{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:21:00Z","timestamp":1774462860788,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008363","name":"Sichuan Agricultural University","doi-asserted-by":"publisher","award":["00770107"],"award-info":[{"award-number":["00770107"]}],"id":[{"id":"10.13039\/501100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jri.2023.104132","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T11:48:31Z","timestamp":1691581711000},"page":"104132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Active immunization against gonadotropin-releasing hormone affects thymic T cell production, migration, and colonization in male rat lymphoid tissue"],"prefix":"10.1016","volume":"159","author":[{"given":"Dong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinfa","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengyan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guixian","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanli","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzeng","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2023.104132_bib1","doi-asserted-by":"crossref","first-page":"188730","DOI":"10.1016\/j.bbcan.2022.188730","article-title":"Recent thymic emigrants as the bridge between thymoma and autoimmune diseases","volume":"1877","author":"Ao","year":"2022","journal-title":"Biochim. Biophys. Acta Rev. Cancer."},{"key":"10.1016\/j.jri.2023.104132_bib2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11010-017-2989-x","article-title":"Sex and age as determinants of rat t-cell phenotypic characteristics: influence of peripubertal gonadectomy","volume":"431","author":"Arsenovi\u0107-Ranin","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jri.2023.104132_bib3","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1242\/dev.103614","article-title":"Regeneration of the aged thymus by a single transcription factor","volume":"141","author":"Bredenkamp","year":"2014","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.jri.2023.104132_bib4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri2991","article-title":"Epigenetics of haematopoietic cell development","volume":"11","author":"Cedar","year":"2011","journal-title":"Nat. Rev. Immunol.."},{"key":"10.1016\/j.jri.2023.104132_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/imr.12418","article-title":"Thymus: the next (re)generation","volume":"271","author":"Chaudhry","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jri.2023.104132_bib6","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood-2008-05-156265","article-title":"Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner","volume":"113","author":"Chen","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jri.2023.104132_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2017.12.006","article-title":"Reinterpreting recent thymic emigrant function: defective or adaptive?","volume":"51","author":"Cunningham","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jri.2023.104132_bib8","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1172\/JCI30248","article-title":"Ghrelin promotes thymopoiesis during aging","volume":"117","author":"Dixit","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jri.2023.104132_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-4877.2010.00185.x","article-title":"Review of issues concerning the use of reproductive inhibitors, with particular emphasis on resolving human-wildlife conflicts in north america","volume":"5","author":"Fagerstone","year":"2010","journal-title":"Integr. Zool."},{"key":"10.1016\/j.jri.2023.104132_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-immunol-032712-100010","article-title":"The biology of recent thymic emigrants","volume":"31","author":"Fink","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jri.2023.104132_bib11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev-cellbio-111315-125324","article-title":"Tcr signal strength and t cell development","volume":"32","author":"Gascoigne","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.jri.2023.104132_bib12","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1097\/01.tp.0000183962.64777.da","article-title":"Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation","volume":"80","author":"Goldberg","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.jri.2023.104132_bib13","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.4049\/jimmunol.178.11.7473","article-title":"Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation","volume":"178","author":"Goldberg","year":"2007","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.jri.2023.104132_bib14","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1002\/1521-4141(200009)30:9<2586::AID-IMMU2586>3.0.CO;2-L","article-title":"Sex steroids induce apoptosis of cd8+cd4+ double-positive thymocytes via tnf-alpha","volume":"30","author":"Guevara Pati\u00f1o","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jri.2023.104132_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.theriogenology.2019.03.017","article-title":"Mechanistic insight into the role of immunocastration on eliminating skatole in boars","volume":"131","author":"Han","year":"2019","journal-title":"Theriogenology"},{"key":"10.1016\/j.jri.2023.104132_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.4103\/1008-682X.156856","article-title":"Active immunization with gnrh-tandem-dimer peptide in young male rats reduces serum reproductive hormone concentrations, testicular development and spermatogenesis","volume":"18","author":"Han","year":"2016","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.jri.2023.104132_bib17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1385\/IR:22:2-3:253","article-title":"The human thymus during aging","volume":"22","author":"Haynes","year":"2000","journal-title":"Immunol. Res."},{"key":"10.1016\/j.jri.2023.104132_bib18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cellimm.2007.10.007","article-title":"The role of sex steroids and gonadectomy in the control of thymic involution","volume":"252","author":"Hince","year":"2008","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jri.2023.104132_bib19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1600-065X.2010.00954.x","article-title":"From the cradle to the grave: activities of gata-3 throughout t-cell development and differentiation","volume":"238","author":"Hosoya","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jri.2023.104132_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152767","article-title":"Changes induced by chronic exposure to high arsenic concentrations in the intestine and its microenvironment","volume":"456","author":"Li","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.jri.2023.104132_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153532","article-title":"Thallium exposure induces changes in b and t cell generation in mice","volume":"492","author":"Li","year":"2023","journal-title":"Toxicology"},{"key":"10.1016\/j.jri.2023.104132_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1084\/jem.194.2.127","article-title":"Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development","volume":"194","author":"Lind","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2023.104132_bib23","doi-asserted-by":"crossref","first-page":"20052","DOI":"10.7448\/IAS.18.1.20052","article-title":"Cd4:Cd8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed hiv-positive patients","volume":"18","author":"Lu","year":"2015","journal-title":"J. Int. AIDS Soc."},{"key":"10.1016\/j.jri.2023.104132_bib24","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000356827","article-title":"The inverted cd4:Cd8 ratio is associated with cytomegalovirus, poor cognitive and functional states in older adults","volume":"21","author":"Luz Correa","year":"2014","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.jri.2023.104132_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.clim.2005.08.015","article-title":"Reassessing the role of growth hormone and sex steroids in thymic involution","volume":"118","author":"Min","year":"2006","journal-title":"Clin. Immunol. (Orlando, Fla.)"},{"key":"10.1016\/j.jri.2023.104132_bib26","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/S0264-410X(98)80101-1","article-title":"New gnrh-like peptide construct to optimize efficient immunocastration of male pigs by immunoneutralization of gnrh","volume":"16","author":"Oonk","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/j.jri.2023.104132_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrendo.2015.168","article-title":"Hormonal control of t-cell development in health and disease","volume":"12","author":"Savino","year":"2016","journal-title":"Nat. Rev. Endocrinol.."},{"key":"10.1016\/j.jri.2023.104132_bib28","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.4049\/jimmunol.1302259","article-title":"An overview of the intrathymic intricacies of t cell development","volume":"192","author":"Shah","year":"2014","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.jri.2023.104132_bib29","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.exger.2007.05.001","article-title":"No immune risk profile among individuals who reach 100 years of age: Findings from the swedish nona immune longitudinal study","volume":"42","author":"Strindhall","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jri.2023.104132_bib30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ygcen.2013.01.013","article-title":"The compensatory expression of reproductive hormone receptors in the thymus of the male rat following active immunization against gnrh","volume":"185","author":"Su","year":"2013","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.jri.2023.104132_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2017.02.001","article-title":"Effect of gonadotropin-releasing hormone vaccination on t lymphocyte changes in male rats","volume":"120","author":"Su","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104132_bib32","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.it.2017.07.010","article-title":"The mechanisms of t cell selection in the thymus","volume":"38","author":"Takaba","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jri.2023.104132_bib33","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1084\/jem.20131289","article-title":"Sex steroid blockade enhances thymopoiesis by modulating notch signaling","volume":"211","author":"Velardi","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2023.104132_bib34","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1080\/08820139.2021.1937208","article-title":"Activation of gonadotropin-releasing hormone receptor impedes the immunosuppressive activity of decidual regulatory t cells via deactivating the mechanistic target of rapamycin signaling","volume":"51","author":"Wang","year":"2022","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.jri.2023.104132_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature10279","article-title":"A critical role for tcf-1 in t-lineage specification and differentiation","volume":"476","author":"Weber","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.104132_bib36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0047-6374(97)00151-6","article-title":"Changes in cd8 and cd4 lymphocyte subsets, t cell proliferation responses and non-survival in the very old: the swedish longitudinal octo-immune study","volume":"102","author":"Wikby","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.jri.2023.104132_bib37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-065X.2010.00956.x","article-title":"T-cell lineage determination","volume":"238","author":"Yang","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jri.2023.104132_bib38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1439-0531.2001.00256.x","article-title":"Active immunization against gonadotrophin-releasing hormone in chinese male pigs","volume":"36","author":"Zeng","year":"2001","journal-title":"Reprod. Domest. Anim. = Zuchthyg."},{"key":"10.1016\/j.jri.2023.104132_bib39","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/ni.3537","article-title":"Foxn1 regulates key target genes essential for t cell development in postnatal thymic epithelial cells","volume":"17","author":"\u017duklys","year":"2016","journal-title":"Nat. Immunol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823003388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823003388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:35:56Z","timestamp":1759034156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037823003388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":39,"alternative-id":["S0165037823003388"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2023.104132","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Active immunization against gonadotropin-releasing hormone affects thymic T cell production, migration, and colonization in male rat lymphoid tissue","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2023.104132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104132"}}