{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:14:51Z","timestamp":1781190891848,"version":"3.54.1"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jri.2025.104746","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T21:42:16Z","timestamp":1761342136000},"page":"104746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Endometrial immune profiling: Bridging pre-eclampsia research with infertility solutions"],"prefix":"10.1016","volume":"172","author":[{"given":"Nathalie","family":"L\u00e9d\u00e9e","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada J.","family":"Habeichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Petitbarat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2025.104746_bib1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0015-0282(99)00605-6","article-title":"Endometrial dating and determination of the window of implantation in healthy fertile women","volume":"73","author":"Acosta","year":"2000","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2025.104746_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013663","article-title":"A new mouse model to explore therapies for preeclampsia","volume":"5","author":"Ahmed","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2025.104746_bib3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ni1037","article-title":"Regulatory T cells mediate maternal tolerance to the fetus","volume":"5","author":"Aluvihare","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib4","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1053\/beog.2000.0116","article-title":"The cell biological basis of human implantation","volume":"14","author":"Aplin","year":"2000","journal-title":"Baillieres Best. Pr. Res Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.jri.2025.104746_bib5","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.4049\/jimmunol.171.6.2937","article-title":"Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy","volume":"171","author":"Ashkar","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib6","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00109-008-0342-2","article-title":"Interaction between dendritic cells and natural killer cells during pregnancy in mice","volume":"86","author":"Blois","year":"2008","journal-title":"J. Mol. Med (Berl. )"},{"key":"10.1016\/j.jri.2025.104746_bib7","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0140-6736(95)91387-4","article-title":"Uterine junctional zone: function and disease","volume":"346","author":"Brosens","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2025.104746_bib8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jri.2016.09.002","article-title":"The role of decidual NK cells in pregnancies with impaired vascular remodelling","volume":"119","author":"Cartwright","year":"2017","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nrneph.2014.102","article-title":"Pre-eclampsia part 1: current understanding of its pathophysiology","volume":"10","author":"Chaiworapongsa","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jri.2025.104746_bib10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.imlet.2004.01.011","article-title":"Reproductive immunology 2003: reassessing the Th1\/Th2 paradigm?","volume":"92","author":"Chaouat","year":"2004","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jri.2025.104746_bib11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1600-0897.2005.00269.x","article-title":"Immunological similarities between implantation and pre-eclampsia","volume":"53","author":"Chaouat","year":"2005","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2025.104525","article-title":"Measurement of four novel endometrial NK cell subsets by multiplex staining in women with reproductive failure: A comparison with fertile controls","volume":"169","author":"Chen","year":"2025","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/14767058.2012.722712","article-title":"Effects of amniotic and maternal CD-146, TGF-beta1, IL-12, IL-18 and IFN-gamma, on adverse pregnancy outcome","volume":"26","author":"Cift","year":"2013","journal-title":"J. Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jri.2025.104746_bib14","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/AOG.0000000000002114","article-title":"Pregnancy-Related Mortality in the United States, 2011-2013","volume":"130","author":"Creanga","year":"2017","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2025.104746_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/hy02t2.102904","article-title":"Discovery of a spontaneous genetic mouse model of preeclampsia","volume":"39","author":"Davisson","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2025.104746_bib16","unstructured":"European Ivf Monitoring Consortium, for the European Society of Human Reproduction, Embryology, C. Wyns, C. De Geyter, C. Calhaz-Jorge, M. S. Kupka, T. Motrenko, J. Smeenk, C. Bergh, A. Tandler-Schneider, I. A. Rugescu, and V. Goossens. 2022. ART in Europe, 2018: results generated from European registries by ESHRE, Hum Reprod Open, 2022: hoac022."},{"key":"10.1016\/j.jri.2025.104746_bib17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/humrep\/dey001","article-title":"Endometrial natural killer (NK) cells reveal a tissue-specific receptor repertoire","volume":"33","author":"Feyaerts","year":"2018","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2025.104746_bib18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-2007-991042","article-title":"Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives","volume":"25","author":"Gellersen","year":"2007","journal-title":"Semin Reprod. Med"},{"key":"10.1016\/j.jri.2025.104746_bib19","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/humrep\/den011","article-title":"Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage","volume":"23","author":"Hiby","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2025.104746_bib20","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jri.2006.06.005","article-title":"Elevated serum levels of interleukin-15 and interleukin-16 in preeclampsia","volume":"73","author":"Hu","year":"2007","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib21","doi-asserted-by":"crossref","first-page":"1200330","DOI":"10.3389\/fcell.2023.1200330","article-title":"Establishment of the fetal-maternal interface: developmental events in human implantation and placentation","volume":"11","author":"Huang","year":"2023","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.jri.2025.104746_bib22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jri.2004.09.003","article-title":"Serum and placental interleukin-18 are elevated in preeclampsia","volume":"65","author":"Huang","year":"2005","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000382","article-title":"Periodic accumulation of regulatory T cells in the uterus: preparation for the implantation of a semi-allogeneic fetus?","volume":"2","author":"Kallikourdis","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2025.104746_bib24","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1600-0897.1996.tb00041.x","article-title":"Functions of human decidual NK cells","volume":"35","author":"King","year":"1996","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib25","first-page":"41","article-title":"Human uterine natural killer cells","volume":"15","author":"King","year":"1996","journal-title":"Nat. Immun."},{"key":"10.1016\/j.jri.2025.104746_bib26","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1084\/jem.20030305","article-title":"Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential","volume":"198","author":"Koopman","year":"2003","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.jri.2025.104746_bib27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1189\/jlb.1A0815-351R","article-title":"Decidual macrophages: key regulators of vascular remodeling in human pregnancy","volume":"100","author":"Lash","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jri.2025.104746_bib28","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000087906","article-title":"Physiological role of IL-15 and IL-18 at the maternal-fetal interface","volume":"89","author":"Laskarin","year":"2005","journal-title":"Chem. Immunol. Allergy"},{"key":"10.1016\/j.jri.2025.104746_bib29","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jri.2011.01.007","article-title":"New pre-conception immune biomarkers for clinical practice: interleukin-18, interleukin-15 and TWEAK on the endometrial side, G-CSF on the follicular side","volume":"88","author":"Ledee","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib30","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3389\/fimmu.2020.01032","article-title":"Endometrial Immune Profiling: A Method to Design Personalized Care in Assisted Reproductive Medicine","volume":"11","author":"Ledee","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103207","article-title":"The uterine immune profile: A method for individualizing the management of women who have failed to implant an embryo after IVF\/ICSI","volume":"142","author":"Ledee","year":"2020","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib32","first-page":"24","article-title":"The Next Frontier in ART: Harnessing the Uterine Immune Profile for Improved Performance","author":"Ledee","year":"2023","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jri.2025.104746_bib33","doi-asserted-by":"crossref","first-page":"1523871","DOI":"10.3389\/fimmu.2025.1523871","article-title":"Endometrial immune profiling and precision therapy increase live birth rate after embryo transfer: a randomised controlled trial","volume":"16","author":"Ledee","year":"2025","journal-title":"Front Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib34","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.fertnstert.2004.11.021","article-title":"Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization-embryo transfer failure","volume":"83","author":"Ledee-Bataille","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2025.104746_bib35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jri.2009.08.005","article-title":"Modulation of innate immunity by IL-18","volume":"83","author":"Li","year":"2009","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib36","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.ajpath.2013.05.029","article-title":"Decidual cell regulation of natural killer cell-recruiting chemokines: implications for the pathogenesis and prediction of preeclampsia","volume":"183","author":"Lockwood","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jri.2025.104746_bib37","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.cell.2005.09.022","article-title":"TWEAK attenuates the transition from innate to adaptive immunity","volume":"123","author":"Maecker","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jri.2025.104746_bib38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1600-0897.2009.00794.x","article-title":"The unique properties of uterine NK cells","volume":"63","author":"Manaster","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib39","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.4049\/jimmunol.181.3.1869","article-title":"Endometrial NK cells are special immature cells that await pregnancy","volume":"181","author":"Manaster","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1478-7954-10-17","article-title":"Measuring infertility in populations: constructing a standard definition for use with demographic and reproductive health surveys","volume":"10","author":"Mascarenhas","year":"2012","journal-title":"Popul Health Metr."},{"key":"10.1016\/j.jri.2025.104746_bib41","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.163422","article-title":"Vascular changes in the cycling and early pregnant uterus","volume":"8","author":"Massri","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.jri.2025.104746_bib42","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nri1897","article-title":"Immunology of placentation in eutherian mammals","volume":"6","author":"Moffett","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib43","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.rbmo.2016.08.019","article-title":"Variation of maternal KIR and fetal HLA-C genes in reproductive failure: too early for clinical intervention","volume":"33","author":"Moffett","year":"2016","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.jri.2025.104746_bib44","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3389\/fimmu.2018.00763","article-title":"Unique Action of Interleukin-18 on T Cells and Other Immune Cells","volume":"9","author":"Nakanishi","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib45","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.smim.2013.10.014","article-title":"Interleukin-18, more than a Th1 cytokine","volume":"25","author":"Novick","year":"2013","journal-title":"Semin Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib46","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1080\/14767058.2018.1560406","article-title":"Risk of preeclampsia following assisted reproductive technology: systematic review and meta-analysis of 72 cohort studies","volume":"33","author":"Omani-Samani","year":"2020","journal-title":"J. Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jri.2025.104746_bib47","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.274.5288.792","article-title":"Protection from natural killer cell-mediated lysis by HLA-G expression on target cells","volume":"274","author":"Pazmany","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jri.2025.104746_bib48","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.fertnstert.2009.10.049","article-title":"Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)\/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium","volume":"94","author":"Petitbarat","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2025.104746_bib49","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.fertnstert.2009.10.049","article-title":"Tumor necrosis factor-like weak inducer of apoptosis (TWEAK)\/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium","volume":"94","author":"Petitbarat","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2025.104746_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014497","article-title":"TWEAK appears as a modulator of endometrial IL-18 related cytotoxic activity of uterine natural killers","volume":"6","author":"Petitbarat","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2025.104746_bib51","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/imm.12588","article-title":"Endogenous TWEAK is critical for regulating the function of mouse uterine natural killer cells in an immunological model of pregnancy loss","volume":"148","author":"Qi","year":"2016","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.jri.2025.104746_bib52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000354200","article-title":"Cytokines as key players in the pathophysiology of preeclampsia","volume":"22","author":"Raghupathy","year":"2013","journal-title":"Med Princ. Pr."},{"key":"10.1016\/j.jri.2025.104746_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223888","article-title":"Increased BMI has a linear association with late-onset preeclampsia: A population-based study","volume":"14","author":"Robillard","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2025.104746_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2023.103968","article-title":"Preeclampsia in 2023: Time for preventing early onset- and term preeclampsia: The paramount role of gestational weight gain","volume":"158","author":"Robillard","year":"2023","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib55","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1055\/s-2007-991041","article-title":"Cytokines and chemokines during human embryo implantation: roles in implantation and early placentation","volume":"25","author":"Salamonsen","year":"2007","journal-title":"Semin Reprod. Med"},{"key":"10.1016\/j.jri.2025.104746_bib56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12522-011-0102-9","article-title":"Mechanism of maternal vascular remodeling during human pregnancy","volume":"11","author":"Sato","year":"2012","journal-title":"Reprod. Med Biol."},{"key":"10.1016\/j.jri.2025.104746_bib57","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejogrb.2019.01.020","article-title":"Evaluation of soluble TNF-like weak inducer of apoptosis (sTWEAK) levels to predict preeclampsia in early weeks of pregnancy","volume":"234","author":"Shahid","year":"2019","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.jri.2025.104746_bib58","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.immuni.2021.03.021","article-title":"The CD94\/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice","volume":"54","author":"Shreeve","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.jri.2025.104746_bib59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-7580.2008.01034.x","article-title":"Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation","volume":"215","author":"Singh","year":"2009","journal-title":"J. Anat."},{"key":"10.1016\/j.jri.2025.104746_bib60","doi-asserted-by":"crossref","first-page":"R490","DOI":"10.1152\/ajpregu.00176.2014","article-title":"Role of decidual natural killer cells, interleukin-15, and interferon-gamma in placental development and preeclampsia","volume":"307","author":"Sones","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jri.2025.104746_bib61","doi-asserted-by":"crossref","first-page":"S895","DOI":"10.1016\/j.ajog.2020.09.026","article-title":"Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia","volume":"226","author":"Staff","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2025.104746_bib62","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2025.104746_bib63","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1034\/j.1600-0897.2002.01132.x","article-title":"IL-18 is present at the maternal-fetal interface and enhances cytotoxic activity of decidual lymphocytes","volume":"48","author":"Tokmadzic","year":"2002","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib64","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1600-0897.2010.00879.x","article-title":"Placental interleukin-15 expression in recurrent miscarriage","volume":"64","author":"Toth","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib65","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.tjog.2022.09.005","article-title":"Alteration in IFN-gamma and CCL2 serum levels at first trimester of pregnancy contribute to development of preeclampsia and fetal growth restriction","volume":"62","author":"Vafaei","year":"2023","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2025.104746_bib66","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1095\/biolreprod62.4.959","article-title":"Human decidual natural killer cells express the receptor for and respond to the cytokine interleukin 15","volume":"62","author":"Verma","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jri.2025.104746_bib67","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-0897.1987.tb00156.x","article-title":"Placental immunotrophism: maternal T cells enhance placental growth and function","volume":"15","author":"Wegmann","year":"1987","journal-title":"Am. J. Reprod. Immunol. Microbiol"},{"key":"10.1016\/j.jri.2025.104746_bib68","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","article-title":"Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?","volume":"14","author":"Wegmann","year":"1993","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jri.2025.104746_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.951482","article-title":"The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy","volume":"13","author":"Wei","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib70","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1530\/REP-09-0007","article-title":"Altered decidual leucocyte populations in the placental bed in pre-eclampsia and foetal growth restriction: a comparison with late normal pregnancy","volume":"138","author":"Williams","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2025.104746_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.592010","article-title":"Roles of HLA-G in the maternal-fetal immune microenvironment","volume":"11","author":"Xu","year":"2020","journal-title":"Front Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib72","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/aji.12298","article-title":"Interleukin-18 and interferon gamma levels in preeclampsia: a systematic review and meta-analysis","volume":"72","author":"Yang","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib73","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5930589","article-title":"Soluble TNF-Like Weak Inducer of Apoptosis as a New Marker in Preeclampsia: A Pilot Clinical Study","volume":"2016","author":"Yildirim","year":"2016","journal-title":"Dis. Markers"},{"key":"10.1016\/j.jri.2025.104746_bib74","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/molehr\/7.7.649","article-title":"Evidence for the expression of interleukin (IL)-18, IL-18 receptor and IL-18 binding protein in the human endometrium","volume":"7","author":"Yoshino","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2025.104746_bib75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cmi.2010.38","article-title":"Natural killer cell-triggered vascular transformation: maternal care before birth?","volume":"8","author":"Zhang","year":"2010","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.jri.2025.104746_bib76","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00441-015-2315-4","article-title":"To serve and to protect: the role of decidual innate immune cells on human pregnancy","volume":"363","author":"Zhang","year":"2016","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jri.2025.104746_bib77","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.placenta.2023.05.013","article-title":"Unraveling the mysteries of spiral artery remodeling","volume":"141","author":"Zhang","year":"2023","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2025.104746_bib78","article-title":"Role of decidual natural killer cells in human pregnancy and related pregnancy complications","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037825003249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037825003249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T14:47:59Z","timestamp":1781189279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037825003249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":78,"alternative-id":["S0165037825003249"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2025.104746","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endometrial immune profiling: Bridging pre-eclampsia research with infertility solutions","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2025.104746","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104746"}}