{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:32:54Z","timestamp":1788345174173,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015777","name":"Division of Research Capacity Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015777","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016979","name":"National Treasury","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016979","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jsams.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Science and Medicine in Sport"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jsams.2026.04.002","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:00:40Z","timestamp":1776067240000},"page":"1101-1108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The VEGFA and KDR genes are associated with bilateral and multiple chronic Achilles tendon injuries"],"prefix":"10.1016","volume":"29","author":[{"given":"Christina D.","family":"Brazier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nonhlanhla S.","family":"Mkumbuzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Jessica N.","family":"Laguette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison V.","family":"September","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jsams.2026.04.002_bb0005","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s40279-014-0209-3","article-title":"Achilles tendon injury risk factors associated with running","volume":"44","author":"Lorimer","year":"2014","journal-title":"Sports Med"},{"issue":"19","key":"10.1016\/j.jsams.2026.04.002_bb0010","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1136\/bjsports-2015-095422","article-title":"Revisiting the continuum model of tendon pathology: what is its merit in clinical practice and research?","volume":"50","author":"Cook","year":"2016","journal-title":"Br J Sports Med"},{"issue":"4","key":"10.1016\/j.jsams.2026.04.002_bb0015","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jphys.2022.09.010","article-title":"Physiotherapy management of Achilles tendinopathy","volume":"68","author":"Malliaras","year":"2022","journal-title":"J Physiother"},{"issue":"1","key":"10.1016\/j.jsams.2026.04.002_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bjsports-2019-100608","article-title":"Neovascularisation in tendinopathy: from eradication to stabilisation?","volume":"54","author":"Jarvinen","year":"2020","journal-title":"Br J Sports Med"},{"issue":"18","key":"10.1016\/j.jsams.2026.04.002_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/app11188310","article-title":"Neovascularization in meniscus and tendon pathology as a potential mechanism in regenerative therapies: special reference to platelet-rich plasma treatment","volume":"11","author":"Szwedowski","year":"2021","journal-title":"Appl Sci"},{"key":"10.1016\/j.jsams.2026.04.002_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01267","article-title":"Painful understanding of VEGF","volume":"9","author":"Llorian-Salvador","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jsams.2026.04.002_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.766080","article-title":"The role of vascular endothelial growth factor in tendon healing","volume":"12","author":"Liu","year":"2021","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.jsams.2026.04.002_bb0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5114\/biolsport.2018.78902","article-title":"The VEGFA gene and anterior cruciate ligament rupture risk in the Caucasian population","volume":"36","author":"Lulinska-Kuklik","year":"2019","journal-title":"Biol Sport"},{"issue":"12","key":"10.1016\/j.jsams.2026.04.002_bb0045","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/jor.22705","article-title":"The association of genes involved in the angiogenesis-associated signaling pathway with risk of anterior cruciate ligament rupture","volume":"32","author":"Rahim","year":"2014","journal-title":"J Orthop Res"},{"issue":"9","key":"10.1016\/j.jsams.2026.04.002_bb0050","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1089\/omi.2016.0116","article-title":"Human genetic variation, sport and exercise medicine, and Achilles tendinopathy: role for angiogenesis-associated genes","volume":"20","author":"Rahim","year":"2016","journal-title":"OMICS"},{"issue":"5","key":"10.1016\/j.jsams.2026.04.002_bb0055","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/02640414.2017.1322710","article-title":"Investigation of angiogenesis genes with anterior cruciate ligament rupture risk in a South African population","volume":"36","author":"Rahim","year":"2018","journal-title":"J Sports Sci"},{"issue":"12","key":"10.1016\/j.jsams.2026.04.002_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167717","article-title":"Vascular endothelial growth factor receptor-2 polymorphisms have protective effect against the development of tendinopathy in volleyball athletes","volume":"11","author":"Salles","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.jsams.2026.04.002_bb0070","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jsams.2019.10.016","article-title":"Characterisation of Achilles tendon pain in recreational runners using multidimensional pain scales","volume":"23","author":"Mkumbuzi","year":"2020","journal-title":"J Sci Med Sport"},{"issue":"4","key":"10.1016\/j.jsams.2026.04.002_bb0075","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2362.2009.02125.x","article-title":"STrengthening the REporting of Genetic Association studies (STREGA)\u2014an extension of the STROBE statement","volume":"39","author":"Little","year":"2009","journal-title":"Eur J Clin Invest"},{"issue":"Suppl 11","key":"10.1016\/j.jsams.2026.04.002_bb0080","first-page":"S240","volume":"63","author":"Hawker","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"1","key":"10.1016\/j.jsams.2026.04.002_bb0085","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jphys.2015.07.001","article-title":"The Brief Pain Inventory (BPI)","volume":"62","author":"Poquet","year":"2016","journal-title":"J Physiother"},{"issue":"5","key":"10.1016\/j.jsams.2026.04.002_bb0090","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1136\/bjsm.35.5.335","article-title":"The VISA-A questionnaire: a valid and reliable index of the clinical severity of Achilles tendinopathy","volume":"35","author":"Robinson","year":"2001","journal-title":"Br J Sports Med"},{"issue":"1","key":"10.1016\/j.jsams.2026.04.002_bb0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0838.2005.00439.x","article-title":"The COL5A1 gene and Achilles tendon pathology","volume":"16","author":"Mokone","year":"2006","journal-title":"Scand J Med Sci Sports"},{"issue":"6","key":"10.1016\/j.jsams.2026.04.002_bb0100","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/1040638720905833","article-title":"Guidelines for Sanger sequencing and molecular assay monitoring","volume":"32","author":"Crossley","year":"2020","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.jsams.2026.04.002_bb0105","series-title":"genetics: Population Genetics","author":"Warnes","year":"2021"},{"issue":"5","key":"10.1016\/j.jsams.2026.04.002_bb0110","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/bioinformatics\/btm025","article-title":"SNPassoc: an R package to perform whole genome association studies","volume":"23","author":"Gonzalez","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jsams.2026.04.002_bb0115","series-title":"haplo.stats: Statistical Analysis of Haplotypes With Traits and Covariates When Linkage Phase is Ambiguous","author":"Schaid","year":"2024"},{"issue":"6","key":"10.1016\/j.jsams.2026.04.002_bb0120","first-page":"7681","article-title":"Association of the rs2071559 (T\/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma","volume":"14","author":"Hu","year":"2017","journal-title":"Oncol Lett"},{"issue":"9","key":"10.1016\/j.jsams.2026.04.002_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13092242","article-title":"Polymorphisms in VEGF signaling pathway genes and their potential impact on type 2 diabetes mellitus and associated complications: a scoping review","volume":"13","author":"Lima","year":"2025","journal-title":"Biomedicines"},{"issue":"8","key":"10.1016\/j.jsams.2026.04.002_bb0130","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jacc.2007.04.074","article-title":"Polymorphisms of KDR gene are associated with coronary heart disease","volume":"50","author":"Wang","year":"2007","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jsams.2026.04.002_bb0135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12576-013-0293-4","article-title":"VEGFA rSNPs, transcriptional factor binding sites and human disease","volume":"64","author":"Buroker","year":"2014","journal-title":"J Physiol Sci"},{"issue":"24","key":"10.1016\/j.jsams.2026.04.002_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417292","article-title":"Genetic variability in VEGFA gene influences the effectiveness of tennis elbow therapy with PRP: a two-year prospective cohort study","volume":"24","author":"Niemiec","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jsams.2026.04.002_bb0145","first-page":"3","article-title":"A novel combination of genomic loci in ITGB2, COL5A1 and VEGFA associated with anterior cruciate ligament rupture susceptibility: insights from Australian, Polish, Swedish, and South African cohorts","volume":"43","author":"Dlamini","year":"2026","journal-title":"Biol Sport"},{"issue":"5","key":"10.1016\/j.jsams.2026.04.002_bb0150","first-page":"663","article-title":"Tendon and ligament genetics: how do they contribute to disease and injury? A narrative review","volume":"12","author":"Ribbans","year":"2022","journal-title":"Life (Basel)"},{"key":"10.1016\/j.jsams.2026.04.002_bb0155","series-title":"Physiology, Cellular Receptors","author":"Khalil","year":"2025"}],"container-title":["Journal of Science and Medicine in Sport"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244026001416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244026001416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:26:12Z","timestamp":1788301572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1440244026001416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1440244026001416"],"URL":"https:\/\/doi.org\/10.1016\/j.jsams.2026.04.002","relation":{},"ISSN":["1440-2440"],"issn-type":[{"value":"1440-2440","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The VEGFA and KDR genes are associated with bilateral and multiple chronic Achilles tendon injuries","name":"articletitle","label":"Article Title"},{"value":"Journal of Science and Medicine in Sport","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsams.2026.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd on behalf of Sports Medicine Australia.","name":"copyright","label":"Copyright"}]}}