{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:10:46Z","timestamp":1780391446205,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006264","name":"RIKEN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BH93\/1-4"],"award-info":[{"award-number":["BH93\/1-4"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BH93\/4-1"],"award-info":[{"award-number":["BH93\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jri.2023.104169","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T20:49:48Z","timestamp":1700513388000},"page":"104169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Role of macrophage colony stimulating factor and interferon regulatory factor 7 in modulating the immune profile of mouse testicular macrophages"],"prefix":"10.1016","volume":"161","author":[{"given":"Yalong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Fijak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Gabriela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meinhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-8108","authenticated-orcid":false,"given":"Sudhanshu","family":"Bhushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2023.104169_bib1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.immuni.2016.10.026","article-title":"Gm-csf: from growth factor to central mediator of tissue inflammation","volume":"45","author":"Becher","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.104169_bib2","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.4049\/jimmunol.1401132","article-title":"Differential activation of inflammatory pathways in testicular macrophages provides a rationale for their subdued inflammatory capacity","volume":"194","author":"Bhushan","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2023.104169_bib3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2020.05.014","article-title":"Determinants of resident tissue macrophage identity and function","volume":"52","author":"Bleriot","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.104169_bib4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nn.3599","article-title":"Identification of a unique tgf-beta-dependent molecular and functional signature in microglia","volume":"17","author":"Butovsky","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jri.2023.104169_bib5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.122.059062","article-title":"Macrophage-derived 25-hydroxycholesterol promotes vascular inflammation, atherogenesis, and lesion remodeling","volume":"147","author":"Canfran-Duque","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jri.2023.104169_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8893305","article-title":"Multiple roles of 25-hydroxycholesterol in lipid metabolism, antivirus process, inflammatory response, and cell survival","volume":"2020","author":"Cao","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jri.2023.104169_bib7","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.15252\/embj.201489293","article-title":"Chronic exposure to tgfbeta1 regulates myeloid cell inflammatory response in an irf7-dependent manner","volume":"33","author":"Cohen","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.jri.2023.104169_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.immuni.2013.11.019","article-title":"Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation","volume":"40","author":"Epelman","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.104169_bib9","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jri.2023.104169_bib10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-resident macrophage ontogeny and homeostasis","volume":"44","author":"Ginhoux","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.104169_bib11","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.cell.2014.11.023","article-title":"Environment drives selection and function of enhancers controlling tissue-specific macrophage identities","volume":"159","author":"Gosselin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jri.2023.104169_bib12","article-title":"Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions","volume":"14","author":"Gu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jri.2023.104169_bib13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.immuni.2015.03.011","article-title":"C-myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages","volume":"42","author":"Hoeffel","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.104169_bib14","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.4049\/jimmunol.0901753","article-title":"Injury-induced type i ifn signaling regulates inflammatory responses in the central nervous system","volume":"185","author":"Khorooshi","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2023.104169_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jneuroim.2007.04.014","article-title":"Inhibition of smad7, a negative regulator of tgf-beta signaling, suppresses autoimmune encephalomyelitis","volume":"187","author":"Kleiter","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jri.2023.104169_bib16","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nri3695","article-title":"Macrophages: Peritoneal population depends on gata6","volume":"14","author":"Leavy","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2023.104169_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2012.11.005","article-title":"Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol","volume":"38","author":"Liu","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.104169_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.08.009","article-title":"Fate mapping via ms4a3-expression history traces monocyte-derived cells","volume":"178","author":"Liu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jri.2023.104169_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18206-0","article-title":"Generation, localization and functions of macrophages during the development of testis","volume":"11","author":"Lokka","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jri.2023.104169_bib20","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1095\/biolreprod64.3.790","article-title":"Production of 25-hydroxycholesterol by testicular macrophages and its effects on leydig cells","volume":"64","author":"Lukyanenko","year":"2001","journal-title":"Biol. Reprod.."},{"key":"10.1016\/j.jri.2023.104169_bib21","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/JLB.3MR0318-086RR","article-title":"Microenvironmental signals govern the cellular identity of testicular macrophages","volume":"104","author":"Meinhardt","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jri.2023.104169_bib22","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/endo.141.3.7350","article-title":"Identification of the lipophilic factor produced by macrophages that stimulates steroidogenesis","volume":"141","author":"Nes","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.jri.2023.104169_bib23","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.cell.2014.04.016","article-title":"Tissue-specific signals control reversible program of localization and functional polarization of macrophages","volume":"157","author":"Okabe","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jri.2023.104169_bib24","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1095\/biolreprod56.5.1290","article-title":"Effect of the colony-stimulating factor-1 null mutation, osteopetrotic (csfm(op)), on the distribution of macrophages in the male mouse reproductive tract","volume":"56","author":"Pollard","year":"1997","journal-title":"Biol. Reprod.."},{"key":"10.1016\/j.jri.2023.104169_bib25","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/ni.3005","article-title":"Induction of the nuclear receptor ppar-gamma by the cytokine gm-csf is critical for the differentiation of fetal monocytes into alveolar macrophages","volume":"15","author":"Schneider","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2023.104169_bib26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.1219179","article-title":"A lineage of myeloid cells independent of myb and hematopoietic stem cells","volume":"336","author":"Schulz","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jri.2023.104169_bib27","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1084\/jem.20180019","article-title":"Tissue-resident macrophages in the intestine are long lived and defined by tim-4 and cd4 expression","volume":"215","author":"Shaw","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2023.104169_bib28","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S1074-7613(01)00218-7","article-title":"Gm-csf regulates alveolar macrophage differentiation and innate immunity in the lung through pu.1","volume":"15","author":"Shibata","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2023.104169_bib29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1189\/jlb.3RU0316-144R","article-title":"Biological role of granulocyte macrophage colony-stimulating factor (gm-csf) and macrophage colony-stimulating factor (m-csf) on cells of the myeloid lineage","volume":"100","author":"Ushach","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jri.2023.104169_bib30","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.4049\/jimmunol.1700162","article-title":"Characterization of the micro-environment of the testis that shapes the phenotype and function of testicular macrophages","volume":"198","author":"Wang","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2023.104169_bib31","article-title":"Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jri.2023.104169_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1189\/jlb.1010557","article-title":"Rat resident testicular macrophages have an alternatively activated phenotype and constitutively produce interleukin-10 in vitro","volume":"90","author":"Winnall","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jri.2023.104169_bib33","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-020-01869-3","article-title":"25-hydroxycholesterol amplifies microglial il-1beta production in an apoe isoform-dependent manner","volume":"17","author":"Wong","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.jri.2023.104169_bib34","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1136\/annrheumdis-2019-215208","article-title":"Interferon regulatory factor 7 (irf7) represents a link between inflammation and fibrosis in the pathogenesis of systemic sclerosis","volume":"78","author":"Wu","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jri.2023.104169_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.583276","article-title":"Corticosterone enhances the ampk-mediated immunosuppressive phenotype of testicular macrophages during uropathogenic Escherichia coli induced orchitis","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823003753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823003753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:34:10Z","timestamp":1759034050000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037823003753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":35,"alternative-id":["S0165037823003753"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2023.104169","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of macrophage colony stimulating factor and interferon regulatory factor 7 in modulating the immune profile of mouse testicular macrophages","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2023.104169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104169"}}