{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:14:08Z","timestamp":1788257648441,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jri.2020.103164","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T10:51:09Z","timestamp":1591527069000},"page":"103164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["LIF in embryo culture medium is a predictive marker for clinical pregnancy following IVF-ET of patients with fallopian tube obstruction"],"prefix":"10.1016","volume":"141","author":[{"given":"Zewu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuenan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2020.103164_bib0005","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1196\/annals.1335.020","article-title":"Leukemia inhibitory factor and human embryo implantation","volume":"1034","author":"Aghajanova","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.jri.2020.103164_bib0010","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/GCO.0b013e32833848e5","article-title":"Update on the role of leukemia inhibitory factor in assisted reproduction","volume":"22","author":"Aghajanova","year":"2010","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.jri.2020.103164_bib0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1071\/RDv26n1Ab91","article-title":"91 effect of leukemia inhibitory factor (LIF) on maturation of porcine oocytes in vitro maturation and development of parthenogenetic embryos","volume":"26","author":"Choi","year":"2013","journal-title":"Reprod. Fert. Develop."},{"issue":"6","key":"10.1016\/j.jri.2020.103164_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157696","article-title":"Integrative analyses of uterine transcriptome and MicroRNAome reveal compromised LIF-STAT3 signaling and progesterone response in the endometrium of patients with Recurrent\/Repeated implantation failure (RIF)","volume":"11","author":"Choi","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jri.2020.103164_bib0025","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1016\/j.fertnstert.2007.10.061","article-title":"Leukemia inhibitory factor induces cumulus expansion in immature human and mouse oocytes and improves mouse two-cell rate and delivery rates when it is present during mouse in vitro oocyte maturation","volume":"90","author":"De Matos","year":"2008","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.jri.2020.103164_bib0030","first-page":"1155","article-title":"MicroRNA-223-3p suppresses leukemia inhibitory factor expression and pinopodes formation during embryo implantation in mice","volume":"8","author":"Dong","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.jri.2020.103164_bib0035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/oxfordjournals.humrep.a019016","article-title":"Leukaemia inhibitory factor significantly enhances the blastocyst formation rates of human embryos cultured in serum-free medium","volume":"11","author":"Dunglison","year":"1996","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.jri.2020.103164_bib0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/humupd\/dmg021","article-title":"Selection based on morphological assessment of oocytes and embryos at different stages of preimplantation development: a review","volume":"9","author":"Ebner","year":"2003","journal-title":"Hum. Reprod. Update"},{"issue":"9","key":"10.1016\/j.jri.2020.103164_bib0045","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/humrep\/det278","article-title":"Nyboe Andersen A; European IVF-Monitoring (EIM) Consortium for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE","volume":"28","author":"Ferraretti","year":"2013","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.jri.2020.103164_bib0050","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1095\/biolreprod46.3.470","article-title":"Human leukemia inhibitory factor improves the viability of cultured ovine embryos","volume":"46","author":"Fry","year":"1992","journal-title":"Biol. Reprod."},{"issue":"4","key":"10.1016\/j.jri.2020.103164_bib0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1089\/cell.2009.0097","article-title":"Leukemia inhibitory factor (LIF) enhances germ cell differentiation from primate embryonic stem cells","volume":"12","author":"Fukunaga","year":"2010","journal-title":"Cell. Reprogram."},{"issue":"12","key":"10.1016\/j.jri.2020.103164_bib0060","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1093\/humrep\/13.12.3434","article-title":"A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization","volume":"13","author":"Gardner","year":"1998","journal-title":"Hum. Reprod."},{"issue":"3-4","key":"10.1016\/j.jri.2020.103164_bib0065","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.anireprosci.2005.06.013","article-title":"Pregnancy rates and gravid uterine parameters in single, twin and triplet pregnancies in naturally bred ewes and ewes after transfer of in vitro produced embryos","volume":"92","author":"Grazul-Bilska","year":"2006","journal-title":"Anim. Reprod. Sci."},{"issue":"4","key":"10.1016\/j.jri.2020.103164_bib0070","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1530\/rep.0.1230553","article-title":"Kinetics of early in vitro development of bovine in vivo- and in vitro-derived zygotes produced and\/or cultured in chemically defined or serum-containing media","volume":"123","author":"Holm","year":"2002","journal-title":"Reproduction"},{"issue":"5","key":"10.1016\/j.jri.2020.103164_bib0075","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/molehr\/gap012","article-title":"The role of proteomics in defining the human embryonic secretome","volume":"15","author":"Katz-Jaffe","year":"2009","journal-title":"Mol. Hum. Reprod."},{"issue":"2","key":"10.1016\/j.jri.2020.103164_bib0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF02211386","article-title":"Coculture cells that express leukemia inhibitory factor (LIF) enhance mouse blastocyst development in vitro","volume":"12","author":"Kauma","year":"1995","journal-title":"J. Assist. Reprod. Genet."},{"issue":"2","key":"10.1016\/j.jri.2020.103164_bib0085","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.rbmo.2016.04.014","article-title":"Higher beta-HCG concentrations and higher birthweights ensue from single vitrified embryo transfers","volume":"33","author":"Keane","year":"2016","journal-title":"Reprod. Biomed. Online"},{"issue":"10","key":"10.1016\/j.jri.2020.103164_bib0090","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1093\/humrep\/deu175","article-title":"European IVF-Monitoring Consortium, for the European Society of Human Reproduction and Embryology. Assisted reproductive technology in Europe, 2010: results generated from European registers by ESHRE\u2020","volume":"29","author":"Kupka","year":"2014","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.jri.2020.103164_bib0095","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.rbmo.2017.12.020","article-title":"Leukaemia inhibitory factor in serum and follicular fluid of women with polycystic ovary syndrome and its correlation with IVF outcome","volume":"36","author":"Li","year":"2018","journal-title":"Reprod. Biomed. Online"},{"issue":"3","key":"10.1016\/j.jri.2020.103164_bib0100","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.fertnstert.2015.11.003","article-title":"Time-lapse deselection model for human day 3 in vitro fertilization embryos: the combination of qualitative and quantitative measures of embryo growth","volume":"105","author":"Liu","year":"2016","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.jri.2020.103164_bib0105","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1586\/eci.11.60","article-title":"Understanding the link between the IL-6 cytokine family and pregnancy: implications for future therapeutics","volume":"7","author":"Markert","year":"2011","journal-title":"Expert Rev. Clin. Immunol."},{"issue":"2","key":"10.1016\/j.jri.2020.103164_bib0110","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1095\/biolreprod67.2.460","article-title":"In vivo effect of leukemia inhibitory factor (LIF) and an anti-LIF polyclonal antibody on murine embryo and fetal development following exposure at the time of transcervical blastocyst transfer","volume":"67","author":"Mitchell","year":"2002","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.jri.2020.103164_bib0115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/humrep\/dem339","article-title":"Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis","volume":"23","author":"Papanikolaou","year":"2008","journal-title":"Hum. Reprod."},{"issue":"11","key":"10.1016\/j.jri.2020.103164_bib0120","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1093\/humrep\/deh450","article-title":"Human chorionic gonadotropin and growth factors at the embryonic-endometrial interface control leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) secretion by human endometrial epithelium","volume":"19","author":"Perrier d\u2019Hauterive","year":"2004","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.jri.2020.103164_bib0125","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.rbmo.2009.12.007","article-title":"Prediction of in-vitro developmental competence of early cleavage-stage mouse embryos with compact time-lapse equipment","volume":"20","author":"Pribenszky","year":"2010","journal-title":"Reprod. Biomed. Online"},{"issue":"5","key":"10.1016\/j.jri.2020.103164_bib0130","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.fertnstert.2014.07.738","article-title":"Clinical validation of embryo culture and selection by morphokinetic analysis: a randomized, controlled trial of the EmbryoScope","volume":"102","author":"Rubio","year":"2014","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.jri.2020.103164_bib0135","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.fertnstert.2009.03.078","article-title":"Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer","volume":"94","author":"Seli","year":"2010","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.jri.2020.103164_bib0140","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1262\/jrd.09-097A","article-title":"Relationship between the length of cell cycles, cleavage pattern and developmental competence in bovine embryos generated by in vitro fertilization or parthenogenesis","volume":"56","author":"Somfai","year":"2010","journal-title":"J. Reprod. Dev."},{"issue":"6","key":"10.1016\/j.jri.2020.103164_bib0145","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1023\/A:1009413329977","article-title":"Effect of different concentrations of recombinant leukemia inhibitory factor on different development stage of mouse embryo in vitro","volume":"17","author":"Tsai","year":"2000","journal-title":"J. Assist. Reprod. Genet."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037820300851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037820300851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:26:12Z","timestamp":1759033572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037820300851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":29,"alternative-id":["S0165037820300851"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2020.103164","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LIF in embryo culture medium is a predictive marker for clinical pregnancy following IVF-ET of patients with fallopian tube obstruction","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2020.103164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103164"}}