{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:14:24Z","timestamp":1783358064719,"version":"3.54.6"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jri.2025.104830","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T23:30:05Z","timestamp":1767223805000},"page":"104830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Exploratory evaluation of the bacterial load of uterine microbiota: Potential implications for implantation and treatment response in assisted reproductive technology"],"prefix":"10.1016","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5310-989X","authenticated-orcid":false,"given":"Daisuke","family":"Kadogami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Nakaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2025.104830_bib1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fimmu.2018.00208","article-title":"Uterine microbiota: residents, tourists, or invaders?","volume":"9","author":"Baker","year":"2018","journal-title":"Front Immunol."},{"issue":"4","key":"10.1016\/j.jri.2025.104830_bib2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.immuni.2017.04.008","article-title":"Homeostatic immunity and the microbiota","volume":"46","author":"Belkaid","year":"2017","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.jri.2025.104830_bib3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41467-017-00901-0","article-title":"The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases","volume":"8","author":"Chen","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jri.2025.104830_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrmicro3552","article-title":"Gut biogeography of the bacterial microbiota","volume":"14","author":"Donaldson","year":"2016","journal-title":"Nat. Rev. Microbiol"},{"key":"10.1016\/j.jri.2025.104830_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1447190","article-title":"Less is more! Low amount of Fusobacterium nucleatum supports macrophage-mediated trophoblast functions in vitro","volume":"15","author":"Einenkel","year":"2024","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.jri.2025.104830_bib6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.tim.2018.11.003","article-title":"Contamination in low microbial biomass microbiome studies: issues and recommendations","volume":"27","author":"Eisenhofer","year":"2019","journal-title":"Trends Microbiol"},{"issue":"1","key":"10.1016\/j.jri.2025.104830_bib7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10815-015-0614-z","article-title":"Endometrial microbiome at the time of embryo transfer: next-generation sequencing of the 16S ribosomal subunit","volume":"33","author":"Franasiak","year":"2016","journal-title":"J. Assist Reprod. Genet"},{"issue":"6","key":"10.1016\/j.jri.2025.104830_bib8","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0015-0282(00)00518-5","article-title":"Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer","volume":"73","author":"Gardner","year":"2000","journal-title":"Fertil. Steril."},{"issue":"6285","key":"10.1016\/j.jri.2025.104830_bib9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1126\/science.aad9378","article-title":"How colonization by microbiota in early life shapes the immune system","volume":"352","author":"Gensollen","year":"2016","journal-title":"Sci"},{"issue":"6","key":"10.1016\/j.jri.2025.104830_bib10","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.fertnstert.2015.10.010","article-title":"Gynecologic health and disease in relation to the microbiome of the female reproductive tract","volume":"104","author":"Green","year":"2015","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.jri.2025.104830_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/humrep\/dew026","article-title":"Abnormal vaginal microbiota may be associated with poor reproductive outcomes: a prospective study in IVF patients","volume":"31","author":"Haahr","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2025.104830_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.698045","article-title":"Low abundance Fusobacterium nucleatum supports early pregnancy development \u2014 an in vitro study","volume":"12","author":"Heusler","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2025.104830_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1487990","article-title":"Diverse vaginal microbiota in healthy Japanese women; a combined relative and quantitative analysis","volume":"14","author":"Ito","year":"2025","journal-title":"Front. Cell. Infect. Microbiol"},{"issue":"3","key":"10.1016\/j.jri.2025.104830_bib14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.repbio.2020.07.001","article-title":"Use of a vaginal probiotic suppository and antibiotics to influence the composition of the endometrial microbiota","volume":"20","author":"Kadogami","year":"2020","journal-title":"Reprod. Biol."},{"issue":"4","key":"10.1016\/j.jri.2025.104830_bib15","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/aji.12277","article-title":"Comprehensive endometrial immunoglobulin subclass analysis in infertile women suffering from repeated implantation failure with or without chronic endometritis","volume":"72","author":"Kitaya","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"issue":"7","key":"10.1016\/j.jri.2025.104830_bib16","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41579-018-0029-9","article-title":"Best practices for analysing microbiomes","volume":"16","author":"Knight","year":"2018","journal-title":"Nat. Rev. Microbiol"},{"issue":"6","key":"10.1016\/j.jri.2025.104830_bib17","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/humrep\/dez065","article-title":"The vaginal microbiome as a predictor for outcome of in vitro fertilization with or without intracytoplasmic sperm injection: a prospective study","volume":"34","author":"Koedooder","year":"2019","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.jri.2025.104830_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.fertnstert.2018.06.036","article-title":"Cervicovaginal microbiota, women's health, and reproductive outcomes","volume":"110","author":"Kroon","year":"2018","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.jri.2025.104830_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/rmb2.12105","article-title":"Analysis of endometrial microbiota by 16S ribosomal RNA gene sequencing among infertile patients: a single-center pilot study","volume":"17","author":"Kyono","year":"2018","journal-title":"Reprod. Med Biol."},{"key":"10.1016\/j.jri.2025.104830_bib20","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1373\/clinchem.2018.289306","article-title":"Systematic comparison of bacterial colonization of endometrial tissue and fluid samples in recurrent miscarriage patients: implications for future endometrial microbiome studies","volume":"64","author":"Liu","year":"2018","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.jri.2025.104830_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13073-016-0307-y","article-title":"The healthy human microbiome","volume":"8","author":"Lloyd-Price","year":"2016","journal-title":"Genome Med"},{"key":"10.1016\/j.jri.2025.104830_bib22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40168-015-0094-5","article-title":"The vocabulary of microbiome research: a proposal","volume":"3","author":"Marchesi","year":"2015","journal-title":"Microbiome"},{"issue":"5","key":"10.1016\/j.jri.2025.104830_bib23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ajog.2014.11.043","article-title":"Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women","volume":"212","author":"Mitchell","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.jri.2025.104830_bib24","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ajog.2016.09.075","article-title":"Evidence that the endometrial microbiota affects implantation success or failure","volume":"215","author":"Moreno","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.jri.2025.104830_bib25","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/humrep\/der108","article-title":"Microbial colonization of follicular fluid: alterations in cytokine expression and adverse assisted reproduction technology outcomes","volume":"26","author":"Pelzer","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2025.104830_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13073-016-0291-2","article-title":"Translating the vaginal microbiome: gaps and challenges","volume":"8","author":"Ravel","year":"2016","journal-title":"Genome Med"},{"issue":"5","key":"10.1016\/j.jri.2025.104830_bib27","first-page":"567","article-title":"Infection through structured polymicrobial Gardnerella biofilms (stPM-GB)","volume":"29","author":"Swidsinski","year":"2014","journal-title":"Histol. Histopathol."},{"issue":"1","key":"10.1016\/j.jri.2025.104830_bib28","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3390\/ijms25010622","article-title":"Clinical relevance of vaginal and endometrial microbiome investigation in women with repeated implantation failure and recurrent pregnancy loss","volume":"25","author":"Xushan","year":"2024","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jri.2025.104830_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12941-024-00710-6","article-title":"Chronic endometritis and the endometrial microbiota: implications for reproductive success in patients with recurrent implantation failure","volume":"23","author":"Zhang","year":"2024","journal-title":"Ann. Clin. Microbiol Antimicrob."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037825004085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037825004085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:17:46Z","timestamp":1783354666000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037825004085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":29,"alternative-id":["S0165037825004085"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2025.104830","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploratory evaluation of the bacterial load of uterine microbiota: Potential implications for implantation and treatment response in assisted reproductive technology","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2025.104830","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104830"}}