{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:16:16Z","timestamp":1778627776776,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council of Australia","doi-asserted-by":"publisher","award":["434220"],"award-info":[{"award-number":["434220"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000152","name":"National Science Foundation MCB","doi-asserted-by":"publisher","award":["0346650"],"award-info":[{"award-number":["0346650"]}],"id":[{"id":"10.13039\/100000152","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association \u2013 United States","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Doctoral Fellowship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Structural Biology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.jsb.2017.08.007","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T23:32:03Z","timestamp":1504222323000},"page":"376-387","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The concerted movement of the switch region of Troponin I in cardiac muscle thin filaments as tracked by conventional and pulsed (DEER) EPR"],"prefix":"10.1016","volume":"200","author":[{"given":"Phani R.","family":"Potluri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Chamoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Badr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna A.","family":"Guse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roni","family":"Rayes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Cordina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dane","family":"McCamey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr G.","family":"Fajer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsb.2017.08.007_b0005","doi-asserted-by":"crossref","first-page":"10671","DOI":"10.1074\/jbc.M109.082925","article-title":"Switch action of troponin on muscle thin filament as revealed by spin labeling and pulsed EPR","volume":"285","author":"Aihara","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2017.08.007_b0010","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/oxfordjournals.jbchem.a134910","article-title":"The environment of the high-affinity cation binding site on actin and the separation between cation and ATP sites as revealed by proton NMR and fluorescence spectroscopy","volume":"96","author":"Barden","year":"1984","journal-title":"J. Biochem."},{"key":"10.1016\/j.jsb.2017.08.007_b0015","doi-asserted-by":"crossref","first-page":"21924","DOI":"10.1074\/jbc.M500574200","article-title":"Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex","volume":"280","author":"Blumenschein","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2017.08.007_b0020","doi-asserted-by":"crossref","first-page":"12765","DOI":"10.1073\/pnas.202477399","article-title":"Structure of the inhibitory region of troponin by site directed spin labeling electron paramagnetic resonance","volume":"99","author":"Brown","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jsb.2017.08.007_b0025","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/pro.2124","article-title":"Interdomain orientation of cardiac troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state","volume":"21","author":"Cordina","year":"2012","journal-title":"Protein Sci."},{"key":"10.1016\/j.jsb.2017.08.007_b0030","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1021\/bi4000172","article-title":"Effects of calcium binding and the hypertrophic cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac troponin C","volume":"52","author":"Cordina","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.jsb.2017.08.007_b0035","doi-asserted-by":"crossref","first-page":"e112976","DOI":"10.1371\/journal.pone.0112976","article-title":"Ca2+-induced PRE-NMR changes in the troponin complex reveal the possessive nature of the cardiac isoform for its regulatory switch","volume":"9","author":"Cordina","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jsb.2017.08.007_b0040","doi-asserted-by":"crossref","first-page":"42394","DOI":"10.1074\/jbc.M304858200","article-title":"Kinetics of conformational transitions in cardiac troponin induced by Ca2+ dissociation determined by Forster resonance energy transfer","volume":"278","author":"Dong","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2017.08.007_b0045","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.1021\/bi962226d","article-title":"Conformation of the N-terminal segment of a monocysteine mutant of troponin I from cardiac muscle","volume":"36","author":"Dong","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.jsb.2017.08.007_b0050","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/S0006-3495(97)78719-8","article-title":"Disparate fluorescence properties of 2-[40-(iodoacetamido)anilino]-naphthalene-6-sulfonic acid attached to Cys-84 and Cys-35 of troponin C in cardiac muscle troponin","volume":"72","author":"Dong","year":"1997","journal-title":"Biophys. J."},{"key":"10.1016\/j.jsb.2017.08.007_b0055","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0167-4838(96)00028-3","article-title":"Calcium-induced conformational change in cardiac troponin C studied by fluorescence probes attached to Cys-84","volume":"1295","author":"Dong","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsb.2017.08.007_b0060","doi-asserted-by":"crossref","first-page":"31382","DOI":"10.1074\/jbc.274.44.31382","article-title":"Conformation of the regulatory domain of cardiac muscle troponin C in its complex with cardiac troponin I","volume":"274","author":"Dong","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2017.08.007_b0065","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1074\/jbc.M212886200","article-title":"Ca2+-induced conformational transition in the inhibitory and regulatory regions of cardiac troponin I","volume":"278","author":"Dong","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2017.08.007_b0070","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/oxfordjournals.jbchem.a129961","article-title":"Separation of troponin into its three components","volume":"72","author":"Ebashi","year":"1972","journal-title":"J. Biochem."},{"key":"10.1016\/j.jsb.2017.08.007_b0075","series-title":"ESR Spectroscopy in Membrane Biophysics","first-page":"95","article-title":"Practical Pulsed Dipolar ESR (DEER)","author":"Fajer","year":"2007"},{"key":"10.1016\/j.jsb.2017.08.007_b0080","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1096\/fasebj.9.9.7601340","article-title":"The troponin complex and regulation of muscle contraction","volume":"9","author":"Farah","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.jsb.2017.08.007_b0085","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1152\/physrev.2000.80.2.853","article-title":"Regulation of contraction in striated muscle","volume":"80","author":"Gordon","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jsb.2017.08.007_b0090","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/prep.1996.0041","article-title":"Specific replacement of consecutive AGG codons results in high-level expression of human cardiac troponin T in Escherichia coli","volume":"7","author":"Hu","year":"1996","journal-title":"Protein Exp. Purif."},{"key":"10.1016\/j.jsb.2017.08.007_b0095","doi-asserted-by":"crossref","first-page":"e87135","DOI":"10.1371\/journal.pone.0087135","article-title":"Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints","volume":"9","author":"Jayasundar","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jsb.2017.08.007_b0100","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev-physchem-032511-143716","article-title":"DEER distance measurements on proteins","volume":"63","author":"Jeschke","year":"2012","journal-title":"Annu. Rev. Phys. Chem."},{"key":"10.1016\/j.jsb.2017.08.007_b0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.physiol.67.040403.114025","article-title":"Calcium, thin filaments, and the integrative biology of cardiac contractility","volume":"67","author":"Kobayashi","year":"2005","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jsb.2017.08.007_b0110","doi-asserted-by":"crossref","first-page":"8289","DOI":"10.1021\/bi9901679","article-title":"Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C","volume":"38","author":"Li","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.jsb.2017.08.007_b0115","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10974-004-5879-2","article-title":"Structural based insights into the role of troponin in cardiac muscle pathophysiology","volume":"25","author":"Li","year":"2004","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.1016\/j.jsb.2017.08.007_b0120","doi-asserted-by":"crossref","first-page":"11913","DOI":"10.1021\/bi000977g","article-title":"Actomyosin regulatory properties of yeast tropomyosin are dependent upon N-terminal modification","volume":"39","author":"Maytum","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.jsb.2017.08.007_b0125","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1006\/jmre.2002.2529","article-title":"Structural determination of spin label immobilization and orientation: a Monte Carlo minimization approach","volume":"156","author":"Sale","year":"2002","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.jsb.2017.08.007_b0130","doi-asserted-by":"crossref","first-page":"9334","DOI":"10.1021\/ja051652w","article-title":"Explicit treatment of spin labels in modeling of distance constraints from dipolar EPR and DEER","volume":"127","author":"Sale","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jsb.2017.08.007_b0135","doi-asserted-by":"crossref","first-page":"11639","DOI":"10.1021\/bi700859p","article-title":"Protein dynamics and monomer-monomer interactions in AntR activation by electron paramagnetic resonance and double electron-electron resonance","volume":"46","author":"Sen","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.jsb.2017.08.007_b0140","doi-asserted-by":"crossref","first-page":"15953","DOI":"10.1021\/bi00049a010","article-title":"NMR solution structure of calcium-saturated skeletal muscle troponin C","volume":"34","author":"Slupsky","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.jsb.2017.08.007_b0145","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1016\/S0021-9258(18)62016-2","article-title":"The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin","volume":"246","author":"Spudich","year":"1971","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2017.08.007_b0150","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nature01780","article-title":"Structure of the core domain of human cardiac troponin in the Ca2+-saturated form","volume":"424","author":"Takeda","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jsb.2017.08.007_b0155","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1073\/pnas.0408882102","article-title":"Ca2+ -regulated structural changes in troponin","volume":"102","author":"Vinogradova","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Journal of Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847717301387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847717301387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T03:16:31Z","timestamp":1760930191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047847717301387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S1047847717301387"],"URL":"https:\/\/doi.org\/10.1016\/j.jsb.2017.08.007","relation":{},"ISSN":["1047-8477"],"issn-type":[{"value":"1047-8477","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The concerted movement of the switch region of Troponin I in cardiac muscle thin filaments as tracked by conventional and pulsed (DEER) EPR","name":"articletitle","label":"Article Title"},{"value":"Journal of Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsb.2017.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}