{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:36:00Z","timestamp":1793885760048,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jsams.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Science and Medicine in Sport"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.jsams.2023.09.010","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T13:20:02Z","timestamp":1695129602000},"page":"616-621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dose\u2013response relationship between leisure-time physical activity and biomarkers of inflammation and oxidative stress in overweight\/obese populations"],"prefix":"10.1016","volume":"26","author":[{"given":"Yijian","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jsams.2023.09.010_bb0005","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s13679-015-0169-4","article-title":"Overweight and obesity: prevalence, consequences, and causes of a growing public health problem","volume":"4","author":"Williams","year":"2015","journal-title":"Curr Obes Rep"},{"issue":"3","key":"10.1016\/j.jsams.2023.09.010_bb0010","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","article-title":"Adipose tissue inflammation and metabolic dysfunction in obesity","volume":"320","author":"Kawai","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"10.1016\/j.jsams.2023.09.010_bb0015","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.3390\/ijms12053117","article-title":"Inflammation, oxidative stress, and obesity","volume":"12","author":"Fernandez-Sanchez","year":"2011","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jsams.2023.09.010_bb0020","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s13105-012-0154-2","article-title":"Oxidative stress and inflammation interactions in human obesity","volume":"68","author":"Bondia-Pons","year":"2012","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.jsams.2023.09.010_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/105828","article-title":"Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer\u2019s disease","volume":"2015","author":"Verdile","year":"2015","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.jsams.2023.09.010_bb0030","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/291546","article-title":"Obesity as a major risk factor for cancer","volume":"2013","author":"De Pergola","year":"2013","journal-title":"J Obes"},{"key":"10.1016\/j.jsams.2023.09.010_bb0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.lfs.2016.02.002","article-title":"Oxidative stress and metabolic disorders: pathogenesis and therapeutic strategies","volume":"148","author":"Rani","year":"2016","journal-title":"Life Sci"},{"issue":"5","key":"10.1016\/j.jsams.2023.09.010_bb0040","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1467-789X.2011.00956.x","article-title":"Endothelial dysfunction, inflammation, and oxidative stress in obese children and adolescents: markers and effect of lifestyle intervention","volume":"13","author":"Montero","year":"2012","journal-title":"Obes Rev"},{"issue":"4","key":"10.1016\/j.jsams.2023.09.010_bb0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40279-013-0023-3","article-title":"Effects of exercise training on chronic inflammation in obesity: current evidence and potential mechanisms","volume":"43","author":"You","year":"2013","journal-title":"Sports Med"},{"key":"10.1016\/j.jsams.2023.09.010_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9410954","article-title":"Exercise training attenuates the dysregulated expression of adipokines and oxidative stress in white adipose tissue","volume":"2017","author":"Sakurai","year":"2017","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"10.1016\/j.jsams.2023.09.010_bb0055","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1467-789X.2012.00988.x","article-title":"Resistance training, visceral obesity and inflammatory response: a review of the evidence","volume":"13","author":"Strasser","year":"2012","journal-title":"Obes Rev"},{"key":"10.1016\/j.jsams.2023.09.010_bb0060","first-page":"105","article-title":"Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice","volume":"16","author":"Kawanishi","year":"2010","journal-title":"Exerc Immunol Rev"},{"key":"10.1016\/j.jsams.2023.09.010_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/7239639","article-title":"Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases","volume":"2016","author":"Sallam","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"15","key":"10.1016\/j.jsams.2023.09.010_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158713","article-title":"Effect of physical activity\/exercise on oxidative stress and inflammation in muscle and vascular aging","volume":"23","author":"El Assar","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jsams.2023.09.010_bb0075","author":"WHO"},{"issue":"11","key":"10.1016\/j.jsams.2023.09.010_bb0080","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1159\/000511685","article-title":"Leisure-time physical activity and mortality in CKD: a 1999\u20132012 NHANES analysis","volume":"51","author":"Zhang","year":"2020","journal-title":"Am J Nephrol"},{"issue":"6 Suppl","key":"10.1016\/j.jsams.2023.09.010_bb0085","doi-asserted-by":"crossref","first-page":"S521","DOI":"10.1097\/00005768-200106001-00023","article-title":"Physical activity, total and regional obesity: dose-response considerations","volume":"33","author":"Ross","year":"2001","journal-title":"Med Sci Sports Exerc"},{"issue":"6","key":"10.1016\/j.jsams.2023.09.010_bb0090","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1249\/MSS.0000000000001934","article-title":"High-intensity interval training for cardiometabolic disease prevention","volume":"51","author":"Campbell","year":"2019","journal-title":"Med Sci Sports Exerc"},{"issue":"10","key":"10.1016\/j.jsams.2023.09.010_bb0095","doi-asserted-by":"crossref","first-page":"E1248","DOI":"10.1152\/ajpendo.00260.2013","article-title":"Pancreatic beta-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes","volume":"305","author":"Malin","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jsams.2023.09.010_bb0100","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3846122","article-title":"Effects of exercise-induced ROS on the pathophysiological functions of skeletal muscle","volume":"2021","author":"Wang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"issue":"6","key":"10.1016\/j.jsams.2023.09.010_bb0105","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/obr.12532","article-title":"The effects of high-intensity interval training vs. moderate-intensity continuous training on body composition in overweight and obese adults: a systematic review and meta-analysis","volume":"18","author":"Wewege","year":"2017","journal-title":"Obes Rev"},{"issue":"4","key":"10.1016\/j.jsams.2023.09.010_bb0110","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2165\/00007256-200636040-00003","article-title":"The impact of exercise training intensity on change in physiological function in patients with chronic obstructive pulmonary disease","volume":"36","author":"Butcher","year":"2006","journal-title":"Sports Med"},{"issue":"Suppl 3","key":"10.1016\/j.jsams.2023.09.010_bb0115","first-page":"S21","article-title":"Exercise training, lipid regulation, and insulin action: a tangled web of cause and effect","volume":"17","author":"Kraus","year":"2009","journal-title":"Obesity (Silver Spring)"},{"issue":"2","key":"10.1016\/j.jsams.2023.09.010_bb0120","first-page":"215","article-title":"High intensity interval training is associated with greater impact on physical fitness, insulin sensitivity and muscle mitochondrial content in males with overweight\/obesity, as opposed to continuous endurance training: a randomized controlled trial","volume":"18","author":"De Strijcker","year":"2018","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"1","key":"10.1016\/j.jsams.2023.09.010_bb0125","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cardiores.2005.03.010","article-title":"Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function","volume":"67","author":"Kemi","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jsams.2023.09.010_bb0130","first-page":"1","article-title":"Dose\u2013 and intensity\u2013response associations between leisure-time physical activity and markers of inflammation and oxidative stress in older adults","author":"Ding","year":"2022","journal-title":"J Aging Phys Act"},{"issue":"Suppl 1","key":"10.1016\/j.jsams.2023.09.010_bb0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/dmrr.2514","article-title":"Physical exercise as therapy for type 2 diabetes mellitus","volume":"30","author":"Balducci","year":"2014","journal-title":"Diabetes Metab Res Rev"},{"issue":"2","key":"10.1016\/j.jsams.2023.09.010_bb0140","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1249\/MSS.0000000000002800","article-title":"Exercise\/physical activity in individuals with type 2 diabetes: a consensus statement from the American College of Sports Medicine","volume":"54","author":"Kanaley","year":"2022","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"10.1016\/j.jsams.2023.09.010_bb0145","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1755-5949.2011.00264.x","article-title":"From hypertension to stroke: mechanisms and potential prevention strategies","volume":"17","author":"Yu","year":"2011","journal-title":"CNS Neurosci Ther"},{"issue":"3","key":"10.1016\/j.jsams.2023.09.010_bb0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1524-6175.2005.04590.x","article-title":"Systemic inflammation, blood pressure, and stroke outcome","volume":"8","author":"Di Napoli","year":"2006","journal-title":"J Clin Hypertens (Greenwich)"}],"container-title":["Journal of Science and Medicine in Sport"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244023004115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244023004115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T17:56:39Z","timestamp":1761414999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1440244023004115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1440244023004115"],"URL":"https:\/\/doi.org\/10.1016\/j.jsams.2023.09.010","relation":{},"ISSN":["1440-2440"],"issn-type":[{"value":"1440-2440","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dose\u2013response relationship between leisure-time physical activity and biomarkers of inflammation and oxidative stress in overweight\/obese populations","name":"articletitle","label":"Article Title"},{"value":"Journal of Science and Medicine in Sport","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsams.2023.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}