{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:48:13Z","timestamp":1790876893603,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003945","name":"Link\u00f6pings Universitet","doi-asserted-by":"publisher","award":["221-2011-512"],"award-info":[{"award-number":["221-2011-512"]}],"id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003945","name":"Link\u00f6pings Universitet","doi-asserted-by":"publisher","award":["378091\/3129712013-2016"],"award-info":[{"award-number":["378091\/3129712013-2016"]}],"id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["521-2011-6353"],"award-info":[{"award-number":["521-2011-6353"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004360","name":"Sveriges Lantbruksuniversitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007288","name":"Mahasarakham University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["221-2010-1241"],"award-info":[{"award-number":["221-2010-1241"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.jri.2020.103179","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T10:48:11Z","timestamp":1595069291000},"page":"103179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Bull seminal plasma stimulates in vitro production of TGF-\u03b2, IL-6 and IL-8 from bovine endometrial epithelial cells, depending on dose and bull fertility"],"prefix":"10.1016","volume":"142","author":[{"given":"Thanapol","family":"Nongbua","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3588-091X","authenticated-orcid":false,"given":"Theodoros","family":"Ntallaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Rub\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heriberto","family":"Rodriguez-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Humblot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-7331","authenticated-orcid":false,"given":"Jane M.","family":"Morrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2020.103179_bib0005","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.anireprosci.2008.10.015","article-title":"Species-specific interaction of seminal plasma on sperm-neutrophil binding","volume":"114","author":"Alghamdi","year":"2009","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.jri.2020.103179_bib0010","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.2527\/1994.7292441x","article-title":"Fertility of range beef bulls grouped according to presence or absence of heparin-binding proteins in sperm membranes and seminal fluid","volume":"72","author":"Bellin","year":"1994","journal-title":"J. Anim. Sci."},{"issue":"143","key":"10.1016\/j.jri.2020.103179_bib0015","first-page":"149","article-title":"Inflammatory cytokine and acute phase protein concentrations in the peripehral blood and uterine washings of cows with subclinical endometritis in the late postpartum period","volume":"39","author":"Brodzki","year":"2015","journal-title":"Vet. Res. Comm."},{"key":"10.1016\/j.jri.2020.103179_bib0020","doi-asserted-by":"crossref","first-page":"R223","DOI":"10.1530\/REP-16-0313","article-title":"A role for seminal plasma in modulating pregnancy outcomes in domestic species","volume":"52","author":"Bromfield","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2020.103179_bib0025","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/mrd.1080260404","article-title":"Identification of heparin-binding proteins in bovine seminal plasma","volume":"26","author":"Chandonnet","year":"1990","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jri.2020.103179_bib0030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.repbio.2017.05.006","article-title":"Bovine Herpes virus type 4 alters TNF-\u03b1and IL-8 profiles and impairs the survival of bovine endometrial epithelial cells","volume":"17","author":"Chanrot","year":"2017","journal-title":"Reprod. Biol."},{"key":"10.1016\/j.jri.2020.103179_bib0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.anireprosci.2016.12.002","article-title":"Dose related effects of LPS on endometrial epithelial cell populations from dioestrus cows","volume":"177","author":"Chanrot","year":"2017","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.jri.2020.103179_bib0040","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1530\/jrf.0.1170315","article-title":"Correlation of increased concentration of ovine endometrial cyclooxygenase 2 with the increase in PGE2 and PGD2 in the late luteal phase","volume":"117","author":"Charpigny","year":"1999","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.jri.2020.103179_bib0045","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1530\/REP-09-0375","article-title":"Proteomic comparison of detergent-extracted sperm proteins from bulls with different fertility indexes","volume":"139","author":"D\u2019Amours","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2020.103179_bib0050","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1210\/endo.130.6.1375903","article-title":"Expression of transforming growth factor-\u03b2 isoforms (\u03b22 and \u03b23) in the mouse uterus: analysis of the periimplantation period and effects of ovarian steroids","volume":"130","author":"Das","year":"1992","journal-title":"Endocrinology"},{"issue":"83","key":"10.1016\/j.jri.2020.103179_bib0055","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1095\/biolreprod.110.086074","article-title":"The Chemokine IL8 Is Up-Regulated in Bovine Endometrial Stromal Cells by the BoHV-4 IE2 Gene Product, ORF50\/Rta: A Step Ahead Toward a Mechanism for BoHV-4 Induced Endometritis","volume":"2010","author":"Donofrio","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2020.103179_bib0060","article-title":"Differential gene expression in bovine endometrial epithelial cells after challenge with LPS; specific implications for genes involved in embryo maternal interactions","author":"Guo","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2020.103179_bib0065","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1055\/s-0028-1108011","article-title":"The role of growth factors and cytokines during implantation: endocrine and paracrine interactions","volume":"27","author":"Guzeloglu-Kayisili","year":"2009","journal-title":"Semin. Reprod. Med."},{"issue":"5 Pt 1","key":"10.1016\/j.jri.2020.103179_bib0070","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1203\/01.PDR.0000156212.03459.A9","article-title":"Expression of toll-like receptor 4 and endotoxin responsiveness in mice during perinatal period","volume":"57","author":"Harju","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jri.2020.103179_bib0075","doi-asserted-by":"crossref","first-page":"7060","DOI":"10.1038\/srep07060","article-title":"Endometrial cells sense and react to tissues damage during infection of the bovine endometrium via interleukin","volume":"4","author":"Healy","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jri.2020.103179_bib0080","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.anireprosci.2014.10.022","article-title":"Genome-wide association study for semen volume and total number of sperm in Holstein-Friesian bulls","volume":"151","author":"Hering","year":"2014","journal-title":"Anim. Reprod. Sci."},{"issue":"March (3)","key":"10.1016\/j.jri.2020.103179_bib0085","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1093\/biolre\/ioy226","article-title":"Seminal plasma modulates expression of endometrial inflammatory meditators in the bovine","volume":"100","author":"Ibrahim","year":"2019","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2020.103179_bib0090","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3168\/jds.S0022-0302(80)82901-8","article-title":"Accuracy of predicting stages of bovine estrous cycle by gross appearance of the corpus luteum","volume":"63","author":"Ireland","year":"1980","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jri.2020.103179_bib0095","doi-asserted-by":"crossref","first-page":"536","DOI":"10.2164\/jandrol.110.012583","article-title":"Seminal Plasma: An Essential Attribute to Spermatozoa","volume":"33","author":"Juyena","year":"2012","journal-title":"J. Androl."},{"key":"10.1016\/j.jri.2020.103179_bib0100","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1095\/biolreprod49.6.1202","article-title":"Fertility-associated proteins in Holstein bull seminal plasma","volume":"49","author":"Killian","year":"1993","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2020.103179_bib0105","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13676","article-title":"Regulation of inflammatory mediator expression in bovine endometrial cells: effects of lipopolysaccharide, interleukin 1 beta, and tumor necrosis factor alpha","volume":"6","author":"Koh","year":"2018","journal-title":"Physiol. Rep."},{"issue":"Suppl 1","key":"10.1016\/j.jri.2020.103179_bib0110","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1017\/S1751731114000524","article-title":"Reproductive tract inflammatory disease in postpartum dairy cows","volume":"8","author":"LeBlanc","year":"2014","journal-title":"Animal"},{"key":"10.1016\/j.jri.2020.103179_bib0115","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1126\/science.8009224","article-title":"Maternal rescue of transforming growth factor-beta 1 null mice","volume":"264","author":"Letterio","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jri.2020.103179_bib0120","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/mrd.1080360412","article-title":"Mitogenic and cytogenetic evaluation of transforming growth-factor-beta on murine preimplantation embryonic-development in-vitro","volume":"36","author":"Lim","year":"1993","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jri.2020.103179_bib0125","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1439-0531.2006.00811.x","article-title":"Retained functional integrity of bull spermatozoa after double freezing and thawing using PureSperm\u00ae density gradient centrifugation","volume":"42","author":"Maxwell","year":"2007","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.jri.2020.103179_bib0130","first-page":"67","article-title":"Fast Protein Liquid Chromatography of Swedish Red and Holstein bull seminal plasma proteins in relation to bull fertility","volume":"50","author":"Morrell","year":"2015","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.jri.2020.103179_bib0135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2164\/jandrol.05089","article-title":"Identification of proteins in the accessory sex gland fluid associated with fertility indexes of dairy bulls: a proteomic approach","volume":"27","author":"Moura","year":"2006","journal-title":"J. Androl."},{"key":"10.1016\/j.jri.2020.103179_bib0140","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/rda.12954","article-title":"Effects of single layer centrifugation (SLC) on bull spermatozoa prior to freezing on post\u2010thaw semen characteristics","volume":"52","author":"Nongbua","year":"2017","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.jri.2020.103179_bib0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/rda.13069","article-title":"Effect of bovine seminal plasma on bovine endometrial epithelial cells in culture","volume":"53","author":"Nongbua","year":"2018","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.jri.2020.103179_bib0150","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/19396368.2018.1455245","article-title":"Adding bovine seminal plasma prior to freezing improves post-thaw bull sperm kinematics but decreases mitochondrial activity","volume":"64","author":"Nongbua","year":"2019","journal-title":"Syst. Biol. Reprod. Med."},{"issue":"September (4)","key":"10.1016\/j.jri.2020.103179_bib0155","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.theriogenology.2009.04.013","volume":"72","author":"Odhiambo","year":"2009","journal-title":"Theriogenology"},{"issue":"July (7)","key":"10.1016\/j.jri.2020.103179_bib0160","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.3168\/jds.2019-16251","article-title":"Effects of intrauterine infusion of seminal plasma at artificial insemination on fertility of lactating Holstein cows","volume":"102","author":"Ortiz","year":"2019","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.jri.2020.103179_bib0165","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1752-0509-2-19","article-title":"Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility","volume":"2","author":"Peddinti","year":"2008","journal-title":"BMC Syst. Biol."},{"issue":"July (1-2)","key":"10.1016\/j.jri.2020.103179_bib0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.anireprosci.2012.06.011","article-title":"Exposure of beef females to the biostimulatory effects of bulls with or without deposition of seminal plasma prior to AI","volume":"133","author":"Pfeiffer","year":"2012","journal-title":"Anim. Reprod. Sci."},{"issue":"60","key":"10.1016\/j.jri.2020.103179_bib0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00265-006-0178-0","article-title":"Complexity of seminal fluid: a review","volume":"2006","author":"Poiani","year":"2006","journal-title":"Behav. Ecol. Sociobiol. (Print)"},{"key":"10.1016\/j.jri.2020.103179_bib0180","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/2049-1891-5-52","article-title":"Transforming growth factor \u03b2 signaling in uterine development and function","volume":"5","author":"Qinglei","year":"2014","journal-title":"Anim Sci Biotechnol"},{"issue":"December (6)","key":"10.1016\/j.jri.2020.103179_bib0185","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1530\/REP-19-0421","article-title":"Effect of seminal plasma or transforming growth factor on bovine endometrial cells","volume":"158","author":"Rizo","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2020.103179_bib0190","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00441-005-1127-3","article-title":"Seminal plasma and male factor signalling in the female reproductive tract","volume":"322","author":"Robertson","year":"2005","journal-title":"Cell Tissue Res."},{"issue":"13 Suppl","key":"10.1016\/j.jri.2020.103179_bib0195","doi-asserted-by":"crossref","first-page":"E36","DOI":"10.2527\/jas.2006-578","article-title":"Seminal fluid signaling in the female reproductive tract: lessons from rodents and pigs","volume":"85","author":"Robertson","year":"2007","journal-title":"J. Anim. Sci."},{"issue":"4","key":"10.1016\/j.jri.2020.103179_bib0200","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/smim.2000.0320","article-title":"The role of semen in induction of maternal immune tolerance to pregnancy","volume":"13","author":"Robertson","year":"2001","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jri.2020.103179_bib0205","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1046\/j.1439-0531.2003.00436.x","article-title":"Laboratory Semen Assessment and Prediction of Fertility still Utopia?","volume":"38","author":"Rodriguez-Martinez","year":"2003","journal-title":"Reprod. Domest. Anim."},{"issue":"Suppl 1","key":"10.1016\/j.jri.2020.103179_bib0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0897.2011.01033.x","article-title":"Seminal plasma proteins: what role do they play?","volume":"66","author":"Rodriguez-Martinez","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2020.103179_bib0215","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1071\/RD98111","article-title":"Immunoelectronmicroscopic imaging of spermadhesin AWN epitopes on boar spermatozoa bound in vivo to the zona pellucida","volume":"10","author":"Rodr\u00edguez-Mart\u00ednez","year":"1998","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.jri.2020.103179_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1098-2795(199801)49:1<1::AID-MRD1>3.0.CO;2-U","article-title":"Molecular cloning, genetic mapping, and developmental expression of a bovine transforming growth factor beta (TGF-beta) type I receptor","volume":"49","author":"Roelen","year":"1998","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jri.2020.103179_bib0225","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jri.2016.07.002","article-title":"Innate immunity and the sensing of infection, damage and danger in the female genital tract","volume":"119","author":"Sheldon","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2020.103179_bib0230","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/BF02815625","article-title":"Cytokines and other important inflammatory mediators in gestation and bacterial intraamniotic infections","volume":"46","author":"Splichal","year":"2001","journal-title":"Folia Microbiol (praha)"},{"key":"10.1016\/j.jri.2020.103179_bib0235","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/1477-7827-8-120","article-title":"Transforming growth factor beta family expression at the bovine feto-maternal interface","volume":"8","author":"Sugawara","year":"2010","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"April (4)","key":"10.1016\/j.jri.2020.103179_bib0240","doi-asserted-by":"crossref","first-page":"e0195279","DOI":"10.1371\/journal.pone.0195279","article-title":"Metabolomic markers of fertility in bull seminal plasma","volume":"13","author":"Velho","year":"2018","journal-title":"PLoS One"},{"issue":"November (1)","key":"10.1016\/j.jri.2020.103179_bib0245","doi-asserted-by":"crossref","first-page":"16323","DOI":"10.1038\/s41598-018-34152-w","article-title":"Proteomic landscape of seminal plasma associated with dairy bull fertility","volume":"8","author":"Viana","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037820301005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037820301005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:26:50Z","timestamp":1759033610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037820301005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":49,"alternative-id":["S0165037820301005"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2020.103179","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bull seminal plasma stimulates in vitro production of TGF-\u03b2, IL-6 and IL-8 from bovine endometrial epithelial cells, depending on dose and bull fertility","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2020.103179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103179"}}