{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:48:35Z","timestamp":1771465715097,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jri.2024.104238","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T04:54:50Z","timestamp":1709873690000},"page":"104238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Associations between cytokines and the risk of female and male infertility: A two-sample Mendelian randomization analysis"],"prefix":"10.1016","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1279-7822","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Honglin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letian","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jri.2024.104238_bib1","article-title":"Obesity: a doorway to a molecular path leading to infertility","volume":"14","author":"Ahmad","year":"2022","journal-title":"Cureus"},{"issue":"8 Pt 1","key":"10.1016\/j.jri.2024.104238_bib2","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.4049\/jimmunol.150.8.3442","article-title":"RANTES is a chemotactic and activating factor for human eosinophils","volume":"150","author":"Alam","year":"1993","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.jri.2024.104238_bib3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/molehr\/gan031","article-title":"RANTES and human sperm fertilizing ability: effect on acrosome reaction and sperm\/oocyte fusion","volume":"14","author":"Barbonetti","year":"2008","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.jri.2024.104238_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12916-021-02193-0","article-title":"Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis","volume":"20","author":"Bouras","year":"2022","journal-title":"BMC Med"},{"issue":"5","key":"10.1016\/j.jri.2024.104238_bib5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.jri.2024.104238_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and management of infertility: a review","volume":"326","author":"Carson","year":"2021","journal-title":"Jama"},{"key":"10.1016\/j.jri.2024.104238_bib7","unstructured":"Chandra, A., Copen, C.E., & Stephen, E.H. (2013). Infertility and impaired fecundity in the United States, 1982-2010: data from the National Survey of Family Growth. Natl Health Stat Report (67), 1-18, 11 p following 19."},{"issue":"6509","key":"10.1016\/j.jri.2024.104238_bib8","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Consortium","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jri.2024.104238_bib9","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/molehr\/2.1.2","article-title":"The receptor encoded by the human C-MET oncogene is expressed in testicular tissue and on human spermatozoa","volume":"2","author":"Depuydt","year":"1996","journal-title":"Mol. Hum. Reprod."},{"issue":"5","key":"10.1016\/j.jri.2024.104238_bib10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1365-2605.1997.00074.x","article-title":"Purification and characterization of hepatocyte growth factor (HGF) from human seminal plasma","volume":"20","author":"Depuydt","year":"1997","journal-title":"Int J. Androl."},{"issue":"2","key":"10.1016\/j.jri.2024.104238_bib11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/j.1939-4640.1998.tb01985.x","article-title":"Levels of hepatocyte growth factor\/scatter factor (HGF\/SF) in seminal plasma of patients with andrological diseases","volume":"19","author":"Depuydt","year":"1998","journal-title":"J. Androl."},{"issue":"4","key":"10.1016\/j.jri.2024.104238_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ogc.2012.09.006","article-title":"Tubal factor infertility: diagnosis and management in the era of assisted reproductive technology","volume":"39","author":"Dun","year":"2012","journal-title":"Obstet. Gynecol. Clin. North Am."},{"issue":"Suppl 3","key":"10.1016\/j.jri.2024.104238_bib13","article-title":"Insurance coverage of male infertility: what should the standard be?","volume":"7","author":"Dupree","year":"2018","journal-title":"Transl. Androl. Urol."},{"issue":"6","key":"10.1016\/j.jri.2024.104238_bib14","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.fertnstert.2015.03.014","article-title":"Regulatory T cells, inflammation, and endoplasmic reticulum stress in women with defective endometrial receptivity","volume":"103","author":"Galgani","year":"2015","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.jri.2024.104238_bib15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5603\/GP.2020.0039","article-title":"The role of biological markers in predicting infertility associated with non-obstructive endometriosis","volume":"91","author":"Gica","year":"2020","journal-title":"Ginekol. Pol."},{"issue":"6","key":"10.1016\/j.jri.2024.104238_bib16","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.fertnstert.2010.02.022","article-title":"Local injury of the endometrium induces an inflammatory response that promotes successful implantation","volume":"94","author":"Gnainsky","year":"2010","journal-title":"Fertil. Steril."},{"issue":"1","key":"10.1016\/j.jri.2024.104238_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1530\/REP-14-0395","article-title":"Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action","volume":"149","author":"Gnainsky","year":"2015","journal-title":"Reproduction"},{"issue":"5","key":"10.1016\/j.jri.2024.104238_bib18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/humupd\/dml024","article-title":"Obesity and the role of gut and adipose hormones in female reproduction","volume":"12","author":"Gosman","year":"2006","journal-title":"Hum. Reprod. Update"},{"issue":"5","key":"10.1016\/j.jri.2024.104238_bib19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/humupd\/dmr015","article-title":"Defining infertility--a systematic review of prevalence studies.","volume":"17","author":"Gurunath","year":"2011","journal-title":"Hum. Reprod. Update"},{"issue":"2","key":"10.1016\/j.jri.2024.104238_bib20","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1034\/j.1600-0897.2003.00056.x","article-title":"Fibroblast growth factor (FGF), intracellular adhesion molecule (sICAM-1) level in serum and follicular fluid of infertile women with polycystic ovarian syndrome, endometriosis and tubal damage, and their effect on ICSI outcome","volume":"50","author":"Hammadeh","year":"2003","journal-title":"Am. J. Reprod. Immunol."},{"issue":"5","key":"10.1016\/j.jri.2024.104238_bib21","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.fertnstert.2017.03.013","article-title":"Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility","volume":"107","author":"J\u00f8rgensen","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2024.104238_bib22","doi-asserted-by":"crossref","unstructured":"Karhunen, V., Gill, D., Malik, R., Ponsford, M.J., Ahola-Olli, A., Papadopoulou, A., Dehghan, A. (2020). Genetic study of circulating cytokines offers insight into the determinants, cascades and effects of systemic inflammation. medRxiv, 2020.2010.2026.20219477. doi:10.1101\/2020.10.26.20219477.","DOI":"10.1101\/2020.10.26.20219477"},{"issue":"7944","key":"10.1016\/j.jri.2024.104238_bib23","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jri.2024.104238_bib24","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgad376","article-title":"Circulating inflammatory cytokines and female reproductive diseases: a Mendelian randomization analysis","author":"Lin","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2024.104238_bib25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fendo.2017.00307","article-title":"Cytokines in male fertility and reproductive pathologies: immunoregulation and beyond","volume":"8","author":"Loveland","year":"2017","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"10","key":"10.1016\/j.jri.2024.104238_bib26","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1093\/humrep\/deu195","article-title":"The role of the cervix in fertility: is it time for a reappraisal?","volume":"29","author":"Martyn","year":"2014","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.jri.2024.104238_bib27","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/S0002-9378(99)70331-5","article-title":"The pattern of infertility diagnoses in women of advanced reproductive age","volume":"181","author":"Miller","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.jri.2024.104238_bib28","first-page":"151","article-title":"Changes in soluble interleukin-2 receptor level in serum and Na+-K+-exchanging ATPase activity in semen of infertile men caused by antisperm antibody","volume":"2","author":"Ni","year":"2000","journal-title":"Asian J. Androl."},{"issue":"4","key":"10.1016\/j.jri.2024.104238_bib29","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.2741\/220","article-title":"Role of chemokines in the pathogenesis of endometriosis","volume":"3","author":"Nishida","year":"2011","journal-title":"Front Biosci."},{"issue":"2","key":"10.1016\/j.jri.2024.104238_bib30","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.eururo.2006.07.016","article-title":"Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis\/chronic pelvic pain syndrome and benign prostatic hyperplasia","volume":"51","author":"Penna","year":"2007","journal-title":"Eur. Urol."},{"issue":"6","key":"10.1016\/j.jri.2024.104238_bib31","first-page":"623","article-title":"Infertility: evaluation and Management","volume":"107","author":"Phillips","year":"2023","journal-title":"Am. Fam. Physician"},{"issue":"2","key":"10.1016\/j.jri.2024.104238_bib32","first-page":"91","article-title":"Assisted reproductive technology in China: compliance and non-compliance","volume":"3","author":"Qiao","year":"2014","journal-title":"Transl. Pedia"},{"issue":"4","key":"10.1016\/j.jri.2024.104238_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0282579","article-title":"Acetylcholinesterase, pro-inflammatory cytokines, and association of ACHE SNP rs 17228602 with male infertility","volume":"18","author":"Sadia","year":"2023","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jri.2024.104238_bib34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.fertnstert.2008.09.083","article-title":"Circulating level of macrophage colony-stimulating factor can be predictive for human in vitro fertilization outcome","volume":"93","author":"Salmassi","year":"2010","journal-title":"Fertil. Steril."},{"issue":"11","key":"10.1016\/j.jri.2024.104238_bib35","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.jri.2024.104238_bib36","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030430","article-title":"Towards a better understanding of endometriosis-related infertility: a review on how endometriosis affects endometrial receptivity","volume":"13","author":"Shan","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jri.2024.104238_bib37","article-title":"Systemic inflammatory regulators and proliferative diabetic retinopathy: a bidirectional Mendelian randomization study","volume":"14","author":"Shi","year":"2023","journal-title":"Front Immunol."},{"issue":"1","key":"10.1016\/j.jri.2024.104238_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejogrb.2004.11.044","article-title":"Peritoneal fluid cytokines and sICAM-1 in minimal endometriosis: search for discriminating factors between infertility and\/or endometriosis","volume":"122","author":"Skrzypczak","year":"2005","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jri.2024.104238_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2023.07.005","article-title":"Pre-pregnancy obesity is associated with greater systemic inflammation and increased risk of antenatal depression","author":"Sominsky","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jri.2024.104238_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1131198","article-title":"Genetically predicted circulating levels of cytokines and the risk of osteoarthritis: a mendelian randomization study","volume":"14","author":"Su","year":"2023","journal-title":"Front Genet"},{"issue":"6","key":"10.1016\/j.jri.2024.104238_bib41","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/gepi.20164","article-title":"Stratified false discovery control for large-scale hypothesis testing with application to genome-wide association studies","volume":"30","author":"Sun","year":"2006","journal-title":"Genet Epidemiol."},{"issue":"6","key":"10.1016\/j.jri.2024.104238_bib42","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.rbmo.2014.09.006","article-title":"Clinical implications of congenital uterine anomalies: a meta-analysis of comparative studies","volume":"29","author":"Venetis","year":"2014","journal-title":"Reprod. Biomed. Online"},{"issue":"11","key":"10.1016\/j.jri.2024.104238_bib43","doi-asserted-by":"crossref","first-page":"977","DOI":"10.2174\/1381612013397627","article-title":"Role of dendritic cell-derived cytokines in immune regulation","volume":"7","author":"Wan","year":"2001","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jri.2024.104238_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1175421","article-title":"Circulating levels of cytokines and risk of cardiovascular disease: a Mendelian randomization study","volume":"14","author":"Wei","year":"2023","journal-title":"Front Immunol."},{"key":"10.1016\/j.jri.2024.104238_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00084","article-title":"Eotaxin-1 (CCL11)","volume":"6","author":"Williams","year":"2015","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.jri.2024.104238_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/nu15112589","article-title":"Can Dietary Patterns Impact Fertility Outcomes? A Systematic Review and Meta-Analysis","volume":"15","author":"Winter","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jri.2024.104238_bib47","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/(SICI)1098-2795(199701)46:1<62::AID-MRD10>3.0.CO;2-5","article-title":"Relative role of CSF-1, MCP-1\/JE, and RANTES in macrophage recruitment during successful pregnancy","volume":"46","author":"Wood","year":"1997","journal-title":"Mol. Reprod. Dev."},{"issue":"1","key":"10.1016\/j.jri.2024.104238_bib48","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1186\/s12884-020-03322-y","article-title":"A cross-sectional study on the correlation between cytokines in a pelvic environment and tubal factor infertility","volume":"20","author":"Yan","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"issue":"11","key":"10.1016\/j.jri.2024.104238_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15112930","article-title":"Mendelian randomization analyses of chronic immune-mediated diseases, circulating inflammatory biomarkers, and cytokines in relation to liver cancer","volume":"15","author":"Yin","year":"2023","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.jri.2024.104238_bib50","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13064","article-title":"Cervico-vaginal secretion cytokine profile: a non-invasive approach to study the endometrial receptivity in IVF cycles","volume":"81","author":"Zanotta","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"issue":"5","key":"10.1016\/j.jri.2024.104238_bib51","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.fertnstert.2009.09.009","article-title":"International committee for monitoring assisted reproductive technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009.","volume":"92","author":"Zegers-Hochschild","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2024.104238_bib52","article-title":"Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study","volume":"17","author":"Zhang","year":"2023","journal-title":"Front Neurosci."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037824000470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037824000470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T04:35:47Z","timestamp":1719549347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037824000470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":52,"alternative-id":["S0165037824000470"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2024.104238","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between cytokines and the risk of female and male infertility: A two-sample Mendelian randomization analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2024.104238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104238"}}