{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:14:20Z","timestamp":1780938860535,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","journalofsubstanceabusetreatment.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Substance Abuse Treatment"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jsat.2019.07.002","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T10:37:55Z","timestamp":1563014275000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of ascending buprenorphine doses on measures of experimental pain: A pilot study"],"prefix":"10.1016","volume":"104","author":[{"given":"S.","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Demirkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lintzeris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsat.2019.07.002_bb0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.7326\/0003-4819-144-2-200601170-00010","article-title":"Acute pain management for patients receiving maintenance methadone or buprenorphine therapy","volume":"144","author":"Alford","year":"2006","journal-title":"Annals of Internal Medicine"},{"issue":"1\u20132","key":"10.1016\/j.jsat.2019.07.002_bb0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0376-8716(99)00074-5","article-title":"Efficacy of daily and alternate-day dosing regimens with the combination buprenorphine-naloxone tablet","volume":"58","author":"Amass","year":"2000","journal-title":"Drug and Alcohol Dependence"},{"issue":"1","key":"10.1016\/j.jsat.2019.07.002_bb0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/pm\/pny025","article-title":"Buprenorphine maintenance subjects are hyperalgesic and have no antinociceptive response to a very high morphine dose","volume":"20","author":"Athanasos","year":"2019","journal-title":"Pain Medicine"},{"issue":"2","key":"10.1016\/j.jsat.2019.07.002_bb0020","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/10550490902772470","article-title":"Pain and substance-related pain-reduction behaviors among opioid dependent individuals seeking methadone maintenance treatment","volume":"18","author":"Barry","year":"2009","journal-title":"The American Journal on Addictions"},{"issue":"2","key":"10.1016\/j.jsat.2019.07.002_bb0025","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.drugalcdep.2003.10.012","article-title":"Prescription opioid abuse in patients presenting for methadone maintenance treatment","volume":"73","author":"Brands","year":"2004","journal-title":"Drug and Alcohol Dependence"},{"issue":"2","key":"10.1016\/j.jsat.2019.07.002_bb0030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3959(89)90126-7","article-title":"Human pain responsivity in a tonic pain model: Psychological determinants","volume":"37","author":"Chen","year":"1989","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.jsat.2019.07.002_bb0035","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jpain.2012.01.001","article-title":"Hyperalgesia in heroin dependent patients and the effects of opioid substitution therapy","volume":"13","author":"Compton","year":"2012","journal-title":"The Journal of Pain"},{"issue":"1\u20133","key":"10.1016\/j.jsat.2019.07.002_bb0040","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.drugalcdep.2010.01.006","article-title":"Gabapentin improves cold-pressor pain responses in methadone-maintained patients","volume":"109","author":"Compton","year":"2010","journal-title":"Drug and Alcohol Dependence"},{"issue":"5","key":"10.1016\/j.jsat.2019.07.002_bb0045","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/bja\/ael051","article-title":"Buprenorphine induces ceiling in respiratory depression but not in analgesia","volume":"96","author":"Dahan","year":"2006","journal-title":"British Journal of Anaesthesia"},{"issue":"8","key":"10.1016\/j.jsat.2019.07.002_bb0050","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.clinthera.2007.08.007","article-title":"Pharmacokinetic and pharmacodynamic properties of buprenorphine after a single intravenous administration in healthy volunteers: A randomized, double-blind, placebo-controlled, crossover study","volume":"29","author":"Escher","year":"2007","journal-title":"Clinical Therapeutics"},{"issue":"5","key":"10.1016\/j.jsat.2019.07.002_bb0055","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1177\/0310057X1103900505","article-title":"Acute pain management in opioid-tolerant patients: A growing challenge","volume":"39","author":"Huxtable","year":"2011","journal-title":"Anaesthesia and Intensive Care"},{"issue":"1","key":"10.1016\/j.jsat.2019.07.002_bb0060","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0885-3924(99)00144-X","article-title":"Characteristics of methadone maintenance patients with chronic pain","volume":"19","author":"Jamison","year":"2000","journal-title":"Journal of Pain and Symptom Management"},{"issue":"1","key":"10.1016\/j.jsat.2019.07.002_bb0065","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1742-7843.2008.00250.x","article-title":"Pharmacokinetic-pharmacodynamic relationships of cognitive and psychomotor effects of intravenous buprenorphine infusion in human volunteers","volume":"103","author":"Jensen","year":"2008","journal-title":"Basic & Clinical Pharmacology & Toxicology"},{"issue":"1\u20133","key":"10.1016\/j.jsat.2019.07.002_bb0070","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pain.2006.06.028","article-title":"Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine","volume":"126","author":"Koltzenburg","year":"2006","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.jsat.2019.07.002_bb0075","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1465-3362.2011.00304.x","article-title":"The availability, diversion and injection of pharmaceutical opioids in South Asia","volume":"30","author":"Larance","year":"2011","journal-title":"Drug and Alcohol Review"},{"issue":"2 Suppl","key":"10.1016\/j.jsat.2019.07.002_bb0080","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/S0376-8716(03)00059-0","article-title":"Clinical efficacy of buprenorphine: Comparisons to methadone and placebo","volume":"70","author":"Ling","year":"2003","journal-title":"Drug and Alcohol Dependence"},{"issue":"5","key":"10.1016\/j.jsat.2019.07.002_bb0085","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/archpsyc.1996.01830050035005","article-title":"A controlled trial comparing buprenorphine and methadone maintenance in opioid dependence","volume":"53","author":"Ling","year":"1996","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jsat.2019.07.002_bb0090","first-page":"CD002207","article-title":"Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence","volume":"3","author":"Mattick","year":"2004","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"10.1016\/j.jsat.2019.07.002_bb0095","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1465-3362.2011.00291.x","article-title":"The prescription drug epidemic in the United States: A perfect storm","volume":"30","author":"Maxwell","year":"2011","journal-title":"Drug and Alcohol Review"},{"issue":"4","key":"10.1016\/j.jsat.2019.07.002_bb0100","first-page":"233","article-title":"Temperature and the cold pressor test","volume":"5","author":"Mitchell","year":"2004","journal-title":"The Journal of Pain"},{"issue":"4","key":"10.1016\/j.jsat.2019.07.002_bb0105","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s11606-007-0129-0","article-title":"Primary care office-based buprenorphine treatment: Comparison of heroin and prescription opioid dependent patients","volume":"22","author":"Moore","year":"2007","journal-title":"Journal of General Internal Medicine"},{"issue":"3","key":"10.1016\/j.jsat.2019.07.002_bb0110","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1445-5994.2012.02714.x","article-title":"Management of opioid substitution therapy during medical intervention","volume":"42","author":"Murnion","year":"2012","journal-title":"Internal Medicine Journal"},{"issue":"5","key":"10.1016\/j.jsat.2019.07.002_bb0115","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/dar.12041","article-title":"Correlates of pain in an in-treatment sample of opioid-dependent people","volume":"32","author":"Nielsen","year":"2013","journal-title":"Drug and Alcohol Review"},{"issue":"3","key":"10.1016\/j.jsat.2019.07.002_bb0120","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pain.2004.11.011","article-title":"Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain","volume":"113","author":"Peles","year":"2005","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.jsat.2019.07.002_bb0125","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF03016532","article-title":"Review article: Perioperative pain management of patients on methadone therapy","volume":"52","author":"Peng","year":"2005","journal-title":"Canadian Journal of Anaesthesia"},{"issue":"7","key":"10.1016\/j.jsat.2019.07.002_bb0130","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1001\/jama.1997.03550070084043","article-title":"Pain management and chemical dependency: Evolving perspectives","volume":"278","author":"Portenoy","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jsat.2019.07.002_bb0135","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.289.18.2370","article-title":"Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities","volume":"289","author":"Rosenblum","year":"2003","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.jsat.2019.07.002_bb0140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1300\/J069v26n03_10","article-title":"Buprenorphine 101: Treating opioid dependence with buprenorphine in an office-based setting","volume":"26","author":"Torrington","year":"2007","journal-title":"Journal of Addictive Diseases"},{"key":"10.1016\/j.jsat.2019.07.002_bb0145","series-title":"Abuse-deterrent opioids\u2014Evaluation and labeling guidance for industry","author":"U.S. Department of Health and Human Services Food and Drug Administration","year":"2015"},{"issue":"1","key":"10.1016\/j.jsat.2019.07.002_bb0150","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1136\/jnnp.51.1.10","article-title":"Recovery of cognitive function soon after stroke: A study of visual neglect, attention span and verbal recall","volume":"51","author":"Wade","year":"1988","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"1","key":"10.1016\/j.jsat.2019.07.002_bb0155","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0022-3565(25)10510-7","article-title":"Acute administration of buprenorphine in humans: Partial agonist and blockade effects","volume":"274","author":"Walsh","year":"1995","journal-title":"Journal of Pharmacology & Experimental Therapeutics"},{"issue":"5","key":"10.1016\/j.jsat.2019.07.002_bb0160","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/clpt.1994.71","article-title":"Clinical pharmacology of buprenorphine: Ceiling effects at high doses","volume":"55","author":"Walsh","year":"1994","journal-title":"Clinical Pharmacology and Therapeutics"},{"key":"10.1016\/j.jsat.2019.07.002_bb0165","series-title":"Manual for the Wechsler adult intelligence scale","author":"Wechsler","year":"1955"},{"key":"10.1016\/j.jsat.2019.07.002_bb0170","series-title":"D. Wechsler adult intelligence scale\u2014Revised","author":"Wechsler","year":"1981"},{"issue":"12","key":"10.1016\/j.jsat.2019.07.002_bb0175","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1001\/archgenpsychiatry.2011.121","article-title":"A two-phase randomized controlled trial of adjunctive counseling during brief and extended buprenorphine-naloxone treatment for prescription opioid dependence","volume":"68","author":"Weiss","year":"2011","journal-title":"Archives of General Psychiatry"},{"key":"10.1016\/j.jsat.2019.07.002_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/CMRT.S9921","article-title":"Safety and efficacy of buprenorphine patch in the management of chronic pain","volume":"7","author":"Yang","year":"2015","journal-title":"Clinical Medicine Reviews in Therapeutics"}],"container-title":["Journal of Substance Abuse Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074054721930282X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074054721930282X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:50:39Z","timestamp":1760039439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074054721930282X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":36,"alternative-id":["S074054721930282X"],"URL":"https:\/\/doi.org\/10.1016\/j.jsat.2019.07.002","relation":{},"ISSN":["0740-5472"],"issn-type":[{"value":"0740-5472","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of ascending buprenorphine doses on measures of experimental pain: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Journal of Substance Abuse Treatment","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsat.2019.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}