{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:28:45Z","timestamp":1791264525964,"version":"4.1.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Structural Biology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.jsb.2008.03.003","type":"journal-article","created":{"date-parts":[[2008,3,16]],"date-time":"2008-03-16T07:42:50Z","timestamp":1205653370000},"page":"468-479","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Intracellular precipitation of hydroxyapatite mineral and implications for pathologic calcification"],"prefix":"10.1016","volume":"162","author":[{"given":"Fereshteh","family":"Azari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hojatollah","family":"Vali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Guerquin-Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Croisy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Kelly","family":"Sears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Tabrizian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc D.","family":"McKee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsb.2008.03.003_bib1","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1073\/pnas.82.12.4110","article-title":"Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization","volume":"82","author":"Addadi","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jsb.2008.03.003_bib2","doi-asserted-by":"crossref","first-page":"15872","DOI":"10.1074\/jbc.M701116200","article-title":"Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity","volume":"282","author":"Addison","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2008.03.003_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1083\/jcb.41.1.59","article-title":"Vesicles associated with calcification in the matrix of epiphyseal cartilage","volume":"41","author":"Anderson","year":"1969","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib4","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0889-857X(21)00966-2","article-title":"Mechanisms of pathologic calcification","volume":"14","author":"Anderson","year":"1988","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.jsb.2008.03.003_bib5","series-title":"In Pathology Reviews","article-title":"Biology of disease-mechanism of mineral formation in bone","author":"Anderson","year":"1990"},{"key":"10.1016\/j.jsb.2008.03.003_bib6","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00003086-199505000-00034","article-title":"Molecular biology of matrix vesicles","author":"Anderson","year":"1995","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib7","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s11926-003-0071-z","article-title":"Matrix vesicles and calcification","volume":"5","author":"Anderson","year":"2003","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.jsb.2008.03.003_bib8","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0002-9440(10)63172-0","article-title":"Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice","volume":"164","author":"Anderson","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jsb.2008.03.003_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1538\/expanim.53.81","article-title":"Histological and ultrastructural features in the early stage of Purkinje cell degeneration in the cerebellar calcification (CC) rat","volume":"53","author":"Ando","year":"2004","journal-title":"Exp. Anim."},{"key":"10.1016\/j.jsb.2008.03.003_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF02556874","article-title":"Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations","volume":"38","author":"Bellows","year":"1986","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jsb.2008.03.003_bib11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00223-002-1057-y","article-title":"von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation","volume":"72","author":"Bonewald","year":"2003","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jsb.2008.03.003_bib12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/BF00337312","article-title":"Fine structure and histochemistry of \u201ccalcifying globules\u201d in epiphyseal cartilage","volume":"103","author":"Bonucci","year":"1970","journal-title":"Z. Zellforsch. Mikrosk. Anat."},{"key":"10.1016\/j.jsb.2008.03.003_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00418-003-0601-9","article-title":"Direct visualization of intracellular calcium in rat osteoblasts by energy-filtering transmission electron microscopy","volume":"121","author":"Bordat","year":"2004","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0169-6009(89)90044-5","article-title":"Noncollagenous matrix proteins and their role in mineralization","volume":"6","author":"Boskey","year":"1989","journal-title":"Bone Miner."},{"key":"10.1016\/j.jsb.2008.03.003_bib15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s002239900339","article-title":"Effects of bone CS-proteoglycans, DS-decorin, and DS-biglycan on hydroxyapatite formation in a gelatin gel","volume":"61","author":"Boskey","year":"1997","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jsb.2008.03.003_bib16","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/(SICI)1097-4644(19970315)64:4<632::AID-JCB11>3.0.CO;2-E","article-title":"Effects of proteoglycan modification on mineral formation in a differentiating chick limb-bud mesenchymal cell culture system","volume":"64","author":"Boskey","year":"1997","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jsb.2008.03.003_bib17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/BF02555132","article-title":"Loss of proteoglycans during decalcification of fresh metaphyses with disodium ethylenediaminetetraacetate (EDTA)","volume":"41","author":"Campo","year":"1987","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jsb.2008.03.003_bib18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1083\/jcb.136.2.445","article-title":"Retinoic acid receptor alpha function in vertebrate limb skeletogenesis: a modulator of chondrogenesis","volume":"136","author":"Cash","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib19","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1359\/jbmr.2003.18.4.644","article-title":"Renal calcification in mice homozygous for the disrupted type IIa Na\/Pi cotransporter gene Npt2","volume":"18","author":"Chau","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF02553709","article-title":"Mechanisms of proteoglycan inhibition of hydroxyapatite growth","volume":"37","author":"Chen","year":"1985","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jsb.2008.03.003_bib21","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1359\/jbmr.2002.17.7.1180","article-title":"Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues","volume":"17","author":"Corsi","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1050-1738(98)00014-0","article-title":"Noncollagenous matrix proteins controlling mineralization; possible role in pathologic calcification of vascular tissue","volume":"8","author":"Donley","year":"1998","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.jsb.2008.03.003_bib23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s100249900050","article-title":"Massive myocardial calcification in the perinatal period","volume":"1","author":"Drut","year":"1998","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.jsb.2008.03.003_bib24","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1083\/jcb.96.3.639","article-title":"Osteoblasts isolated from mouse calvaria initiate matrix mineralization in culture","volume":"96","author":"Ecarot-Charrier","year":"1983","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib25","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1161\/01.ATV.0000147029.63303.28","article-title":"Decorin promotes aortic smooth muscle cell calcification and colocalizes to calcified regions in human atherosclerotic lesions","volume":"24","author":"Fischer","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib26","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1074\/jbc.M604732200","article-title":"Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite","volume":"282","author":"Gajjeraman","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2008.03.003_bib27","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.bone.2004.02.010","article-title":"Primary culture of rat growth plate chondrocytes: an in vitro model of growth plate histotype, matrix vesicle biogenesis and mineralization","volume":"34","author":"Garimella","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jsb.2008.03.003_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/019131201300343874","article-title":"As you like it, Part 3: a critique and historical review of calcification as seen with the electron microscope","volume":"25","author":"Ghadially","year":"2001","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.jsb.2008.03.003_bib29","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0002-9440(10)65313-8","article-title":"Ectopic calcification: gathering hard facts about soft tissue mineralization","volume":"154","author":"Giachelli","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jsb.2008.03.003_bib30","doi-asserted-by":"crossref","first-page":"S300","DOI":"10.1097\/01.ASN.0000081663.52165.66","article-title":"Vascular calcification: in vitro evidence for the role of inorganic phosphate","volume":"14","author":"Giachelli","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jsb.2008.03.003_bib31","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1097\/01.ASN.0000145894.57533.C4","article-title":"Vascular calcification mechanisms","volume":"15","author":"Giachelli","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jsb.2008.03.003_bib32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1601-6343.2005.00345.x","article-title":"Inducers and inhibitors of biomineralization: lessons from pathological calcification","volume":"8","author":"Giachelli","year":"2005","journal-title":"Orthod. Craniofac. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib33","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbagen.2005.05.013","article-title":"Progress in analytical imaging of the cell by dynamic secondary ion mass spectrometry (SIMS microscopy)","volume":"1724","author":"Guerquin-Kern","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsb.2008.03.003_bib34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nmat945","article-title":"Nucleation of apatite crystals in vitro by self-assembled dentin matrix protein 1","volume":"2","author":"He","year":"2003","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jsb.2008.03.003_bib35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-2249.1991.tb05587.x","article-title":"Human cartilage is degraded by rheumatoid arthritis synovial fluid but not by recombinant cytokines in vitro","volume":"83","author":"Hollander","year":"1991","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jsb.2008.03.003_bib36","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1359\/jbmr.2001.16.2.289","article-title":"Localizational alterations of calcium, phosphorus, and calcification-related organics such as proteoglycans and alkaline phosphatase during bone calcification","volume":"16","author":"Hoshi","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib37","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1073\/pnas.75.8.3805","article-title":"Calcification of isolated matrix vesicles and reconstituted vesicles from fetal bovine cartilage","volume":"75","author":"Hsu","year":"1978","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jsb.2008.03.003_bib38","doi-asserted-by":"crossref","first-page":"8562","DOI":"10.1073\/pnas.90.18.8562","article-title":"Nucleation of hydroxyapatite by bone sialoprotein","volume":"90","author":"Hunter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jsb.2008.03.003_bib39","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1365-2796.2006.01692.x","article-title":"Vascular smooth muscle cell phenotypic plasticity and the regulation of vascular calcification","volume":"260","author":"Iyemere","year":"2006","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jsb.2008.03.003_bib40","doi-asserted-by":"crossref","DOI":"10.1007\/s00109-007-0294-y","article-title":"Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcification","author":"Jahnen-Dechent","year":"2008","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.jsb.2008.03.003_bib41","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/modpathol.3800747","article-title":"Cellular and molecular mechanisms of abnormal calcification following ischemia-reperfusion injury in human liver transplantation","volume":"20","author":"Kalantari","year":"2007","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.jsb.2008.03.003_bib42","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1016\/j.biomaterials.2004.11.022","article-title":"Process and kinetics of bonelike apatite formation on sintered hydroxyapatite in a simulated body fluid","volume":"26","author":"Kim","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jsb.2008.03.003_bib43","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/10520298109067325","article-title":"A rapid procedure for routine double staining of cartilage and bone in fetal and adult animals","volume":"56","author":"Kimmel","year":"1981","journal-title":"Stain Technol."},{"key":"10.1016\/j.jsb.2008.03.003_bib44","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1083\/jcb.137.5.1149","article-title":"Regulated production of mineralization-competent matrix vesicles in hypertrophic chondrocytes","volume":"137","author":"Kirsch","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib45","first-page":"191","article-title":"Proteoglycans in haemopoietic cells","volume":"1032","author":"Kolset","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsb.2008.03.003_bib46","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1042\/bj20031230","article-title":"Intracellular proteoglycans","volume":"379","author":"Kolset","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.jsb.2008.03.003_bib47","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.148.2.227","article-title":"The elusive functions of proteoglycans: in vivo veritas","volume":"148","author":"Lander","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib48","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/(SICI)1097-0029(19960201)33:2<192::AID-JEMT9>3.0.CO;2-V","article-title":"Structural relations between collagen and mineral in bone as determined by high voltage electron microscopic tomography","volume":"33","author":"Landis","year":"1996","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jsb.2008.03.003_bib49","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/MNH.0b013e3281c55ef1","article-title":"Sodium-dependent phosphate cotransporters and vascular calcification","volume":"16","author":"Li","year":"2007","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.jsb.2008.03.003_bib50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00041552-200007000-00005","article-title":"Renal cell-urinary crystal interactions","volume":"9","author":"Lieske","year":"2000","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.jsb.2008.03.003_bib51","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/386078a0","article-title":"Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein","volume":"386","author":"Luo","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jsb.2008.03.003_bib52","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/bies.20254","article-title":"Cartilage formation in growth plate and arteries: from physiology to pathology","volume":"27","author":"Magne","year":"2005","journal-title":"Bioessays"},{"key":"10.1016\/j.jsb.2008.03.003_bib53","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/BF00121697","article-title":"Formation of hydroxyapatite in serum","volume":"5","author":"Martin","year":"1994","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.jsb.2008.03.003_bib54","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000091379","article-title":"Hierarchies of extracellular matrix and mineral organization in bone of the craniofacial complex and skeleton","volume":"181","author":"McKee","year":"2005","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.jsb.2008.03.003_bib55","first-page":"473","article-title":"Mitochondrial calcium deposition in association with cyclosporine therapy and myocardial magnesium depletion: a serial histologic study in heart transplant recipients","volume":"13","author":"Millane","year":"1994","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.jsb.2008.03.003_bib56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1067\/mnc.2003.0012","article-title":"Vascular calcification and its relation to bone calcification: possible underlying mechanisms","volume":"10","author":"Mody","year":"2003","journal-title":"J. Nucl. Cardiol."},{"key":"10.1016\/j.jsb.2008.03.003_bib57","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1152\/ajprenal.1998.275.5.F827","article-title":"Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose","volume":"275","author":"Mogyorosi","year":"1998","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.jsb.2008.03.003_bib58","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1447-073x.2004.00078.x","article-title":"Immunocytochemistry of keratan sulfate proteoglycan and dermatan sulfate proteoglycan in porcine tooth-germ dentin","volume":"79","author":"Moriguchi","year":"2004","journal-title":"Anat. Sci. Int."},{"key":"10.1016\/j.jsb.2008.03.003_bib59","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1101\/gad.1276205","article-title":"Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone","volume":"19","author":"Murshed","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.jsb.2008.03.003_bib60","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bone.2007.06.011","article-title":"ATP-mediated mineralization of MC3T3-E1 osteoblast cultures","volume":"41","author":"Nakano","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.jsb.2008.03.003_bib61","first-page":"499","article-title":"The nucleation and growth of calcium phosphate crystals at protein and phosphatidylserine liposome surfaces","volume":"10","author":"Nancollas","year":"1996","journal-title":"Scanning Microsc."},{"key":"10.1016\/j.jsb.2008.03.003_bib62","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1042\/bj20031150","article-title":"Inhibition of hydroxyapatite formation by osteopontin phosphopeptides","volume":"378","author":"Pampena","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.jsb.2008.03.003_bib63","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1046\/j.1365-2818.1996.67430.x","article-title":"Early mineralization of matrix vesicles in the epiphyseal growth plate","volume":"183","author":"Plate","year":"1996","journal-title":"J. Microsc."},{"key":"10.1016\/j.jsb.2008.03.003_bib64","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/01.RES.87.11.1055","article-title":"Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies","volume":"87","author":"Proudfoot","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib65","unstructured":"Rasband, W.S., 1997-2006. ImageJ, http:\/\/rsb.info.nih.gov\/ij\/, US National Institutes of Health, Bethesda, MD, USA."},{"key":"10.1016\/j.jsb.2008.03.003_bib66","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0304-4165(01)00209-4","article-title":"Interaction of bone proteoglycans and proteoglycan components with hydroxyapatite","volume":"1568","author":"Rees","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsb.2008.03.003_bib67","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0142-9612(03)00618-5","article-title":"Effect of serum albumin on glycosaminoglycan inhibition of hydroxyapatite formation","volume":"25","author":"Rees","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jsb.2008.03.003_bib68","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1097\/01.ASN.0000141960.01035.28","article-title":"Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD","volume":"15","author":"Reynolds","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jsb.2008.03.003_bib69","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00223-007-9013-5","article-title":"Exocytotic process as a novel model for mineralization by osteoblasts in vitro and in vivo determined by electron microscopic analysis","volume":"80","author":"Rohde","year":"2007","journal-title":"Calcif. Tissue Int."},{"issue":"Pt 3","key":"10.1016\/j.jsb.2008.03.003_bib70","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1042\/bj3180779","article-title":"Presence of pro-forms of decorin and biglycan in human articular cartilage","volume":"318","author":"Roughley","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.jsb.2008.03.003_bib71","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S8756-3282(97)00149-X","article-title":"Mineral induction by immobilized phosphoproteins","volume":"21","author":"Saito","year":"1997","journal-title":"Bone"},{"key":"10.1016\/j.jsb.2008.03.003_bib72","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.athoracsur.2004.06.033","article-title":"Calcification of tissue heart valve substitutes: progress toward understanding and prevention","volume":"79","author":"Schoen","year":"2005","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.jsb.2008.03.003_bib73","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/01.mnh.0000172723.52499.38","article-title":"Vascular calcification","volume":"14","author":"Shanahan","year":"2005","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.jsb.2008.03.003_bib74","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1161\/01.CIR.100.21.2168","article-title":"Medial localization of mineralization-regulating proteins in association with Monckeberg\u2019s sclerosis: evidence for smooth muscle cell-mediated vascular calcification","volume":"100","author":"Shanahan","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jsb.2008.03.003_bib75","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1161\/01.ATV.15.11.2003","article-title":"Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells","volume":"15","author":"Shioi","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib76","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1078\/0944-7113-00377","article-title":"The effect of garlic on arteriosclerotic nanoplaque formation and size","volume":"11","author":"Siegel","year":"2004","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jsb.2008.03.003_bib77","doi-asserted-by":"crossref","first-page":"9420","DOI":"10.1074\/jbc.270.16.9420","article-title":"Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-01 BSP)","volume":"270","author":"Stanford","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2008.03.003_bib78","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1161\/hh2401.101070","article-title":"Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers","volume":"89","author":"Steitz","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib79","doi-asserted-by":"crossref","first-page":"18115","DOI":"10.1074\/jbc.M314114200","article-title":"In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions","volume":"279","author":"Tartaix","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2008.03.003_bib80","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1242\/jeb.01070","article-title":"Purification of a soluble glycoprotein from the uncalcified ecdysial cuticle of the blue crab Callinectes sapidus and its possible role in initial mineralization","volume":"207","author":"Tweedie","year":"2004","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib81","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1161\/01.ATV.0000059406.92165.31","article-title":"Osteo\/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification","volume":"23","author":"Tyson","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib82","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0021-9797(88)90122-1","article-title":"Ultrastructure and flow behavior of colloidal smectile dispersions","volume":"126","author":"Vali","year":"1988","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jsb.2008.03.003_bib83","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0016-7037(00)00525-1","article-title":"Nanoforms: a new type of protein-associated mineralization","volume":"65","author":"Vali","year":"2001","journal-title":"Geochem Cosmochim Acta"},{"issue":"Suppl 2","key":"10.1016\/j.jsb.2008.03.003_bib84","doi-asserted-by":"crossref","first-page":"S493","DOI":"10.1002\/jbmr.5650081312","article-title":"Mineral-matrix interactions in bone and dentin","volume":"8","author":"Veis","year":"1993","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib85","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/01.RES.84.2.166","article-title":"Calcification of vascular smooth muscle cell cultures: inhibition by osteopontin","volume":"84","author":"Wada","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib86","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0945-053X(98)90079-8","article-title":"Structural analysis of proteoglycans synthesized by mineralizing bone cells in vitro in the presence of fluoride","volume":"17","author":"Waddington","year":"1998","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jsb.2008.03.003_bib87","doi-asserted-by":"crossref","first-page":"12","DOI":"10.22203\/eCM.v006a02","article-title":"Differential roles for small leucine-rich proteoglycans in bone formation","volume":"6","author":"Waddington","year":"2003","journal-title":"Eur. Cell Mater."},{"key":"10.1016\/j.jsb.2008.03.003_bib88","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1042\/bj3160985","article-title":"Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycemia","volume":"316","author":"Wahab","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.jsb.2008.03.003_bib89","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1359\/jbmr.1999.14.6.893","article-title":"Isolation and characterization of MC3T3-E1 preosteoblast subclones with distinct in vitro and in vivo differentiation\/mineralization potential","volume":"14","author":"Wang","year":"1999","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsb.2008.03.003_bib90","first-page":"364","article-title":"Small leucine-rich proteoglycans in the aging skeleton","volume":"6","author":"Young","year":"2006","journal-title":"J. Musculoskelet. Neuronal Interact."}],"container-title":["Journal of Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847708000750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847708000750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T03:09:16Z","timestamp":1760929756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047847708000750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":90,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S1047847708000750"],"URL":"https:\/\/doi.org\/10.1016\/j.jsb.2008.03.003","relation":{},"ISSN":["1047-8477"],"issn-type":[{"value":"1047-8477","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracellular precipitation of hydroxyapatite mineral and implications for pathologic calcification","name":"articletitle","label":"Article Title"},{"value":"Journal of Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsb.2008.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}