{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:14:10Z","timestamp":1773173650448,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFD0500601"],"award-info":[{"award-number":["2017YFD0500601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["DUT20LK29"],"award-info":[{"award-number":["DUT20LK29"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701719"],"award-info":[{"award-number":["31701719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010909","name":"Young Scientists Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010909","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jri.2023.103946","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T13:43:52Z","timestamp":1680702232000},"page":"103946","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Protective efficacy of a recombinant enterotoxin antigen in a maternal immunization model and the inhibition of specific maternal antibodies to neonatal oral vaccination"],"prefix":"10.1016","volume":"157","author":[{"given":"Hong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haofei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jibin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2023.103946_bib1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1586\/14760584.7.6.795","article-title":"Vaccines against enterotoxigenic Escherichia coli","volume":"7","author":"Ann-Mari","year":"2008","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jri.2023.103946_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.dci.2008.07.003","article-title":"The mucosal immune system: recent developments and future directions in the pig","volume":"33","author":"Bailey","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jri.2023.103946_bib3","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3945\/jn.110.133652","article-title":"Premature delivery influences the immunological composition of colostrum and transitional and mature human milk","volume":"141","author":"Castellote","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.jri.2023.103946_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0264-410X(99)00168-1","article-title":"The role of cAMP in mucosal adjuvanticity of Escherichia coli heat-labile enterotoxin (LT)","volume":"18","author":"Cheng","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2023.103946_bib5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.addr.2015.03.007","article-title":"Delivery strategies to enhance oral vaccination against enteric infections","volume":"91","author":"Davitt","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jri.2023.103946_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1203\/00006450-199408000-00005","article-title":"Insulin-like growth factors and insulin-like growth factor binding proteins in porcine serum and milk throughout lactation","volume":"36","author":"Donovan","year":"1994","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jri.2023.103946_bib7","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13567-020-00818-5","article-title":"A multivalent vaccine candidate targeting enterotoxigenic Escherichia coli fimbriae for broadly protecting against porcine post-weaning diarrhea","volume":"51","author":"Duan","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.jri.2023.103946_bib8","first-page":"75","article-title":"Enterotoxigenic Escherichia coli and probiotics in swine: what the bleep do we know?","volume":"36","author":"Dubreuil","year":"2019","journal-title":"Food Health"},{"key":"10.1016\/j.jri.2023.103946_bib9","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s42770-021-00567-3","article-title":"Pig vaccination strategies based on enterotoxigenic Escherichia coli toxins","volume":"52","author":"Dubreuil","year":"2021","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.jri.2023.103946_bib10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40813-021-00232-z","article-title":"Post-weaning diarrhea in pigs weaned without medicinal zinc: risk factors, pathogen dynamics, and association to growth rate","volume":"7","author":"Eriksen","year":"2021","journal-title":"Porc. Health Manag"},{"key":"10.1016\/j.jri.2023.103946_bib11","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1089\/fpd.2015.1959","article-title":"Enterotoxigenic Escherichia coli subclinical infection in pigs: bacteriological and genotypic characterization and antimicrobial resistance profiles","volume":"12","author":"Fabiana","year":"2015","journal-title":"Foodborne Pathog. Dis."},{"key":"10.1016\/j.jri.2023.103946_bib12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1203\/00006450-198912000-00023","article-title":"Transplacental or enteral transfer of maternal immunization induced antibody protects suckling rats from type III group B streptococcal infection","volume":"26","author":"Heiman","year":"1989","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jri.2023.103946_bib13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1439-0396.2012.01284.x","article-title":"Gastrointestinal health and function in weaned pigs: a review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds","volume":"97","author":"Heo","year":"2013","journal-title":"J. Anim. Physiol. Anim. Nutr. (Berl. )"},{"key":"10.1016\/j.jri.2023.103946_bib14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3390\/nu3040442","article-title":"Perspectives on immunoglobulins in colostrum and milk","volume":"3","author":"Hurley","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.jri.2023.103946_bib15","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/S0042-207X(02)00283-X","article-title":"Influence of maternal antibodies on efficacy of a subunit vaccine: transmission of classical swine fever virus between pigs vaccinated at 2 weeks of age","volume":"20","author":"Klinkenberg","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2023.103946_bib16","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1080\/14760584.2016.1182868","article-title":"Recent advances in nontoxic Escherichia coli heat-labile toxin and its derivative adjuvants","volume":"15","author":"Ma","year":"2016","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jri.2023.103946_bib17","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1093\/infdis\/jix176","article-title":"Effect of prepregnancy pertussis vaccination in young infants","volume":"215","author":"Maertens","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jri.2023.103946_bib18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3390\/nu8050279","article-title":"Review of infant feeding: key features of breast milk and infant formula","volume":"8","author":"Martin","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.jri.2023.103946_bib19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jri.2015.11.004","article-title":"Maternal colostral leukocytes appear to enhance cell-mediated recall response, but inhibit humoral recall response in prime-boost vaccinated","volume":"113","author":"Meganck","year":"2016","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103946_bib20","first-page":"S21","article-title":"Immune responsiveness in the neonatal period","volume":"S1","author":"Morein","year":"2007","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.jri.2023.103946_bib21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13567-015-0210-3","article-title":"Maternal immunity enhances systemic recall immune responses upon oral immunization of piglets with F4 fimbriae","volume":"46","author":"Nguyen","year":"2015","journal-title":"Vet. Res"},{"key":"10.1016\/j.jri.2023.103946_bib22","first-page":"16","article-title":"Maternal antibodies: clinical significance, mechanism of interference with immune responses, and possible vaccination strategies","author":"Niewiesk","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103946_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1574-695X.2002.tb00599.x","article-title":"Epitope analysis of the FanC subunit protein of the K99 (F5) fimbriae of enterotoxigenic Escherichia coli using a recombinant fusion technique","volume":"34","author":"Ogunniyi","year":"2002","journal-title":"Fems Immunol. Med. Mic."},{"key":"10.1016\/j.jri.2023.103946_bib24","first-page":"242","article-title":"Protection against enteric disease caused by Escherichia coli - a model for vaccination with a virulence determinant?","author":"Rutter","year":"1973","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.103946_bib25","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.dci.2008.07.007","article-title":"Humoral and cellular factors of maternal immunity in swine","volume":"33","author":"Salmon","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.jri.2023.103946_bib26","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1016\/S0264-410X(03)00342-6","article-title":"Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants","volume":"21","author":"Siegrist","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2023.103946_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri2508","article-title":"B-cell responses to vaccination at the extremes of age","volume":"9","author":"Siegrist","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2023.103946_bib28","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1038\/s41467-021-24719-z","article-title":"Vertically transferred maternal immune cells promote neonatal immunity against early life infections","volume":"12","author":"Stelzer","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jri.2023.103946_bib29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-1135(02)00357-7","article-title":"The influence of maternal immunity on the efficacy of a classical swine fever vaccine against classical swine fever virus, genogroup 2.2, infection","volume":"97","author":"Suradhat","year":"2003","journal-title":"Vet. Microbiol"},{"key":"10.1016\/j.jri.2023.103946_bib30","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1016\/j.vaccine.2020.09.003","article-title":"Elucidating the difference in the kinetics of antibody titres of infants in Belgium and Vietnam","volume":"38","author":"Tran","year":"2020","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2023.103946_bib31","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.celrep.2019.07.047","article-title":"Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers","volume":"28","author":"Vono","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.jri.2023.103946_bib32","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3389\/fimmu.2020.01153","article-title":"The immature gut barrier and its importance in establishing immunity in newborn mammals","volume":"11","author":"Westr\u00f6m","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103946_bib33","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1080\/21645515.2018.1496768","article-title":"Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin","volume":"15","author":"Zegeye","year":"2019","journal-title":"Hum. Vaccin Immunother."},{"key":"10.1016\/j.jri.2023.103946_bib34","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10930-021-09973-w","article-title":"Expression and purification of a recombinant enterotoxin protein using different E. coli host strains and expression vectors","volume":"40","author":"Zhao","year":"2021","journal-title":"Protein J."},{"key":"10.1016\/j.jri.2023.103946_bib35","doi-asserted-by":"crossref","DOI":"10.4142\/jvs.21068","article-title":"Protective efficacy of a novel multivalent vaccine in the prevention of diarrhea induced by enterotoxigenic Escherichia coli in a murine model","volume":"23","author":"Zhao","year":"2022","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.jri.2023.103946_bib36","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1056\/NEJMra012493","article-title":"Maternal antibodies, childhood infections, and autoimmune diseases","volume":"345","author":"Zinkernagel","year":"2001","journal-title":"New Engl. J. Med."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823001523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823001523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:34:30Z","timestamp":1759034070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037823001523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":36,"alternative-id":["S0165037823001523"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2023.103946","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective efficacy of a recombinant enterotoxin antigen in a maternal immunization model and the inhibition of specific maternal antibodies to neonatal oral vaccination","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2023.103946","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103946"}}