{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:02:28Z","timestamp":1789509748619,"version":"build-2803163510"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jsams.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Science and Medicine in Sport"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jsams.2026.09.002","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:06:33Z","timestamp":1788793593000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is overtraining syndrome an acquired T-cell exhaustion state? Rethinking chronic exercise-induced immune dysfunction"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4934-4889","authenticated-orcid":false,"given":"Ay\u015fe","family":"Arslan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-9539","authenticated-orcid":false,"given":"G\u00fcfat","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jsams.2026.09.002_bb0005","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1249\/MSS.0b013e318279a10a","article-title":"Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine","volume":"45","author":"Meeusen","year":"2013","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"10.1016\/j.jsams.2026.09.002_bb0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2165\/00007256-199520040-00004","article-title":"Blood hormones as markers of training stress and overtraining","volume":"20","author":"Urhausen","year":"1995","journal-title":"Sports Med"},{"issue":"8091","key":"10.1016\/j.jsams.2026.09.002_bb0015","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/s41586-025-09539-1","article-title":"Proteotoxic stress response drives T cell exhaustion and immune evasion","volume":"647","author":"Wang","year":"2025","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.jsams.2026.09.002_bb0020","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1038\/s41590-024-01999-3","article-title":"Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism","volume":"25","author":"Peralta","year":"2024","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.jsams.2026.09.002_bb0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1146\/annurev-immunol-090222-110914","article-title":"T cell exhaustion","volume":"42","author":"Baessler","year":"2024","journal-title":"Annu Rev Immunol"},{"issue":"20","key":"10.1016\/j.jsams.2026.09.002_bb0030","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.183810","article-title":"Immune exhaustion in ME\/CFS and long COVID","volume":"9","author":"Eaton-Fitch","year":"2024","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.jsams.2026.09.002_bb0035","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1177\/19417381211044739","article-title":"Diagnosing overtraining syndrome: a scoping review","volume":"14","author":"Carrard","year":"2022","journal-title":"Sports Health"},{"issue":"6","key":"10.1016\/j.jsams.2026.09.002_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110121","article-title":"Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss","volume":"27","author":"Voltarelli","year":"2024","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.jsams.2026.09.002_bb0045","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.immuni.2016.07.008","article-title":"Bioenergetic insufficiencies due to metabolic alterations regulated by the inhibitory receptor PD-1 are an early driver of CD8(+) T cell exhaustion","volume":"45","author":"Bengsch","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jsams.2026.09.002_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.998925","article-title":"Lymphocyte and dendritic cell response to a period of intensified training in young healthy humans and rodents: a systematic review and meta-analysis","volume":"13","author":"Baker","year":"2022","journal-title":"Front Physiol"}],"container-title":["Journal of Science and Medicine in Sport"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244026005591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1440244026005591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:06:47Z","timestamp":1789506407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1440244026005591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":10,"alternative-id":["S1440244026005591"],"URL":"https:\/\/doi.org\/10.1016\/j.jsams.2026.09.002","relation":{},"ISSN":["1440-2440"],"issn-type":[{"value":"1440-2440","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is overtraining syndrome an acquired T-cell exhaustion state? Rethinking chronic exercise-induced immune dysfunction","name":"articletitle","label":"Article Title"},{"value":"Journal of Science and Medicine in Sport","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsams.2026.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Sports Medicine Australia. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}