{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:14:59Z","timestamp":1781190899858,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009110","name":"Natural Science Foundation of Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2020D01C244"],"award-info":[{"award-number":["2020D01C244"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jri.2025.104738","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:13:48Z","timestamp":1760145228000},"page":"104738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The expression of MCOLN1 in preeclampsia maintains the balance of autophagy and pyroptosis induced by reactive oxygen species"],"prefix":"10.1016","volume":"172","author":[{"given":"Jianli","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2025.104738_bib1","article-title":"The role of xanthine oxidase in pregnancy complications: a systematic review","volume":"13","author":"Annesi","year":"2024","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.jri.2025.104738_bib2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41419-019-2162-4","article-title":"Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors","volume":"10","author":"Cheng","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jri.2025.104738_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2018.12.005","article-title":"Oxidative stress: normal pregnancy versus preeclampsia","volume":"1866","author":"Chiarello","year":"2020","journal-title":"Biochim Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.jri.2025.104738_bib4","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1158\/1541-7786.MCR-18-0910","article-title":"MST1 suppresses pancreatic cancer progression via ROS-Induced pyroptosis","volume":"17","author":"Cui","year":"2019","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jri.2025.104738_bib5","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1007\/s11064-021-03404-z","article-title":"Hyperoside reduces Rotenone-induced neuronal injury by suppressing autophagy","volume":"46","author":"Fan","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.jri.2025.104738_bib6","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1007\/s13577-023-00901-x","article-title":"Downregulation of argininosuccinate synthase 1 (ASS1) is associated with hypoxia in placental development","volume":"36","author":"Fantone","year":"2023","journal-title":"Hum. Cell"},{"key":"10.1016\/j.jri.2025.104738_bib7","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1080\/15548627.2019.1586256","article-title":"Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis","volume":"15","author":"Fernandez-Mosquera","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.jri.2025.104738_bib8","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1016\/j.ajog.2015.08.042","article-title":"Why is placentation abnormal in preeclampsia?","volume":"213","author":"Fisher","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2025.104738_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/biom10060953","article-title":"Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta","volume":"10","author":"Jena","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jri.2025.104738_bib10","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000010024","article-title":"Plasma and membrane Ca2+ and Mg2+ concentrations in normal pregnancy and in preeclampsia","volume":"46","author":"Kisters","year":"1998","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.jri.2025.104738_bib11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","article-title":"Gasdermins: effectors of pyroptosis","volume":"27","author":"Kovacs","year":"2017","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jri.2025.104738_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41419-019-1728-5","article-title":"Adrenomedullin alleviates the pyroptosis of leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jri.2025.104738_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuro.2017.09.015","article-title":"Rifampicin inhibits rotenone-induced microglial inflammation via enhancement of autophagy","volume":"63","author":"Liang","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.jri.2025.104738_bib14","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2025.5499","article-title":"Importance of STAT3 signaling in preeclampsia (Review)","volume":"55","author":"Marzioni","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jri.2025.104738_bib15","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/1873-3468.13741","article-title":"Rotenone-induced reactive oxygen species signal the recruitment of STAT3 to mitochondria","volume":"594","author":"Mohammed","year":"2020","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jri.2025.104738_bib16","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1080\/15548627.2019.1707494","article-title":"Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia","volume":"16","author":"Nakashima","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.jri.2025.104738_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112828","article-title":"NLRP3 activation and its relationship to endothelial dysfunction and oxidative stress: implications for preeclampsia and pharmacological interventions","volume":"10","author":"Nunes","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jri.2025.104738_bib18","doi-asserted-by":"crossref","first-page":"19266","DOI":"10.1073\/pnas.2003236117","article-title":"Mitochondria-lysosome contacts regulate mitochondrial Ca(2+) dynamics via lysosomal TRPML1","volume":"117","author":"Peng","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jri.2025.104738_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.placenta.2021.05.008","article-title":"Vitamin d alleviates hypoxia\/reoxygenation-induced injury of human trophoblast HTR-8 cells by activating autophagy","volume":"111","author":"Pi","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2025.104738_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112802","article-title":"HOXA9-induced chemerin signals through CMKLR1\/AMPK\/TXNIP\/NLRP3 pathway to induce pyroptosis of trophoblasts and aggravate preeclampsia","volume":"408","author":"Quan","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jri.2025.104738_bib21","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res"},{"key":"10.1016\/j.jri.2025.104738_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133263","article-title":"Preeclampsia: the relationship between uterine artery blood flow and trophoblast function","volume":"20","author":"Ridder","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jri.2025.104738_bib23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","article-title":"Regulation of autophagy by ROS: physiology and pathology","volume":"36","author":"Scherz-Shouval","year":"2011","journal-title":"Trends Biochem Sci."},{"key":"10.1016\/j.jri.2025.104738_bib24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jri.2025.104738_bib25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.placenta.2020.08.011","article-title":"MiR-124-3p promotes trophoblast cell HTR-8\/SVneo pyroptosis by targeting placental growth factor","volume":"101","author":"Tao","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2025.104738_bib26","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/jmcb\/mjz020","article-title":"Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation","volume":"11","author":"Wang","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.jri.2025.104738_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.placenta.2021.08.002","article-title":"Placental growth factor is negatively regulated by epidermal growth factor receptor (EGFR) signaling","volume":"114","author":"Whigham","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2025.104738_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8186877","article-title":"GDF-11 protects the traumatically injured spinal cord by suppressing pyroptosis and necroptosis via TFE3-Mediated autophagy augmentation","volume":"2021","author":"Xu","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.jri.2025.104738_bib29","doi-asserted-by":"crossref","first-page":"8607","DOI":"10.2147\/CMAR.S216538","article-title":"Downregulated MCOLN1 attenuates the progression of Non-Small-Cell lung cancer by inhibiting Lysosome-Autophagy","volume":"11","author":"Yin","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.jri.2025.104738_bib30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000511207","article-title":"Suppression of NLRP3 inflammasome, pyroptosis, and cell death by NIM811 in Rotenone-Exposed cells as an in vitro model of parkinson's disease","volume":"20","author":"Zhang","year":"2020","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.jri.2025.104738_bib31","article-title":"MCOLN1 is a ROS sensor in lysosomes that regulates autophagy","volume":"7","author":"Zhang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jri.2025.104738_bib32","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1080\/15548627.2016.1212787","article-title":"Lysosome calcium in ROS regulation of autophagy","volume":"12","author":"Zhang","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.jri.2025.104738_bib33","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.placenta.2016.09.015","article-title":"Autophagy protects against oxidized low density lipoprotein-mediated inflammation associated with preeclampsia","volume":"48","author":"Zhang","year":"2016","journal-title":"Placenta"}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503782500316X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503782500316X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:49:22Z","timestamp":1781189362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503782500316X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":33,"alternative-id":["S016503782500316X"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2025.104738","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The expression of MCOLN1 in preeclampsia maintains the balance of autophagy and pyroptosis induced by reactive oxygen species","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2025.104738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104738"}}