{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:11:32Z","timestamp":1789593092921,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Reproductive Immunology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jri.2026.104961","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:50:54Z","timestamp":1788364254000},"page":"104961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Aberrant integrin expression on peripheral blood NK cells of women with recurrent pregnancy losses and repeated implantation failures"],"prefix":"10.1016","volume":"177","author":[{"given":"Ayano","family":"Yamaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-8946","authenticated-orcid":false,"given":"Umida","family":"Ganieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Vinh","family":"Luu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Thees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-7458","authenticated-orcid":false,"given":"Atsushi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Dambaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-1645","authenticated-orcid":false,"given":"Joanne","family":"Kwak-Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jri.2026.104961_bib1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1600-0897.2010.00913.x","article-title":"Immunologic characteristics of preeclampsia, a comprehensive review","volume":"65","author":"Ahn","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2024.104295","article-title":"The impact of reproductive hormones on t cell immunity; normal and assisted reproductive cycles","volume":"165","author":"Alanazi","year":"2024","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1600-0897.1996.tb00497.x","article-title":"Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in vitro fertilization cycles","volume":"35","author":"Beer","year":"1996","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib4","first-page":"6","article-title":"Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium","author":"Brighton","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.jri.2026.104961_bib5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/oxfordjournals.humrep.a137430","article-title":"Granulated lymphocytes in human endometrium: Histochemical and immunohistochemical studies","volume":"6","author":"Bulmer","year":"1991","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2026.104961_bib6","article-title":"Peripheral blood natural killer cell cytotoxicity in recurrent miscarriage: A systematic review and meta-analysis","volume":"158","author":"Cavalcante","year":"2023","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1083\/jcb.107.1.321","article-title":"Lymphocyte function-associated antigen-1 (lfa-1) interaction with intercellular adhesion molecule-1 (icam-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells","volume":"107","author":"Dustin","year":"1988","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.jri.2026.104961_bib8","article-title":"Vla-1 binding to collagen IV controls effector T cell suppression by myeloid-derived suppressor cells in the splenic red pulp","volume":"11","author":"Eckert","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13024","article-title":"Dysregulated uterine natural killer cells and vascular remodeling in women with recurrent pregnancy losses","volume":"80","author":"El-Azzamy","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib10","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/molehr\/5.11.1083","article-title":"Leukocyte function-associated antigen-1 expression on decidual natural killer cells in patients with early pregnancy loss","volume":"5","author":"Fukui","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2026.104961_bib11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-0897.2006.00431.x","article-title":"Expression of natural cytotoxicity receptors and a2v-atpase on peripheral blood nk cell subsets in women with recurrent spontaneous abortions and implantation failures","volume":"56","author":"Fukui","year":"2006","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib12","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1432-1033.1997.00215.x","article-title":"Leukocyte adhesion--structure and function of human leukocyte beta2-integrins and their cellular ligands","volume":"245","author":"Gahmberg","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jri.2026.104961_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010848","article-title":"Lfa-1\/ icam-1 promotes nk cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model","volume":"16","author":"Gao","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jri.2026.104961_bib14","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fimmu.2017.00467","article-title":"Uterine natural killer cells: Functional distinctions and influence on pregnancy in humans and mice","volume":"8","author":"Gaynor","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-0897.1999.tb00081.x","article-title":"Natural killer (nk) cell subsets and nk cell cytotoxicity in women with histories of recurrent spontaneous abortions","volume":"41","author":"Gilman-Sachs","year":"1999","journal-title":"Am. J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.jri.2026.104961_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41421-020-00236-z","article-title":"Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss","volume":"7","author":"Guo","year":"2021","journal-title":"Cell. Discov."},{"key":"10.1016\/j.jri.2026.104961_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/biom13081194","article-title":"Lfa-1\/icam-1 adhesion pathway mediates the homeostatic migration of lymphocytes from peripheral tissues into lymph nodes through lymphatic vessels","volume":"13","author":"Guo","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jri.2026.104961_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2021.103346","article-title":"Menopause is an inflection point of age-related immune changes in women","volume":"146","author":"Han","year":"2021","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib19","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nm1452","article-title":"Decidual nk cells regulate key developmental processes at the human fetal-maternal interface","volume":"12","author":"Hanna","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.jri.2026.104961_bib20","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1210\/jc.2004-0507","article-title":"Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation","volume":"89","author":"Jones","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2026.104961_bib21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0167-5699(91)90014-K","article-title":"On the nature and function of human uterine granular lymphocytes","volume":"12","author":"King","year":"1991","journal-title":"Immunol. Today"},{"key":"10.1016\/j.jri.2026.104961_bib22","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1210\/jc.2002-020980","article-title":"Expression of macrophage inflammatory protein-1beta in human endometrium: Its role in endometrial recruitment of natural killer cells","volume":"88","author":"Kitaya","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2026.104961_bib23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/aji.12316","article-title":"Resistance of uterine radial artery blood flow was correlated with peripheral blood nk cell fraction and improved with low molecular weight heparin therapy in women with unexplained recurrent pregnancy loss","volume":"73","author":"Koo","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1600-0897.1996.tb00495.x","article-title":"Elevated peripheral blood natural killer cells are effectively downregulated by immunoglobulin g infusion in women with recurrent spontaneous abortions","volume":"35","author":"Kwak","year":"1996","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib25","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/humrep\/deg156","article-title":"Increased t helper 1 cytokine responses by circulating t cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after ivf","volume":"18","author":"Kwak-Kim","year":"2003","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jri.2026.104961_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/aji.12234","article-title":"Immunological modes of pregnancy loss: Inflammation, immune effectors, and stress","volume":"72","author":"Kwak-Kim","year":"2014","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib27","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.4049\/jimmunol.156.10.4027","article-title":"Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome","volume":"156","author":"Lachapelle","year":"1996","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.jri.2026.104961_bib28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/mccm.6.4.161.164","article-title":"Icam-1 (cd54) expression on T lymphocytes and natural killer cells from umbilical cord blood: Regulation with interleukin-12 and interleukin-15","volume":"6","author":"Lin","year":"2000","journal-title":"Cytokines Cell. Mol. Ther."},{"key":"10.1016\/j.jri.2026.104961_bib29","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1182\/blood-2010-04-282301","article-title":"Cd57 defines a functionally distinct population of mature nk cells in the human cd56dimcd16+ nk-cell subset","volume":"116","author":"Lopez-Verg\u00e8s","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jri.2026.104961_bib30","first-page":"646","article-title":"Unique eomes(+) nk cell subsets are present in uterus and decidua during early pregnancy","volume":"6","author":"Montaldo","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fimmu.2013.00422","article-title":"Functional significance of cd57 expression on human nk cells and relevance to disease","volume":"4","author":"Nielsen","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib32","first-page":"4765","article-title":"Progesterone enhances interleukin-15 production in human endometrial stromal cells in vitro","volume":"85","author":"Okada","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jri.2026.104961_bib33","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/cncr.2820690517","article-title":"Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor-infiltrating lymphocytes","volume":"69","author":"Pandolfi","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/j.jri.2026.104961_bib34","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib35","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1006\/smim.2001.0316","article-title":"Pregnancy: Success and failure within the th1\/th2\/th3 paradigm","volume":"13","author":"Raghupathy","year":"2001","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.yhbeh.2012.02.023","article-title":"Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis","volume":"62","author":"Robinson","year":"2012","journal-title":"Horm. Behav."},{"key":"10.1016\/j.jri.2026.104961_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.647358","article-title":"Natural killer cell integrins and their functions in tissue residency","volume":"12","author":"Shannon","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib38","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2007-0001","article-title":"The complex role of estrogens in inflammation","volume":"28","author":"Straub","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jri.2026.104961_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abb7800","article-title":"Continuous human uterine nk cell differentiation in response to endometrial regeneration and pregnancy","volume":"6","author":"Strunz","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib40","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/molehr\/5.1.64","article-title":"Expression of intercellular adhesion molecules icam-1 and icam-2 in human endometrium: Regulation by interferon-gamma","volume":"5","author":"Thomson","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jri.2026.104961_bib41","doi-asserted-by":"crossref","first-page":"11918","DOI":"10.1073\/pnas.1001749107","article-title":"Crosstalk between decidual nk and cd14+ myelomonocytic cells results in induction of tregs and immunosuppression","volume":"107","author":"Vacca","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jri.2026.104961_bib42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1081\/IMM-200064488","article-title":"Trafficking of circulating pro-nk cells to the decidualizing uterus: Regulatory mechanisms in the mouse and human","volume":"34","author":"Van Den Heuvel","year":"2005","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.jri.2026.104961_bib43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0897.1994.tb01104.x","article-title":"Expression of intercellular adhesion molecule-1 (icam-1) on cultured human endometrial stromal cells and its role in the interaction with natural killers","volume":"32","author":"Vigan\u00f3","year":"1994","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib44","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1189\/jlb.0611308","article-title":"Natural killer cell-produced ifn-\u03b3 and tnf-\u03b1 induce target cell cytolysis through up-regulation of icam-1","volume":"91","author":"Wang","year":"2012","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jri.2026.104961_bib45","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1600-0897.2010.00811.x","article-title":"Women with multiple implantation failures and recurrent pregnancy losses have increased peripheral blood t cell activation","volume":"63","author":"Yang","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jri.2026.104961_bib46","article-title":"Role of decidual natural killer cells in human pregnancy and related pregnancy complications","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037826001300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165037826001300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:00:10Z","timestamp":1789592410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165037826001300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"alternative-id":["S0165037826001300"],"URL":"https:\/\/doi.org\/10.1016\/j.jri.2026.104961","relation":{},"ISSN":["0165-0378"],"issn-type":[{"value":"0165-0378","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant integrin expression on peripheral blood NK cells of women with recurrent pregnancy losses and repeated implantation failures","name":"articletitle","label":"Article Title"},{"value":"Journal of Reproductive Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jri.2026.104961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104961"}}