{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:37:45Z","timestamp":1793227065124,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019033","name":"Key Research and Development Program of Liaoning Province","doi-asserted-by":"publisher","award":["2022JH1\/10800070"],"award-info":[{"award-number":["2022JH1\/10800070"]}],"id":[{"id":"10.13039\/501100019033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jri.2025.104630","type":"journal-article","created":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T14:06:40Z","timestamp":1753625200000},"page":"104630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Association of elevated ACSL4 expression with impaired endometrial receptivity in endometriosis and restoration by ACSL4 inhibitor PRGL493"],"prefix":"10.1016","volume":"171","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5802-4985","authenticated-orcid":false,"given":"Lei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9380-2567","authenticated-orcid":false,"given":"YuHong","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2025.104630_bib1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.fertnstert.2016.04.002","article-title":"Endometrial expression and in vitro modulation of the iron transporter divalent metal transporter-1: implications for endometriosis","volume":"106","author":"Alvarado-D\u00edaz","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2025.104630_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/360438","article-title":"Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal","volume":"2014","author":"Ayala","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.jri.2025.104630_bib3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jri.2025.104630_bib4","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41574-019-0245-z","article-title":"Rethinking mechanisms, diagnosis and management of endometriosis","volume":"15","author":"Chapron","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jri.2025.104630_bib5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jri.2025.104630_bib6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/humupd\/dmy044","article-title":"Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis","volume":"25","author":"Craciunas","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2025.104630_bib7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/molehr\/gan033","article-title":"Potential involvement of iron in the pathogenesis of peritoneal endometriosis","volume":"14","author":"Defr\u00e8re","year":"2008","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2025.104630_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jri.2025.104630_bib9","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/humrep\/det457","article-title":"ESHRE guideline: management of women with endometriosis","volume":"29","author":"Dunselman","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2025.104630_bib10","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrendo.2016.116","article-title":"Fertile ground: human endometrial programming and lessons in health and disease","volume":"12","author":"Evans","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jri.2025.104630_bib11","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1172\/JCI99032","article-title":"Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma","volume":"128","author":"Hassannia","year":"2018","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jri.2025.104630_bib12","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jmig.2009.06.017","article-title":"Endometriosis and mechanisms of pelvic pain","volume":"16","author":"Howard","year":"2009","journal-title":"J. Minim. Invasive Gynecol."},{"key":"10.1016\/j.jri.2025.104630_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000514972","article-title":"Relationship between cyst fluid concentrations of iron and severity of dysmenorrhea in patients with ovarian endometrioma","volume":"86","author":"Imanaka","year":"2021","journal-title":"Gynecol. Obstet. Investig."},{"key":"10.1016\/j.jri.2025.104630_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0002-9378(15)32693-4","article-title":"Peritoneal endometriosis, due to the menstrual dissemination of endometrial tissue into the peritoneal cavity","volume":"15","author":"Ishimaru","year":"1928","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2025.104630_bib15","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1369\/jhc.2009.952085","article-title":"The human endometrium expresses the glycoprotein mucin-1 and shows positive correlation for thomsen-friedenreich epitope expression and galectin-1 binding","volume":"57","author":"Jeschke","year":"2009","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jri.2025.104630_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jri.2025.104630_bib17","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1095\/biolreprod.103.020651","article-title":"Osteopontin: roles in implantation and placentation","volume":"69","author":"Johnson","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2025.104630_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jri.2025.104630_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/science.1247125","article-title":"Organogenesis in a dish: modeling development and disease using organoid technologies","volume":"345","author":"Lancaster","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jri.2025.104630_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2017.05.031","article-title":"Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why","volume":"108","author":"Lessey","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2025.104630_bib21","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.fertnstert.2019.02.009","article-title":"What exactly is endometrial receptivity?","volume":"111","author":"Lessey","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2025.104630_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115415","article-title":"The emerging role of ferroptosis in female reproductive disorders","volume":"166","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jri.2025.104630_bib23","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2741\/4431","article-title":"Inflammation and endometriosis","volume":"21","author":"Liu","year":"2016","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jri.2025.104630_bib24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2741\/e358","article-title":"Peritoneal endometriosis is an inflammatory disease","volume":"E4","author":"Lousse","year":"2012","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jri.2025.104630_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1055\/s-2000-12561","article-title":"Endometrial receptivity: changes in cell-surface morphology","volume":"18","author":"Nikas","year":"2000","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.jri.2025.104630_bib26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.21037\/atm-23-97","article-title":"Investigation of hub ferroptosis-related genes and the immune landscape in recurrent pregnancy loss and unexplained infertility using bioinformatics analysis","volume":"11","author":"Nong","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.jri.2025.104630_bib27","first-page":"173","article-title":"MicroRNAs and endometriosis: distinguishing drivers from passengers in disease pathogenesis","volume":"35","author":"Nothnick","year":"2016","journal-title":"Thieme Med. Publ."},{"key":"10.1016\/j.jri.2025.104630_bib28","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jri.2025.104630_bib29","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.biopha.2010.09.012","article-title":"Reduced expression of HOXA10 in the midluteal endometrium from infertile women with minimal endometriosis","volume":"64","author":"Szczepa\u0144ska","year":"2010","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jri.2025.104630_bib30","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/aogs.13082","article-title":"Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options","volume":"96","author":"Tanbo","year":"2017","journal-title":"Acta Obstet. Et. Gynecol. Scand."},{"key":"10.1016\/j.jri.2025.104630_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/humupd\/6.1.75","article-title":"The role of HOX genes in human implantation","volume":"6","author":"Taylor","year":"2000","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jri.2025.104630_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/s12958-019-0526-3","article-title":"Hashimoto\u2019s thyroiditis impairs embryo implantation by compromising endometrial morphology and receptivity markers in euthyroid mice","volume":"17","author":"Wu","year":"2019","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jri.2025.104630_bib33","article-title":"Ferroptosis: mechanisms and links with diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jri.2025.104630_bib34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jri.2025.104630_bib35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jri.2025.104630_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1067648","article-title":"Infertile human endometrial organoid apical protein secretions are dysregulated and impair trophoblast progenitor cell adhesion","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Endocrinol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037825002086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037825002086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:49:56Z","timestamp":1772783396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037825002086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":36,"alternative-id":["S0165037825002086"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2025.104630","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of elevated ACSL4 expression with impaired endometrial receptivity in endometriosis and restoration by ACSL4 inhibitor PRGL493","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2025.104630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104630"}}