{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:01:40Z","timestamp":1790226100826,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"am","delay-in-days":315,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009633","name":"NICHD","doi-asserted-by":"publisher","award":["1K99HD101653"],"award-info":[{"award-number":["1K99HD101653"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jri.2023.103988","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T20:58:03Z","timestamp":1688763483000},"page":"103988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating I\u03baB\u03b1"],"prefix":"10.1016","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7378-8033","authenticated-orcid":false,"given":"Mancy","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacy N.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon D.","family":"Whirledge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikki M.","family":"Abrahams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2023.103988_bib1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2023.103988_bib2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fimmu.2018.00208","article-title":"Uterine Microbiota: Residents, Tourists, or Invaders?","volume":"9","author":"Baker","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.jri.2023.103988_bib3","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1210\/jc.2003-031351","article-title":"Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures","volume":"89","author":"Bauer","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl 2","key":"10.1016\/j.jri.2023.103988_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/jmf.16.2.9.12","article-title":"Cervicovaginal infections during pregnancy: epidemiological and microbiological aspects","volume":"16","author":"Benedetto","year":"2004","journal-title":"J. Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jri.2023.103988_bib5","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1038\/srep03894","article-title":"Uterine selection of human embryos at implantation","volume":"4","author":"Brosens","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jri.2023.103988_bib6","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1177\/1933719113508817","article-title":"Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment","volume":"21","author":"Cicinelli","year":"2014","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.jri.2023.103988_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12862","article-title":"Prevalence of HHV-6 in endometrium from women with recurrent implantation failure","volume":"80","author":"Coulam","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103988_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0266144","article-title":"Anti-inflammatory effects of progesterone through NF-kappaB and MAPK pathway in lipopolysaccharide- or Escherichia coli-stimulated bovine endometrial stromal cells","volume":"17","author":"Cui","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2023.103988_bib9","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/molehr\/gax037","article-title":"Deregulation of the endometrial stromal cell secretome precedes embryo implantation failure","volume":"23","author":"Durairaj","year":"2017","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2023.103988_bib10","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/mi.2008.20","article-title":"Estradiol selectively regulates innate immune function by polarized human uterine epithelial cells in culture","volume":"1","author":"Fahey","year":"2008","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jri.2023.103988_bib11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1600-0897.2010.00949.x","article-title":"New approaches to making the microenvironment of the female reproductive tract hostile to HIV","volume":"65","author":"Fahey","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103988_bib12","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/humrep\/deh775","article-title":"Characterization of Toll-like receptors in the female reproductive tract in humans","volume":"20","author":"Fazeli","year":"2005","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2023.103988_bib13","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jri.2023.103988_bib14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/humupd\/dmv041","article-title":"The role of infection in miscarriage","volume":"22","author":"Giakoumelou","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2023.103988_bib15","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1210\/me.2006-0118","article-title":"Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization","volume":"20","author":"Kajihara","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jri.2023.103988_bib16","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1210\/en.2003-1606","article-title":"A novel immortalized human endometrial stromal cell line with normal progestational response","volume":"145","author":"Krikun","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jri.2023.103988_bib17","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5653\/cerm.2011.38.3.119","article-title":"Role of endometrial immune cells in implantation","volume":"38","author":"Lee","year":"2011","journal-title":"Clin. Exp. Reprod. Med"},{"key":"10.1016\/j.jri.2023.103988_bib18","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1096\/fj.09-149153","article-title":"Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals","volume":"24","author":"Leitao","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.jri.2023.103988_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/humupd\/dmad013","article-title":"Endometrial responses to bacterial and viral infection: a scoping review","author":"Lindsay","year":"2023","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2023.103988_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158304","article-title":"Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility","volume":"11","author":"Marci","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2023.103988_bib21","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ajog.2016.09.075","article-title":"Evidence that the endometrial microbiota has an effect on implantation success or failure","volume":"215","author":"Moreno","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2023.103988_bib22","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00281-016-0574-0","article-title":"The decidua-the maternal bed embracing the embryo-maintains the pregnancy","volume":"38","author":"Mori","year":"2016","journal-title":"Semin Immunopathol."},{"key":"10.1016\/j.jri.2023.103988_bib23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/rmb2.12088","article-title":"Decidualization of the human endometrium","volume":"17","author":"Okada","year":"2018","journal-title":"Reprod. Med Biol."},{"key":"10.1016\/j.jri.2023.103988_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1371\/journal.pone.0035654","article-title":"Uterine Epithelial Cells Specifically Induce Interferon-Stimulated Genes in Response to Polyinosinic-Polycytidylic Acid Independently of Estradiol","volume":"7","author":"Patel","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jri.2023.103988_bib25","first-page":"3954","article-title":"Uterine DCs are crucial for decidua formation during embryo implantation in mice","volume":"118","author":"Plaks","year":"2008","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.jri.2023.103988_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0163-7258(03)00016-0","article-title":"The p38 mitogen-activated protein kinase pathway and its role in interferon signaling","volume":"98","author":"Platanias","year":"2003","journal-title":"Pharm. Ther."},{"key":"10.1016\/j.jri.2023.103988_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010287","article-title":"Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss","volume":"5","author":"Salker","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2023.103988_bib28","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/nm.2498","article-title":"Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure","volume":"17","author":"Salker","year":"2011","journal-title":"Nat. Med"},{"key":"10.1016\/j.jri.2023.103988_bib29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/humupd\/dmt056","article-title":"Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis","volume":"20","author":"Seshadri","year":"2014","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2023.103988_bib30","first-page":"9","article-title":"The Role of Uterine Natural Killer Cells on Recurrent Miscarriage and Recurrent Implantation Failure: From Pathophysiology to Treatment","author":"Sfakianoudis","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jri.2023.103988_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/jmcb\/mjs058","article-title":"Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells","volume":"5","author":"Shah","year":"2013","journal-title":"J. Mol. Cell Biol."},{"issue":"Suppl A","key":"10.1016\/j.jri.2023.103988_bib32","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1016\/j.placenta.2006.12.002","article-title":"The role of oxygen radical-mediated signaling pathways in endometrial function","volume":"28","author":"Sugino","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2023.103988_bib33","doi-asserted-by":"crossref","first-page":"E719","DOI":"10.1210\/jc.2011-3251","article-title":"Progesterone receptor-A and -B have opposite effects on proinflammatory gene expression in human myometrial cells: implications for progesterone actions in human pregnancy and parturition","volume":"97","author":"Tan","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2023.103988_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ogc.2019.10.006","article-title":"Immunology of the Placenta","volume":"47","author":"Tong","year":"2020","journal-title":"Obstet. Gynecol. Clin. North Am."},{"key":"10.1016\/j.jri.2023.103988_bib35","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1900262","article-title":"Lipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps","author":"Tong","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2023.103988_bib36","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/art.42068","article-title":"Antiphospholipid Antibodies Increase Endometrial Stromal Cell Decidualization, Senescence, and Inflammation via Toll-like Receptor 4, Reactive Oxygen Species, and p38 MAPK Signaling","volume":"74","author":"Tong","year":"2022","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.jri.2023.103988_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8689436","article-title":"Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity","volume":"2016","author":"Vinketova","year":"2016","journal-title":"J. Pregnancy"},{"key":"10.1016\/j.jri.2023.103988_bib38","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/humupd\/dmac006","article-title":"Number and function of uterine natural killer cells in recurrent miscarriage and implantation failure: a systematic review and meta-analysis","volume":"28","author":"Von Woon","year":"2022","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2023.103988_bib39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/aji.12168","article-title":"Progesterone Activates Multiple Innate Immune Pathways in Chlamydia trachomatis-Infected Endocervical Cells","volume":"71","author":"Wan","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.103988_bib40","doi-asserted-by":"crossref","first-page":"15166","DOI":"10.1073\/pnas.1508056112","article-title":"Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization","volume":"112","author":"Whirledge","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jri.2023.103988_bib41","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1097\/QAD.0b013e3283060ea4","article-title":"A new strategy to understand how HIV infects women: identification of a window of vulnerability during the menstrual cycle","volume":"22","author":"Wira","year":"2008","journal-title":"AIDS"},{"key":"10.1016\/j.jri.2023.103988_bib42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.placenta.2010.12.005","article-title":"TNF-alpha inhibits trophoblast integration into endothelial cellular networks","volume":"32","author":"Xu","year":"2011","journal-title":"Placenta"}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823001948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823001948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:33:21Z","timestamp":1759034001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037823001948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":42,"alternative-id":["S0165037823001948"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2023.103988","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decidualization dampens toll-like receptor mediated inflammatory responses in human endometrial stromal cells by upregulating I\u03baB\u03b1","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2023.103988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103988"}}