{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:06:16Z","timestamp":1769051176668,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jri.2021.103430","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T13:36:47Z","timestamp":1633009007000},"page":"103430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Impact of TNF-\u03b1 profile in recurrent pregnancy loss pathogenesis: A patient based study from Assam"],"prefix":"10.1016","volume":"148","author":[{"given":"Anjuma","family":"Begum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archana","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandana Ray","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somdatta","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratul","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-9592","authenticated-orcid":false,"given":"Natasha","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Purabi Deka","family":"Bose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujoy","family":"Bose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jri.2021.103430_bib0005","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12016-016-8596-x","article-title":"Tumor necrosis factor-alpha and pregnancy: focus on biologics. An updated and comprehensive review","volume":"53","author":"Alijotas-Reig","year":"2017","journal-title":"Clin. Rev. Allergy and Immunol."},{"key":"10.1016\/j.jri.2021.103430_bib0010","series-title":"Association of Tumor Necrosis Factor- \u03b1 (TNF- \u03b1) -308G > a and -238G > a Polymorphisms With Recurrent Pregnancy","first-page":"284","author":"Aslebahar","year":"2019"},{"issue":"3","key":"10.1016\/j.jri.2021.103430_bib0015","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ogc.2006.05.012","article-title":"Thrombophilia and recurrent pregnancy loss","volume":"33","author":"Carp","year":"2006","journal-title":"Obstet. Gynecol. Clin. North Am."},{"issue":"2","key":"10.1016\/j.jri.2021.103430_bib0020","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1530\/jrf.0.0890447","article-title":"Control of fetal survival in CBA x DBA\/2 mice by lymphokine therapy","volume":"89","author":"Chaouat","year":"1990","journal-title":"J. Reprod. Fertil."},{"issue":"1","key":"10.1016\/j.jri.2021.103430_bib0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0301-2115(98)00252-8","article-title":"Tumor necrosis factor during pregnancy and at the onset of labor and spontaneous abortion","volume":"83","author":"Daher","year":"1999","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"6","key":"10.1016\/j.jri.2021.103430_bib0030","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.devcel.2011.09.010","article-title":"Conditional deletion of MSX homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity","volume":"21","author":"Daikoku","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jri.2021.103430_bib0035","article-title":"Recurrent miscarriage","volume":"2011","author":"Duckitt","year":"2011","journal-title":"BMJ Clin. Evid."},{"issue":"3","key":"10.1016\/j.jri.2021.103430_bib0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbadis.2009.01.007","article-title":"Tumor necrosis factor alpha - 308 gene locus promoter polymorphism: an analysis of association with health and disease","volume":"1792","author":"Elahi","year":"2009","journal-title":"Biochimica et Biophysica Acta \u2013 Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.jri.2021.103430_bib0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF03179068","article-title":"Serum levels of TNF-\u03b1 and antioxidant enzymes and placental TNF-\u03b1 expression in unexplained recurrent spontaneous miscarriage","volume":"65","author":"El-Far","year":"2009","journal-title":"J. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.jri.2021.103430_bib0050","doi-asserted-by":"crossref","DOI":"10.1186\/s40064-016-3197-y","article-title":"TNF-\u03b1 gene polymorphisms and expression","volume":"5","author":"El-Tahan","year":"2016","journal-title":"SpringerPlus"},{"issue":"2","key":"10.1016\/j.jri.2021.103430_bib0055","first-page":"76","article-title":"Recurrent pregnancy loss: etiology, diagnosis, and therapy","volume":"2","author":"Ford","year":"2009","journal-title":"Rev. Obstet. Gynecol."},{"issue":"9","key":"10.1016\/j.jri.2021.103430_bib0060","first-page":"1362","article-title":"Association between cytokine gene polymorphisms and recurrent spontaneous abortion","volume":"36","author":"Gan","year":"2016","journal-title":"J. Shanghai Jiaotong Univ. (Med. Sci.)"},{"issue":"1","key":"10.1016\/j.jri.2021.103430_bib0065","first-page":"28","article-title":"Early recurrent pregnancy loss","volume":"25","author":"Geyser","year":"2015","journal-title":"Obstet. Gynaecol. Forum"},{"issue":"2","key":"10.1016\/j.jri.2021.103430_bib0070","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cyto.2012.05.018","article-title":"Association of CTLA-4 and TNF-\u03b1 polymorphism with recurrent miscarriage among North Indian women","volume":"60","author":"Gupta","year":"2012","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.jri.2021.103430_bib0075","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.placenta.2008.10.012","article-title":"Human Tumour Necrosis Factor: Physiological and Pathological Roles in Placenta and Endometrium","volume":"30","author":"Haider","year":"2009","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.jri.2021.103430_bib0080","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.fertnstert.2009.01.166","article-title":"Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses","volume":"93","author":"Jaslow","year":"2010","journal-title":"Fertil. Steril."},{"issue":"6","key":"10.1016\/j.jri.2021.103430_bib0085","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0015-0282(00)00517-3","article-title":"Evidence of a T(H) 1 type response associated with recurrent miscarriage","volume":"73","author":"Jenkins","year":"2000","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.jri.2021.103430_bib0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/14647273.2018.1543899","article-title":"Tumour necrosis factor alpha gene polymorphisms in women with recurrent pregnancy loss: a meta-analysis","volume":"23","author":"Kim","year":"2020","journal-title":"Hum. Fertil."},{"issue":"18","key":"10.1016\/j.jri.2021.103430_bib0095","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","article-title":"Human placenta and trophoblast development: key molecular mechanisms and model systems","volume":"76","author":"Kn\u00f6fler","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"9","key":"10.1016\/j.jri.2021.103430_bib0100","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/molehr\/gas017","article-title":"Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss","volume":"18","author":"Krieg","year":"2012","journal-title":"Mol. Hum. Reprod."},{"issue":"2","key":"10.1016\/j.jri.2021.103430_bib0105","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/0974-1208.86090","article-title":"Recurrent pregnancy loss: TNF-\u03b1 and IL-10 polymorphisms","volume":"4","author":"Kuar","year":"2011","journal-title":"J. Hum. Reprod. Sci."},{"issue":"3","key":"10.1016\/j.jri.2021.103430_bib0110","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1034\/j.1600-0897.2002.t01-2-00013.x","article-title":"T helper 1 and 2 cytokine expression in women with recurrent spontaneous abortions and infertility of repeated implantation failures","volume":"48","author":"Kwak-Kim","year":"2002","journal-title":"Am. J. Reprod. Immunol."},{"issue":"7","key":"10.1016\/j.jri.2021.103430_bib0115","first-page":"261","article-title":"Recurrent pregnancy loss","volume":"4","author":"Li","year":"2018","journal-title":"Ambulatory Gynecol."},{"issue":"1","key":"10.1016\/j.jri.2021.103430_bib0120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12958-016-0140-6","article-title":"Association of TNF-a\u03b1 genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis","volume":"14","author":"Li","year":"2016","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"6","key":"10.1016\/j.jri.2021.103430_bib0125","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/humupd\/2.6.469","article-title":"Cytokines and immuno-endocrine factors in recurrent miscarriage","volume":"2","author":"Lim","year":"1996","journal-title":"Hum. Reprod. Update"},{"issue":"9","key":"10.1016\/j.jri.2021.103430_bib0130","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1093\/humrep\/15.9.2011","article-title":"Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions","volume":"15","author":"Makhseed","year":"2000","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2021.103430_bib0135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/BF02390365","article-title":"Gynecology recurrent miscarriage","author":"Mallmann","year":"1991","journal-title":"Arch. Gynecol. Obstet."},{"issue":"4","key":"10.1016\/j.jri.2021.103430_bib0140","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.fertnstert.2009.06.041","article-title":"Etiology of recurrent pregnancy loss in women over the age of 35 years","volume":"94","author":"Marquard","year":"2010","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.jri.2021.103430_bib0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2003.12.001","article-title":"Lack of association of TNF\u03b1 gene polymorphisms and recurrent pregnancy loss in Caucasian women","volume":"61","author":"Pietrowski","year":"2004","journal-title":"J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.jri.2021.103430_bib0150","doi-asserted-by":"crossref","first-page":"314","DOI":"10.14310\/horm.2002.1505","article-title":"Hormonal causes of recurrent pregnancy loss (RPL)","volume":"13","author":"Pluchino","year":"2014","journal-title":"Hormones"},{"issue":"3","key":"10.1016\/j.jri.2021.103430_bib0155","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/humrep\/15.3.713","article-title":"Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion","volume":"15","author":"Raghupathy","year":"2000","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.jri.2021.103430_bib0160","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1600-0897.2010.00852.x","article-title":"Th1\/Th2\/Th17 and Regulatory T-Cell Paradigm in Pregnancy","volume":"63","author":"Saito","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"issue":"7","key":"10.1016\/j.jri.2021.103430_bib0165","first-page":"345","article-title":"The role of Th1 and Th2 cytokines among women with recurrent spontaneous miscarriage a r t I C l e I N F O","volume":"3","author":"Sharief","year":"2014","journal-title":"Sci. J. Med. Sci."},{"issue":"17","key":"10.1016\/j.jri.2021.103430_bib0170","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.3760\/cma.j.issn.0366-6999.20133072","article-title":"Immune system modifications and feto-maternal immune tolerance","volume":"127","author":"Song","year":"2014","journal-title":"Chin. Med. J."},{"issue":"1","key":"10.1016\/j.jri.2021.103430_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40738-021-00101-x","article-title":"Association of Tumor Necrosis Factor-\u03b1 -308G&A, -238G&A and -376G&A polymorphisms with recurrent pregnancy loss risk in the Greek population","volume":"7","author":"Stavros","year":"2021","journal-title":"Fertil. Res. Pract."},{"issue":"2","key":"10.1016\/j.jri.2021.103430_bib0180","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4103\/0974-1208.183516","article-title":"Association of tumor necrosis factor-alpha 308G\/A polymorphism with recurrent miscarriages in women","volume":"9","author":"Sudhir","year":"2016","journal-title":"J. Hum. Reprod. Sci."},{"issue":"4","key":"10.1016\/j.jri.2021.103430_bib0185","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1095\/biolreprod49.4.850","article-title":"Expression of cytokines in placentas of mice undergoing immunologically mediated spontaneous fetal resorptions","volume":"49","author":"Tangri","year":"1993","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2021.103430_bib0190","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jri.2016.10.001","article-title":"Preterm delivery and associated negative pregnancy outcome \u2013 a tale of faulty progesterone receptor signalling pathway and linked derailed immunomodulation: a study from Northeast India","volume":"118","author":"Tiwari","year":"2016","journal-title":"J. Reprod. Immunol."},{"issue":"2","key":"10.1016\/j.jri.2021.103430_bib0195","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1053\/j.semperi.2018.12.003","article-title":"Uterine factor in recurrent pregnancy loss","volume":"43","author":"Turocy","year":"2019","journal-title":"Semin. Perinatol."},{"issue":"1","key":"10.1016\/j.jri.2021.103430_bib0200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.imlet.2007.09.014","article-title":"Fetal tolerance in human pregnancy-A crucial balance between acceptance and limitation of trophoblast invasion","volume":"115","author":"von Rango","year":"2008","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.jri.2021.103430_bib0205","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/aji.12447","article-title":"Association between serum TNF-\u03b1 levels and recurrent spontaneous miscarriage: a meta-analysis","volume":"75","author":"Zhang","year":"2016","journal-title":"Am. J. Reprod. Immunol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037821001601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037821001601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:32:06Z","timestamp":1759033926000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037821001601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":41,"alternative-id":["S0165037821001601"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2021.103430","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of TNF-\u03b1 profile in recurrent pregnancy loss pathogenesis: A patient based study from Assam","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2021.103430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103430"}}