{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:48:13Z","timestamp":1782190093936,"version":"3.54.5"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jri.2026.104852","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T16:23:32Z","timestamp":1769790212000},"page":"104852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Why reproduction has probably been very problematic in Neanderthals: The fabulous history of (pre)eclampsia"],"prefix":"10.1016","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-9045","authenticated-orcid":false,"given":"Pierre-Yves","family":"Robillard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustaaf","family":"Dekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2026.104852_bib1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jri.2018.05.007","article-title":"The duration of sexual relationship and its effects on adverse pregnancy outcomes","volume":"128","author":"Andraweera","year":"2018","journal-title":"J. Reprod. Immunol."},{"issue":"11","key":"10.1016\/j.jri.2026.104852_bib2","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.3390\/ijms20112837","article-title":"The role of epigenetics in placental development and the etiology of preeclampsia","volume":"20","author":"Apicella","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jri.2026.104852_bib3","first-page":"S1","article-title":"Current growth standards, definitions, diagnosis and classification of fetal growth retardation","volume":"52","author":"Bakketeig","year":"1998","journal-title":"Eur. J. Clin. Nutr."},{"issue":"5","key":"10.1016\/j.jri.2026.104852_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.siny.2004.03.007","article-title":"Prenatal diagnosis of fetal growth restriction","volume":"9","author":"Bamberg","year":"2004","journal-title":"Semin Fetal Neonatal Med"},{"issue":"5","key":"10.1016\/j.jri.2026.104852_bib5","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1552-6909.2010.01172.x","article-title":"A historical overview of preeclampsia-eclampsia","volume":"39","author":"Bell","year":"2010","journal-title":"J. Obstet. Gynecol. Neonatal Nurs."},{"issue":"3","key":"10.1016\/j.jri.2026.104852_bib6","doi-asserted-by":"crossref","DOI":"10.1590\/1984-3143-ar2024-0042","article-title":"Interaction of semen with female reproductive tract tissues: what we know, what we guess and what we need to do","volume":"21","author":"Bromfield","year":"2024","journal-title":"Anim. Reprod."},{"issue":"3","key":"10.1016\/j.jri.2026.104852_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \"great obstetrical syndromes\" are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104852_bib8","first-page":"177","article-title":"The role of the spiral arteries in the pathogenesis of preeclampsia","volume":"1","author":"Brosens","year":"1972","journal-title":"Obstet. Gynecol. Annu"},{"issue":"4","key":"10.1016\/j.jri.2026.104852_bib9","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/00003081-198412000-00004","article-title":"History and epidemiology of preeclampsia-eclampsia","volume":"27","author":"Chesley","year":"1984","journal-title":"Clin. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104852_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1477-7827-10-24","article-title":"hCG, the wonder of today's science","volume":"10","author":"Cole","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jri.2026.104852_bib11","first-page":"124","article-title":"The evolution of the primate, hominid and human brain","volume":"4","author":"Cole","year":"2015","journal-title":"J. Prima"},{"issue":"5","key":"10.1016\/j.jri.2026.104852_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216742","article-title":"Living on the edge: was demographic weakness the cause of Neanderthal demise?","volume":"14","author":"Degioanni","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jri.2026.104852_bib13","first-page":"325","article-title":"Preeclampsia\u2014an immune disease? An epidemiologic narrative","volume":"1","author":"Dekker","year":"2021","journal-title":"Explor Immunol."},{"issue":"1","key":"10.1016\/j.jri.2026.104852_bib14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia [published correction appears in Nat Rev Dis Primers","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"1","key":"10.1016\/j.jri.2026.104852_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF02778058","article-title":"Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma","volume":"7","author":"Elliott","year":"1997","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.jri.2026.104852_bib16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1053\/j.semperi.2011.09.011","article-title":"Maternal mortality from preeclampsia\/eclampsia","volume":"36","author":"Ghulmiyyah","year":"2012","journal-title":"Semin Perinatol."},{"issue":"5368","key":"10.1016\/j.jri.2026.104852_bib17","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.280.5368.1345","article-title":"Solving the brain's energy crisis","volume":"280","author":"Gibbons","year":"1998","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.jri.2026.104852_bib18","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1084\/jem.20041214","article-title":"Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success","volume":"200","author":"Hiby","year":"2004","journal-title":"J. Exp. Med"},{"issue":"2","key":"10.1016\/j.jri.2026.104852_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00001703-199804000-00009","article-title":"Pre-eclampsia--still a disease of theories?","volume":"10","author":"Higgins","year":"1998","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.jri.2026.104852_bib20","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/1471-0528.13858","article-title":"Predicting pre-eclampsia: 100 years of trying and failing","volume":"123","author":"Jauniaux","year":"2016","journal-title":"BJOG"},{"issue":"3","key":"10.1016\/j.jri.2026.104852_bib21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ajog.2021.11.1357","article-title":"Clinical opinion: the diagnosis and management of suspected fetal growth restriction: an evidence-based approach","volume":"226","author":"Lees","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104852_bib22","series-title":"Chesley's Hypertensive Disorders in Pregnancy","first-page":"3","article-title":"L. Introduction, history, controversies and definitions","author":"Lindheimer","year":"1999"},{"issue":"4","key":"10.1016\/j.jri.2026.104852_bib23","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/AOG.0000000000000472","article-title":"Maternal morbidity associated with early-onset and late-onset preeclampsia","volume":"124","author":"Lisonkova","year":"2014","journal-title":"Obstet. Gynecol."},{"issue":"19","key":"10.1016\/j.jri.2026.104852_bib24","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMra2109523","article-title":"Preeclampsia","volume":"386","author":"Magee","year":"2022","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.jri.2026.104852_bib25","article-title":"A maternal-fetal PIEZO1 incompatibility as a barrier to Neanderthal-modern human admixture","author":"Makhro","year":"2025","journal-title":"bioRxiv"},{"issue":"3","key":"10.1016\/j.jri.2026.104852_bib26","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1053\/j.semperi.2008.02.011","article-title":"Doppler vascular changes in intrauterine growth restriction","volume":"32","author":"Mari","year":"2008","journal-title":"Semin Perinatol."},{"issue":"4","key":"10.1016\/j.jri.2026.104852_bib27","first-page":"149","article-title":"Scaling of the mammalian barrier: the maternal energy hypothesis","author":"Martin","year":"1996","journal-title":"N. Physiol. Sc."},{"issue":"2","key":"10.1016\/j.jri.2026.104852_bib28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0165-0378(03)00042-1","article-title":"Human reproduction: a comparative background for medical hypotheses","volume":"59","author":"Martin","year":"2003","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2026.104852_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169311","article-title":"Prediction of small for gestational age infants in healthy nulliparous women using clinical and ultrasound risk factors combined with early pregnancy biomarkers","volume":"12","author":"McCowan","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jri.2026.104852_bib30","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s43032-023-01330-9","article-title":"Early fetal growth restriction with or without hypertensive disorders: a clinical overview","volume":"31","author":"Mecacci","year":"2024","journal-title":"Reprod. Sci."},{"issue":"1","key":"10.1016\/j.jri.2026.104852_bib31","first-page":"1","article-title":"Co-evolution of NK cell receptors, HLA-C and KIR2D","volume":"267","author":"Moffett","year":"2014","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.jri.2026.104852_bib32","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41576-018-0092-0","article-title":"Genomic imprinting disorders: lessons on how genome, epigenome and environment interact","volume":"20","author":"Monk","year":"2019","journal-title":"Nat. Rev. Genet"},{"issue":"2","key":"10.1016\/j.jri.2026.104852_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri3370","article-title":"Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution","volume":"13","author":"Parham","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2026.104852_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0143-4004(80)80012-9","article-title":"Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy","volume":"1","author":"Pijnenborg","year":"1980","journal-title":"Placenta"},{"issue":"8858","key":"10.1016\/j.jri.2026.104852_bib35","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/0140-6736(93)90889-O","article-title":"Pre-eclampsia: more than pregnancy-induced hypertension [published correction appears in Lancet","volume":"341","author":"Roberts","year":"1993","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jri.2026.104852_bib36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/aji.12107","article-title":"Seminal fluid and the generation of regulatory T cells for embryo implantation","volume":"69","author":"Robertson","year":"2013","journal-title":"Am. J. Reprod. Immunol."},{"issue":"8928","key":"10.1016\/j.jri.2026.104852_bib37","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0140-6736(94)91638-1","article-title":"Association of pregnancy-induced hypertension with duration of sexual cohabitation before conception","volume":"344","author":"Robillard","year":"1994","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jri.2026.104852_bib38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0165-0378(03)00040-8","article-title":"Preeclampsia and human reproduction. An essay of a long term reflection","volume":"59","author":"Robillard","year":"2003","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104852_bib39","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jri.2017.09.006","article-title":"Historical evolution of ideas on eclampsia\/preeclampsia: a proposed optimistic view of preeclampsia","volume":"123","author":"Robillard","year":"2017","journal-title":"J. Reprod. Immunol."},{"issue":"10","key":"10.1016\/j.jri.2026.104852_bib40","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1080\/14767058.2017.1312333","article-title":"La \"Donna di Ostuni\", a case of eclampsia 28,000 years ago?","volume":"31","author":"Robillard","year":"2018","journal-title":"J. Matern Fetal Neonatal Med"},{"issue":"2S","key":"10.1016\/j.jri.2026.104852_bib41","doi-asserted-by":"crossref","first-page":"S867","DOI":"10.1016\/j.ajog.2021.11.019","article-title":"Progress in the understanding of the pathophysiology of immunologic maladaptation related to early-onset preeclampsia and metabolic syndrome related to late-onset preeclampsia","volume":"226","author":"Robillard","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jri.2026.104852_bib42","first-page":"158","article-title":"Quantitative discrimination of small for gestational age (SGA) singleton newborns. incidences. risk factors and f\u0153tal outcomes of the three major subtypes of SGA: a 23-year cohort of 8,601 singleton SGA (out of 83,917 births)","author":"Robillard","year":"2024","journal-title":"J. Pediatr. Perinatol. Child Health"},{"issue":"1","key":"10.1016\/j.jri.2026.104852_bib43","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12884-020-02909-9","article-title":"Preeclampsia management modalities and perinatal death: a retrospective study in Woldia general hospital","volume":"20","author":"Tlaye","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"issue":"11","key":"10.1016\/j.jri.2026.104852_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0225117","article-title":"Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction","volume":"14","author":"Vaesen","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jri.2026.104852_bib45","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1038\/s41598-021-84410-7","article-title":"An emerging consensus in palaeoanthropology: demography was the main factor responsible for the disappearance of Neanderthals [published correction appears in Sci Rep","volume":"11","author":"Vaesen","year":"2021","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.jri.2026.104852_bib46","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.placenta.2009.02.011","article-title":"The H19 gene imprinting in normal pregnancy and pre-eclampsia","volume":"30","author":"Yu","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.jri.2026.104852_bib47","first-page":"672","article-title":"Eklampsie","author":"Zweifel","year":"1916","journal-title":"Handb. Der Geburtshilfe Bergman"}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037826000215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037826000215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:15:58Z","timestamp":1782188158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037826000215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":47,"alternative-id":["S0165037826000215"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2026.104852","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Why reproduction has probably been very problematic in Neanderthals: The fabulous history of (pre)eclampsia","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2026.104852","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104852"}}