{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:55:15Z","timestamp":1787968515728,"version":"build-2784847793"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.jri.2023.104186","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T19:00:35Z","timestamp":1702926035000},"page":"104186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Extra villous trophoblast-derived PDL1 can ameliorate macrophage inflammation and promote immune adaptation associated with preeclampsia"],"prefix":"10.1016","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-5101","authenticated-orcid":false,"given":"Yutong","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanqiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2023.104186_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.placenta.2016.12.007","article-title":"HTR-8\/SVneo cell line contains a mixed population of cells","author":"Abou-Kheir","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2023.104186_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jri.2012.03.488","article-title":"Trophoblast debris modulates the expression of immune proteins in macrophages: a key to maternal tolerance of the fetal allograft?","author":"Abumaree","year":"2012","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22834","article-title":"Association of pro- and anti-inflammatory cytokines in preeclampsia","author":"Aggarwal","year":"2019","journal-title":"J. Clin. Lab Anal."},{"key":"10.1016\/j.jri.2023.104186_bib4","article-title":"Oxidative stress induces expression of the toll-like receptors (tlrs) 2 and 4 in the human peripheral blood mononuclear cells: implications for metabolic inflammation","author":"Akhter","year":"2019","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.jri.2023.104186_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aak9679","article-title":"Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation","author":"Allen","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jri.2023.104186_bib6","doi-asserted-by":"crossref","DOI":"10.1158\/1535-7163.MCT-18-0679","article-title":"CD3-bispecific antibody therapy turns solid tumors into inflammatory sites but does not install protective memory","author":"Benonisson","year":"2019","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jri.2023.104186_bib7","doi-asserted-by":"crossref","DOI":"10.1007\/7651_2016_350","article-title":"CoCl2 administration to vascular MSC cultures as an in vitro hypoxic system to study stem cell survival and angiogenesis","author":"Ciavarella","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jri.2023.104186_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0897.1997.tb00222.x","article-title":"Placental cytokines and the pathogenesis of preeclampsia","author":"Conrad","year":"1997","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41379-019-0285-x","article-title":"DNA methylation-based classification of sinonasal undifferentiated carcinoma","author":"Dogan","year":"2019","journal-title":"Mod. Pathol.: Off. J. U. S. Can. Acad. Pathol., Inc."},{"key":"10.1016\/j.jri.2023.104186_bib10","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.cmet.2019.01.006","article-title":"IGF-2 preprograms maturing macrophages to acquire oxidative phosphorylation-dependent anti-inflammatory properties","author":"Du","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.jri.2023.104186_bib11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1161\/HYPERTENSIONAHA.120.15619","article-title":"Functional evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in placentation, preeclampsia, and preterm birth","author":"Dunk","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2023.104186_bib12","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-immunol-032712-100003","article-title":"Immunology of the maternal-fetal interface","author":"Erlebacher","year":"2013","journal-title":"Annu Rev. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib13","article-title":"Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222","author":"Espinoza","year":"2020","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2023.104186_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.placenta.2017.03.001","article-title":"Uterine NK cells and macrophages in pregnancy","author":"Faas","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2023.104186_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00298","article-title":"Monocytes and macrophages in pregnancy and pre-eclampsia","author":"Faas","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.01030","article-title":"LPS induces preeclampsia-like phenotype in rats and HTR8\/SVneo cells dysfunction through TLR4\/p38 MAPK pathway","author":"Fan","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jri.2023.104186_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.531543","article-title":"Maternal-fetal inflammation in the placenta and the developmental origins of health and disease","author":"Goldstein","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13193","article-title":"Maternal soluble PD-1 levels are significantly increased in women with preeclampsia","author":"Gu","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41564-019-0405-x","article-title":"Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus","author":"Hallez","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.jri.2023.104186_bib20","doi-asserted-by":"crossref","unstructured":"A.C. Harmon, D.C. Cornelius, L.M. Amaral, J.L. Faulkner, M.W. Cunningham, Jr., K. Wallace et al., The role of inflammation in the pathology of preeclampsia, Clin Sci (Lond) 2016. doi: 10.1042\/CS20150702.","DOI":"10.1042\/CS20150702"},{"key":"10.1016\/j.jri.2023.104186_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00125","article-title":"Innate and adaptive immune interactions at the fetal-maternal interface in healthy human pregnancy and pre-eclampsia","author":"Hsu","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib22","article-title":"A newly intervention strategy in preeclampsia: targeting PD-1\/Tim-3 signaling pathways to modulate the polarization of decidual macrophages","author":"Hu","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.jri.2023.104186_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jri.2023.104186_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-019-0200-1","article-title":"Engineering universal cells that evade immune detection","author":"Lanza","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-020-0227-y","article-title":"Cellular adaptation to hypoxia through hypoxia inducible factors and beyond","author":"Lee","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jri.2023.104186_bib26","article-title":"Modulation of decidual macrophage polarization by macrophage colony-stimulating factor derived from first-trimester decidual cells: implication in preeclampsia","author":"Li","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2023.104186_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.683249","article-title":"Total glucosides of paeony ameliorate pristane-induced lupus nephritis by inducing PD-1 ligands (+) macrophages via activating IL-4\/STAT6\/PD-L2 signaling","author":"Liang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.placenta.2017.03.010","article-title":"Hypoxia and HIF pathway in cancer and the placenta","author":"Macklin","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2023.104186_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deaa177","article-title":"Fallopian tube epithelial cells express androgen receptor and have a distinct hormonal responsiveness when compared with endometrial epithelium","author":"Maclean","year":"2020","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2023.104186_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030583","article-title":"Involvement of the PD-1\/PD-L1 Co-inhibitory pathway in the pathogenesis of the inflammatory stage of early-onset preeclampsia","author":"Meggyes","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jri.2023.104186_bib31","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0897.2010.00813.x","article-title":"The contribution of macrophages to normal and pathological pregnancies","author":"Nagamatsu","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12477","article-title":"The role of decidual macrophages during normal and pathological pregnancy","author":"Ning","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib33","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20131916","article-title":"PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation","author":"Noman","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jri.2023.104186_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00086","article-title":"Elevated soluble PD-L1 in pregnant women's serum suppresses the immune reaction","author":"Okuyama","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2013.00159","article-title":"Macrophages and chemokines as mediators of angiogenesis","author":"Owen","year":"2013","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jri.2023.104186_bib36","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.102.010058","article-title":"B7 family molecules are favorably positioned at the human maternal-fetal interface","author":"Petroff","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2023.104186_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2012.05.004","article-title":"Interleukin-6 in pregnancy and gestational disorders","author":"Prins","year":"2012","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib38","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.116.308304","article-title":"CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia","author":"Przybyl","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.jri.2023.104186_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.10.050","article-title":"Beta-arrestin1 prevents preeclampsia by downregulation of mechanosensitive AT1-B2 receptor heteromers","author":"Quitterer","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jri.2023.104186_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0897.2010.00831.x","article-title":"Immunology of pre-eclampsia","author":"Redman","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib41","doi-asserted-by":"crossref","DOI":"10.1080\/08820130802191375","article-title":"The role of macrophages in utero-placental interactions during normal and pathological pregnancy","author":"Renaud","year":"2008","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.jri.2023.104186_bib42","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.106.056143","article-title":"Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice","author":"Robertson","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2023.104186_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.30077","article-title":"PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma","author":"Ruf","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jri.2023.104186_bib44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jri.2013.08.001","article-title":"Human decidual macrophages suppress IFN-gamma production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy","author":"Sayama","year":"2013","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aak9670","article-title":"Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade","author":"Schmittnaegel","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jri.2023.104186_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajpath.2010.10.011","article-title":"Differential distribution and phenotype of decidual macrophages in preeclamptic versus control pregnancies","author":"Schonkeren","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2023.104186_bib47","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0897.2007.00486.x","article-title":"Leptin, IL-10 and inflammatory markers (TNF-alpha, IL-6 and IL-8) in pre-eclamptic, normotensive pregnant and healthy non-pregnant women","author":"Sharma","year":"2007","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2021.103379","article-title":"Trophoblast-derived interleukin 9 mediates immune cell conversion and contributes to maternal-fetal tolerance","author":"Sun","year":"2021","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib49","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.107.066324","article-title":"Expression and function of PDCD1 at the human maternal-fetal interface1","author":"Taglauer","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2023.104186_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/nri.2017.103","article-title":"Regulation of immunity and inflammation by hypoxia in immunological niches","author":"Taylor","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib51","doi-asserted-by":"crossref","unstructured":"M.B. Ten\u00f3rio, R.C. Ferreira, F.A. Moura, N.B. Bueno, A.C.M. de Oliveira and M.O.F. Goulart, Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia Oxidative Medicine and Cellular Longevity 2019. doi:","DOI":"10.1155\/2019\/8238727"},{"key":"10.1016\/j.jri.2023.104186_bib52","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12345","article-title":"Uterine spiral artery remodeling: the role of uterine natural killer cells and extravillous trophoblasts in normal and high-risk human pregnancies","author":"Tessier","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib53","article-title":"The PD-1\/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats","author":"Tian","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jri.2023.104186_bib54","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1172\/JCI97354","article-title":"Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response","author":"Ubil","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jri.2023.104186_bib55","doi-asserted-by":"crossref","DOI":"10.1189\/jlb.0708395","article-title":"Embryonic implantation: cytokines, adhesion molecules, and immune cells in establishing an implantation environment","author":"van Mourik","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jri.2023.104186_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jri.2023.104186_bib57","doi-asserted-by":"crossref","DOI":"10.1186\/s40425-019-0619-8","article-title":"DNA damage repair gene mutations and their association with tumor immune regulatory gene expression in muscle invasive bladder cancer subtypes","author":"Vidotto","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jri.2023.104186_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153695","article-title":"Role of the monocyte-macrophage system in normal pregnancy and preeclampsia","author":"Vishnyakova","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jri.2023.104186_bib59","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s43032-022-01003-z","article-title":"Excessive immune activation and the correlation with decreased expression of PD-1 at the maternal-fetal interface in preeclampsia","author":"Wang","year":"2023","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.jri.2023.104186_bib60","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab045","article-title":"Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK\/NF-kappaB pathway","author":"Wang","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2023.104186_bib61","doi-asserted-by":"crossref","DOI":"10.1530\/REP-09-0007","article-title":"Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy","author":"Williams","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2023.104186_bib62","article-title":"The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis","author":"Xie","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jri.2023.104186_bib63","article-title":"Crosstalk between trophoblasts and decidual immune cells: the cornerstone of maternal-fetal immunotolerance","author":"Xu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmed.2016.11.001","article-title":"Co-signaling molecules in maternal-fetal immunity","author":"Xu","year":"2017","journal-title":"Trends Mol. Med"},{"key":"10.1016\/j.jri.2023.104186_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00792","article-title":"Macrophage polarization in physiological and pathological pregnancy","author":"Yao","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib66","article-title":"The altered PD-1\/PD-L1 pathway delivers the 'one-two punch' effects to promote the Treg\/Th17 imbalance in pre-eclampsia","author":"Zhang","year":"2018","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.jri.2023.104186_bib67","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/JLB.1A0420-012RR","article-title":"Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function","author":"Zhang","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jri.2023.104186_bib68","doi-asserted-by":"crossref","unstructured":"M.L. Zhang Y, Hu X, et al., The role of the PD-1\/PD-L1 axis in macrophage differentiation and function during pregnancy., Hum Reprod 2019. doi:","DOI":"10.1093\/humrep\/dey347"}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823003923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037823003923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:34:44Z","timestamp":1759034084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037823003923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":68,"alternative-id":["S0165037823003923"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2023.104186","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extra villous trophoblast-derived PDL1 can ameliorate macrophage inflammation and promote immune adaptation associated with preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2023.104186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104186"}}