{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:02:58Z","timestamp":1786993378042,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsubstanceabusetreatment.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Substance Abuse Treatment"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.jsat.2012.07.004","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T02:02:29Z","timestamp":1347415349000},"page":"241-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"title":["Opioid overdose prevention with intranasal naloxone among people who take methadone"],"prefix":"10.1016","volume":"44","author":[{"given":"Alexander Y.","family":"Walley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Doe-Simkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al","family":"Ozonoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jsat.2012.07.004_bb0005","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1111\/j.1360-0443.2005.01259.x","article-title":"Take-home naloxone to reduce heroin death","volume":"100","author":"Baca","year":"2005","journal-title":"Addiction"},{"issue":"1","key":"10.1016\/j.jsat.2012.07.004_bb0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1001\/jama.290.1.40","article-title":"Increase in deaths due to methadone in North Carolina","volume":"290","author":"Ballesteros","year":"2003","journal-title":"Journal of the American Medical Association"},{"issue":"6","key":"10.1016\/j.jsat.2012.07.004_bb0250","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s11524-011-9600-7","article-title":"Characteristics of an overdose prevention, response, and naloxone distribution program in Pittsburgh and Allegheny County, Pennsylvania","volume":"88","author":"Bennett","year":"2011","journal-title":"Journal of Urban Health"},{"issue":"2","key":"10.1016\/j.jsat.2012.07.004_bb0015","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1056\/NEJMsa064115","article-title":"Release from prison\u2014A high risk of death for former inmates","volume":"356","author":"Binswanger","year":"2007","journal-title":"The New England Journal of Medicine"},{"issue":"7","key":"10.1016\/j.jsat.2012.07.004_bb0020","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1360-0443.2005.01089.x","article-title":"Evaluating the impact of methadone maintenance programmes on mortality due to overdose and AIDS in a cohort of heroin users in Spain","volume":"100","author":"Brugal","year":"2005","journal-title":"Addiction"},{"issue":"3","key":"10.1016\/j.jsat.2012.07.004_bb0025","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0955-3959(01)00080-9","article-title":"Legal aspects of providing naloxone to heroin users in the United States","volume":"12","author":"Burris","year":"2001","journal-title":"The International Journal on Drug Policy"},{"issue":"8","key":"10.1016\/j.jsat.2012.07.004_bb0030","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1046\/j.1360-0443.2002.00179.x","article-title":"An increase in overdose mortality during the first 2weeks after entering or re-entering methadone treatment in Amsterdam","volume":"97","author":"Buster","year":"2002","journal-title":"Addiction"},{"issue":"1","key":"10.1016\/j.jsat.2012.07.004_bb0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/09595239800187551","article-title":"Deaths in the first two weeks of maintenance treatment in NSW in 1994: Identifying cases of iatrogenic methadone toxicity","volume":"17","author":"Caplehorn","year":"1998","journal-title":"Drug and Alcohol Review"},{"issue":"4","key":"10.1016\/j.jsat.2012.07.004_bb0040","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1467-842X.2002.tb00185.x","article-title":"Fatal methadone toxicity: Signs and circumstances, and the role of benzodiazepines","volume":"26","author":"Caplehorn","year":"2002","journal-title":"Australian and New Zealand Journal of Public Health"},{"issue":"2","key":"10.1016\/j.jsat.2012.07.004_bb0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jpain.2008.10.008","article-title":"Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain","volume":"10","author":"Chou","year":"2009","journal-title":"The Journal of Pain"},{"issue":"5","key":"10.1016\/j.jsat.2012.07.004_bb0050","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.amepre.2010.01.022","article-title":"Hospitalizations for poisoning by prescription opioids, sedatives, and tranquilizers","volume":"38","author":"Coben","year":"2010","journal-title":"American Journal of Preventive Medicine"},{"issue":"6","key":"10.1016\/j.jsat.2012.07.004_bb0055","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1046\/j.1360-0443.2003.00376.x","article-title":"Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990\u201398","volume":"98","author":"Coffin","year":"2003","journal-title":"Addiction"},{"issue":"7","key":"10.1016\/j.jsat.2012.07.004_bb0060","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1197\/j.aem.2007.04.005","article-title":"Identifying injection drug users at risk of nonfatal overdose","volume":"14","author":"Coffin","year":"2007","journal-title":"Academic Emergency Medicine"},{"issue":"3","key":"10.1016\/j.jsat.2012.07.004_bb0065","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jsat.2011.05.001","article-title":"Risk of drug-related mortality during periods of transition in methadone maintenance treatment: A cohort study","volume":"41","author":"Cousins","year":"2011","journal-title":"Journal of Substance Abuse Treatment"},{"issue":"5","key":"10.1016\/j.jsat.2012.07.004_bb0070","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jpainsymman.2007.11.003","article-title":"Methadone: To ECG or not to ECG\u2026that is still the question","volume":"36","author":"Cruciani","year":"2008","journal-title":"Journal of Pain and Symptom Management"},{"issue":"12","key":"10.1016\/j.jsat.2012.07.004_bb0075","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1111\/j.1360-0443.2007.02025.x","article-title":"Risk of fatal overdose during and after specialist drug treatment: The VEdeTTE study, a national multi-site prospective cohort study","volume":"102","author":"Davoli","year":"2007","journal-title":"Addiction"},{"issue":"1\u20132","key":"10.1016\/j.jsat.2012.07.004_bb0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.drugalcdep.2009.05.021","article-title":"Mortality among clients of a state-wide opioid pharmacotherapy program over 20years: Risk factors and lives saved","volume":"105","author":"Degenhardt","year":"2009","journal-title":"Drug and Alcohol Dependence"},{"issue":"7291","key":"10.1016\/j.jsat.2012.07.004_bb0085","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1136\/bmj.322.7291.895","article-title":"Take home naloxone and the prevention of deaths from opiate overdose: Two pilot schemes","volume":"322","author":"Dettmer","year":"2001","journal-title":"British Medical Journal"},{"issue":"5","key":"10.1016\/j.jsat.2012.07.004_bb0090","doi-asserted-by":"crossref","first-page":"788","DOI":"10.2105\/AJPH.2008.146647","article-title":"Saved by the nose: Bystander-administered intranasal naloxone hydrochloride for opioid overdose","volume":"99","author":"Doe-Simkins","year":"2009","journal-title":"American Journal of Public Health"},{"issue":"6","key":"10.1016\/j.jsat.2012.07.004_bb0095","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s11524-010-9495-8","article-title":"Overdose prevention and naloxone prescription for opioid users in San Francisco","volume":"87","author":"Enteen","year":"2010","journal-title":"Journal of Urban Health"},{"issue":"3","key":"10.1016\/j.jsat.2012.07.004_bb0100","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1503\/cmaj.1031416","article-title":"Determinants of overdose incidents among illicit opioid users in 5 Canadian cities","volume":"171","author":"Fischer","year":"2004","journal-title":"Canadian Medical Association Journal"},{"issue":"3","key":"10.1016\/j.jsat.2012.07.004_bb0105","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1360-0443.2007.02090.x","article-title":"Exposure to opioid maintenance treatment reduces long-term mortality","volume":"103","author":"Gibson","year":"2008","journal-title":"Addiction"},{"issue":"3","key":"10.1016\/j.jsat.2012.07.004_bb0110","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/00952990802010892","article-title":"Methadone- and heroin-related deaths in Florida","volume":"34","author":"Graham","year":"2008","journal-title":"The American Journal of Drug and Alcohol Abuse"},{"issue":"6","key":"10.1016\/j.jsat.2012.07.004_bb0115","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1360-0443.2008.02182.x","article-title":"Distinguishing signs of opioid overdose and indication for naloxone: An evaluation of six overdose training and naloxone distribution programs in the United States","volume":"103","author":"Green","year":"2008","journal-title":"Addiction"},{"issue":"5","key":"10.1016\/j.jsat.2012.07.004_bb0120","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0740-5472(94)90099-X","article-title":"Illicit use of methadone among I.V. drug users in Montreal","volume":"11","author":"Lauzon","year":"1994","journal-title":"Journal of Substance Abuse Treatment"},{"key":"10.1016\/j.jsat.2012.07.004_bb0125","first-page":"42","article-title":"Intranasal naloxone for at-home opioid rescue","author":"Leavitt","year":"2010","journal-title":"Practical Pain Management"},{"issue":"4","key":"10.1016\/j.jsat.2012.07.004_bb0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/J354v19n04_05","article-title":"Pharmacokinetics of methadone","volume":"19","author":"Lugo","year":"2005","journal-title":"Journal of Pain & Palliative Care Pharmacotherapy"},{"issue":"2 Suppl","key":"10.1016\/j.jsat.2012.07.004_bb0135","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.36076\/ppj.2008\/11\/S63","article-title":"Therapeutic opioids: A ten-year perspective on the complexities and complications of the escalating use, abuse, and nonmedical use of opioids","volume":"11","author":"Manchikanti","year":"2008","journal-title":"Pain Physician"},{"key":"10.1016\/j.jsat.2012.07.004_bb0140","author":"Massachusetts Department of Public Health Bureau of Substance Abuse Services"},{"key":"10.1016\/j.jsat.2012.07.004_bb0145","first-page":"CD002209","article-title":"Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence","author":"Mattick","year":"2009","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"issue":"3","key":"10.1016\/j.jsat.2012.07.004_bb0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1300\/J069v25n03_11","article-title":"Prescribing naloxone to actively injecting heroin users: A program to reduce heroin overdose deaths","volume":"25","author":"Maxwell","year":"2006","journal-title":"Journal of Addictive Diseases"},{"issue":"1","key":"10.1016\/j.jsat.2012.07.004_bb0155","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3109\/14659891.2010.487555","article-title":"The impact of drug-related death on staff who have experienced it as part of their caseload: An exploratory study","volume":"16","author":"Mcauley","year":"2011","journal-title":"Journal of Substance Use"},{"issue":"4","key":"10.1016\/j.jsat.2012.07.004_bb0160","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11606-009-1225-0","article-title":"Methadone deaths: Risk factors in pain and addicted populations","volume":"25","author":"Modesto-Lowe","year":"2010","journal-title":"Journal of General Internal Medicine"},{"key":"10.1016\/j.jsat.2012.07.004_bb0165","author":"Office of National Drug Control Policy"},{"key":"10.1016\/j.jsat.2012.07.004_bb0170","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/1471-2458-8-375","article-title":"Correlates of illicit methadone use in New York City: A cross-sectional study","volume":"8","author":"Ompad","year":"2008","journal-title":"BMC Public Health"},{"issue":"7","key":"10.1016\/j.jsat.2012.07.004_bb0175","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1080\/10826080701801261","article-title":"Evaluation of a naloxone distribution and administration program in New York City","volume":"43","author":"Piper","year":"2008","journal-title":"Substance Use & Misuse"},{"issue":"2","key":"10.1016\/j.jsat.2012.07.004_bb0180","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/jurban\/jti053","article-title":"Naloxone distribution and cardiopulmonary resuscitation training for injection drug users to prevent heroin overdose death: A pilot intervention study","volume":"82","author":"Seal","year":"2005","journal-title":"Journal of Urban Health"},{"issue":"2","key":"10.1016\/j.jsat.2012.07.004_bb0185","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S1478951508000254","article-title":"Consensus guideline on parenteral methadone use in pain and palliative care","volume":"6","author":"Shaiova","year":"2008","journal-title":"Palliative & Supportive Care"},{"key":"10.1016\/j.jsat.2012.07.004_bb0190","author":"Sorg"},{"issue":"2","key":"10.1016\/j.jsat.2012.07.004_bb0195","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.annemergmed.2006.05.025","article-title":"Prescription naloxone: A novel approach to heroin overdose prevention","volume":"49","author":"Sporer","year":"2007","journal-title":"Annals of Emergency Medicine"},{"issue":"3","key":"10.1016\/j.jsat.2012.07.004_bb0200","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1300\/J069v25n03_02","article-title":"Methadone induction doses: Are our current practices safe?","volume":"25","author":"Srivastava","year":"2006","journal-title":"Journal of Addictive Diseases"},{"issue":"6","key":"10.1016\/j.jsat.2012.07.004_bb0205","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0955-3959(00)00070-0","article-title":"Peer-initiated overdose resuscitation: Fellow drug users could be mobilised to implement resuscitation","volume":"11","author":"Strang","year":"2000","journal-title":"The International Journal on Drug Policy"},{"issue":"7396","key":"10.1016\/j.jsat.2012.07.004_bb0210","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/bmj.326.7396.959","article-title":"Loss of tolerance and overdose mortality after inpatient opiate detoxification: Follow up study","volume":"326","author":"Strang","year":"2003","journal-title":"British Medical Journal (Clinical Research Ed.)"},{"issue":"2","key":"10.1016\/j.jsat.2012.07.004_bb0255","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.drugpo.2008.03.002","article-title":"Evaluation of the Staying Alive programme: Training injection drug users to properly administer naloxone and save lives","volume":"20","author":"Tobin","year":"2009","journal-title":"The International Journal on Drug Policy"},{"issue":"2 Suppl","key":"10.1016\/j.jsat.2012.07.004_bb0215","first-page":"S5","article-title":"Opioids in the management of chronic non-cancer pain: An update of American Society of the Interventional Pain Physicians' (ASIPP) guidelines","volume":"11","author":"Trescot","year":"2008","journal-title":"Pain Physician"},{"key":"10.1016\/j.jsat.2012.07.004_bb0220","author":"U. S. Census Bureau"},{"key":"10.1016\/j.jsat.2012.07.004_bb0225","author":"US Food and Drug Administration FDA"},{"issue":"3","key":"10.1016\/j.jsat.2012.07.004_bb0230","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.drugpo.2009.01.003","article-title":"Evaluation of an overdose prevention and response training programme for injection drug users in the Skid Row area of Los Angeles, CA","volume":"21","author":"Wagner","year":"2010","journal-title":"The International Journal on Drug Policy"},{"issue":"7","key":"10.1016\/j.jsat.2012.07.004_bb0235","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1592\/phco.30.7.627","article-title":"Opioid harm reduction strategies: Focus on expanded access to intranasal naloxone","volume":"30","author":"Wermeling","year":"2010","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jsat.2012.07.004_bb0240","first-page":"101","article-title":"Community-based opioid overdose prevention programs providing naloxone\u2014United States, 2010","volume":"61","author":"Wheeler","year":"2012","journal-title":"Morbidity and Mortality Weekly Report"},{"issue":"1","key":"10.1016\/j.jsat.2012.07.004_bb0245","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1360-0443.2000.951778.x","article-title":"Deaths in methadone maintenance treatment in New South Wales, Australia 1990\u20131995","volume":"95","author":"Zador","year":"2000","journal-title":"Addiction"}],"container-title":["Journal of Substance Abuse Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740547212001213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740547212001213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:38:15Z","timestamp":1760038695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0740547212001213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0740547212001213"],"URL":"https:\/\/doi.org\/10.1016\/j.jsat.2012.07.004","relation":{},"ISSN":["0740-5472"],"issn-type":[{"value":"0740-5472","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Opioid overdose prevention with intranasal naloxone among people who take methadone","name":"articletitle","label":"Article Title"},{"value":"Journal of Substance Abuse Treatment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsat.2012.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}