{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:54:20Z","timestamp":1768323260583,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"am","delay-in-days":316,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K09442"],"award-info":[{"award-number":["21K09442"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jri.2023.104153","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T09:26:39Z","timestamp":1694942799000},"page":"104153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Upregulation of autotaxin by oxidative stress via Nrf2 activation: A novel insight into the compensation mechanism in preeclamptic placenta"],"prefix":"10.1016","volume":"160","author":[{"given":"Manami","family":"Yanagisawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nagamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kurano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumi","family":"Misumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Akiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Kumasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Iriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yatomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Osuga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2023.104153_bib1","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1017\/S1751731113000396","article-title":"Oxidative stress index (OSi) as a new tool to assess redox status in dairy cattle during the transition period","volume":"7","author":"Abuelo","year":"2013","journal-title":"Animal"},{"key":"10.1016\/j.jri.2023.104153_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-10-49","article-title":"The effects of oxidative stress on female reproduction: a review","volume":"10","author":"Agarwal","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jri.2023.104153_bib3","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.15252\/embj.201696290","article-title":"Autotaxin-lysophosphatidic acid-LPA(3) signaling at the embryo-epithelial boundary controls decidualization pathways","volume":"36","author":"Aikawa","year":"2017","journal-title":"Embo J."},{"key":"10.1016\/j.jri.2023.104153_bib4","first-page":"347","article-title":"Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis","author":"Ananth","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.jri.2023.104153_bib5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Et. Biophys. Acta (BBA) - Mol. Cell Res."},{"key":"10.1016\/j.jri.2023.104153_bib6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \"antioxidant power\": the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.jri.2023.104153_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2023.104153_bib8","first-page":"127","article-title":"A simple test to monitor oxidative stress","volume":"18","author":"Cesarone","year":"1999","journal-title":"Int. Angiol."},{"key":"10.1016\/j.jri.2023.104153_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13064","article-title":"Lysophosphatidic acid receptor LPA3 prevents oxidative stress and cellular senescence in Hutchinson\u2013Gilford progeria syndrome","volume":"19","author":"Chen","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.jri.2023.104153_bib10","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2174\/1381612043452901","article-title":"Induction of cytoprotective genes through Nrf2\/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases","volume":"10","author":"Chen","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jri.2023.104153_bib11","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1161\/CIRCULATIONAHA.106.660134","article-title":"Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1","volume":"115","author":"Cudmore","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jri.2023.104153_bib12","doi-asserted-by":"crossref","first-page":"18162","DOI":"10.1074\/jbc.M301158200","article-title":"Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation: up-regulated expression with adipocyte differentiation and obesity","volume":"278","author":"Ferry","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jri.2023.104153_bib13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.104153_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13176","article-title":"Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia","volume":"82","author":"Fujii","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104153_bib15","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1111\/jog.12742","article-title":"Placental autotaxin expression is diminished in women with pre-eclampsia","volume":"41","author":"Ichikawa","year":"2015","journal-title":"J. Obstet. Gynaecol. Res"},{"key":"10.1016\/j.jri.2023.104153_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.jri.2023.104153_bib17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1600-0897.2009.00715.x","article-title":"Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta","volume":"62","author":"Iwasawa","year":"2009","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104153_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-39041-4","article-title":"Molecular mechanism of lysophosphatidic acid-induced hypertensive response","volume":"9","author":"Kano","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jri.2023.104153_bib19","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2009.07.035","article-title":"Nrf2: INrf2 (Keap1) signaling in oxidative stress","volume":"47","author":"Kaspar","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jri.2023.104153_bib20","first-page":"1809","article-title":"Human cytotrophoblast differentiation\/invasion is abnormal in pre-eclampsia","volume":"151","author":"Lim","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2023.104153_bib21","first-page":"2014","article-title":"Oxidative stress-mediated aging during the fetal and perinatal periods","author":"Marseglia","year":"2014","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.jri.2023.104153_bib22","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1016\/j.cca.2011.06.039","article-title":"Serum autotaxin measurements in pregnant women: application for the differentiation of normal pregnancy and pregnancy-induced hypertension","volume":"412","author":"Masuda","year":"2011","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jri.2023.104153_bib23","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1128\/MCB.02419-05","article-title":"Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development","volume":"26","author":"van Meeteren","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jri.2023.104153_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177994","article-title":"A Rho-associated coiled-coil containing kinases (ROCK) inhibitor, Y-27632, enhances adhesion, viability and differentiation of human term placenta-derived trophoblasts in vitro","volume":"12","author":"Motomura","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2023.104153_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23041966","article-title":"Divergent regulation of decidual oxidative-stress response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction","volume":"23","author":"Mundal","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jri.2023.104153_bib26","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00418-004-0677-x","article-title":"Oxidative stress in the placenta","volume":"122","author":"Myatt","year":"2004","journal-title":"Histochem Cell Biol."},{"key":"10.1016\/j.jri.2023.104153_bib27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cca.2007.10.005","article-title":"Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation","volume":"388","author":"Nakamura","year":"2008","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.jri.2023.104153_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aam5711","article-title":"Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes","volume":"10","author":"Nezu","year":"2017","journal-title":"Sci. Signal"},{"key":"10.1016\/j.jri.2023.104153_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1624","article-title":"Recent insights explaining susceptibility to endometriosis-From genetics to environment","author":"Pais","year":"2023","journal-title":"WIREs Mech. Dis."},{"key":"10.1016\/j.jri.2023.104153_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1479-828X.2006.00532.x","article-title":"Endogenous anti\u2010oxidants in pregnancy and preeclampsia","volume":"46","author":"Perkins","year":"2006","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"10.1016\/j.jri.2023.104153_bib31","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(06)68433-X","article-title":"Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial","volume":"367","author":"Poston","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2023.104153_bib32","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/j.freeradbiomed.2010.09.006","article-title":"Oxidative stress, inflammation, and cancer: how are they linked?","volume":"49","author":"Reuter","year":"2010","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.jri.2023.104153_bib33","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1056\/NEJMoa0908056","article-title":"Vitamins C and E to prevent complications of pregnancy-associated hypertension","volume":"362","author":"Roberts","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jri.2023.104153_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2020.108255","article-title":"Oxidative stress in pregnancy complicated by preeclampsia","volume":"681","author":"San Juan-Reyes","year":"2020","journal-title":"Arch. Biochem Biophys."},{"key":"10.1016\/j.jri.2023.104153_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00413","article-title":"Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction","volume":"5","author":"Staiculescu","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jri.2023.104153_bib36","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/S0021-9258(18)45911-X","article-title":"Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein","volume":"267","author":"Stracke","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jri.2023.104153_bib37","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13496","article-title":"The role of nuclear factor erythroid 2-related factor 2 (NRF2) in normal and pathological pregnancy: a systematic review","volume":"86","author":"Tantengco","year":"2021","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104153_bib38","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/BF02533598","article-title":"Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species","volume":"13","author":"Tokumura","year":"1978","journal-title":"Lipids"},{"key":"10.1016\/j.jri.2023.104153_bib39","first-page":"97","article-title":"The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP","volume":"4","author":"Tranquilli","year":"2014"},{"key":"10.1016\/j.jri.2023.104153_bib40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/ijms23010099","article-title":"Anti-inflammatory, antioxidant, and antifibrotic effects of gingival-derived mscs on bleomycin-induced pulmonary fibrosis in mice","volume":"23","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jri.2023.104153_bib41","first-page":"631","article-title":"Clinical introduction of lysophosphatidic acid and autotaxin assays","volume":"58","author":"Yatomi","year":"2010","journal-title":"Rinsho Byori"},{"key":"10.1016\/j.jri.2023.104153_bib42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature03505","article-title":"LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing","volume":"435","author":"Ye","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.104153_bib43","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1194\/jlr.R046458","article-title":"LPA receptor signaling: pharmacology, physiology, and pathophysiology","volume":"55","author":"Yung","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jri.2023.104153_bib44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/13510002.2022.2046423","article-title":"Role of mitochondrial reactive oxygen species in homeostasis regulation","volume":"27","author":"Zhang","year":"2022","journal-title":"Redox Rep."},{"key":"10.1016\/j.jri.2023.104153_bib45","article-title":"The expression regulation and biological function of autotaxin","volume":"10","author":"Zhang","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jri.2023.104153_bib46","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.placenta.2009.07.012","article-title":"Effect of heme oxygenase-1 deficiency on placental development","volume":"30","author":"Zhao","year":"2009","journal-title":"Placenta"}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823003595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823003595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:35:24Z","timestamp":1759034124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037823003595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":46,"alternative-id":["S0165037823003595"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2023.104153","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulation of autotaxin by oxidative stress via Nrf2 activation: A novel insight into the compensation mechanism in preeclamptic placenta","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2023.104153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104153"}}