{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T17:15:56Z","timestamp":1774890956399,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"am","delay-in-days":304,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K18371"],"award-info":[{"award-number":["19K18371"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jri.2023.103970","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T02:19:24Z","timestamp":1685067564000},"page":"103970","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions"],"prefix":"10.1016","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-2379","authenticated-orcid":false,"given":"Taketo","family":"Inoue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Aoyama-Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiko","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kohama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritomo","family":"Fujisaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromoto","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taihei","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jri.2023.103970_bib1","first-page":"15","article-title":"Over-expression of IL-18, ICE and IL-18 R in testicular tissue from sexually immature as compared to mature mice","volume":"19","author":"Abu Elhija","year":"2008","journal-title":"Eur. Cytokine Netw."},{"issue":"2","key":"10.1016\/j.jri.2023.103970_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-0897.2008.00607.x","article-title":"Lipopolysaccharide increased the expression levels of IL-18, ICE and IL-18 R in murine Leydig cells","volume":"60","author":"Abu Elhija","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"issue":"4","key":"10.1016\/j.jri.2023.103970_bib3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0897.2008.00636.x","article-title":"LPS increases the expression levels of IL-18, ICE and IL-18 R in mouse testes","volume":"60","author":"Abu Elhija","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2023.103970_bib4","first-page":"25","article-title":"Constitutive expression of IL-18 binding protein in murine testicular tissues and cells","volume":"19","author":"Abu Elhija","year":"2008","journal-title":"Eur. Cytokine Netw."},{"issue":"3","key":"10.1016\/j.jri.2023.103970_bib5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s15010-008-8203-z","article-title":"Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry","volume":"37","author":"Beale","year":"2009","journal-title":"Infection"},{"issue":"11","key":"10.1016\/j.jri.2023.103970_bib6","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.4049\/jimmunol.171.11.6164","article-title":"Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms","volume":"171","author":"Bruewer","year":"2003","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.jri.2023.103970_bib7","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.bbamem.2008.08.027","article-title":"Cytokine regulation of tight junctions","volume":"1788","author":"Capaldo","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.jri.2023.103970_bib8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1124\/pr.110.002790","article-title":"The blood-testis barrier and its implications for male contraception","volume":"64","author":"Cheng","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jri.2023.103970_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.theriogenology.2021.11.020","article-title":"The ameliorative effect of melatonin on LPS-induced Sertoli cells inflammatory and tight junctions damage via suppression of the TLR4\/MyD88\/NF-\u03baB signaling pathway in newborn calf","volume":"179","author":"Feng","year":"2022","journal-title":"Theriogenology"},{"issue":"6","key":"10.1016\/j.jri.2023.103970_bib10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000515740","article-title":"Intracellular and extracellular lipopolysaccharide signaling in sepsis: avenues for novel therapeutic strategies","volume":"13","author":"Gabarin","year":"2021","journal-title":"J. Innate. Immun."},{"issue":"6","key":"10.1016\/j.jri.2023.103970_bib11","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1093\/humrep\/deab026","article-title":"Semen impairment and occurrence of SARS-CoV-2 virus in semen after recovery from COVID-19","volume":"36","author":"Gacci","year":"2021","journal-title":"Hum. Reprod."},{"issue":"5","key":"10.1016\/j.jri.2023.103970_bib12","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000477419","article-title":"Update of sepsis in the intensive care unit","volume":"9","author":"Genga","year":"2017","journal-title":"J. Innate. Immun."},{"issue":"2","key":"10.1016\/j.jri.2023.103970_bib13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/nano9020139","article-title":"Differential cytotoxicity of different sizes of graphene oxide nanoparticles in leydig (TM3) and sertoli (TM4) cells","volume":"9","author":"Gurunathan","year":"2019","journal-title":"Nanomaterials (Basel)"},{"issue":"2","key":"10.1016\/j.jri.2023.103970_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1530\/REP-14-0427","article-title":"Endogenous interleukin 18 regulates testicular germ cell apoptosis during endotoxemia","volume":"150","author":"Inoue","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2023.103970_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103167","article-title":"Interleukin-18 levels and mouse Leydig cell apoptosis during lipopolysaccharide-induced acute inflammatory conditions","volume":"141","author":"Inoue","year":"2020","journal-title":"J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.jri.2023.103970_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.aucc.2021.04.010","article-title":"The effects of intensive care unit-initiated transitional care interventions on elements of post-intensive care syndrome: A systematic review and meta-analysis","volume":"35","author":"Johanna Josepha Op't Hoog","year":"2022","journal-title":"Aust. Crit. Care"},{"issue":"1","key":"10.1016\/j.jri.2023.103970_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1439-0272.2010.01090.x","article-title":"Presence of IL-18 in testicular tissue of fertile and infertile men","volume":"44","author":"Komsky","year":"2012","journal-title":"Andrologia"},{"issue":"2","key":"10.1016\/j.jri.2023.103970_bib18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbadis.2011.09.019","article-title":"Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury","volume":"1822","author":"Li","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jri.2023.103970_bib19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.reprotox.2015.11.003","article-title":"Anti-inflammatory potential of \u03b2-cryptoxanthin against LPS-induced inflammation in mouse Sertoli cells","volume":"60","author":"Liu","year":"2016","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.jri.2023.103970_bib20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40635-021-00423-6","article-title":"Molecular mechanisms of postintensive care syndrome","volume":"9","author":"Mart\u00edn-Vicente","year":"2021","journal-title":"Intensive Care Med. Exp."},{"issue":"2","key":"10.1016\/j.jri.2023.103970_bib21","doi-asserted-by":"crossref","DOI":"10.4161\/21565562.2014.979110","article-title":"Implications of Sertoli cell induced germ cell apoptosis to testicular pathology","volume":"4","author":"Murphy","year":"2015","journal-title":"Spermatogenesis"},{"issue":"2","key":"10.1016\/j.jri.2023.103970_bib22","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/CCM.0b013e318232da75","article-title":"Improving long-term outcomes after discharge from intensive care unit: report from a stakeholders' conference","volume":"40","author":"Needham","year":"2012","journal-title":"Crit. Care Med."},{"issue":"8","key":"10.1016\/j.jri.2023.103970_bib23","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41419-019-1782-z","article-title":"Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis","volume":"10","author":"Ni","year":"2019","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.jri.2023.103970_bib24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrmicro.2016.25","article-title":"Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model","volume":"14","author":"Okuda","year":"2016","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1016\/j.jri.2023.103970_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.866675","article-title":"Mechanisms of SARS-CoV-2 and male infertility: could connexin and pannexin play a role?","volume":"13","author":"Omolaoye","year":"2022","journal-title":"Front. Physiol."},{"issue":"6","key":"10.1016\/j.jri.2023.103970_bib26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1023\/B:BILE.0000019559.84305.47","article-title":"Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper--Excel-based tool using pair-wise correlations","volume":"26","author":"Pfaffl","year":"2004","journal-title":"Biotechnol. Lett."},{"issue":"10219","key":"10.1016\/j.jri.2023.103970_bib27","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jri.2023.103970_bib28","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3390\/antiox11030548","article-title":"COVID-19, oxidative stress and male reproduction: possible role of antioxidants","volume":"11","author":"Sengupta","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"1\u20132","key":"10.1016\/j.jri.2023.103970_bib29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mce.2005.05.011","article-title":"Interleukin-18 is expressed in rat testis and may promote germ cell growth","volume":"240","author":"Strand","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.jri.2023.103970_bib30","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/biolre\/ioy235","article-title":"Lipopolysaccharide-induced testicular dysfunction and epididymitis in mice: a critical role of tumor necrosis factor alpha","volume":"100","author":"Wang","year":"2019","journal-title":"Biol. Reprod."},{"issue":"11","key":"10.1016\/j.jri.2023.103970_bib31","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/mrd.22534","article-title":"Lipopolysaccharide-induced expression of FAS ligand in cultured immature boar sertoli cells through the regulation of pro-inflammatory cytokines and miR-187","volume":"82","author":"Wang","year":"2015","journal-title":"Mol. Reprod. Dev."},{"issue":"8","key":"10.1016\/j.jri.2023.103970_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009688","article-title":"Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function","volume":"17","author":"Yamamuro","year":"2021","journal-title":"PLoS. Genet."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823001766?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823001766?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:34:08Z","timestamp":1759034048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037823001766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":32,"alternative-id":["S0165037823001766"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2023.103970","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2023.103970","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103970"}}