{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:22:20Z","timestamp":1782944540261,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Structural Biology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.jsb.2016.01.014","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T16:49:49Z","timestamp":1454086189000},"page":"68-77","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5"],"prefix":"10.1016","volume":"194","author":[{"given":"Klaus","family":"Brandenburg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Heinbockel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmar","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fukuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gutsmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Z\u00e4hringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel H.J.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jsb.2016.01.014_b0005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/mcbr.1999.0149","article-title":"Direct visualization of gram-negative bacterial lipopolysaccharide self-assembly","volume":"2","author":"Aurell","year":"1999","journal-title":"Mol. Cell Biol. Res. Commun."},{"issue":"1","key":"10.1016\/j.jsb.2016.01.014_b0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.colsurfb.2006.06.007","article-title":"Aggregation behavior and size of lipopolysaccharide from Escherichia coli O55:B5","volume":"53","author":"Bergstrand","year":"2006","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.jsb.2016.01.014_b0015","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0168-9002(86)90694-7","article-title":"Data appraisal, evaluation and display for synchrotron radiation experiments: Hardware and software","volume":"A249","author":"Boulin","year":"1986","journal-title":"Nucl. Instrum. Methods"},{"key":"10.1016\/j.jsb.2016.01.014_b0020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1432-1033.1983.tb07249.x","article-title":"Differential determination of the 3-deoxy-D-mannooctulosonic acid in lipopolysaccharides of Salmonella minnesota rough mutants","volume":"131","author":"Brade","year":"1983","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jsb.2016.01.014_b0025","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1432-1033.1990.tb19114.x","article-title":"Investigation into the fluidity of lipopolysaccharide and free lipid A membrane systems by Fourier-transform infrared spectroscopy and differential scanning calorimetry","volume":"191","author":"Brandenburg","year":"1990","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jsb.2016.01.014_b0030","series-title":"Infrared Spectroscopy of Biomolecules","first-page":"203","article-title":"Fourier transform infrared spectroscopy of cell surface polysaccharides","author":"Brandenburg","year":"1996"},{"key":"10.1016\/j.jsb.2016.01.014_b0035","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0009-3084(98)00078-4","article-title":"Infrared spectroscopy of glycolipids","volume":"96","author":"Brandenburg","year":"1998","journal-title":"Chem. Phys. Lipids"},{"issue":"11","key":"10.1016\/j.jsb.2016.01.014_b0040","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2174\/1568026043388213","article-title":"Endotoxins: relationships between structure, function, and activity","volume":"4","author":"Brandenburg","year":"2004","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jsb.2016.01.014_b0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/1047-8477(90)90093-R","article-title":"Phase diagram of lipid A from Salmonella minnesota and Escherichia coli rough mutant lipopolysaccharide","volume":"105","author":"Brandenburg","year":"1990","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jsb.2016.01.014_b0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/1047-8477(92)90010-8","article-title":"Phase diagramm of deep rough mutant lipopolysaccharide from Salmonella minnesota R595","volume":"108","author":"Brandenburg","year":"1992","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jsb.2016.01.014_b0055","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1432-1033.1993.tb18409.x","article-title":"Influence of the supramolecular structure of free lipid A on its biological activity","volume":"218","author":"Brandenburg","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jsb.2016.01.014_b0060","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0009-3084(97)00093-5","article-title":"Characterization of the nonlamellar cubic and H II structures of lipid A from Salmonella enterica serovar Minnesota by X-ray diffraction and freeze-fracture electron microscopy","volume":"91","author":"Brandenburg","year":"1998","journal-title":"Chem. Phys. Lipids"},{"issue":"23","key":"10.1016\/j.jsb.2016.01.014_b0065","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.carres.2003.08.008","article-title":"Physicochemical properties of bacterial glycopolymers in relation to bioactivity","volume":"338","author":"Brandenburg","year":"2003","journal-title":"Carbohydre Res."},{"key":"10.1016\/j.jsb.2016.01.014_b0070","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1063\/1.1134870","article-title":"Position-sensitive X-ray detector","volume":"48","author":"Gabriel","year":"1977","journal-title":"Rev. Sci. Instrum."},{"key":"10.1016\/j.jsb.2016.01.014_b0075","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1432-1033.1969.tb00601.x","article-title":"A new method for the extraction of R lipopolysaccharides","volume":"9","author":"Galanos","year":"1969","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jsb.2016.01.014_b0080","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0021-9673(00)94543-6","article-title":"Large-scale fractionation of S-form lipopolysaccharide from Salmonella abortus equi. Chemical and serological characterization of the fractions","volume":"440","author":"Galanos","year":"1988","journal-title":"J. Chromatogr."},{"issue":"9","key":"10.1016\/j.jsb.2016.01.014_b0085","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1128\/AAC.00534-10","article-title":"New antiseptic peptides to protect against endotoxin-mediated shock","volume":"54","author":"Gutsmann","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"issue":"3","key":"10.1016\/j.jsb.2016.01.014_b0090","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1128\/AAC.02066-12","article-title":"Preclinical investigations reveal the broad-spectrum neutralizing activity of peptide Pep19-2.5 on bacterial pathogenicity factors","volume":"57","author":"Heinbockel","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jsb.2016.01.014_b0095","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1432-1033.1989.tb14676.x","article-title":"Characterization of the lipid A component of genuine smooth-form lipopolysaccharide","volume":"180","author":"Jiao","year":"1989","journal-title":"Eur. J. Biochem."},{"issue":"11","key":"10.1016\/j.jsb.2016.01.014_b0100","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.bpj.2011.04.041","article-title":"Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides","volume":"100","author":"Kaconis","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.jsb.2016.01.014_b0105","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0167-5087(83)91169-9","article-title":"X-ray diffraction and scattering on disordered systems using synchrotron radiation","volume":"208","author":"Koch","year":"1983","journal-title":"Nucl. Instrum. Methods"},{"issue":"5259","key":"10.1016\/j.jsb.2016.01.014_b0110","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.jsb.2016.01.014_b0115","series-title":"Lipids and Membranes: Past, Present, and Future","article-title":"Lipid polymorphism revisited: Structural aspects and biological implications","author":"Luzzati","year":"1986"},{"issue":"9","key":"10.1016\/j.jsb.2016.01.014_b0120","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.2174\/138945012802002410","article-title":"Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines","volume":"13","author":"Martinez de Tejada","year":"2012","journal-title":"Curr. Drug Targets"},{"issue":"25","key":"10.1016\/j.jsb.2016.01.014_b0125","doi-asserted-by":"crossref","first-page":"26307","DOI":"10.1074\/jbc.M401231200","article-title":"Aggregates are the biologically active units of endotoxin","volume":"279","author":"Mueller","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jsb.2016.01.014_b0130","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/MMBR.67.4.593-656.2003","article-title":"Molecular basis of bacterial outer membrane permeability revisited","volume":"67","author":"Nikaido","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev."},{"issue":"5","key":"10.1016\/j.jsb.2016.01.014_b0135","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/1753425910372434","article-title":"Morphology, size distribution, and aggregate structure of lipopolysaccharide and lipid A dispersions from enterobacterial origin","volume":"17","author":"Richter","year":"2011","journal-title":"Innate Immun"},{"key":"10.1016\/j.jsb.2016.01.014_b0140","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/scientificamerican0892-54","article-title":"Bacterial endotoxins","volume":"267","author":"Rietschel","year":"1992","journal-title":"Sci. Am."},{"key":"10.1016\/j.jsb.2016.01.014_b0145","series-title":"Bacterial Endotoxic Lipopolysaccharides","first-page":"3","article-title":"Biochemistry of lipopolysaccharides","volume":"1","author":"Rietschel","year":"1992"},{"issue":"1","key":"10.1016\/j.jsb.2016.01.014_b0150","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/cbic.200390020","article-title":"Evaluation of lipopolysaccharide aggregation by light scattering spectroscopy","volume":"4","author":"Santos","year":"2003","journal-title":"Chem. Bio. Chem."},{"key":"10.1016\/j.jsb.2016.01.014_b0155","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1006\/jsbi.1993.1026","article-title":"Structural polymorphisms of rough mutant lipopolysaccharides Rd to Ra from Salmonella minnesota","volume":"110","author":"Seydel","year":"1993","journal-title":"J. Struct. Biol."},{"issue":"4328","key":"10.1016\/j.jsb.2016.01.014_b0160","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/170626a0","article-title":"Determination of yeast carbohydrates with the anthrone reagent","volume":"170","author":"Trevelyan","year":"1952","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jsb.2016.01.014_b0165","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0003-2697(82)90673-X","article-title":"A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels","volume":"119","author":"Tsai","year":"1982","journal-title":"Anal. Biochem."},{"issue":"6","key":"10.1016\/j.jsb.2016.01.014_b0170","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.4049\/jimmunol.130.6.2804","article-title":"Conversion of lipopolysaccharides to molecular aggregates with reduced subunit heterogeneity: demonstration of LPS-responsiveness in \u201cendotoxin-unresponsive\u201d C3H\/HeJ splenocytes","volume":"130","author":"Vukajlovich","year":"1983","journal-title":"J. Immunol."},{"key":"10.1016\/j.jsb.2016.01.014_b0175","first-page":"83","article-title":"Bacterial lipopolysaccharides. Extraction with phenol:water and further application of the procedure","volume":"5","author":"Westphal","year":"1965","journal-title":"Methods Carbohydr. Chem."}],"container-title":["Journal of Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847716300132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847716300132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T17:39:09Z","timestamp":1692207549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047847716300132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1047847716300132"],"URL":"https:\/\/doi.org\/10.1016\/j.jsb.2016.01.014","relation":{},"ISSN":["1047-8477"],"issn-type":[{"value":"1047-8477","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Supramolecular structure of enterobacterial wild-type lipopolysaccharides (LPS), fractions thereof, and their neutralization by Pep19-2.5","name":"articletitle","label":"Article Title"},{"value":"Journal of Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsb.2016.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}