{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:09:12Z","timestamp":1785294552910,"version":"3.55.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20lk0201108h0001"],"award-info":[{"award-number":["20lk0201108h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23lk0201158h0002"],"award-info":[{"award-number":["23lk0201158h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24lk0201158h0003"],"award-info":[{"award-number":["24lk0201158h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22lk0201158h0001"],"award-info":[{"award-number":["22lk0201158h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2021E-1"],"award-info":[{"award-number":["2021E-1"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2025C-22"],"award-info":[{"award-number":["2025C-22"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2022S-3"],"award-info":[{"award-number":["2022S-3"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2024S-1"],"award-info":[{"award-number":["2024S-1"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jri.2026.104904","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:01:02Z","timestamp":1777474862000},"page":"104904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Efficacy of tacrolimus treatment in two-dose single-group controlled trial for patients with refractory infertility"],"prefix":"10.1016","volume":"175","author":[{"given":"Michi","family":"Hisano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takakazu","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidefumi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9471-1078","authenticated-orcid":false,"given":"Koushi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2026.104904_bib1","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.biopha.2016.10.062","article-title":"Novel immunotherapeutic approaches for treatment of infertility","volume":"84","author":"Abdolmohammadi-Vahid","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jri.2026.104904_bib2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and management of infertility: a review","volume":"326","author":"Carson","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jri.2026.104904_bib3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1600-0897.2009.00790.x","article-title":"CD3-CD56+CD16+ natural killer cells and improvement of pregnancy outcome in IVF\/ICSI failure after additional IVIG-treatment","volume":"63","author":"Heilmann","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib4","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000034317","article-title":"Multicenter, 2-dose single-group controlled trial of tacrolimus for the severe infertility patients","volume":"102","author":"Hisano","year":"2023","journal-title":"Medicine"},{"key":"10.1016\/j.jri.2026.104904_bib5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/01.TP.0000084823.89528.89","article-title":"Pregnancy after liver transplantation with tacrolimus immunosuppression: a single center\u2019s experience update at 13 years","volume":"76","author":"Jain","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.jri.2026.104904_bib6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/01.TP.0000117564.50117.FB","article-title":"Pregnancy after kidney and kidney-pancreas transplantation under tacrolimus: a single center's experience","volume":"77","author":"Jain","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.jri.2026.104904_bib7","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1097\/00007890-200012270-00010","article-title":"Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus","volume":"70","author":"Kainz","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.jri.2026.104904_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/aji.12234","article-title":"Immunological modes of pregnancy loss: inflammation, immune effectors, and stress","volume":"72","author":"Kwak-Kim","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib9","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.fertnstert.2022.04.009","article-title":"The role of immunologic tests for subfertility in the clinical environment","volume":"117","author":"Kwak-Kim","year":"2022","journal-title":"Fertil. Steril."},{"issue":"4","key":"10.1016\/j.jri.2026.104904_bib10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ja.2012.116","article-title":"Streptomyces tsukubensis sp. nov., a producer of the immunosuppressant tacrolimus","volume":"66","author":"Muramatsu","year":"2013","journal-title":"J. Antibiot."},{"key":"10.1016\/j.jri.2026.104904_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/aji.12338","article-title":"Immunosuppression with tacrolimus improved reproductive outcome of women with repeated implantation failure and elevated peripheral blood Th1\/Th2 cell ratios","volume":"73","author":"Nakagawa","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1600-0897.2010.00852.x","article-title":"Th1\/Th2\/Th17 and regulatory T-cell paradigm in pregnancy","volume":"63","author":"Saito","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1600-0897.2012.01169.x","article-title":"Intravenous immunoglobulin for repeated IVF failure and unexplained infertility","volume":"68","author":"Virro","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1600-0897.2008.00669.x","article-title":"Treatment with adalimumab (Humira) and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF","volume":"61","author":"Winger","year":"2009","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1600-0897.2010.00946.x","article-title":"Degree of TNF-\u03b1\/IL-10 cytokine elevation correlates with IVF success rates in women undergoing treatment with Adalimumab (Humira) and IVIG","volume":"65","author":"Winger","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13097","article-title":"Tacrolimus treatment for infertility related to maternal-fetal immune interactions","volume":"81","author":"Yamaguchi","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib17","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","article-title":"Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib18","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/oxfordjournals.humrep.a138581","article-title":"Analysis of the fourth to eighth in-vitro fertilization treatments after three previously failed attempts","volume":"9","author":"Yovel","year":"1994","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2026.104904_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2022.103785","article-title":"Unexplained recurrent pregnancy loss: novel causes and advanced treatment","volume":"155","author":"Yu","year":"2023","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104904_bib20","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.fertnstert.2012.12.043","article-title":"A randomized clinical trial to evaluate the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) in embryo culture medium for in vitro fertilization","volume":"99","author":"Ziebe","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jri.2026.104904_bib21","unstructured":"World Health Organization, 2023. Infertility prevalence estimates, 1990\u20132021. Accessed January 9, 2026. \u3008https:\/\/iris.who.int\/server\/api\/core\/bitstreams\/a22ced65-46b1-4482-bf85-058719fec649\/content\u3009."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037826000732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037826000732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:08:06Z","timestamp":1783152486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037826000732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":21,"alternative-id":["S0165037826000732"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2026.104904","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of tacrolimus treatment in two-dose single-group controlled trial for patients with refractory infertility","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2026.104904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104904"}}