{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:28:21Z","timestamp":1768886901422,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jsams.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Science and Medicine in Sport"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jsams.2017.10.038","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T22:19:03Z","timestamp":1510093143000},"page":"564-568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The association of novel polymorphisms with stress fracture injury in Elite Athletes: Further insights from the SFEA cohort"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-8921","authenticated-orcid":false,"given":"Ian","family":"Varley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4539-3093","authenticated-orcid":false,"given":"David C.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie P.","family":"Greeves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trent","family":"Stellingwerff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Ranson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Sale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jsams.2017.10.038_bib0005","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0278-5919(20)31190-X","article-title":"Stress fractures in runners","volume":"4","author":"McBryde","year":"1985","journal-title":"Clin Sports Med"},{"issue":"Suppl. 1","key":"10.1016\/j.jsams.2017.10.038_bib0010","doi-asserted-by":"crossref","first-page":"i38","DOI":"10.1136\/bjsm.2007.037804","article-title":"Stress fracture risk factors in female football players and their clinical implications","volume":"41","author":"Warden","year":"2007","journal-title":"Br J Sports Med"},{"issue":"10","key":"10.1016\/j.jsams.2017.10.038_bib0015","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1136\/bjsm.2006.030783","article-title":"Regional bone mineral density in male athletes: a comparison of soccer players, runners and controls","volume":"41","author":"Fredericson","year":"2007","journal-title":"Br J Sports Med"},{"issue":"2","key":"10.1016\/j.jsams.2017.10.038_bib0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0278-5919(05)70016-8","article-title":"Epidemiology and site specificity of stress fractures","volume":"16","author":"Bennell","year":"1997","journal-title":"Clin Sports Med"},{"issue":"10","key":"10.1016\/j.jsams.2017.10.038_bib0025","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1136\/bjsm.2006.030783","article-title":"Regional bone mineral density in male athletes: a comparison of soccer players, runners and controls","volume":"41","author":"Fredericson","year":"2007","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.jsams.2017.10.038_bib0030","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1302\/0301-620X.92B12.24913","article-title":"Injuries to the lower back in elite fast bowlers: acute stress changes on MRI predict stress fracture","volume":"12","author":"Ranson","year":"2010","journal-title":"J Bone Joint Surg Br"},{"issue":"2","key":"10.1016\/j.jsams.2017.10.038_bib0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2165\/00007256-199928020-00004","article-title":"Risk factors for stress fractures","volume":"28","author":"Bennell","year":"1999","journal-title":"Sports Med"},{"issue":"4","key":"10.1016\/j.jsams.2017.10.038_bib0040","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/0363546513520295","article-title":"Higher incidence of bone stress injuries with increasing female athlete triad-related risk factors: a prospective multisite study of exercising girls and women","volume":"42","author":"Barrack","year":"2014","journal-title":"Am J Sports Med"},{"issue":"3","key":"10.1016\/j.jsams.2017.10.038_bib0045","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/00913847.1994.11710482","article-title":"Stress fractures. A risk of increased training in freshmen: overuse in youth","volume":"22","author":"Goldberg","year":"1994","journal-title":"Phys Sportsmed"},{"issue":"4","key":"10.1016\/j.jsams.2017.10.038_bib0050","doi-asserted-by":"crossref","first-page":"e399","DOI":"10.1542\/peds.2004-1868","article-title":"Correlates of stress fractures among preadolescent and adolescent girls","volume":"115","author":"Loud","year":"2005","journal-title":"Pediatrics"},{"issue":"10","key":"10.1016\/j.jsams.2017.10.038_bib0055","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1249\/MSS.0b013e3182963d75","article-title":"Identifying sex-specific risk factors for stress fractures in adolescent runners","volume":"45","author":"Tenforde","year":"2013","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"10.1016\/j.jsams.2017.10.038_bib0060","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1123\/ijsnem.22.5.374","article-title":"Dietary and training predictors of stress fractures in female runners","volume":"22","author":"Wentz","year":"2012","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"95","key":"10.1016\/j.jsams.2017.10.038_bib0065","first-page":"1","article-title":"Genetic predisposition for femoral neck stress fractures in military conscripts","volume":"11","author":"Korvala","year":"2010","journal-title":"BMC Genet"},{"issue":"8","key":"10.1016\/j.jsams.2017.10.038_bib0070","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1055\/s-0029-1216375","article-title":"Polymorphisms of the vitamin D receptor gene and stress fractures","volume":"41","author":"Chatzipapas","year":"2009","journal-title":"Horm Metab Res"},{"issue":"1","key":"10.1016\/j.jsams.2017.10.038_bib0075","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11302-016-9495-6","article-title":"Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury","volume":"12","author":"Varley","year":"2016","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.jsams.2017.10.038_bib0080","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bone.2014.10.004","article-title":"RANK\/RANKL\/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes","volume":"71","author":"Varley","year":"2015","journal-title":"Bone"},{"issue":"12","key":"10.1016\/j.jsams.2017.10.038_bib0085","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.1210\/jc.2005-1153","article-title":"Contribution of the collagen I \u03b11 and vitamin D receptor genes to the risk of hip fracture in elderly women","volume":"90","author":"Nguyen","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.jsams.2017.10.038_bib0090","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1359\/JBMR.040133","article-title":"Female premenopausal fracture risk is associated with gc phenotype","volume":"19","author":"Lauridsen","year":"2004","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.jsams.2017.10.038_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pmed.0030090","article-title":"Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study","volume":"3","author":"Ralston","year":"2006","journal-title":"PLoS Med"},{"issue":"12","key":"10.1016\/j.jsams.2017.10.038_bib0100","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1359\/jbmr.090524","article-title":"High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men","volume":"24","author":"Yerges","year":"2009","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.jsams.2017.10.038_bib0105","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i4.50","article-title":"Mechanical signaling for bone modeling and remodeling","volume":"19","author":"Robling","year":"2009","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"2","key":"10.1016\/j.jsams.2017.10.038_bib0110","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.gene.2004.05.014","article-title":"Genetics and biology of vitamin D receptor polymorphisms","volume":"338","author":"Uitterlinden","year":"2004","journal-title":"Gene"},{"issue":"5","key":"10.1016\/j.jsams.2017.10.038_bib0115","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/hmg\/10.5.537","article-title":"Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)","volume":"10","author":"Balemans","year":"2001","journal-title":"Hum Mol Gen"},{"issue":"6","key":"10.1016\/j.jsams.2017.10.038_bib0120","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1359\/jbmr.080216","article-title":"Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength","volume":"23","author":"Li","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"9","key":"10.1016\/j.jsams.2017.10.038_bib0125","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1007\/s00198-013-2353-2","article-title":"Sclerostin and Pref-1 have differential effects on bone mineral density and strength parameters in adolescent athletes compared with non-athletes","volume":"24","author":"Fazeli","year":"2013","journal-title":"Osteoporos Int"},{"issue":"5","key":"10.1016\/j.jsams.2017.10.038_bib0130","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.2249","article-title":"Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture","volume":"44","author":"Estrada","year":"2012","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.jsams.2017.10.038_bib0135","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1359\/jbmr.081235","article-title":"Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone","volume":"24","author":"Williams","year":"2009","journal-title":"J Bone Miner Res"},{"issue":"3","key":"10.1016\/j.jsams.2017.10.038_bib0140","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1006\/bbrc.1997.7986","article-title":"Vitamin D receptor gene polymorphisms: analysis of ligand binding and hormone responsiveness in cultured skin fibroblasts","volume":"242","author":"Gross","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jsams.2017.10.038_bib0145","article-title":"Activation of Wnt signaling by mechanical loading is impaired in the bone of old mice","volume":"30","author":"Holguin","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"3","key":"10.1016\/j.jsams.2017.10.038_bib0150","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s00198-013-2517-0","article-title":"Relative influence of heritability, environment and genetics on serum sclerostin","volume":"25","author":"Kuipers","year":"2014","journal-title":"Osteoporos Int"},{"issue":"5","key":"10.1016\/j.jsams.2017.10.038_bib0155","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1172\/JCI28551","article-title":"Regulation of bone mass by Wnt signaling","volume":"116","author":"Krishnan","year":"2006","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.jsams.2017.10.038_bib0160","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00198-015-3310-z","article-title":"Differential sclerostin and parathyroid hormone response to exercise in boys and men","volume":"27","author":"Falk","year":"2016","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jsams.2017.10.038_bib0165","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.matbio.2016.02.010","article-title":"PTH signaling mediates perilacunar remodeling during exercise","volume":"52\u201354","author":"Gardinier","year":"2016","journal-title":"Matrix Biol"},{"issue":"1","key":"10.1016\/j.jsams.2017.10.038_bib0170","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI116539","article-title":"Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1, 25 dihydroxyvitamin D3","volume":"92","author":"Kristjansson","year":"1993","journal-title":"J Clin Invest"},{"issue":"18","key":"10.1016\/j.jsams.2017.10.038_bib0175","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1101\/gad.1449506","article-title":"Genetic regulation of bone mass and susceptibility to osteoporosis","volume":"20","author":"Ralston","year":"2006","journal-title":"Genes Dev"},{"issue":"6","key":"10.1016\/j.jsams.2017.10.038_bib0180","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1753-4887.2010.00295.x","article-title":"Vitamin D and stress fracture: the contribution of vitamin D receptor gene polymorphisms","volume":"68","author":"McClung","year":"2010","journal-title":"Nutr Rev"},{"issue":"12","key":"10.1016\/j.jsams.2017.10.038_bib0185","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1002\/jbmr.2001","article-title":"Analyses of RANK and RANKL in the post-GWAS context; functional evidence of vitamin D stimulation through a RANKL distal region","volume":"28","author":"Yoskovitz","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.jsams.2017.10.038_bib0190","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1378\/chest.11-0523","article-title":"Correction for multiple testing: is there a resolution","volume":"140","author":"Streiner","year":"2011","journal-title":"Chest"}],"container-title":["Journal of Science and Medicine in Sport"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244017317516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244017317516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T08:15:21Z","timestamp":1603268121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1440244017317516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S1440244017317516"],"URL":"https:\/\/doi.org\/10.1016\/j.jsams.2017.10.038","relation":{},"ISSN":["1440-2440"],"issn-type":[{"value":"1440-2440","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association of novel polymorphisms with stress fracture injury in Elite Athletes: Further insights from the SFEA cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Science and Medicine in Sport","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsams.2017.10.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd on behalf of Sports Medicine Australia.","name":"copyright","label":"Copyright"}]}}