{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:48:11Z","timestamp":1782190091465,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jri.2026.104851","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:15:40Z","timestamp":1770336940000},"page":"104851","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["circVEGFC strengthens high glucose-induced trophoblast cell inflammation and apoptosis"],"prefix":"10.1016","volume":"174","author":[{"given":"Fang","family":"Miao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8439-1865","authenticated-orcid":false,"given":"Chunli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2026.104851_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cca.2021.09.003","article-title":"Pyroptosis in diabetic nephropathy","volume":"523","author":"Al Mamun","year":"2021","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.jri.2026.104851_bib2","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/bab.2233","article-title":"Caspase-3: Structure, function, and biotechnological aspects","volume":"69","author":"Asadi","year":"2022","journal-title":"Biotechnol. Appl. Biochem"},{"issue":"3","key":"10.1016\/j.jri.2026.104851_bib3","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s11033-021-06967-w","article-title":"Structural and functional changes in the kidney caused by adverse fetal and neonatal environments","volume":"49","author":"Awazu","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"10","key":"10.1016\/j.jri.2026.104851_bib4","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.7150\/jca.111680","article-title":"The dual roles of circular RNAs in breast cancer distant metastasis and their clinical applications","volume":"16","author":"Bao","year":"2025","journal-title":"J. Cancer"},{"issue":"8","key":"10.1016\/j.jri.2026.104851_bib5","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.3390\/ijms22083948","article-title":"Molecular imaging of apoptosis: the case of Caspase-3 Radiotracers","volume":"22","author":"Beroske","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"36","key":"10.1016\/j.jri.2026.104851_bib6","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.2174\/1381612827666210125155428","article-title":"Gestational diabetes mellitus pharmacological prevention and treatment","volume":"27","author":"Chatzakis","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jri.2026.104851_bib7","first-page":"9","article-title":"Circular RNA circNCOA3 promotes tumor progression and anti-PD-1 resistance in colorectal cancer","volume":"7","author":"Chen","year":"2024","journal-title":"Cancer Drug Resist"},{"issue":"2","key":"10.1016\/j.jri.2026.104851_bib8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/biom11020226","article-title":"Involvement of miR-30a-5p and miR-30d in endothelial to mesenchymal transition and early osteogenic commitment under inflammatory stress in HUVEC","volume":"11","author":"Ciavarella","year":"2021","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.jri.2026.104851_bib9","doi-asserted-by":"crossref","first-page":"8187","DOI":"10.1080\/21655979.2021.2006964","article-title":"Danhong injection represses diabetic retinopathy and nephropathy advancement in diabetic mice by upregulating microRNA-30d-5p and targeting JAK1","volume":"13","author":"Deng","year":"2022","journal-title":"Bioengineered"},{"issue":"7","key":"10.1016\/j.jri.2026.104851_bib10","doi-asserted-by":"crossref","first-page":"6186","DOI":"10.3390\/ijms24076186","article-title":"Circulating microRNA as biomarkers for gestational diabetes mellitus-a systematic review and meta-analysis","volume":"24","author":"Dinesen","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.jri.2026.104851_bib11","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.3390\/ijms21114020","article-title":"Non-Coding RNA: role in gestational diabetes pathophysiology and complications","volume":"21","author":"Filardi","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jri.2026.104851_bib12","first-page":"17","article-title":"Immunoregulatory biomarkers of the remission phase in Type 1 diabetes: miR-30d-5p modulates PD-1 expression and regulatory T cell expansion","volume":"9","author":"Gomez-Munoz","year":"2023","journal-title":"Noncoding RNA"},{"issue":"7","key":"10.1016\/j.jri.2026.104851_bib13","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.3390\/ijms21072437","article-title":"Diabetes mellitus and cardiovascular risk assessment in mothers with a history of gestational diabetes mellitus based on postpartal expression profile of MicroRNAs associated with diabetes mellitus and cardiovascular and cerebrovascular diseases","volume":"21","author":"Hromadnikova","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.jri.2026.104851_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117589","article-title":"Empagliflozin attenuating renal interstitial fibrosis in diabetic kidney disease by inhibiting lymphangiogenesis and lymphatic endothelial-to-mesenchymal transition via the VEGF-C\/VEGFR3 pathway","volume":"180","author":"Huang","year":"2024","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.jri.2026.104851_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.placenta.2019.12.003","article-title":"Decreased placental apoptosis and autophagy in pregnancies complicated by gestational diabetes with large-for-gestational age fetuses","volume":"90","author":"Hung","year":"2020","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.jri.2026.104851_bib16","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1042\/EBC20200060","article-title":"Circular RNAs as microRNA sponges: evidence and controversies","volume":"65","author":"Jarlstad Olesen","year":"2021","journal-title":"Essays Biochem"},{"key":"10.1016\/j.jri.2026.104851_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/bs.apcsb.2021.01.006","article-title":"Cell death mechanisms and their roles in pregnancy related disorders","volume":"126","author":"Kasture","year":"2021","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.jri.2026.104851_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117985","article-title":"Combination therapy with anti-CD20 mAb and IL-10 gene to reverse type 1 diabetes by attenuating pancreatitis and inhibiting apoptosis in NOD mice","volume":"256","author":"Li","year":"2020","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.jri.2026.104851_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3892\/etm.2021.9618","article-title":"Abnormal expression of TRIAP1 and its role in gestational diabetes mellitus-related pancreatic beta cells","volume":"21","author":"Li","year":"2021","journal-title":"Exp. Ther. Med"},{"issue":"4","key":"10.1016\/j.jri.2026.104851_bib20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.jri.2026.104851_bib21","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41392-023-01561-x","article-title":"Circular RNA vaccine in disease prevention and treatment","volume":"8","author":"Niu","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.jri.2026.104851_bib22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s11033-025-10778-8","article-title":"miR-27a-3p, miR-222-3p and miR-340-5p as indicators of the antioxidant response activation in gestational diabetes","volume":"52","author":"Penezic","year":"2025","journal-title":"Mol. Biol. Rep."},{"issue":"11","key":"10.1016\/j.jri.2026.104851_bib23","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.3390\/ijms19113342","article-title":"The pathophysiology of gestational diabetes mellitus","volume":"19","author":"Plows","year":"2018","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jri.2026.104851_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12933-019-0918-x","article-title":"Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review","volume":"18","author":"Pordzik","year":"2019","journal-title":"Cardiovasc Diabetol."},{"key":"10.1016\/j.jri.2026.104851_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1399694","article-title":"Genetic and inflammatory factors underlying gestational diabetes mellitus: a review","volume":"15","author":"Ray","year":"2024","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"10","key":"10.1016\/j.jri.2026.104851_bib26","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3390\/antiox12101812","article-title":"Role of oxidative stress and inflammation in gestational diabetes mellitus","volume":"12","author":"Saucedo","year":"2023","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.jri.2026.104851_bib27","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.2147\/DMSO.S334728","article-title":"CircRNA circVEGFC is highly expressed in gestational diabetes mellitus (GDM) and it is correlated with multiple adverse events","volume":"14","author":"She","year":"2021","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.jri.2026.104851_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.reprotox.2019.02.001","article-title":"Mitochondrial-related gene associated to obesity can be modulated by in utero hyperglycemic environment","volume":"85","author":"Silveira","year":"2019","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.jri.2026.104851_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144654","article-title":"hsa_circ_0041795 contributes to human retinal pigment epithelial cells (ARPE 19) injury induced by high glucose via sponging miR-646 and activating VEGFC","volume":"747","author":"Sun","year":"2020","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.jri.2026.104851_bib30","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/pr.2014.72","article-title":"Maternal pregravid obesity changes gene expression profiles toward greater inflammation and reduced insulin sensitivity in umbilical cord","volume":"76","author":"Thakali","year":"2014","journal-title":"Pedia Res"},{"issue":"21","key":"10.1016\/j.jri.2026.104851_bib31","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1042\/CS20160305","article-title":"Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA","volume":"130","author":"Tryggestad","year":"2016","journal-title":"Clin. Sci. (Lond. )"},{"key":"10.1016\/j.jri.2026.104851_bib32","article-title":"Suppression of microRNA-222-3p ameliorates ulcerative colitis and colitis-associated colorectal cancer to protect against oxidative stress via targeting BRG1 to activate Nrf2\/HO-1 signaling pathway","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol."},{"issue":"14","key":"10.1016\/j.jri.2026.104851_bib33","doi-asserted-by":"crossref","first-page":"14365","DOI":"10.18632\/aging.103478","article-title":"Circular RNA circVEGFC accelerates high glucose-induced vascular endothelial cells apoptosis through miR-338-3p\/HIF-1alpha\/VEGFA axis","volume":"12","author":"Wei","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jri.2026.104851_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116561","article-title":"Impact of imidacloprid exposure on gestational hyperglycemia: a multi-omics analysis","volume":"280","author":"Wen","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"3","key":"10.1016\/j.jri.2026.104851_bib35","doi-asserted-by":"crossref","first-page":"333","DOI":"10.4093\/dmj.2022.0348","article-title":"Gestational diabetes mellitus and its implications across the life span","volume":"47","author":"Wicklow","year":"2023","journal-title":"Diabetes Metab. J."},{"issue":"19","key":"10.1016\/j.jri.2026.104851_bib36","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.3390\/nu14193930","article-title":"High folate, perturbed one-carbon metabolism and gestational diabetes mellitus","volume":"14","author":"Williamson","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jri.2026.104851_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116815","article-title":"The crosstalk between cell death and pregnancy related diseases: a narrative review","volume":"176","author":"Xie","year":"2024","journal-title":"Biomed. Pharm."},{"issue":"6","key":"10.1016\/j.jri.2026.104851_bib38","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.32604\/or.2024.047524","article-title":"CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression","volume":"32","author":"Yi","year":"2024","journal-title":"Oncol. Res"},{"issue":"8","key":"10.1016\/j.jri.2026.104851_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdiacomp.2021.107959","article-title":"Down-regulation of microRNA-30d-5p is associated with gestational diabetes mellitus by targeting RAB8A","volume":"35","author":"Zhang","year":"2021","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.jri.2026.104851_bib40","first-page":"30","article-title":"The role of circRNAs and miRNAs in drug resistance and targeted therapy responses in breast cancer","volume":"7","author":"Zhang","year":"2024","journal-title":"Cancer Drug Resist"},{"key":"10.1016\/j.jri.2026.104851_bib41","article-title":"Non-coding RNAs and extracellular vehicles: their role in the pathogenesis of gestational diabetes mellitus","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jri.2026.104851_bib42","article-title":"Unraveling molecular networks in thymic epithelial tumors: deciphering the unique signatures","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2026.104851_bib43","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12943-020-01286-3","article-title":"Circular RNA: metabolism, functions and interactions with proteins","volume":"19","author":"Zhou","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jri.2026.104851_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.738325","article-title":"The role of the VEGF family in coronary heart disease","volume":"8","author":"Zhou","year":"2021","journal-title":"Front. Cardiovasc. Med."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037826000203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037826000203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:15:51Z","timestamp":1782188151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037826000203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":44,"alternative-id":["S0165037826000203"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2026.104851","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"circVEGFC strengthens high glucose-induced trophoblast cell inflammation and apoptosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2026.104851","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104851"}}