{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:24:10Z","timestamp":1789914250475,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China (973 Program)","doi-asserted-by":"crossref","award":["2011CB966302"],"award-info":[{"award-number":["2011CB966302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China (973 Program)","doi-asserted-by":"crossref","award":["2011CB911104"],"award-info":[{"award-number":["2011CB911104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Chinese National Natural Science Foundation","doi-asserted-by":"crossref","award":["30830031"],"award-info":[{"award-number":["30830031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"\u201cOutstanding technical talent\u201d project of the Chinese Academy of Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Structural Biology"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.jsb.2011.11.022","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T04:44:28Z","timestamp":1323319468000},"page":"459-468","source":"Crossref","is-referenced-by-count":21,"title":["Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure"],"prefix":"10.1016","volume":"177","author":[{"given":"Zhenhua","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fudong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley M.-H.","family":"Sy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deshun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.Y.","family":"Huen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingguo","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsb.2011.11.022_b0005","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1101\/gad.914401","article-title":"Cell cycle checkpoint signaling through the ATM and ATR kinases","volume":"15","author":"Abraham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.jsb.2011.11.022_b0010","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1107\/S0907444905007894","article-title":"A robust bulk-solvent correction and anisotropic scaling procedure","volume":"61","author":"Afonine","year":"2005","journal-title":"Acta Crystallogr. Sect D: Biol. Crystallogr."},{"key":"10.1016\/j.jsb.2011.11.022_b0015","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"The Ccp4 suite \u2013 programs for protein crystallography","volume":"50","author":"Bailey","year":"1994","journal-title":"Acta Crystallogr. Sect. D: Biol. Crystallogr."},{"key":"10.1016\/j.jsb.2011.11.022_b0020","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.dnarep.2004.06.001","article-title":"The cellular response to general and programmed DNA double strand breaks","volume":"3","author":"Bassing","year":"2004","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.jsb.2011.11.022_b0025","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular dynamics with coupling to an external bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jsb.2011.11.022_b0030","doi-asserted-by":"crossref","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi","year":"2007","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jsb.2011.11.022_b0035","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.str.2009.12.008","article-title":"Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1","volume":"18","author":"Campbell","year":"2010","journal-title":"Structure"},{"key":"10.1016\/j.jsb.2011.11.022_b0040","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nsmb775","article-title":"Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer","volume":"11","author":"Clapperton","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jsb.2011.11.022_b0045","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1021\/bi2003795","article-title":"Impact of BRCA1 BRCT domain missense substitutions on phosphopeptide recognition","volume":"50","author":"Coquelle","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.jsb.2011.11.022_b0050","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. Sect. D: Biol. Crystallogr."},{"key":"10.1016\/j.jsb.2011.11.022_b0055","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1063\/1.470117","article-title":"A smooth particle mesh Ewald method","volume":"103","author":"Essmann","year":"1995","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jsb.2011.11.022_b0060","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.dnarep.2004.03.024","article-title":"H2AX: the histone guardian of the genome","volume":"3","author":"Fernandez-Capetillo","year":"2004","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.jsb.2011.11.022_b0065","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1021\/ct700200b","article-title":"P-LINCS: a parallel linear constraint solver for molecular simulation","volume":"4","author":"Hess","year":"2008","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.jsb.2011.11.022_b0070","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","article-title":"GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation","volume":"4","author":"Hess","year":"2008","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.jsb.2011.11.022_b0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/jmbi.1993.1489","article-title":"Protein structure comparison by alignment of distance matrices","volume":"233","author":"Holm","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jsb.2011.11.022_b0080","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.molcel.2009.12.040","article-title":"Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1\/MUM1","volume":"37","author":"Huen","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jsb.2011.11.022_b0085","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1086\/341283","article-title":"Identification of microcephalin, a protein implicated in determining the size of the human brain","volume":"71","author":"Jackson","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jsb.2011.11.022_b0090","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1101\/gad.959202","article-title":"Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brcal1 BRCT structure","volume":"16","author":"Joo","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.jsb.2011.11.022_b0095","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1101\/gad.472808","article-title":"Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair","volume":"22","author":"Kilkenny","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.jsb.2011.11.022_b0100","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/BF02708369","article-title":"Primary microcephaly: microcephalin and ASPM determine the size of the human brain","volume":"27","author":"Kumar","year":"2002","journal-title":"J. Biosci."},{"key":"10.1016\/j.jsb.2011.11.022_b0105","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"Procheck \u2013 a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jsb.2011.11.022_b0110","doi-asserted-by":"crossref","first-page":"32053","DOI":"10.1074\/jbc.C500273200","article-title":"Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail","volume":"280","author":"Lee","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2011.11.022_b0115","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1074\/jbc.M110.189555","article-title":"Molecular Basis of BACH1\/FANCJ recognition by TopBP1 in DNA replication checkpoint control","volume":"286","author":"Leung","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2011.11.022_b0120","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(03)00430-6","article-title":"Multiple tumor suppressor pathways negatively regulate telomerase","volume":"113","author":"Lin","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jsb.2011.11.022_b0130","doi-asserted-by":"crossref","first-page":"15105","DOI":"10.1073\/pnas.0507722102","article-title":"BRIT1\/MCPH1 is a DNA damage responsive protein that regulates the Brca1\u2013Chk1 pathway, implicating checkpoint dysfunction in microcephaly","volume":"102","author":"Lin","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jsb.2011.11.022_b0125","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3349\/ymj.2010.51.3.295","article-title":"Multiple roles of BRIT1\/MCPH1 in DNA damage response, DNA repair, and cancer suppression","volume":"51","author":"Lin","year":"2010","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.jsb.2011.11.022_b0135","article-title":"Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation","author":"Lok","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jsb.2011.11.022_b0140","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1021\/jp973084f","article-title":"All-atom empirical potential for molecular modeling and dynamics studies of proteins","volume":"102","author":"MacKerell","year":"1998","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jsb.2011.11.022_b0145","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1107\/S0907444905001617","article-title":"Likelihood-enhanced fast translation functions","volume":"61","author":"McCoy","year":"2005","journal-title":"Acta Crystallogr. Sect. D: Biol. Crystallogr."},{"key":"10.1016\/j.jsb.2011.11.022_b0150","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. Sect. D: Biol. Crystallogr."},{"key":"10.1016\/j.jsb.2011.11.022_b0155","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Macromol. Crystallogr. Pt A"},{"key":"10.1016\/j.jsb.2011.11.022_b0160","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature09658","article-title":"MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites","volume":"470","author":"Pei","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jsb.2011.11.022_b0165","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/ncb1895","article-title":"BRIT1\/MCPH1 links chromatin remodelling to DNA damage response","volume":"11","author":"Peng","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jsb.2011.11.022_b0170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ccr.2006.07.002","article-title":"BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer","volume":"10","author":"Rai","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jsb.2011.11.022_b0175","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1097-2765(04)00238-2","article-title":"Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling","volume":"14","author":"Shiozaki","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jsb.2011.11.022_b0180","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2005.09.038","article-title":"MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks","volume":"123","author":"Stucki","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jsb.2011.11.022_b0190","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1086\/422855","article-title":"Mutations in microcephalin cause aberrant regulation of chromosome condensation","volume":"75","author":"Trimborn","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jsb.2011.11.022_b0185","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/humu.9382","article-title":"The first missense alteration in the MCPH1 gene causes autosomal recessive microcephaly with an extremely mild cellular and clinical phenotype","volume":"26","author":"Trimborn","year":"2005","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jsb.2011.11.022_b0195","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1107\/S0021889897006766","article-title":"MOLREP: an automated program for molecular replacement","volume":"30","author":"Vagin","year":"1997","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.jsb.2011.11.022_b0200","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1103\/PhysRev.159.98","article-title":"Computer experiments on classical fluids: I. Thermodynamical properties of Lennard\u2013Jones molecules","volume":"159","author":"Verlet","year":"1967","journal-title":"Phys. Rev."},{"key":"10.1016\/j.jsb.2011.11.022_b0205","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/hmg\/ddn021","article-title":"A common SNP of MCPH1 is associated with cranial volume variation in Chinese population","volume":"17","author":"Wang","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jsb.2011.11.022_b0210","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1038\/emboj.2009.413","article-title":"Gamma H2A binds Brc1 to maintain genome integrity during S-phase","volume":"29","author":"Williams","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.jsb.2011.11.022_b0215","doi-asserted-by":"crossref","first-page":"35416","DOI":"10.1074\/jbc.M705245200","article-title":"MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage","volume":"282","author":"Wood","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2011.11.022_b0220","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1086\/429930","article-title":"Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings","volume":"76","author":"Woods","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jsb.2011.11.022_b0225","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1158\/0008-5472.CAN-08-4834","article-title":"Microcephalin regulates BRCA2 and Rad51-associated DNA double-strand break repair","volume":"69","author":"Wu","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsb.2011.11.022_b0230","doi-asserted-by":"crossref","first-page":"34091","DOI":"10.1074\/jbc.C400139200","article-title":"Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1","volume":"279","author":"Xu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2011.11.022_b0235","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/embor.2008.128","article-title":"MCPH1\/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis","volume":"9","author":"Yang","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jsb.2011.11.022_b0240","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1016\/j.febslet.2010.05.021","article-title":"Focus on histone variant H2AX: to be or not to be","volume":"584","author":"Yuan","year":"2010","journal-title":"FEBS Lett."}],"container-title":["Journal of Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847711003388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847711003388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T01:21:26Z","timestamp":1588814486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047847711003388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S1047847711003388"],"URL":"https:\/\/doi.org\/10.1016\/j.jsb.2011.11.022","relation":{},"ISSN":["1047-8477"],"issn-type":[{"value":"1047-8477","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}