{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T11:25:14Z","timestamp":1792409114519,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["HRC\/2007\/1"],"award-info":[{"award-number":["HRC\/2007\/1"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsubstanceabusetreatment.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Substance Abuse Treatment"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.jsat.2011.05.001","type":"journal-article","created":{"date-parts":[[2011,6,27]],"date-time":"2011-06-27T03:08:57Z","timestamp":1309144137000},"page":"252-260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"title":["Risk of drug-related mortality during periods of transition in methadone maintenance treatment: A cohort study"],"prefix":"10.1016","volume":"41","author":[{"given":"Gr\u00e1inne","family":"Cousins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Teljeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Motterlini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"McCowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borislav D.","family":"Dimitrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Fahey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsat.2011.05.001_bb0190","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/eurpub\/cki168","article-title":"Drug-related mortality and its impact on adult mortality in eight European countries","volume":"16","author":"Bargagli","year":"2006","journal-title":"Eur J Public Health"},{"key":"10.1016\/j.jsat.2011.05.001_bb0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.drugalcdep.2005.05.010","article-title":"Cycling in and out of treatment; Participation in methadone treatment in NSW, 1990\u20132002","volume":"81","author":"Bell","year":"2006","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.jsat.2011.05.001_bb0010","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/sj.bjc.6601120","article-title":"Survival analysis part III: Multivariate data analysis\u2014Choosing a model and assessing its adequacy and fit","volume":"89","author":"Bradburn","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jsat.2011.05.001_bb0015","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/j.1360-0443.2009.02633.x","article-title":"Opioid agonist pharmacotherapy in New South Wales from 1985 to 2006: Patient characteristics and patterns and predictors of treatment retention","volume":"104","author":"Burns","year":"2009","journal-title":"Addiction"},{"key":"10.1016\/j.jsat.2011.05.001_bb0020","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1046\/j.1360-0443.2002.00179.x","article-title":"An increase in overdose mortality during the first 2 weeks after entering or re-entering methadone treatment in Amsterdam","volume":"97","author":"Buster","year":"2002","journal-title":"Addiction"},{"key":"10.1016\/j.jsat.2011.05.001_bb0025","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/bmj.313.7052.264","article-title":"Characteristics of fatal methadone overdose in Manchester, 1985\u201394","volume":"313","author":"Cairns","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.jsat.2011.05.001_bb0030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/10826089609045806","article-title":"Methadone maintenance and addicts' risk of fatal heroin overdose","volume":"31","author":"Caplehorn","year":"1996","journal-title":"Substance Use & Misuse"},{"key":"10.1016\/j.jsat.2011.05.001_bb0035","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5694\/j.1326-5377.1999.tb127675.x","article-title":"Mortality associated with New South Wales methadone programs in 1994: Lives lost and saved","volume":"170","author":"Caplehorn","year":"1999","journal-title":"Med J Aust"},{"key":"10.1016\/j.jsat.2011.05.001_bb0040","first-page":"162","article-title":"Deprivation and health in Scotland","volume":"48","author":"Carstairs","year":"1990","journal-title":"Health Bull (Edinb)"},{"key":"10.1016\/j.jsat.2011.05.001_bb0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drugalcdep.2007.11.003","article-title":"Mortality prior to, during and after opioid maintenance treatment (OMT): A national prospective cross-registry study","volume":"94","author":"Clausen","year":"2008","journal-title":"Drug & Alcohol Dependence"},{"key":"10.1016\/j.jsat.2011.05.001_bb0050","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1360-0443.2009.02570.x","article-title":"Mortality among opiate users: Opioid maintenance therapy, age and causes of death","volume":"104","author":"Clausen","year":"2009","journal-title":"Addiction"},{"key":"10.1016\/j.jsat.2011.05.001_bb0055","first-page":"341","article-title":"Risk of death during and after opiate substitution treatment in primary care: Prospective observational study in UK General Practice Research Database","volume":"c5475","author":"Cornish","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jsat.2011.05.001_bb0060","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1111\/j.1360-0443.2007.02025.x","article-title":"Risk of fatal overdose during and after specialist drug treatment: The VEdeTTE study, a national multi-site prospective cohort study","volume":"102","author":"Davoli","year":"2007","journal-title":"Addiction"},{"key":"10.1016\/j.jsat.2011.05.001_bb0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.drugalcdep.2009.05.021","article-title":"Mortality among clients of a state-wide opioid pharmacotherapy program over 20 years: Risk factors and lives saved","volume":"105","author":"Degenhardt","year":"2009","journal-title":"Drug & Alcohol Dependence"},{"key":"10.1016\/j.jsat.2011.05.001_bb0070","series-title":"Drug misuse and dependence: UK guidelines on clinical management","author":"Department of Health (England) and the devolved administrations","year":"1999"},{"key":"10.1016\/j.jsat.2011.05.001_bb0075","series-title":"Drug misuse and dependence: UK guidelines on clinical management","author":"Department of Health (England) and the devolved administrations","year":"2007"},{"key":"10.1016\/j.jsat.2011.05.001_bb0080","series-title":"Drug misuse and dependence: UK guidelines on clinical management","author":"Department of Health and the devolved administrations","year":"2007"},{"key":"10.1016\/j.jsat.2011.05.001_bb0085","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0895-4356(92)90133-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases","volume":"45","author":"Deyo","year":"1992","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jsat.2011.05.001_bb0090","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/00000433-199212000-00017","article-title":"Methadone toxicity causing death in ten subjects starting on a methadone maintenance program","volume":"13","author":"Drummer","year":"1992","journal-title":"Am J Forensic Med Pathol"},{"key":"10.1016\/j.jsat.2011.05.001_bb0095","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1360-0443.2006.01714.x","article-title":"Methadone maintenance treatment: The balance between life-saving treatment and fatal poisonings","volume":"102","author":"Fugelstad","year":"2007","journal-title":"Addiction"},{"key":"10.1016\/j.jsat.2011.05.001_bb0100","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/bmj.290.6466.425","article-title":"Deaths of drug addicts in the United Kingdom 1967\u201381","volume":"290","author":"Ghodse","year":"1985","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.jsat.2011.05.001_bb0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1360-0443.2002.00079.x","article-title":"A prospective study of mortality among drug misusers during a 4-year period after seeking treatment","volume":"97","author":"Gossop","year":"2002","journal-title":"Addiction"},{"key":"10.1016\/j.jsat.2011.05.001_bb0110","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0140-6736(93)90427-I","article-title":"Methadone: One person's maintenance dose is another's poison","volume":"341","author":"Harding-Pink","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.jsat.2011.05.001_bb0115","author":"ISD"},{"key":"10.1016\/j.jsat.2011.05.001_bb0120","first-page":"341","article-title":"Survival and cessation in injecting drug users: Prospective observational study of outcomes and effect of opiate substitution treatment","volume":"c3172","author":"Kimber","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.jsat.2011.05.001_bb0125","doi-asserted-by":"crossref","first-page":"774","DOI":"10.2105\/AJPH.91.5.774","article-title":"The impact of harm-reduction-based methadone treatment on mortality among heroin users","volume":"91","author":"Langendam","year":"2001","journal-title":"Am J Public Health"},{"key":"10.1016\/j.jsat.2011.05.001_bb0130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000073724","article-title":"Relationship between prescribing and risk of opiate overdose among drug users in and out of maintenance treatment","volume":"10","author":"Man","year":"2004","journal-title":"Eur Addict Res"},{"key":"10.1016\/j.jsat.2011.05.001_bb0135","first-page":"338","article-title":"Factors associated with mortality in Scottish patients receiving methadone in primary care: Retrospective cohort study","volume":"b2225","author":"McCowan","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.jsat.2011.05.001_bb0140","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/ije\/dyl207","article-title":"Association between availability of heroin and methadone and fatal poisoning in England and Wales 1993\u20132004","volume":"35","author":"Morgan","year":"2006","journal-title":"International Journal of Epidemiology"},{"key":"10.1016\/j.jsat.2011.05.001_bb0145","series-title":"Methadone and buprenorphine for the management of opioid dependence","author":"National Institute for Health and Clinical Excellence","year":"2007"},{"key":"10.1016\/j.jsat.2011.05.001_bb0150","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/aje\/kwp186","article-title":"Proportional hazards frailty models for recurrent methadone maintenance treatment","volume":"170","author":"Nosyk","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jsat.2011.05.001_bb0155","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1046\/j.1360-0443.2000.951116475.x","article-title":"Lethal methadone intoxications in Geneva, Switzerland, from 1994 to 1998","volume":"95","author":"Perret","year":"2000","journal-title":"Addiction"},{"key":"10.1016\/j.jsat.2011.05.001_bb0160","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/bmj.327.7410.321","article-title":"Effect of national guidelines on prescription of methadone: Analysis of NHS prescription data, England 1990\u20132001","volume":"327","author":"Strang","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.jsat.2011.05.001_bb0165","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.jclinepi.2004.03.012","article-title":"New ICD-10 version of the Charlson comorbidity index predicted in-hospital mortality","volume":"57","author":"Sundararajan","year":"2004","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jsat.2011.05.001_bb0170","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1136\/bmj.328.7451.1300","article-title":"Legal issues of data anonymisation in research","volume":"328","author":"Wilson","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.jsat.2011.05.001_bb0175","series-title":"National investigation into drug related deaths in Scotland, 2003","author":"Zador","year":"2005"},{"key":"10.1016\/j.jsat.2011.05.001_bb0180","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1360-0443.2000.951778.x","article-title":"Deaths in methadone maintenance treatment in New South Wales, Australia 1990\u20131995","volume":"95","author":"Zador","year":"2000","journal-title":"Addiction"},{"key":"10.1016\/j.jsat.2011.05.001_bb0185","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0376-8716(98)00097-0","article-title":"One-year mortality rates following methadone treatment discharge","volume":"52","author":"Zanis","year":"1998","journal-title":"Drug and Alcohol Dependence"}],"container-title":["Journal of Substance Abuse Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740547211000973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740547211000973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:36:35Z","timestamp":1760038595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0740547211000973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0740547211000973"],"URL":"https:\/\/doi.org\/10.1016\/j.jsat.2011.05.001","relation":{},"ISSN":["0740-5472"],"issn-type":[{"value":"0740-5472","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of drug-related mortality during periods of transition in methadone maintenance treatment: A cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Substance Abuse Treatment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsat.2011.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}