster","year":"1992","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.jri.2019.103076_bib0085","doi-asserted-by":"crossref","first-page":"8080","DOI":"10.4049\/jimmunol.0804018","article-title":"Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy","volume":"182","author":"Moldenhauer","year":"2009","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.jri.2019.103076_bib0090","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nri2132","article-title":"Tolerogenic dendritic cells and the quest for transplant tolerance","volume":"7","author":"Morelli","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"20","key":"10.1016\/j.jri.2019.103076_bib0095","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1182\/blood-2011-07-365825","article-title":"Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells","volume":"118","author":"Obermajer","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jri.2019.103076_bib0100","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.3389\/fimmu.2017.01514","article-title":"Update on dendritic cell-induced immunological and clinical tolerance","volume":"8","author":"Obregon","year":"2017","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.jri.2019.103076_bib0105","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1365-3083.2000.00690.x","article-title":"Functional and phenotypic characteristics of dendritic cells generated in human plasma supplemented medium","volume":"51","author":"Pietschmann","year":"2000","journal-title":"Scand. J. Immunol."},{"issue":"11","key":"10.1016\/j.jri.2019.103076_bib0110","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1093\/humrep\/dem281","article-title":"Concentrations and significance of cytokines and other immunologic factors in semen of healthy fertile men","volume":"22","author":"Politch","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2019.103076_bib0115","series-title":"Clinical Immunology E-Book: Principles and Practice","author":"Rich","year":"2019"},{"issue":"5","key":"10.1016\/j.jri.2019.103076_bib0120","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1095\/biolreprod.108.074658","article-title":"Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice","volume":"80","author":"Robertson","year":"2009","journal-title":"Biol. Reprod."},{"issue":"5","key":"10.1016\/j.jri.2019.103076_bib0125","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1084\/jem.177.5.1409","article-title":"Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes, and inhibits complement-mediated lysis","volume":"177","author":"Rooney","year":"1993","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.jri.2019.103076_bib0130","first-page":"4791","article-title":"Impact of interleukin-10 on phenotype and gene expression during early monocyte differentiation into dendritic cells","volume":"33","author":"Schwarz","year":"2013","journal-title":"Anticancer Res."},{"issue":"5","key":"10.1016\/j.jri.2019.103076_bib0135","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.4049\/jimmunol.1102736","article-title":"Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus","volume":"188","author":"Sharkey","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2019.103076_bib0140","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jri.2015.02.005","article-title":"Paternal antigen-specific proliferating regulatory T cells are increased in uterine-draining lymph nodes just before implantation and in pregnant uterus just after implantation by seminal plasma-priming in allogeneic mouse pregnancy","volume":"108","author":"Shima","year":"2015","journal-title":"J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.jri.2019.103076_bib0145","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0090-6980(82)90163-0","article-title":"Quantification of prostaglandins in human seminal fluid","volume":"24","author":"Svanborg","year":"1982","journal-title":"Prostaglandins"},{"issue":"12","key":"10.1016\/j.jri.2019.103076_bib0150","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1038\/sj.leu.2401925","article-title":"Extensive characterization of dendritic cells generated in serum-free conditions: regulation of soluble antigen uptake, apoptotic tumor cell phagocytosis, chemotaxis and T cell activation during maturation in vitro","volume":"14","author":"Tarte","year":"2000","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.jri.2019.103076_bib0155","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0015-0282(16)54799-2","article-title":"Inhibition of immunoglobulin (Ig)G-Fc-mediated cytotoxicity by seminal plasma IgG-Fc receptor III antigens","volume":"57","author":"Thaler","year":"1992","journal-title":"Fertil. Steril."},{"issue":"11","key":"10.1016\/j.jri.2019.103076_bib0160","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1002\/eji.200839103","article-title":"Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1","volume":"39","author":"Unger","year":"2009","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2019.103076_bib0165","first-page":"181","article-title":"Seminal plasma suppression of human lymphocyte responses in vitro requires the presence of bovine serum factors","volume":"66","author":"Vallely","year":"1986","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.jri.2019.103076_bib0170","first-page":"451","article-title":"The identification of factors in seminal plasma responsible for suppression of natural killer cell activity","volume":"63","author":"Vallely","year":"1988","journal-title":"Immunology"},{"key":"10.1016\/j.jri.2019.103076_bib0175","series-title":"WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction","author":"WHO","year":"1999"}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037819304383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037819304383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:26:46Z","timestamp":1759033606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037819304383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":35,"alternative-id":["S0165037819304383"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2019.103076","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of seminal plasma on dendritic cell differentiation in vitro depends on the serum source in the culture medium","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2019.103076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103076"}}