{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:29:35Z","timestamp":1793132975906,"version":"4.5.0"},"reference-count":157,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020916","name":"Hungarian Research Network","doi-asserted-by":"publisher","award":["TECH-2024\\u2013042"],"award-info":[{"award-number":["TECH-2024\\u2013042"]}],"id":[{"id":"10.13039\/100020916","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["R21HD115800"],"award-info":[{"award-number":["R21HD115800"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["2024\\u20131.2.3-HU-RIZONT-2024\\u201300062"],"award-info":[{"award-number":["2024\\u20131.2.3-HU-RIZONT-2024\\u201300062"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["00012"],"award-info":[{"award-number":["00012"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015269","name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015498","name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015498","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jri.2026.104846","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:47:34Z","timestamp":1769708854000},"page":"104846","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Pathologic abnormalities of deep placentation in the great obstetrical syndromes: Implications for understanding the pathophysiology, risk assessment in early pregnancy, and personalized prevention"],"prefix":"10.1016","volume":"174","author":[{"given":"Gerg\u0151","family":"Leipold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Robillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Merkely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9","family":"Posta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Szalai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Benk\u0151","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Marton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Valent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi L.","family":"Tarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u00e1ta","family":"Hargitai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Offer","family":"Erez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor G\u00e1bor","family":"Than","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2026.104846_bib1","first-page":"159","article-title":"ACOG committee on practice bulletins, ACOG practice bulletin No. 33: diagnosis and management of preeclampsia and eclampsia","volume":"99","author":"ACOG","year":"2002","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/AOG.0000000000002709","article-title":"ACOG committee opinion No. 743 summary: low-dose aspirin use during pregnancy","volume":"132","author":"ACOG","year":"2018","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.preghy.2010.10.007","article-title":"Preeclampsia and the anti-angiogenic state","volume":"1","author":"Agarwal","year":"2011","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.jri.2026.104846_bib4","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.0000147365.86159.f5","article-title":"Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia","volume":"95","author":"Ahmad","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.jri.2026.104846_bib5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/humrep\/deaa303","article-title":"Something old, something new: digital quantification of uterine vascular remodelling and trophoblast plugging in historical collections provides new insight into adaptation of the utero-placental circulation","volume":"36","author":"Allerkamp","year":"2021","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2026.104846_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/uog.24795","article-title":"Development and validation of model for prediction of placental dysfunction-related stillbirth from maternal factors, fetal weight and uterine artery Doppler at mid-gestation","volume":"59","author":"Ashoor","year":"2022","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib7","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0140-6736(07)60712-0","article-title":"Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data","volume":"369","author":"Askie","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2026.104846_bib8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/path.1927","article-title":"Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion","volume":"208","author":"Ball","year":"2006","journal-title":"J. Pathol."},{"key":"10.1016\/j.jri.2026.104846_bib9","doi-asserted-by":"crossref","first-page":"259 e1","DOI":"10.1016\/j.ajog.2019.09.003","article-title":"Placental growth factor predicts time to delivery in women with signs or symptoms of early preterm preeclampsia: a prospective multicenter study","volume":"222","author":"Barton","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib10","doi-asserted-by":"crossref","first-page":"i1753","DOI":"10.1136\/bmj.i1753","article-title":"Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies","volume":"353","author":"Bartsch","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.jri.2026.104846_bib11","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0140-6736(85)92207-X","article-title":"Prevention of pre-eclampsia by early antiplatelet therapy","volume":"1","author":"Beaufils","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2026.104846_bib12","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jcmg.2020.01.005","article-title":"Myocardial evaluation of post-preeclamptic women by CMR: is early risk stratification possible","volume":"13","author":"Birukov","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.jri.2026.104846_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00018-014-1713-1","article-title":"A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia","volume":"72","author":"Blois","year":"2015","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jri.2026.104846_bib14","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/path.1700930218","article-title":"The physiological response of the vessels of the placental bed to normal pregnancy","volume":"93","author":"Brosens","year":"1967","journal-title":"J. Pathol. Bacteriol."},{"key":"10.1016\/j.jri.2026.104846_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \"Great Obstetrical Syndromes\" are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2024.08.010","article-title":"Prevalence of placental bed spiral artery pathology in preeclampsia and fetal growth restriction: a prospective cohort study","volume":"156","author":"Brouwers","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib17","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/AOG.0b013e3181e9322a","article-title":"Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis","volume":"116","author":"Bujold","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib18","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/pd.4403","article-title":"Low-dose aspirin for prevention of adverse outcomes related to abnormal placentation","volume":"34","author":"Bujold","year":"2014","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.jri.2026.104846_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1469-7580.2008.00978.x","article-title":"Oxygen, the Janus gas; its effects on human placental development and function","volume":"215","author":"Burton","year":"2009","journal-title":"J. Anat."},{"issue":"A","key":"10.1016\/j.jri.2026.104846_bib20","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.placenta.2008.11.003","article-title":"Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib21","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1530\/REP-09-0092","article-title":"Regulation of vascular growth and function in the human placenta","volume":"138","author":"Burton","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.jri.2026.104846_bib22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.placenta.2009.02.009","article-title":"Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib23","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0061","article-title":"Human evolution: brain, birthweight and the immune system","volume":"370","author":"Burton","year":"2015","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.jri.2026.104846_bib24","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM199803123381101","article-title":"Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units","volume":"338","author":"Caritis","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jri.2026.104846_bib25","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ajog.2020.11.007","article-title":"Performance of soluble fms-like tyrosine kinase-1-to-placental growth factor ratio of >\/=85 for ruling in preeclampsia within 4 weeks","volume":"224","author":"Cerdeira","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib26","doi-asserted-by":"crossref","first-page":"650.e1","DOI":"10.1016\/j.ajog.2019.09.041","article-title":"Prospective evaluation of screening performance of first-trimester prediction models for preterm preeclampsia in an Asian population","volume":"221","author":"Chaemsaithong","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib27","doi-asserted-by":"crossref","first-page":"S1071","DOI":"10.1016\/j.ajog.2020.07.020","article-title":"First trimester preeclampsia screening and prediction","volume":"226","author":"Chaemsaithong","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/14767050400028816","article-title":"Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia","volume":"17","author":"Chaiworapongsa","year":"2005","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/14767050701832833","article-title":"The maternal plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated in SGA and the magnitude of the increase relates to Doppler abnormalities in the maternal and fetal circulation","volume":"21","author":"Chaiworapongsa","year":"2008","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib30","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3109\/14767050902994838","article-title":"A subset of patients destined to develop spontaneous preterm labor has an abnormal angiogenic\/anti-angiogenic profile in maternal plasma: evidence in support of pathophysiologic heterogeneity of preterm labor derived from a longitudinal study","volume":"22","author":"Chaiworapongsa","year":"2009","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib31","doi-asserted-by":"crossref","first-page":"287e1","DOI":"10.1016\/j.ajog.2013.01.016","article-title":"Maternal plasma concentrations of angiogenic\/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia","volume":"208","author":"Chaiworapongsa","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib32","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3109\/14767058.2015.1048431","article-title":"The use of angiogenic biomarkers in maternal blood to identify which SGA fetuses will require a preterm delivery and mothers who will develop pre-eclampsia","volume":"29","author":"Chaiworapongsa","year":"2016","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib33","doi-asserted-by":"crossref","first-page":"682.e1","DOI":"10.1016\/j.ajog.2017.10.001","article-title":"The prediction of fetal death with a simple maternal blood test at 20-24 weeks: a role for angiogenic index-1 (PlGF\/sVEGFR-1 ratio)","volume":"217","author":"Chaiworapongsa","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.placenta.2022.07.020","article-title":"Diagnostic capacity of sFlt-1\/PlGF ratio in fetal growth restriction: A systematic review and meta-analysis","volume":"127","author":"Chen","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib35","doi-asserted-by":"crossref","first-page":"486.e1","DOI":"10.1016\/j.ajog.2019.01.227","article-title":"Prediction of small for gestational age neonates: screening by maternal factors, fetal biometry, and biomarkers at 35-37 weeks' gestation","volume":"220","author":"Ciobanu","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib36","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1097\/01.AOG.0000147599.47713.5d","article-title":"World Health Organization systematic review of screening tests for preeclampsia","volume":"104","author":"Conde-Agudelo","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0143-4004(98)90055-8","article-title":"Decidual spiral artery remodelling begins before cellular interaction with cytotrophoblasts","volume":"19","author":"Craven","year":"1998","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/uog.5184","article-title":"Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction","volume":"31","author":"Crispi","year":"2008","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1081\/PRG-120021060","article-title":"Subclassification of preeclampsia","volume":"22","author":"von Dadelszen","year":"2003","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.jri.2026.104846_bib40","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/00003081-199909000-00002","article-title":"Risk factors for preeclampsia","volume":"42","author":"Dekker","year":"1999","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib41","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/14767050902866804","article-title":"The great obstetrical syndromes","volume":"22","author":"Di Renzo","year":"2009","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib42","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/HYPERTENSIONAHA.120.15146","article-title":"Prediction of preeclampsia-related adverse outcomes with the sFlt-1 (Soluble fms-Like Tyrosine Kinase 1)\/PlGF (Placental Growth Factor)-ratio in the clinical routine: a real-world study","volume":"77","author":"Droge","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2026.104846_bib43","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/14767050802034545","article-title":"The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age","volume":"21","author":"Erez","year":"2008","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib44","doi-asserted-by":"crossref","first-page":"S786","DOI":"10.1016\/j.ajog.2021.12.001","article-title":"Preeclampsia and eclampsia: the conceptual evolution of a syndrome","volume":"226","author":"Erez","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib45","doi-asserted-by":"crossref","first-page":"580.e1","DOI":"10.1016\/j.ajog.2022.11.1276","article-title":"Perturbations in kinetics of the thrombin generation assay identify women at risk of preeclampsia in the first trimester and provide the rationale for a preventive approach","volume":"228","author":"Erez","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/14767050600922677","article-title":"A role of the anti-angiogenic factor sVEGFR-1 in the 'mirror syndrome' (Ballantyne's syndrome)","volume":"19","author":"Espinoza","year":"2006","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib47","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1515\/JPM.2006.089","article-title":"Normal and abnormal transformation of the spiral arteries during pregnancy","volume":"34","author":"Espinoza","year":"2006","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.jri.2026.104846_bib48","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/14767050701413022","article-title":"Unexplained fetal death: another anti-angiogenic state","volume":"20","author":"Espinoza","year":"2007","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib49","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1556\/650.2025.33305","article-title":"The effects of environmental factors on the embryonic and late postembryonic life through epigenetic mechanisms","volume":"166","author":"F\u00fcl\u00f6p","year":"2025","journal-title":"Orv. Hetil."},{"key":"10.1016\/j.jri.2026.104846_bib50","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S2352-4642(18)30129-9","article-title":"Screening for fetal growth restriction using ultrasound and the sFLT1\/PlGF ratio in nulliparous women: a prospective cohort study","volume":"2","author":"Gaccioli","year":"2018","journal-title":"Lancet Child Adolesc. Health"},{"key":"10.1016\/j.jri.2026.104846_bib51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1556\/650.2025.33254","article-title":"Fetal growth restriction as the disease of the placenta","volume":"166","author":"G\u00e9recz","year":"2025","journal-title":"Orv. Hetil."},{"key":"10.1016\/j.jri.2026.104846_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajogmf.2023.101000","article-title":"Comparing aspirin 75\u201381 mg vs 150\u2013162 mg for prevention of preterm preeclampsia: systematic review and meta-analysis","volume":"5","author":"Ghesquiere","year":"2023","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"10.1016\/j.jri.2026.104846_bib53","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0140-6736(78)91367-3","article-title":"Aspirin for the treatment of recurrent toxaemia","volume":"2","author":"Goodlin","year":"1978","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2026.104846_bib54","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1586\/14737159.2015.1025757","article-title":"Biomarker development for presymptomatic molecular diagnosis of preeclampsia: feasible, useful or even unnecessary?","volume":"15","author":"Hahn","year":"2015","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.jri.2026.104846_bib55","first-page":"516","article-title":"Oxidative stress in preeclampsia and the role of free fetal hemoglobin","volume":"5","author":"Hansson","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jri.2026.104846_bib56","article-title":"Human extravillous trophoblasts penetrate decidual veins and lymphatics before remodeling spiral arteries during early pregnancy","volume":"12","author":"He","year":"2017","journal-title":"PLOS One"},{"key":"10.1016\/j.jri.2026.104846_bib57","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/uog.18894","article-title":"Longitudinal change of sFlt-1\/PlGF ratio in singleton pregnancy with early-onset fetal growth restriction","volume":"52","author":"Herraiz","year":"2018","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib58","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0140-6736(19)32973-3","article-title":"Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial","volume":"395","author":"Hoffman","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2026.104846_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2023.103985","article-title":"Placental physioxia is based on spatial and temporal variations of placental oxygenation throughout pregnancy","volume":"158","author":"Huppertz","year":"2023","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104846_bib60","doi-asserted-by":"crossref","first-page":"S844","DOI":"10.1016\/j.ajog.2021.11.1356","article-title":"The etiology of preeclampsia","volume":"226","author":"Jung","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib61","first-page":"539","article-title":"Predictive value of the sFlt-1\/PlGF ratio and interleukin-6 for the presence of placental lesions in spontaneous preterm labor with intact membranes with delivery within 7 days","volume":"51","author":"Kacerovsky","year":"2024","journal-title":"Fetal Diagn. Ther."},{"key":"10.1016\/j.jri.2026.104846_bib62","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bpobgyn.2010.10.012","article-title":"Defective deep placentation","volume":"25","author":"Khong","year":"2011","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.jri.2026.104846_bib63","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1067\/mob.2002.127720","article-title":"Failure of physiologic transformation of the spiral arteries in the placental bed in preterm premature rupture of membranes","volume":"187","author":"Kim","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib64","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1067\/S0002-9378(03)00838-X","article-title":"Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes","volume":"189","author":"Kim","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib65","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.3109\/14767058.2014.976198","article-title":"The frequency of acute atherosis in normal pregnancy and preterm labor, preeclampsia, small-for-gestational age, fetal death and midtrimester spontaneous abortion","volume":"28","author":"Kim","year":"2015","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib66","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3109\/14767058.2014.960835","article-title":"Placental lesions associated with acute atherosis","volume":"28","author":"Kim","year":"2015","journal-title":"J. Matern Fetal Neonatal Med"},{"key":"10.1016\/j.jri.2026.104846_bib67","doi-asserted-by":"crossref","first-page":"629.e1","DOI":"10.1016\/j.ajog.2015.11.015","article-title":"Maternal plasma angiogenic index-1 (placental growth factor\/soluble vascular endothelial growth factor receptor-1) is a biomarker for the burden of placental lesions consistent with uteroplacental underperfusion: a longitudinal case-cohort study","volume":"214","author":"Korzeniewski","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib68","doi-asserted-by":"crossref","first-page":"336.e1","DOI":"10.1016\/j.ajog.2022.09.006","article-title":"Low-dose aspirin use in pregnancy and the risk of preterm birth: a Swedish register-based cohort study","volume":"228","author":"Kupka","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib69","doi-asserted-by":"crossref","first-page":"382.e1","DOI":"10.1016\/j.ajog.2008.02.016","article-title":"Twin-to-twin transfusion syndrome: an antiangiogenic state?","volume":"198","author":"Kusanovic","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib70","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3109\/14767050902994754","article-title":"A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia","volume":"22","author":"Kusanovic","year":"2009","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib71","doi-asserted-by":"crossref","first-page":"287e1","DOI":"10.1016\/j.ajog.2016.12.029","article-title":"Failure of physiologic transformation of spiral arteries, endothelial and trophoblast cell activation, and acute atherosis in the basal plate of the placenta","volume":"216","author":"Labarrere","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib72","doi-asserted-by":"crossref","unstructured":"Labarrere, C.A., et al., 2025. Evidence that atherosis of the spiral artery represents atherosclerotic lesions similar to those of native and transplant-induced atherosclerosis: implications for understanding the pathophysiology of obstetrical syndromes and long-term cardiovascular risk. 22:S0002-9378, (25) 00764-1. doi: 10.1016\/j.ajog.2025.10.026.","DOI":"10.1016\/j.ajog.2025.10.026"},{"key":"10.1016\/j.jri.2026.104846_bib73","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1161\/HYPERTENSIONAHA.119.14580","article-title":"Multiplex analysis of circulating maternal cardiovascular biomarkers comparing preeclampsia subtypes","volume":"75","author":"Lekva","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2026.104846_bib74","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jri.2026.104846_bib75","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating antiangiogenic factors in preeclampsia","volume":"355","author":"Levine","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jri.2026.104846_bib76","doi-asserted-by":"crossref","first-page":"251.e1","DOI":"10.1016\/j.ajog.2021.08.004","article-title":"A randomized controlled trial of low-dose aspirin for the prevention of preeclampsia in women at high risk in China","volume":"226","author":"Lin","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib77","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.2147\/IJWH.S283239","article-title":"Reviewing accuracy of first trimester screening for preeclampsia using maternal factors and biomarkers","volume":"14","author":"Malone","year":"2022","journal-title":"Int. J. Women\u2019s. Health"},{"key":"10.1016\/j.jri.2026.104846_bib78","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000087912","article-title":"Immunology of preeclampsia","volume":"89","author":"Matthiesen","year":"2005","journal-title":"Chem. Immunol. Allergy"},{"key":"10.1016\/j.jri.2026.104846_bib79","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.jri.2026.104846_bib80","article-title":"Pravastatin in preeclampsia: a meta-analysis and systematic review","volume":"9","author":"M\u00e9sz\u00e1ros","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.jri.2026.104846_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1336764","article-title":"A meta-analysis on first-trimester blood count parameters-is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening?","volume":"11","author":"M\u00e9sz\u00e1ros","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.jri.2026.104846_bib82","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1067\/S0002-9378(03)00576-3","article-title":"The frequency and severity of placental findings in women with preeclampsia are gestational age dependent","volume":"189","author":"Moldenhauer","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib83","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1136\/bmj.287.6392.580","article-title":"Case-control study of severe pre-eclampsia of early onset","volume":"287","author":"Moore","year":"1983","journal-title":"Br. Med. J. (Clin. Res Ed."},{"key":"10.1016\/j.jri.2026.104846_bib84","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00418-018-1699-0","article-title":"Human trophoblast invasion: new and unexpected routes and functions","volume":"150","author":"Moser","year":"2018","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jri.2026.104846_bib85","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11906-015-0595-4","article-title":"Preeclampsia: syndrome or disease?","volume":"17","author":"Myatt","year":"2015","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.jri.2026.104846_bib86","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4161\/auto.22927","article-title":"Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia","volume":"9","author":"Nakashima","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.jri.2026.104846_bib87","doi-asserted-by":"crossref","first-page":"66.e1","DOI":"10.1016\/j.ajog.2013.09.010","article-title":"Placental pathology suggesting that preeclampsia is more than one disease","volume":"210","author":"Nelson","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib88","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0002-9378(96)70056-X","article-title":"Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications","volume":"175","author":"Ness","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib89","unstructured":"NICE, 2019. Hypertension in pregnancy: diagnosis and management. London. https:\/\/www.nice.org.uk\/guidance\/ng133."},{"key":"10.1016\/j.jri.2026.104846_bib90","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/uog.14889","article-title":"Early prediction and aspirin for prevention of pre-eclampsia (EPAPP) study: a randomized controlled trial","volume":"46","author":"Odibo","year":"2015","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib91","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1515\/jpm.2011.098","article-title":"Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia","volume":"39","author":"Ogge","year":"2011","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.jri.2026.104846_bib92","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1556\/650.2023.32935","article-title":"Immune cell functionality during pregnancy","volume":"164","author":"P\u00e1llinger","year":"2023","journal-title":"Orv. Hetil."},{"key":"10.1016\/j.jri.2026.104846_bib93","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/uog.22129","article-title":"Competing-risks model for prediction of small-for-gestational-age neonate from maternal characteristics and medical history","volume":"56","author":"Papastefanou","year":"2020","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib94","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tcm.2018.04.009","article-title":"Preeclampsia and the cardiovascular system: an update","volume":"28","author":"Perry","year":"2018","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.jri.2026.104846_bib95","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0143-4004(83)80043-5","article-title":"Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy","volume":"4","author":"Pijnenborg","year":"1983","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib96","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1161\/HYPERTENSIONAHA.108.127977","article-title":"First-trimester prediction of hypertensive disorders in pregnancy","volume":"53","author":"Poon","year":"2009","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.jri.2026.104846_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijgo.12802","article-title":"The international federation of gynecology and obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention","volume":"145","author":"Poon","year":"2019","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.jri.2026.104846_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.placenta.2024.07.198","article-title":"The evolution of the Zinc Finger 554 (ZNF554) locus in anthropoid primates and its implications for deep placentation and preeclampsia","volume":"154","author":"Posta","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib99","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCULATIONAHA.111.054361","article-title":"Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia","volume":"125","author":"Rana","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jri.2026.104846_bib100","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.preghy.2018.05.008","article-title":"Angiogenic biomarkers in triage and risk for preeclampsia with severe features","volume":"13","author":"Rana","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.jri.2026.104846_bib101","doi-asserted-by":"crossref","first-page":"S1019","DOI":"10.1016\/j.ajog.2020.10.022","article-title":"Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders","volume":"226","author":"Rana","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib102","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10024-003-8083-2","article-title":"Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns","volume":"7","author":"Redline","year":"2004","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.jri.2026.104846_bib103","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41379-021-00747-4","article-title":"Four major patterns of placental injury: a stepwise guide for understanding and implementing the 2016 Amsterdam consensus","volume":"34","author":"Redline","year":"2021","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.jri.2026.104846_bib104","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.placenta.2013.12.008","article-title":"IFPA senior award lecture: making sense of pre-eclampsia - two placental causes of preeclampsia?","volume":"35","author":"Redman","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib105","article-title":"Performance of the first-trimester fetal medicine foundation competing risks model for preeclampsia prediction: an external validation study in Brazil","volume":"4","author":"Rezende","year":"2024","journal-title":"AJOG Glob. Rep."},{"key":"10.1016\/j.jri.2026.104846_bib106","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/uog.12421","article-title":"Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: a meta-analysis","volume":"41","author":"Roberge","year":"2013","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib107","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajog.2016.09.076","article-title":"The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis","volume":"216","author":"Roberge","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib108","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ajog.2017.12.238","article-title":"Meta-analysis on the effect of aspirin use for prevention of preeclampsia on placental abruption and antepartum hemorrhage","volume":"218","author":"Roberge","year":"2018","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib109","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/0002-9378(89)90665-0","article-title":"Preeclampsia: an endothelial cell disorder","volume":"161","author":"Roberts","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib110","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1161\/HYPERTENSIONAHA.120.14781","article-title":"Subtypes of preeclampsia: recognition and determining clinical usefulness","volume":"77","author":"Roberts","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2026.104846_bib111","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223888","article-title":"Increased BMI has a linear association with late-onset preeclampsia: a population-based study","volume":"14","author":"Robillard","year":"2019","journal-title":"PLOS One"},{"key":"10.1016\/j.jri.2026.104846_bib112","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jri.2019.05.003","article-title":"High incidence of early onset preeclampsia is probably the rule and not the exception worldwide. 20th anniversary of the reunion workshop. A summary","volume":"133","author":"Robillard","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104846_bib113","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1080\/14767058.2020.1786516","article-title":"The blurring boundaries between placental and maternal preeclampsia: a critical appraisal of 1800 consecutive preeclamptic cases","volume":"35","author":"Robillard","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib114","doi-asserted-by":"crossref","first-page":"S867","DOI":"10.1016\/j.ajog.2021.11.019","article-title":"Progress in the understanding of the pathophysiology of immunologic maladaptation related to early-onset preeclampsia and metabolic syndrome related to late-onset preeclampsia","volume":"226","author":"Robillard","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib115","doi-asserted-by":"crossref","first-page":"158","DOI":"10.26502\/jppch.74050197","article-title":"Quantitative discrimination of small for gestational age (SGA) singleton newborns. incidences, risk factors and foetal outcomes of the three major subtypes of SGA: a 23-year cohort of 8,601 singleton SGA (Out of 83,917 Births)","volume":"8","author":"Robillard","year":"2024","journal-title":"J. Pediatr. Perinatol. Child Health"},{"key":"10.1016\/j.jri.2026.104846_bib116","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia","volume":"377","author":"Rolnik","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jri.2026.104846_bib117","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/14767050701830480","volume":"21","author":"Romero","year":"2008","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib118","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1080\/14767050902784171","article-title":"Prenatal medicine: the child is the father of the man","volume":"22","author":"Romero","year":"2009","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib119","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.3109\/14767051003681121","article-title":"An imbalance between angiogenic and anti-angiogenic factors precedes fetal death in a subset of patients: results of a longitudinal study","volume":"23","author":"Romero","year":"2010","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib120","doi-asserted-by":"crossref","first-page":"615.e1","DOI":"10.1016\/j.ajog.2022.04.015","article-title":"Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified according to placental pathology","volume":"227","author":"Romero","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib121","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jri.2013.06.002","article-title":"A review of the mechanism for poor placentation in early-onset preeclampsia: the role of autophagy in trophoblast invasion and vascular remodeling","volume":"101-102","author":"Saito","year":"2014","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104846_bib122","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3109\/10641955.2016.1148162","article-title":"KRYPTOR-automated angiogenic factor assays and risk of preeclampsia-related adverse outcomes","volume":"35","author":"Salahuddin","year":"2016","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.jri.2026.104846_bib123","doi-asserted-by":"crossref","first-page":"828","DOI":"10.3109\/14767050903440471","article-title":"Evidence in support of a role for anti-angiogenic factors in preterm prelabor rupture of membranes","volume":"23","author":"Savasan","year":"2010","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib124","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jri.2015.01.009","article-title":"Endothelial dysfunction and metabolic syndrome in preeclampsia: an alternative viewpoint","volume":"108","author":"Scioscia","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104846_bib125","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jri.2026.104846_bib126","article-title":"A randomized controlled study comparing the efficacy of 75mg Versus 150mg aspirin for the prevention of preeclampsia in high-risk pregnant women","volume":"15","author":"Sinha","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.jri.2026.104846_bib127","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3109\/14767058.2011.591461","article-title":"Late-onset preeclampsia is associated with an imbalance of angiogenic and anti-angiogenic factors in patients with and without placental lesions consistent with maternal underperfusion","volume":"25","author":"Soto","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.jri.2026.104846_bib128","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/HYPERTENSIONAHA.116.08620","article-title":"Prediction of preeclampsia using the soluble fms-like tyrosine kinase 1 to placental growth factor ratio: a prospective cohort study of unselected nulliparous women","volume":"69","author":"Sovio","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2026.104846_bib129","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1161\/HYPERTENSIONAHA.110.157743","article-title":"Learning from the placenta: acute atherosis and vascular remodeling in preeclampsia-novel aspects for atherosclerosis and future cardiovascular health","volume":"56","author":"Staff","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.jri.2026.104846_bib130","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.placenta.2012.11.022","article-title":"Review: Preeclampsia, acute atherosis of the spiral arteries and future cardiovascular disease: two new hypotheses","volume":"34","author":"Staff","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib131","doi-asserted-by":"crossref","first-page":"S895","DOI":"10.1016\/j.ajog.2020.09.026","article-title":"Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia","volume":"226","author":"Staff","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib132","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.placenta.2013.12.003","article-title":"IFPA award in placentology lecture: preeclampsia, the decidual battleground and future maternal cardiovascular disease","volume":"35","author":"Staff","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib133","doi-asserted-by":"crossref","first-page":"234.e1","DOI":"10.1016\/j.ajog.2013.10.015","article-title":"Comparison of placental pathology in preterm, late-preterm, near-term, and term births","volume":"210","author":"Stanek","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib134","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054153","article-title":"Gestation dependant changes in angiogenic factors and their associations with fetal growth measures in normotensive pregnancy","volume":"8","author":"Sundrani","year":"2013","journal-title":"PLOS One"},{"key":"10.1016\/j.jri.2026.104846_bib135","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1556\/650.2023.32702","article-title":"Correlation between placental perfusion measured in the entire placenta versus assessed by sonobiopsy","volume":"164","author":"Sur\u00e1nyi","year":"2023","journal-title":"Orv. Hetil."},{"key":"10.1016\/j.jri.2026.104846_bib136","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12253-014-9872-9","article-title":"Activation of villous trophoblastic p38 and ERK1\/2 signaling pathways in preterm preeclampsia and HELLP syndrome","volume":"21","author":"Szab\u00f3","year":"2015","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.jri.2026.104846_bib137","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110867","article-title":"In vivo experiments reveal the good, the bad and the ugly faces of sFlt-1 in pregnancy","volume":"9","author":"Szalai","year":"2014","journal-title":"PLOS One"},{"key":"10.1016\/j.jri.2026.104846_bib138","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119547","article-title":"Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice","volume":"10","author":"Szalai","year":"2015","journal-title":"PLOS One"},{"key":"10.1016\/j.jri.2026.104846_bib139","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1210\/jc.2003-031244","article-title":"First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia","volume":"89","author":"Thadhani","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2026.104846_bib140","unstructured":"Than, G.N., et al., 1993. Advances in pregnancy-related protein research. Functional and clinical applications. CRC Press: Boca Raton, FL, USA. https:\/\/www.taylorfrancis.com\/books\/edit\/10.1201\/9780367812164\/advances-pregnancy-related-protein-research-functional-clinical-applications-denes-szabo-gabor-bohn."},{"key":"10.1016\/j.jri.2026.104846_bib141","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3389\/fimmu.2018.01661","article-title":"Integrated systems biology approach identifies novel maternal and placental pathways of preeclampsia","volume":"9","author":"Than","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2026.104846_bib142","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.placenta.2022.03.009","article-title":"Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: the intersection of clinical, pathological, and high-dimensional biology studies","volume":"125","author":"Than","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib143","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1515\/jpm-2022-0433","article-title":"Molecular subclasses of preeclampsia characterized by a longitudinal maternal proteomics study: distinct biomarkers, disease pathways and options for prevention","volume":"51","author":"Than","year":"2023","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.jri.2026.104846_bib144","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2023.104172","article-title":"Classification of preeclampsia according to molecular clusters with the goal of achieving personalized prevention","volume":"161","author":"Than","year":"2024","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104846_bib145","doi-asserted-by":"crossref","DOI":"10.3390\/jpm14070698","article-title":"Diagnosis, prevention, and management of fetal growth restriction (FGR)","volume":"14","author":"Tsikouras","year":"2024","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.jri.2026.104846_bib146","doi-asserted-by":"crossref","first-page":"152.e1","DOI":"10.1016\/j.ajog.2010.08.049","article-title":"Circulating angiogenic and antiangiogenic factors in women with eclampsia","volume":"204","author":"Vaisbuch","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib147","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.placenta.2010.04.014","article-title":"Microarray profiling reveals that placental transcriptomes of early-onset HELLP syndrome and preeclampsia are similar","volume":"32","author":"V\u00e1rkonyi","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib148","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2026.104846_bib149","doi-asserted-by":"crossref","first-page":"161.e1","DOI":"10.1016\/j.ajog.2009.09.016","article-title":"An automated method for the determination of the sFlt-1\/PIGF ratio in the assessment of preeclampsia","volume":"202","author":"Verlohren","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib150","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/uog.13310","article-title":"Uterine artery Doppler, birth weight and timing of onset of pre-eclampsia: providing insights into the dual etiology of late-onset pre-eclampsia","volume":"44","author":"Verlohren","year":"2014","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib151","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s13224-022-01636-9","article-title":"Placental growth factor in first trimester of pregnancy for prediction of maternal and perinatal adverse outcomes","volume":"72","author":"Verma","year":"2022","journal-title":"J. Obstet. Gynaecol. India"},{"key":"10.1016\/j.jri.2026.104846_bib152","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1471-0528.2012.03493.x","article-title":"Aspirin in the prevention of pre-eclampsia in high-risk women: a randomised placebo-controlled PREDO trial and a meta-analysis of randomised trials","volume":"120","author":"Villa","year":"2013","journal-title":"BJOG"},{"key":"10.1016\/j.jri.2026.104846_bib153","doi-asserted-by":"crossref","first-page":"310.e1","DOI":"10.1016\/j.ajog.2013.01.017","article-title":"Evidence of an imbalance of angiogenic\/antiangiogenic factors in massive perivillous fibrin deposition (maternal floor infarction): a placental lesion associated with recurrent miscarriage and fetal death","volume":"208","author":"Whitten","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib154","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/humrep\/dex058","article-title":"Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions","volume":"32","author":"Windsperger","year":"2017","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2026.104846_bib155","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/uog.19178","article-title":"Soluble fms-like tyrosine kinase-1 to placental growth factor ratio: ruling out pre-eclampsia for up to 4 weeks and value of retesting","volume":"53","author":"Zeisler","year":"2019","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104846_bib156","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.placenta.2023.05.013","article-title":"Unraveling the mysteries of spiral artery remodeling","volume":"141","author":"Zhang","year":"2023","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104846_bib157","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000512335","article-title":"Performance of the FMF first-trimester preeclampsia-screening algorithm in a high-risk population in The Netherlands","volume":"48","author":"Zwertbroek","year":"2021","journal-title":"Fetal Diagn. Ther."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503782600015X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016503782600015X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:10:32Z","timestamp":1782187832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016503782600015X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":157,"alternative-id":["S016503782600015X"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2026.104846","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathologic abnormalities of deep placentation in the great obstetrical syndromes: Implications for understanding the pathophysiology, risk assessment in early pregnancy, and personalized prevention","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2026.104846","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104846"}}