{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:29:50Z","timestamp":1779910190997,"version":"3.53.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jsams.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Science and Medicine in Sport"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jsams.2021.08.009","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T15:06:25Z","timestamp":1628953585000},"page":"1255-1260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Standing is associated with insulin sensitivity in adults with metabolic syndrome"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2770-5417","authenticated-orcid":false,"given":"Taru","family":"Garthwaite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Sj\u00f6ros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Koivum\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saara","family":"Laine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"V\u00e4h\u00e4-Ypy\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Saarenhovi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri","family":"Kallio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliisa","family":"L\u00f6yttyniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Siev\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noora","family":"Houttu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Laitinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Kalliokoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommi","family":"Vasankari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhani","family":"Knuuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Heinonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jsams.2021.08.009_bb0005","doi-asserted-by":"crossref","first-page":"e1077","DOI":"10.1016\/S2214-109X(18)30357-7","article-title":"Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1.9 million participants","volume":"6","author":"Guthold","year":"2018","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.jsams.2021.08.009_bb0010","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1136\/bjsports-2020-103270","article-title":"Joint associations of accelerometer measured physical activity and sedentary time with all-cause mortality: a harmonised meta-analysis in more than 44 000 middle-aged and older individuals","volume":"54","author":"Ekelund","year":"2020","journal-title":"Br J Sports Med"},{"issue":"2","key":"10.1016\/j.jsams.2021.08.009_bb0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.7326\/M14-1651","article-title":"Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis","volume":"162","author":"Biswas","year":"2015","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.jsams.2021.08.009_bb0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s13105-016-0488-2","article-title":"Fitness, adiposopathy, and adiposity are independent predictors of insulin sensitivity in middle-aged men without diabetes","volume":"72","author":"Huth","year":"2016","journal-title":"J Physiol Biochem"},{"issue":"12","key":"10.1016\/j.jsams.2021.08.009_bb0025","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1007\/s00125-018-4719-7","article-title":"Which is more important for cardiometabolic health: sedentary time, higher intensity physical activity or cardiorespiratory fitness? The Maastricht study","volume":"61","author":"van der Velde","year":"2018","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.jsams.2021.08.009_bb0030","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.2337\/db07-1605","article-title":"Physical activity and insulin sensitivity: the RISC study","volume":"57","author":"Balkau","year":"2008","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jsams.2021.08.009_bb0035","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2337\/dc06-1883","article-title":"Physical activity and metabolic risk in individuals with a family history of type 2 diabetes","volume":"30","author":"Ekelund","year":"2007","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.jsams.2021.08.009_bb0040","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/eurheartj\/ehq451","article-title":"Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06","volume":"32","author":"Healy","year":"2011","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.jsams.2021.08.009_bb0045","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.2337\/dc08-1895","article-title":"Objectively measured moderate- and vigorous-intensity physical activity but not sedentary time predicts insulin resistance in high-risk individuals","volume":"32","author":"Ekelund","year":"2009","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.jsams.2021.08.009_bb0050","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00125-011-2408-x","article-title":"Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes","volume":"55","author":"Cooper","year":"2011","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.jsams.2021.08.009_bb0055","doi-asserted-by":"crossref","first-page":"20578","DOI":"10.1038\/s41598-020-77637-3","article-title":"Both sedentary time and physical activity are associated with cardiometabolic health in overweight adults in a 1 month accelerometer measurement","volume":"10","author":"Sj\u00f6ros","year":"2020","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.jsams.2021.08.009_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134813","article-title":"Validation of cut-points for evaluating the intensity of physical activity with accelerometry-based mean amplitude deviation (MAD)","volume":"10","author":"V\u00e4h\u00e4-Ypy\u00e4","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jsams.2021.08.009_bb0065","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/sms.13017","article-title":"Reliable recognition of lying, sitting, and standing with a hip-worn accelerometer","volume":"28","author":"V\u00e4h\u00e4-Ypy\u00e4","year":"2018","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"10.1016\/j.jsams.2021.08.009_bb0070","doi-asserted-by":"crossref","first-page":"32044","DOI":"10.1038\/srep32044","article-title":"Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: ancillary analysis from randomized clinical trials","volume":"6","author":"Bergouignan","year":"2016","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.jsams.2021.08.009_bb0075","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/ijerph15102280","article-title":"Associations of physical behaviours and behavioural reallocations with markers of metabolic health: a compositional data analysis","volume":"15","author":"Biddle","year":"2018","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"10.1016\/j.jsams.2021.08.009_bb0080","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-014267","article-title":"Associations of reallocating sitting time into standing or stepping with glucose, insulin and insulin sensitivity: a cross-sectional analysis of adults at risk of type 2 diabetes","volume":"7","author":"Edwardson","year":"2017","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.jsams.2021.08.009_bb0085","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2337\/dc15-1240","article-title":"Breaking up prolonged sitting with standing or walking attenuates the postprandial metabolic response in postmenopausal women: a randomized acute study","volume":"39","author":"Henson","year":"2016","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.jsams.2021.08.009_bb0090","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.mayocpiqo.2020.07.017","article-title":"The effect of replacing sitting with standing on cardiovascular risk factors: a systematic review and meta-analysis","volume":"4","author":"Saeidifard","year":"2020","journal-title":"Mayo Clin Proc Innova Qual Outcomes"},{"issue":"3","key":"10.1016\/j.jsams.2021.08.009_bb0095","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jsams.2016.08.012","article-title":"Intermittent walking, but not standing, improves postprandial insulin and glucose relative to sustained sitting: a randomised cross-over study in inactive middle-aged men","volume":"20","author":"Pulsford","year":"2017","journal-title":"J Sci Med Sport"},{"issue":"1","key":"10.1016\/j.jsams.2021.08.009_bb0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/gerona\/glaa227","article-title":"The relationship of accelerometer-assessed standing time with and without ambulation and mortality: the WHI OPACH study","volume":"76","author":"Jain","year":"2021","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"5","key":"10.1016\/j.jsams.2021.08.009_bb0105","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1177\/2047487317752186","article-title":"Differences of energy expenditure while sitting versus standing: a systematic review and meta-analysis","volume":"25","author":"Saeidifard","year":"2018","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jsams.2021.08.009_bb0110","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ypmed.2014.04.005","article-title":"Patterns of sedentary time and cardiometabolic risk among Canadian adults","volume":"65","author":"Carson","year":"2014","journal-title":"Prev Med"},{"issue":"1","key":"10.1016\/j.jsams.2021.08.009_bb0115","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1152\/ajpendo.00645.2007","article-title":"Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage","volume":"294","author":"Muniyappa","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"9468","key":"10.1016\/j.jsams.2021.08.009_bb0120","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.jsams.2021.08.009_bb0125","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1007\/s00125-007-0705-1","article-title":"Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity","volume":"50","author":"Holt","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.jsams.2021.08.009_bb0130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ypmed.2015.11.012","article-title":"Abdominal obesity as a mediator of the influence of physical activity on insulin resistance in Spanish adults","volume":"82","author":"Garc\u00eda-Hermoso","year":"2016","journal-title":"Prev Med"},{"issue":"3","key":"10.1016\/j.jsams.2021.08.009_bb0135","doi-asserted-by":"crossref","first-page":"E548","DOI":"10.1152\/ajpendo.00251.2020","article-title":"Visceral adiposity and liver fat as mediators of the association between cardiorespiratory fitness and plasma glucose-insulin homeostasis","volume":"319","author":"Chartrand","year":"2020","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.jsams.2021.08.009_bb0140","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/oby.20817","article-title":"High sitting time or obesity: which came first? Bidirectional association in a longitudinal study of 31,787 Australian adults","volume":"22","author":"Pedisic","year":"2014","journal-title":"Obesity"},{"issue":"3","key":"10.1016\/j.jsams.2021.08.009_bb0145","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1139\/apnm-2013-0160","article-title":"Waist circumference and cardiorespiratory fitness are independently associated with glucose tolerance and insulin resistance in obese women","volume":"39","author":"Shalev-Goldman","year":"2014","journal-title":"Appl Physiol Nutr Metab"},{"issue":"5","key":"10.1016\/j.jsams.2021.08.009_bb0150","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1007\/s00125-013-2845-9","article-title":"Associations of objectively measured sedentary behaviour and physical activity with markers of cardiometabolic health","volume":"56","author":"Henson","year":"2013","journal-title":"Diabetologia"}],"updated-by":[{"DOI":"10.1016\/j.jsams.2022.03.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000}}],"container-title":["Journal of Science and Medicine in Sport"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244021002048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244021002048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T19:54:46Z","timestamp":1658346886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1440244021002048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1440244021002048"],"URL":"https:\/\/doi.org\/10.1016\/j.jsams.2021.08.009","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jsams.2022.03.002","asserted-by":"object"}]},"ISSN":["1440-2440"],"issn-type":[{"value":"1440-2440","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Standing is associated with insulin sensitivity in adults with metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Science and Medicine in Sport","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsams.2021.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of Sports Medicine Australia.","name":"copyright","label":"Copyright"}]}}