{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:47:47Z","timestamp":1790920067036,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Structural Biology"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1016\/j.jsb.2006.11.009","type":"journal-article","created":{"date-parts":[[2006,12,23]],"date-time":"2006-12-23T07:14:17Z","timestamp":1166858057000},"page":"307-317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Structural differentiation, proliferation, and association of human embryonic stem cell-derived cardiomyocytes in vitro and in their extracardiac tissues"],"prefix":"10.1016","volume":"158","author":[{"given":"Li","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Johkura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Takei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Ogiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsb.2006.11.009_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1474-9728.2004.00137.x","article-title":"Telomere-independent cellular senescence in human fetal cardiomyocytes","volume":"4","author":"Ball","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/j.jsb.2006.11.009_bib2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1023\/A:1021150014764","article-title":"Comparison of connexin expression patterns in the developing mouse heart and human foetal heart","volume":"242","author":"Coppen","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.jsb.2006.11.009_bib3","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1369\/jhc.3A6241.2004","article-title":"Spatial distribution of SSEA-1 and other cell adhesion-related molecules on mouse embryonic stem cells, and its change upon differentiation","volume":"52","author":"Cui","year":"2004","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jsb.2006.11.009_bib4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.cardiores.2004.10.037","article-title":"Can stem cells mend a broken heart?","volume":"65","author":"Davani","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jsb.2006.11.009_bib5","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1161\/01.RES.0000041435.95082.84","article-title":"Derivation and potential applications of human embryonic stem cells","volume":"91","author":"Gepstein","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsb.2006.11.009_bib6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.RES.0000080317.92718.99","article-title":"Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization","volume":"93","author":"He","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsb.2006.11.009_bib7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.0021-8782.2004.00336.x","article-title":"Cytochemical and ultrastructural characterization of growing colonies of human embryonic stem cells","volume":"205","author":"Johkura","year":"2004","journal-title":"J. Anat."},{"key":"10.1016\/j.jsb.2006.11.009_bib8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0008-6363(02)00730-7","article-title":"Survival and function of mouse embryonic stem cell-derived cardiomyocytes in ectopic transplants","volume":"58","author":"Johkura","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jsb.2006.11.009_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/jemt.20152","article-title":"Natriuretic peptides in ectopic myocardial tissues originating from mouse embryonic stem cells","volume":"66","author":"Johkura","year":"2005","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jsb.2006.11.009_bib10","doi-asserted-by":"crossref","first-page":"10716","DOI":"10.1073\/pnas.191362598","article-title":"Hematopoietic colony-forming cells derived from human embryonic stem cells","volume":"98","author":"Kaufman","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jsb.2006.11.009_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI200112131","article-title":"Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes","volume":"108","author":"Kehat","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsb.2006.11.009_bib12","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/nbt1014","article-title":"Electromechanical integration of cardiomyocytes derived from human embryonic stem cells","volume":"22","author":"Kehat","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jsb.2006.11.009_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jtcvs.2004.05.021","article-title":"Injectable bioartificial myocardial tissue for large-scale intramural cell transfer and functional recovery of injured heart muscle","volume":"128","author":"Kofidis","year":"2004","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.jsb.2006.11.009_bib14","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0002-9440(10)62041-X","article-title":"Formation of human myocardium in the rat heart from human embryonic stem cells","volume":"167","author":"Laflamme","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jsb.2006.11.009_bib15","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1172\/JCI5298","article-title":"Cardiomyocytes can be generated from marrow stromal cells in vitro","volume":"103","author":"Makino","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsb.2006.11.009_bib16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nm1181","article-title":"Human embryonic stem cells express an immunogenic nonhuman sialic acid","volume":"11","author":"Martin","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.jsb.2006.11.009_bib17","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.yjmcc.2005.09.007","article-title":"Proliferation of cardiomyocytes derived from human embryonic stem cells is mediated via the IGF\/PI 3-kinase\/Akt signaling pathway","volume":"39","author":"McDevitt","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jsb.2006.11.009_bib18","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1097\/01.tp.0000181163.69108.dd","article-title":"Tissue cardiomyoplasty using bioengineered contractile cardiomyocyte sheets to repair damaged myocardium: their integration with recipient myocardium","volume":"80","author":"Miyagawa","year":"2005","journal-title":"Transplantation."},{"key":"10.1016\/j.jsb.2006.11.009_bib19","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/01.CIR.0000068356.38592.68","article-title":"Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells","volume":"107","author":"Mummery","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jsb.2006.11.009_bib20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/emm.2005.33","article-title":"Identification of a putative transactivation domain in human Nanog","volume":"37","author":"Oh","year":"2005","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jsb.2006.11.009_bib21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1113\/jphysiol.2004.068213","article-title":"Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes","volume":"559","author":"Satin","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.jsb.2006.11.009_bib22","doi-asserted-by":"crossref","first-page":"H2355","DOI":"10.1152\/ajpheart.00020.2003","article-title":"Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes","volume":"285","author":"Snir","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jsb.2006.11.009_bib23","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nm0898-929","article-title":"Regenerating functional myocardium: improved performance after skeletal myoblast transplantation","volume":"4","author":"Taylor","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.jsb.2006.11.009_bib24","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jsb.2006.11.009_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/hc0102.101442","article-title":"Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart","volume":"105","author":"Toma","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jsb.2006.11.009_bib26","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.RES.0000035254.80718.91","article-title":"Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells","volume":"91","author":"Xu","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsb.2006.11.009_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/01.CIR.0000151313.18547.A2","article-title":"Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers","volume":"111","author":"Xue","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jsb.2006.11.009_bib28","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1006\/jmcc.2001.1367","article-title":"Cardiomyocyte grafting for cardiac repair: graft cell death and antideath strategies","volume":"33","author":"Zhang","year":"2001","journal-title":"J. Mol. Cell. Cardiol."}],"container-title":["Journal of Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847706003807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847706003807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T03:09:47Z","timestamp":1760929787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047847706003807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S1047847706003807"],"URL":"https:\/\/doi.org\/10.1016\/j.jsb.2006.11.009","relation":{},"ISSN":["1047-8477"],"issn-type":[{"value":"1047-8477","type":"print"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural differentiation, proliferation, and association of human embryonic stem cell-derived cardiomyocytes in vitro and in their extracardiac tissues","name":"articletitle","label":"Article Title"},{"value":"Journal of Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsb.2006.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}