{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:14:38Z","timestamp":1781190878170,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017614","name":"Xi'an Medical University","doi-asserted-by":"publisher","award":["2024NLTS038"],"award-info":[{"award-number":["2024NLTS038"]}],"id":[{"id":"10.13039\/501100017614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jri.2025.104740","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:06:02Z","timestamp":1760501162000},"page":"104740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Altered immune cell profiles in maternal and umbilical cord blood and fetal growth restriction: A flow cytometric analysis"],"prefix":"10.1016","volume":"172","author":[{"given":"Ji","family":"Ting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Liuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Linlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yajing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Qiuhua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jri.2025.104740_bib1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41577-022-00763-8","article-title":"The roles of extracellular vesicles in the immune system","volume":"23","author":"Buzas","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2025.104740_bib2","article-title":"Novel insights into the complex interplay of immune dysregulation and inflammatory biomarkers in preeclampsia and fetal growth restriction: a two-step mendelian randomization analysis","volume":"8","author":"chumei","year":"2024","journal-title":"J. Transl. Autoimmun."},{"key":"10.1016\/j.jri.2025.104740_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.825075","article-title":"Chronic inflammatory placental disorders associated with recurrent adverse pregnancy outcome","volume":"13","author":"Cornish","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2025.104740_bib4","doi-asserted-by":"crossref","unstructured":"M.M.K. Flow Cytometry: An Overview. Current protocols in immunology, 2018, 120(1): 5.1.-5.1.11.","DOI":"10.1002\/cpim.40"},{"issue":"6","key":"10.1016\/j.jri.2025.104740_bib5","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.immuni.2017.11.018","article-title":"Natural killer cells promote fetal development through the secretion of growth-promoting factors","volume":"47","author":"Fu","year":"2017","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.jri.2025.104740_bib6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jri.2008.08.006","article-title":"Mid-pregnancy circulating cytokine levels, histologic chorioamnionitis and spontaneous preterm birth","volume":"79","author":"Gargano","year":"2008","journal-title":"J. Reprod. Immunol."},{"issue":"10","key":"10.1016\/j.jri.2025.104740_bib7","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm.2446","article-title":"A human memory t cell subset with stem cell\u2013like properties","volume":"17","author":"Gattinoni","year":"2011","journal-title":"Nat. Med."},{"issue":"12","key":"10.1016\/j.jri.2025.104740_bib8","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1084\/jem.194.12.1711","article-title":"Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4+ t cells","volume":"194","author":"Geginat","year":"2001","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.jri.2025.104740_bib9","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1084\/jem.186.9.1407","article-title":"Phenotypic and functional separation of memory and effector human CD8+ t cells","volume":"186","author":"Hamann","year":"1997","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.jri.2025.104740_bib10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1515\/jpm-2018-0286","article-title":"Characterization of fetal monocytes in preeclampsia and fetal growth restriction","volume":"47","author":"i A T, Heather","year":"2019","journal-title":"J. Perinat. Med."},{"issue":"5S","key":"10.1016\/j.jri.2025.104740_bib11","doi-asserted-by":"crossref","DOI":"10.1097\/01.AOG.0000931044.07378.99","article-title":"Effect of the new diagnostic criteria of fetal growth restriction on obstetric and neonatal outcomes [ID: 1376466]","volume":"141","author":"ibirogba","year":"2023","journal-title":"Obstet. Gynecol."},{"issue":"9","key":"10.1016\/j.jri.2025.104740_bib12","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFN\u03b3: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2025.104740_bib13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/1471-2407-11-225","article-title":"T lymphocytes derived from human cord blood provide effective antitumor immunotherapy against a human tumor","volume":"11","author":"Lee","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jri.2025.104740_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1486608","article-title":"Decoding the molecular pathways governing trophoblast migration and placental development; a literature review","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"3","key":"10.1016\/j.jri.2025.104740_bib15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/mi.2016.85","article-title":"Protection against maternal infection-associated fetal growth restriction: proof-of-concept with a microbial-derived immunomodulator","volume":"10","author":"M S N","year":"2017","journal-title":"Mucosal Immunol."},{"issue":"2","key":"10.1016\/j.jri.2025.104740_bib16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00003081-200606000-00006","article-title":"Fetal growth restriction: the etiology","volume":"49","author":"Maulik","year":"2006","journal-title":"Clin. Obstet. Gynecol."},{"issue":"12","key":"10.1016\/j.jri.2025.104740_bib17","doi-asserted-by":"crossref","first-page":"8299","DOI":"10.4049\/jimmunol.180.12.8299","article-title":"The central memory CD4+ t cell population generated during leishmania major infection requires IL-12 to produce IFN-\u03b3","volume":"180","author":"Pakpour","year":"2008","journal-title":"J. Immunol."},{"issue":"6491","key":"10.1016\/j.jri.2025.104740_bib18","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.aaz9330","article-title":"Prenatal development of human immunity","volume":"368","author":"Park","year":"2020","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jri.2025.104740_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-2567.2009.03189.x","article-title":"Plasticity of T-cell phenotype and function: the t helper type 17 example","volume":"129","author":"Peck","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.jri.2025.104740_bib20","doi-asserted-by":"crossref","first-page":"1343124","DOI":"10.3389\/fimmu.2024.1343124","article-title":"CD4\/CD8 ratio and CD8+ T-cell count as prognostic markers for non-AIDS mortality in people living with HIV. A systematic review and meta-analysis","volume":"15","author":"Ron","year":"2024","journal-title":"Front. Immunol."},{"issue":"6754","key":"10.1016\/j.jri.2025.104740_bib21","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory t lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jri.2025.104740_bib22","first-page":"117","article-title":"Combination of haploidentical hematopoietic stem cell transplantation with umbilical cord-derived mesenchymal stem cells in patients with severe aplastic anemia: a retrospective controlled study","volume":"39","author":"Sheng","year":"2022","journal-title":"Turk. J. Hematol."},{"key":"10.1016\/j.jri.2025.104740_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.placenta.2020.05.003","article-title":"The placenta in fetal growth restriction: what is going wrong?","volume":"96","author":"sun","year":"2020","journal-title":"Placenta"},{"issue":"26","key":"10.1016\/j.jri.2025.104740_bib24","article-title":"Better prediction for FGR (fetal growth restriction) with the sFlt-1\/PIGF ratio: a case-control study","volume":"98","author":"valeria","year":"2019","journal-title":"Medicine"},{"issue":"12","key":"10.1016\/j.jri.2025.104740_bib25","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/CM9.0000000000003114","article-title":"Role of maternal\u2013fetal immune tolerance in the establishment and maintenance of pregnancy","volume":"137","author":"Wang","year":"2024","journal-title":"Chin. Med. J."},{"issue":"7","key":"10.1016\/j.jri.2025.104740_bib26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","article-title":"Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?","volume":"14","author":"wegmann","year":"1993","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jri.2025.104740_bib27","unstructured":"Wroclaw Medical University W, Poland, Wroclaw Medical University W, Poland., Wroclaw Medical University W, Poland. Pattern of human monocyte subpopulations in health and disease. Scandinavian journal of immunology, 2020, 92(1): e12883."},{"issue":"1","key":"10.1016\/j.jri.2025.104740_bib28","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40001-018-0311-3","article-title":"Clinical evaluation of haploidentical hematopoietic combined with human umbilical cord-derived mesenchymal stem cells in severe aplastic anemia","volume":"23","author":"Xu","year":"2018","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.jri.2025.104740_bib29","article-title":"Crosstalk between trophoblasts and decidual immune cells: the cornerstone of maternal-fetal immunotolerance","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2025.104740_bib30","first-page":"1","article-title":"The immune microenvironment in maternal-fetal interface contributes to the parturition and preterm labor. Sheng li xue bao","volume":"72","author":"Yuan","year":"2020","journal-title":"Acta Physiol. Sin."},{"key":"10.1016\/j.jri.2025.104740_bib31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jri.2015.11.001","article-title":"New insights into myeloid-derived suppressor cells and their roles in feto-maternal immune cross-talk","volume":"113","author":"Zhao","year":"2016","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2025.104740_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ogc.2019.10.008","article-title":"The placental basis of fetal growth restriction","volume":"47","author":"Zur","year":"2020","journal-title":"Obstet. Gynecol. Clin."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037825003183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037825003183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:45:53Z","timestamp":1781189153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037825003183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":32,"alternative-id":["S0165037825003183"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2025.104740","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered immune cell profiles in maternal and umbilical cord blood and fetal growth restriction: A flow cytometric analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2025.104740","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104740"}}