{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:04:59Z","timestamp":1785783899647,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008883","name":"Nagoya City University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["16K11100"],"award-info":[{"award-number":["16K11100"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["19K18676"],"award-info":[{"award-number":["19K18676"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["211204"],"award-info":[{"award-number":["211204"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jri.2024.104270","type":"journal-article","created":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T10:04:17Z","timestamp":1716717857000},"page":"104270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["MMP2 and MMP9 are associated with the pathogenesis of recurrent pregnancy loss through protein expression rather than genetic polymorphism"],"prefix":"10.1016","volume":"164","author":[{"given":"Shinobu","family":"Goto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiko","family":"Ozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Obayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamao","family":"Kitaori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Sugiura-Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2024.104270_bib1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/molehr\/gar033","article-title":"Human decidua and invasive trophoblasts are rich sources of nearly all human matrix metalloproteinases","volume":"17","author":"Anacker","year":"2011","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib2","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1161\/01.CIR.0000058700.41738.12","article-title":"Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease","volume":"107","author":"Blankenberg","year":"2003","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jri.2024.104270_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.rbmo.2015.09.011","article-title":"Regulation of inflammatory and angiogenesis mediators in a functional model of decidualized endometrial stromal cells","volume":"32","author":"Bourdiec","year":"2016","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.jri.2024.104270_bib4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1530\/REP-10-0294","article-title":"Remodelling at the maternal-fetal interface: relevance to human pregnancy disorders","volume":"140","author":"Cartwright","year":"2010","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2024.104270_bib5","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.4049\/jimmunol.161.12.6845","article-title":"Matrix metalloproteinases generate angiostatin: effects on neovascularization","volume":"161","author":"Cornelius","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2024.104270_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbamcr.2009.07.004","article-title":"Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models","volume":"1803","author":"Fanjul-Fern\u00e1ndez","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jri.2024.104270_bib7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0140-6736(84)90517-8","article-title":"Lupus anticoagulant and pregnancy management","volume":"2","author":"Farquharson","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2024.104270_bib8","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1095\/biolreprod61.4.1070","article-title":"Expression of metalloproteinases and their inhibitors in blood vessels in human endometrium","volume":"61","author":"Freitas","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0301-2115(03)00341-5","article-title":"The role of the matrix metalloproteinases in human endometrial and ovarian cycles","volume":"111","author":"Goldman","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jri.2024.104270_bib10","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/molehr\/gau008","article-title":"Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage","volume":"20","author":"Goto","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib11","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.fertnstert.2013.06.020","article-title":"Genotyping analyses for polymorphisms of ANXA5 gene in patients with recurrent pregnancy loss","volume":"100","author":"Hayashi","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2024.104270_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/molehr\/3.1.27","article-title":"Matrix metalloproteinases as mediators of reproductive function","volume":"3","author":"Hulboy","year":"1997","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib13","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/molehr\/8.12.1111","article-title":"Altered expression of genes involved in the production and degradation of endometrial extracellular matrix in patients with unexplained infertility and recurrent miscarriages","volume":"8","author":"Jokimaa","year":"2002","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1600-0897.2007.00576.x","article-title":"Role of mu-calpain in human decidua for recurrent miscarriage","volume":"59","author":"Kumagai","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2024.104270_bib15","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1038\/s41467-020-19742-5","article-title":"The genetic architecture of sporadic and multiple consecutive miscarriage","volume":"11","author":"Laisk","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jri.2024.104270_bib16","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1083\/jcb.200409115","article-title":"Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors","volume":"169","author":"Lee","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jri.2024.104270_bib17","article-title":"The association of polymorphisms in promoter region of MMP2 and MMP9 with recurrent spontaneous abortion risk in Chinese population","volume":"97","author":"Li","year":"2018","journal-title":"Med. (Baltim. )"},{"key":"10.1016\/j.jri.2024.104270_bib18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00432-004-0621-4","article-title":"A single nucleotide polymorphism in the MMP-9 promoter affects tumor progression and invasive phenotype of gastric cancer","volume":"131","author":"Matsumura","year":"2005","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.jri.2024.104270_bib19","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/humrep\/der035","article-title":"SYCP3 mutation may not be associated with recurrent miscarriage caused by aneuploidy","volume":"26","author":"Mizutani","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib20","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1074\/jbc.274.31.21491","article-title":"Matrix metalloproteinases","volume":"274","author":"Nagase","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jri.2024.104270_bib21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/molehr\/gah172","article-title":"Role of cathepsins and cystatins in patients with recurrent miscarriage","volume":"11","author":"Nakanishi","year":"2005","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib22","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/S0024-3205(00)00416-1","article-title":"Quantitative analysis of matrix metalloproteinases-2 and -9, and their tissue inhibitors-1 and -2 in human placenta throughout gestation","volume":"66","author":"Niu","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.jri.2024.104270_bib23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1177\/096120339600500605","article-title":"Anti beta 2glycoprotein I antibodies and lupus anticoagulant in patients with recurrent pregnancy loss: prevalence and clinical significance","volume":"5","author":"Ogasawara","year":"1996","journal-title":"Lupus"},{"key":"10.1016\/j.jri.2024.104270_bib24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nri1418","article-title":"Matrix metalloproteinases as modulators of inflammation and innate immunity","volume":"4","author":"Parks","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2024.104270_bib25","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.rbmo.2012.01.008","article-title":"Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion","volume":"24","author":"Pereza","year":"2012","journal-title":"Reprod. Biomed. Online."},{"key":"10.1016\/j.jri.2024.104270_bib26","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1093\/humrep\/12.10.2277","article-title":"Reproductive impact of congenital Mullerian anomalies","volume":"12","author":"Raga","year":"1997","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.lungcan.2006.11.021","article-title":"Influence of MMP-2 and MMP-9 promoter polymorphisms on gene expression and clinical outcome of non-small cell lung cancer","volume":"56","author":"Rollin","year":"2007","journal-title":"Lung Cancer"},{"key":"10.1016\/j.jri.2024.104270_bib28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.abb.2011.06.005","article-title":"Role of TGF-\u03b21 and TNF-\u03b1 in IL-1\u03b2 mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease","volume":"513","author":"Roy","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"issue":"Suppl A","key":"10.1016\/j.jri.2024.104270_bib29","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1053\/plac.2002.0928","article-title":"Complex regulation of decidualization: a role for cytokines and proteases--a review","volume":"24","author":"Salamonsen","year":"2003","journal-title":"Placenta"},{"issue":"Suppl 3","key":"10.1016\/j.jri.2024.104270_bib30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/humrep\/15.suppl_3.112","article-title":"Regulation of matrix metalloproteinases in human endometrium","volume":"15","author":"Salamonsen","year":"2000","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010287","article-title":"Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss","volume":"5","author":"Salker","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2024.104270_bib32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.acthis.2004.07.005","article-title":"Distribution patterns of matrix metalloproteinase (MMP)-2 and \u22129 and their inhibitors (TIMP-1 and TIMP-2) in the human decidua during early pregnancy","volume":"106","author":"Seval","year":"2004","journal-title":"Acta Histochem."},{"key":"10.1016\/j.jri.2024.104270_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.rbmo.2011.09.007","article-title":"Functional SNP \u22121562C\/T in the promoter region of MMP9 and recurrent early pregnancy loss","volume":"24","author":"Singh","year":"2012","journal-title":"Reprod. Biomed. Online."},{"key":"10.1016\/j.jri.2024.104270_bib34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.17.1.463","article-title":"How matrix metalloproteinases regulate cell behavior","volume":"17","author":"Sternlicht","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.jri.2024.104270_bib35","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/humrep\/des179","article-title":"Abnormal embryonic karyotype is the most frequent cause of recurrent miscarriage","volume":"27","author":"Sugiura-Ogasawara","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.fertnstert.2003.07.014","article-title":"Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations","volume":"81","author":"Sugiura-Ogasawara","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2024.104270_bib37","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1447-0756.2012.01973.x","article-title":"Frequency of recurrent spontaneous abortion and its influence on further marital relationship and illness: the Okazaki Cohort Study in Japan","volume":"39","author":"Sugiura-Ogasawara","year":"2013","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.jri.2024.104270_bib38","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/molehr\/gaq079","article-title":"The molecular basis of recurrent pregnancy loss: impaired natural embryo selection","volume":"16","author":"Teklenburg","year":"2010","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib39","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.matbio.2003.10.004","article-title":"A haplotype constituted of four MMP-2 promoter polymorphisms (-1575G\/A, -1306C\/T, -790T\/G and -735C\/T) is associated with coronary triple-vessel disease","volume":"22","author":"Vask\u016f","year":"2004","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jri.2024.104270_bib40","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1095\/biolreprod62.4.988","article-title":"Expression of matrix metalloproteinase-2, \u22129, and \u221214, tissue inhibitors of metalloproteinase-1, and matrix proteins in human placenta during the first trimester","volume":"62","author":"Xu","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2024.104270_bib41","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.matbio.2015.02.007","article-title":"Extracellular regulation of metalloproteinases","volume":"44\u201346","author":"Yamamoto","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jri.2024.104270_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145173","article-title":"Association of MMP2 and MMP9 gene polymorphisms with the recurrent spontaneous abortion: a meta-analysis","volume":"767","author":"Yan","year":"2021","journal-title":"Gene"},{"key":"10.1016\/j.jri.2024.104270_bib43","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0945-053X(00)00102-5","article-title":"Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases","volume":"19","author":"Ye","year":"2000","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jri.2024.104270_bib44","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/01.CIR.99.14.1788","article-title":"Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis","volume":"99","author":"Zhang","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jri.2024.104270_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.994888","article-title":"Decidual macrophages in recurrent spontaneous abortion","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2024.104270_bib46","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.fertnstert.2013.09.027","article-title":"Elevated expression levels of matrix metalloproteinase-9 in placental villi and tissue inhibitor of metalloproteinase-2 in decidua are associated with prolonged bleeding after mifepristone-misoprostol medical abortion","volume":"101","author":"Zhuang","year":"2014","journal-title":"Fertil. Steril."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037824000792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037824000792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:28:15Z","timestamp":1777494495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037824000792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":46,"alternative-id":["S0165037824000792"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2024.104270","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MMP2 and MMP9 are associated with the pathogenesis of recurrent pregnancy loss through protein expression rather than genetic polymorphism","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2024.104270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104270"}}