{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T02:31:39Z","timestamp":1786761099732,"version":"build-2736575974"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC0206500"],"award-info":[{"award-number":["2017YFC0206500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271713"],"award-info":[{"award-number":["82271713"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970859"],"award-info":[{"award-number":["31970859"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630036"],"award-info":[{"award-number":["81630036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jri.2023.103980","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T19:29:48Z","timestamp":1686857388000},"page":"103980","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The unique expression pattern of human leukocyte antigen in trophoblasts potentially explains the key mechanism of maternal-fetal tolerance and successful pregnancy"],"prefix":"10.1016","volume":"158","author":[{"given":"Lijin","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingxuan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2023.103980_bib1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/humupd\/dmaa017","article-title":"Investigation of human trophoblast invasion in vitro","volume":"26","author":"Abbas","year":"2020","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2023.103980_bib2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41590-018-0280-2","article-title":"Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells","volume":"20","author":"Akkaya","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/imr.13087","article-title":"Immunity at maternal-fetal interface: KIR\/HLA (Allo)recognition","volume":"308","author":"Alexandrova","year":"2022","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jri.2023.103980_bib4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ni1037","article-title":"Regulatory T cells mediate maternal tolerance to the fetus","volume":"5","author":"Aluvihare","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/jcs.175943","article-title":"Embryo-epithelium interactions during implantation at a glance","volume":"130","author":"Aplin","year":"2017","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jri.2023.103980_bib6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking placental development in health and disease","volume":"16","author":"Aplin","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jri.2023.103980_bib7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2567.2008.03019.x","article-title":"Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies","volume":"127","author":"Apps","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.jri.2023.103980_bib8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nm.3160","article-title":"Fetomaternal immune cross-talk and its consequences for maternal and offspring's health","volume":"19","author":"Arck","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2023.103980_bib9","first-page":"21","article-title":"The molecular and functional characteristics of HLA-G and the interaction with its receptors: where to intervene for cancer immunotherapy?","author":"Attia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jri.2023.103980_bib10","doi-asserted-by":"crossref","unstructured":"Auriti, C., De Rose, D.U., Santisi, A., Martini, L., Piersigilli, F., Bersani, I., Ronchetti, M.P. & Caforio, L., 2021. Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus. Biochim Biophys Acta Mol Basis Dis, 1867, 166198. \u3008https:\/\/doi.org\/10.1016\/j.bbadis.2021.166198\u3009.","DOI":"10.1016\/j.bbadis.2021.166198"},{"key":"10.1016\/j.jri.2023.103980_bib11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0165-0378(00)00070-X","article-title":"HLA-G suppresses proliferation of CD4(+) T-lymphocytes","volume":"48","author":"Bainbridge","year":"2000","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/172603a0","article-title":"Actively acquired tolerance of foreign cells","volume":"172","author":"Billingham","year":"1953","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.103980_bib13","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.4049\/jimmunol.172.10.5893","article-title":"Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1\/Th2 cytokine profile","volume":"172","author":"Blois","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ajog.2019.05.044","article-title":"Placental bed research: I. The placental bed: from spiral arteries remodeling to the great obstetrical syndromes","volume":"221","author":"Brosens","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"385\u2013401","key":"10.1016\/j.jri.2023.103980_bib15","article-title":"An evolutionarily conserved function of polycomb silences the MHC Class I antigen presentation pathway and enables immune evasion in cancer","volume":"36","author":"Burr","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jri.2023.103980_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/vim.2019.0076","article-title":"Protective and pathogenic effects of interferon signaling during pregnancy","volume":"33","author":"Casazza","year":"2020","journal-title":"Viral Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12920-019-0544-1","article-title":"Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes","volume":"12","author":"Castro","year":"2019","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.jri.2023.103980_bib18","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/humupd\/dmac017","article-title":"Immunotherapies to optimize pregnancy outcomes in subfertile women","volume":"28","author":"Cavalcante","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2023.103980_bib19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.gde.2017.08.004","article-title":"The inflammation paradox in the evolution of mammalian pregnancy: turning a foe into a friend","volume":"47","author":"Chavan","year":"2017","journal-title":"Curr. Opin. Genet Dev."},{"key":"10.1016\/j.jri.2023.103980_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.656701","article-title":"The endometrial immune profiling may positively affect the management of recurrent pregnancy loss","volume":"12","author":"Cheloufi","year":"2021","journal-title":"Front. Immunol."},{"issue":"658\u2013671","key":"10.1016\/j.jri.2023.103980_bib21","article-title":"DUX4 suppresses MHC Class I to promote cancer immune evasion and resistance to checkpoint blockade","volume":"50","author":"Chew","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jri.2023.103980_bib22","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/humupd\/dmz015","article-title":"Potential genetic causes of miscarriage in euploid pregnancies: a systematic review","volume":"25","author":"Colley","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2023.103980_bib23","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/44853","article-title":"Complete sequence and gene map of a human major histocompatibility complex","volume":"401","author":"Consortium., T. M. S","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.103980_bib24","first-page":"12","article-title":"MHC class I downregulation in cancer: underlying mechanisms and potential targets for cancer immunotherapy","author":"Cornel","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.jri.2023.103980_bib25","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3324\/haematol.2017.184192","article-title":"Hide or defend, the two strategies of lymphoma immune evasion: potential implications for immunotherapy","volume":"103","author":"De Charette","year":"2018","journal-title":"Haematologica"},{"key":"10.1016\/j.jri.2023.103980_bib26","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.4049\/jimmunol.1901435","article-title":"Human term pregnancy decidual NK cells generate distinct cytotoxic responses","volume":"204","author":"De Mendon\u00e7a Vieira","year":"2020","journal-title":"J. Immunol."},{"issue":"116\u2013131","key":"10.1016\/j.jri.2023.103980_bib27","article-title":"Genome-wide screens identify lineage- and tumor-specific genes modulating MHC-I- and MHC-II-restricted immunosurveillance of human lymphomas","volume":"54","author":"Dersh","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.103980_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-pathmechdis-012418-012743","article-title":"Immunological basis for recurrent fetal loss and pregnancy complications","volume":"14","author":"Deshmukh","year":"2019","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jri.2023.103980_bib29","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/humupd\/dmaa062","article-title":"Uterine natural killer cells: from foe to friend in reproduction","volume":"27","author":"D\u00edaz-Hern\u00e1ndez","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2023.103980_bib30","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41572-020-00228-z","article-title":"Recurrent pregnancy loss","volume":"6","author":"Dimitriadis","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jri.2023.103980_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.758281","article-title":"Crosstalk between trophoblast and macrophage at the maternal-fetal interface: current status and future perspectives","volume":"12","author":"Ding","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib32","doi-asserted-by":"crossref","first-page":"9864","DOI":"10.1073\/pnas.142298299","article-title":"Characterization of the expression of MHC proteins in human embryonic stem cells","volume":"99","author":"Drukker","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jri.2023.103980_bib33","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.4049\/jimmunol.1203425","article-title":"Embryonic trophoblasts induce decidual regulatory T cell differentiation and maternal-fetal tolerance through thymic stromal lymphopoietin instructing dendritic cells","volume":"192","author":"Du","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib34","first-page":"219","article-title":"Toward an understanding of allogeneic conflict in pregnancy and transplantation","author":"Durgam","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2023.103980_bib35","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1158\/2159-8290.CD-18-1090","article-title":"Molecular and genetic characterization of MHC deficiency identifies EZH2 as therapeutic target for enhancing immune recognition","volume":"9","author":"Ennishi","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jri.2023.103980_bib36","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.it.2017.01.009","article-title":"HLA-G: at the interface of maternal-fetal tolerance","volume":"38","author":"Ferreira","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib37","doi-asserted-by":"crossref","unstructured":"Gobin, S.J.P., 1999. The regulation of HLA class I expression is HLA-G the odd one out.","DOI":"10.1006\/scbi.1998.0109"},{"key":"10.1016\/j.jri.2023.103980_bib38","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.4049\/jimmunol.163.3.1428","article-title":"Transactivation of classical and nonclassical HLA Class I genes through the IFN-stimulated response element","volume":"163","author":"Gobin","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib39","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41385-021-00451-1","article-title":"Characterisation of peri-implantation endometrial Treg and identification of an altered phenotype in recurrent pregnancy loss","volume":"15","author":"Granne","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib40","doi-asserted-by":"crossref","unstructured":"Gu, S.S., Zhang, W., Wang, X., Jiang, P., Traugh, N., Li, Z., Meyer, C., Stewig, B., Xie, Y., Bu, X., Manos, M.P., Font-Tello, A., Gjini, E., Lako, A., Lim, K., Conway, J., Tewari, A.K., Zeng, Z., Sahu, A.D., Tokheim, C., Weirather, J.L., Fu, J., Zhang, Y., Kroger, B., Liang, J.H., Cejas, P., Freeman, G.J., Rodig, S., Long, H.W., Gewurz, B.E., Hodi, F.S., Brown, M. & Liu, X.S.. 2021. Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade. Cancer Discov., 11, 1524\u20131541.https:\/\/doi.org\/10.1158\/2159\u20138290.CD-20\u20130812.","DOI":"10.1158\/2159-8290.CD-20-0812"},{"key":"10.1016\/j.jri.2023.103980_bib41","first-page":"77","article-title":"Definitive class I human leukocyte antigen expression in gestational placentation: HLA-F, HLA-E, HLA-C, and HLA-G in extravillous trophoblast invasion on placentation, pregnancy, and parturition","author":"Hackmon","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib42","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1452","article-title":"Decidual NK cells regulate key developmental processes at the human fetal-maternal interface","volume":"12","author":"Hanna","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2023.103980_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.765730","article-title":"The new old CD8+ T cells in the immune paradox of pregnancy","volume":"12","author":"Hardardottir","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib44","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0025-6196(11)60669-1","article-title":"Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents","volume":"84","author":"Holtan","year":"2009","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.jri.2023.103980_bib45","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1158\/1078-0432.CCR-17-2483","article-title":"The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression","volume":"24","author":"Huang","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jri.2023.103980_bib46","doi-asserted-by":"crossref","first-page":"8254289","DOI":"10.1155\/2017\/8254289","article-title":"Modulatory mechanism of polyphenols and Nrf2 signaling pathway in LPS challenged pregnancy disorders","volume":"2017","author":"Hussain","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"issue":"1023\u20131039","key":"10.1016\/j.jri.2023.103980_bib47","article-title":"Capturing human trophoblast development with naive pluripotent stem cells in vitro","volume":"28","author":"Io","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jri.2023.103980_bib48","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3389\/fimmu.2019.01397","article-title":"Features of human decidual NK cells in healthy pregnancy and during viral infection","volume":"10","author":"Jabrane-Ferrat","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib49","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41568-021-00339-z","article-title":"Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion","volume":"21","author":"Jhunjhunwala","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jri.2023.103980_bib50","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3389\/fimmu.2019.00911","article-title":"The tolerogenic function of regulatory T cells in pregnancy and cancer","volume":"10","author":"Jorgensen","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib51","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40364-020-00228-x","article-title":"Roles of IFN-\u03b3 in tumor progression and regression: a review","volume":"8","author":"Jorgovanovic","year":"2020","journal-title":"Biomark. Res."},{"key":"10.1016\/j.jri.2023.103980_bib52","doi-asserted-by":"crossref","first-page":"S803","DOI":"10.1016\/j.ajog.2017.11.575","article-title":"A placenta clinic approach to the diagnosis and management of fetal growth restriction","volume":"218","author":"Kingdom","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2023.103980_bib53","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","article-title":"Human placenta and trophoblast development: key molecular mechanisms and model systems","volume":"76","author":"Knofler","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jri.2023.103980_bib54","first-page":"78","article-title":"Endometrial immune markers are potential predictors of normal fertility and pregnancy after in vitro fertilization","author":"Kofod","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib55","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMra1213566","article-title":"Pregnancy and infection","volume":"370","author":"Kourtis","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jri.2023.103980_bib56","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.2326636","article-title":"A class I antigen, HLA-G, expressed in human trophoblasts","volume":"248","author":"Kovats","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.jri.2023.103980_bib57","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1093\/humrep\/der301","article-title":"An imbalance in interleukin-17-producing T and Foxp3\u207a regulatory T cells in women with idiopathic recurrent pregnancy loss","volume":"26","author":"Lee","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2023.103980_bib58","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1182\/blood-2006-05-024547","article-title":"Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells","volume":"109","author":"Lemaoult","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jri.2023.103980_bib59","first-page":"118","article-title":"ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts","author":"Li","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jri.2023.103980_bib60","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/08830185.2020.1777292","article-title":"Pregnancy immune tolerance at the maternal-fetal interface","volume":"39","author":"Li","year":"2020","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib61","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.7150\/ijbs.73616","article-title":"Human leukocyte antigens: the unique expression in trophoblasts and their crosstalk with local immune cells","volume":"18","author":"Lin","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jri.2023.103980_bib62","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12967-020-02371-3","article-title":"Decidual CD8(+)T cells exhibit both residency and tolerance signatures modulated by decidual stromal cells","volume":"18","author":"Liu","year":"2020","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jri.2023.103980_bib63","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1300567","article-title":"HLA-G5 induces IL-4 secretion critical for successful pregnancy through differential expression of ILT2 receptor on decidual CD4\u207a T cells and macrophages","volume":"191","author":"Lombardelli","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib64","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1016\/j.celrep.2018.06.043","article-title":"Fine-Tuned and cell-cycle-restricted expression of fusogenic protein syncytin-2 maintains functional placental syncytia","volume":"23","author":"Lu","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jri.2023.103980_bib65","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12802","article-title":"Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation","volume":"53","author":"Ma","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.jri.2023.103980_bib66","first-page":"320","article-title":"Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates","volume":"7","author":"Medawar","year":"1953","journal-title":"Symp. Soc. Exp. Biol."},{"key":"10.1016\/j.jri.2023.103980_bib67","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/83183","article-title":"Prevention of T cell\u2013driven complement activation and inflammation by tryptophan catabolism during pregnancy","volume":"2","author":"Mellor","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib68","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.clim.2017.09.004","article-title":"HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients","volume":"183","author":"Melsted","year":"2017","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib69","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cellimm.2017.11.008","article-title":"The choriocarcinoma cell line JEG-3 upregulates regulatory T cell phenotypes and modulates pro-inflammatory cytokines through HLA-G","volume":"324","author":"Melsted","year":"2018","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib70","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/35001608","article-title":"Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis","volume":"403","author":"Mi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.103980_bib71","first-page":"3","article-title":"Majority of B2M-mutant and -deficient colorectal carcinomas achieve clinical benefit from immune checkpoint inhibitor therapy and are microsatellite instability-high","author":"Middha","year":"2019","journal-title":"JCO Precis Oncol."},{"key":"10.1016\/j.jri.2023.103980_bib72","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41423-020-0471-2","article-title":"Maternal and fetal T cells in term pregnancy and preterm labor","volume":"17","author":"Miller","year":"2020","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib73","doi-asserted-by":"crossref","first-page":"11315","DOI":"10.1038\/s41598-017-11803-y","article-title":"IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation","volume":"7","author":"Mitchell","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jri.2023.103980_bib74","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nri1897","article-title":"Immunology of placentation in eutherian mammals","volume":"6","author":"Moffett","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib75","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nri886","article-title":"Natural killer cells and pregnancy","volume":"2","author":"Moffett-King","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib76","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/icb.2017.41","article-title":"An immunogenic phenotype in paternal antigen-specific CD8(+) T cells at embryo implantation elicits later fetal loss in mice","volume":"95","author":"Moldenhauer","year":"2017","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jri.2023.103980_bib77","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41581-018-0039-x","article-title":"HLA in transplantation","volume":"14","author":"Montgomery","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jri.2023.103980_bib78","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3389\/fimmu.2020.01082","article-title":"Analysis of TCR repertoire and PD-1 expression in decidual and peripheral CD8(+) T cells reveals distinct immune mechanisms in miscarriage and preeclampsia","volume":"11","author":"Morita","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.866937","article-title":"Pregnancy and tumour: the parallels and differences in regulatory T cells","volume":"13","author":"Muralidhara","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib80","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/humupd\/dmac007","article-title":"HLA Class Ib-receptor interactions during embryo implantation and early pregnancy","volume":"28","author":"Nilsson","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2023.103980_bib81","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00018-022-04363-6","article-title":"Transcription factor networks in trophoblast development","volume":"79","author":"Papuchova","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jri.2023.103980_bib82","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1038\/s41467-018-06300-3","article-title":"Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA","volume":"9","author":"Paulson","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jri.2023.103980_bib83","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00251-017-0988-4","article-title":"HLA class Ib in pregnancy and pregnancy-related disorders","volume":"69","author":"Persson","year":"2017","journal-title":"Immunogenetics"},{"key":"10.1016\/j.jri.2023.103980_bib84","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/2006","article-title":"Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions","volume":"4","author":"Piccinni","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2023.103980_bib85","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.3389\/fimmu.2018.02597","article-title":"Regulation of placental extravillous trophoblasts by the maternal uterine environment","volume":"9","author":"Pollheimer","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib86","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(21)00682-6","article-title":"Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2023.103980_bib87","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/smim.2001.0316","article-title":"Pregnancy: success and failure within the Th1\/Th2\/Th3 paradigm","volume":"13","author":"Raghupathy","year":"2001","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib88","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/cmi.2014.53","article-title":"HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction","volume":"11","author":"Rajagopalan","year":"2014","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib89","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1084\/jem.189.7.1093","article-title":"A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells","volume":"189","author":"Rajagopalan","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2023.103980_bib90","first-page":"219","article-title":"Trophoblast antigens, fetal blood cell antigens, and the paradox of fetomaternal tolerance","author":"Rizzuto","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2023.103980_bib91","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1172\/JCI122182","article-title":"Regulatory T cells in embryo implantation and the immune response to pregnancy","volume":"128","author":"Robertson","year":"2018","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.jri.2023.103980_bib92","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fimmu.2019.00478","article-title":"Therapeutic potential of regulatory T cells in preeclampsia-opportunities and challenges","volume":"10","author":"Robertson","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib93","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/molehr\/gax043","article-title":"Apposition to endometrial epithelial cells activates mouse blastocysts for implantation","volume":"23","author":"Ruane","year":"2017","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2023.103980_bib94","doi-asserted-by":"crossref","unstructured":"Salvany-Celades, M., Van Der Zwan, A., Benner, M., Setrajcic-Dragos, V., Bougleux GomeS., H.A., Iyer, V., Norwitz, E.R.., Strominger, J.L. & Tilburgs, T., 2019. Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface. Cell Rep, 27, 2537\u20132547.e5. \u3008https:\/\/doi.org\/10.1016\/j.celrep.2019.04.109\u3009.","DOI":"10.1016\/j.celrep.2019.04.109"},{"key":"10.1016\/j.jri.2023.103980_bib95","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.4049\/jimmunol.0901154","article-title":"Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia","volume":"183","author":"Santner-Nanan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib96","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell Physiol."},{"issue":"1231\u20131244","key":"10.1016\/j.jri.2023.103980_bib97","article-title":"The CD94\/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice","volume":"54","author":"Shreeve","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.103980_bib98","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/nbt.3344","article-title":"Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes","volume":"33","author":"Shukla","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jri.2023.103980_bib99","article-title":"Placental immune tolerance and organ transplantation: underlying interconnections and clinical implications","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib100","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.humimm.2012.06.007","article-title":"Full-length HLA-G1 and truncated HLA-G3 differentially increase HLA-E surface localization","volume":"73","author":"Teklemariam","year":"2012","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib101","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jri.2018.06.024","article-title":"HLA-DR is aberrantly expressed at feto-maternal interface in pre-eclampsia","volume":"129","author":"Tersigni","year":"2018","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib102","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jri.2009.05.003","article-title":"Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells","volume":"82","author":"Tilburgs","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib103","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1073\/pnas.1507977112","article-title":"Human HLA-G+ extravillous trophoblasts: immune-activating cells that interact with decidual leukocytes","volume":"112","author":"Tilburgs","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jri.2023.103980_bib104","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1073\/pnas.1517724112","article-title":"The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface","volume":"112","author":"Tilburgs","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jri.2023.103980_bib105","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/biolre\/iox009","article-title":"NLRP2 is a suppressor of NF-\u0199B signaling and HLA-C expression in human trophoblasts\u2020","volume":"96","author":"Tilburgs","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2023.103980_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103098","article-title":"NK cell subsets in idiopathic recurrent miscarriage and renal transplant patients","volume":"138","author":"Toth","year":"2020","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib107","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3389\/fimmu.2019.00573","article-title":"New paradigm in the role of regulatory T cells during pregnancy","volume":"10","author":"Tsuda","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib108","first-page":"146","article-title":"Development of the human placenta","author":"Turco","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.jri.2023.103980_bib109","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.3389\/fimmu.2018.01897","article-title":"Human innate lymphoid cells: their functional and cellular interactions in decidua","volume":"9","author":"Vacca","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib110","first-page":"22","article-title":"A critical assessment of the association between HLA-G expression by carcinomas and clinical outcome","author":"Van De Water","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jri.2023.103980_bib111","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.103980_bib112","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00251-019-01106-z","article-title":"Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance","volume":"71","author":"Vijayan","year":"2019","journal-title":"Immunogenetics"},{"key":"10.1016\/j.jri.2023.103980_bib113","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.gpb.2020.11.002","article-title":"Single-cell immune landscape of human recurrent miscarriage","volume":"19","author":"Wang","year":"2021","journal-title":"Genom. Proteom. Bioinforma."},{"key":"10.1016\/j.jri.2023.103980_bib114","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3389\/fimmu.2020.02025","article-title":"T Helper (Th) Cell profiles in pregnancy and recurrent pregnancy losses: Th1\/Th2\/Th9\/Th17\/Th22\/Tfh cells","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib115","article-title":"Crosstalk between trophoblasts and decidual immune cells: the cornerstone of maternal-fetal immunotolerance","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib116","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.592010","article-title":"Roles of HLA-G in the maternal-fetal immune microenvironment","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib117","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41586-020-2229-5","article-title":"Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I","volume":"581","author":"Yamamoto","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.103980_bib118","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","article-title":"Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib119","doi-asserted-by":"crossref","first-page":"792","DOI":"10.3389\/fimmu.2019.00792","article-title":"Macrophage polarization in physiological and pathological pregnancy","volume":"10","author":"Yao","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib120","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.immuni.2018.07.017","article-title":"Interferons and proinflammatory cytokines in pregnancy and fetal development","volume":"49","author":"Yockey","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.103980_bib121","article-title":"Role of decidual natural killer cells in human pregnancy and related pregnancy complications","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.103980_bib122","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.7150\/ijbs.70629","article-title":"Immunologic memory in pregnancy: focusing on memory regulatory T cells","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823001869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823001869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:28:06Z","timestamp":1777494486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037823001869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":122,"alternative-id":["S0165037823001869"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2023.103980","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The unique expression pattern of human leukocyte antigen in trophoblasts potentially explains the key mechanism of maternal-fetal tolerance and successful pregnancy","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2023.103980","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103980"}}