{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:34:52Z","timestamp":1773923692341,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Structural Biology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jsb.2017.12.010","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T07:59:04Z","timestamp":1514275144000},"page":"113-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["High resolution crystal structures of Clostridium botulinum neurotoxin A3 and A4 binding domains"],"prefix":"10.1016","volume":"202","author":[{"given":"Jonathan R.","family":"Davies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai Man","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Ravi","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsb.2017.12.010_b0005","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature12732","article-title":"Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A","volume":"505","author":"Benoit","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jsb.2017.12.010_b0010","doi-asserted-by":"crossref","first-page":"43588","DOI":"10.1038\/srep43588","article-title":"Crystal structure of the BoNT\/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C","volume":"7","author":"Benoit","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jsb.2017.12.010_b0015","first-page":"12","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"D66","author":"Chen","year":"2010","journal-title":"Acta Cryst."},{"key":"10.1016\/j.jsb.2017.12.010_b0020","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S0022-3565(24)36519-X","article-title":"In vitro characterization of botulinum toxin types A, C and D action on human tissues: combined electrophysiologic, pharmacologic and molecular biologic approaches","volume":"280","author":"Coffield","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jsb.2017.12.010_b0025","first-page":"486","article-title":"Features and development of Coot","volume":"D66","author":"Emsley","year":"2010","journal-title":"Acta Cryst."},{"key":"10.1016\/j.jsb.2017.12.010_b0030","first-page":"1204","article-title":"How good are my data and what is the resolution?","volume":"D69","author":"Evans","year":"2013","journal-title":"Acta Cryst."},{"key":"10.1016\/j.jsb.2017.12.010_b0035","first-page":"831","article-title":"The MORPHEUS II protein crystallization screen","volume":"F71","author":"Gorrec","year":"2015","journal-title":"Acta Cryst."},{"key":"10.1016\/j.jsb.2017.12.010_b0040","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1021\/bi801686b","article-title":"Catalytic properties of botulinum neurotoxin subtypes A3 and A4","volume":"48","author":"Henkel","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.jsb.2017.12.010_b0045","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0072-9752(07)01511-4","volume":"91","author":"Johnson","year":"2008","journal-title":"Botulism Handb. Clin. Neurol."},{"key":"10.1016\/j.jsb.2017.12.010_b0050","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1042\/BCJ20160439","article-title":"Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1","volume":"473","author":"Mahrhold","year":"2016","journal-title":"Biochem. J."},{"key":"10.1016\/j.jsb.2017.12.010_b0055","doi-asserted-by":"crossref","first-page":"e12416","DOI":"10.1371\/journal.pone.0012416","article-title":"Characterization of botulinum neurotoxin type A neutralizing monoclonal antibodies and influence of their half-lives on therapeutic activity","volume":"5","author":"Mazuet","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jsb.2017.12.010_b0060","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.jsb.2017.12.010_b0065","first-page":"386","article-title":"Presenting your structures: the CCP4mg molecular-graphics software","volume":"D67","author":"McNicholas","year":"2011","journal-title":"Acta Cryst."},{"key":"10.1016\/j.jsb.2017.12.010_b0070","first-page":"240","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"D53","author":"Murshudov","year":"1997","journal-title":"Acta Cryst."},{"key":"10.1016\/j.jsb.2017.12.010_b0075","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrmicro3295","article-title":"Botulinum neurotoxins: genetic, structural and mechanistic insights","volume":"12","author":"Rossetto","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jsb.2017.12.010_b0080","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/07391102.2001.10506725","article-title":"Non-hydrogen bond interactions involving the methionine sulfur atom","volume":"19","author":"Pal","year":"2001","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.jsb.2017.12.010_b0085","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1152\/physrev.2000.80.2.717","article-title":"Neurotoxins affecting neuroexocytosis","volume":"80","author":"Schiavo","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jsb.2017.12.010_b0090","doi-asserted-by":"crossref","first-page":"e1000129","DOI":"10.1371\/journal.ppat.1000129","article-title":"Crystal structure of botulinum neurotoxin type A in complex with the cell surface co-receptor GT1b\u2014insight into the toxin\u2013neuron interaction","volume":"4","author":"Stenmark","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jsb.2017.12.010_b0095","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1128\/AEM.07967-11","article-title":"Purification and characterization of a novel subtype A3 botulinum neurotoxin","volume":"78","author":"Tepp","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jsb.2017.12.010_b0100","first-page":"558","article-title":"Diffraction-geometry refinement in the DIALS framework","volume":"D72","author":"Waterman","year":"2016","journal-title":"Acta Cryst."},{"key":"10.1016\/j.jsb.2017.12.010_b0105","doi-asserted-by":"crossref","first-page":"e90252","DOI":"10.1371\/journal.pone.0090252","article-title":"Persistence of botulinum neurotoxin A subtypes 1\u20135 in primary rat spinal cord cells","volume":"9","author":"Whitemarsh","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jsb.2017.12.010_b0110","first-page":"235","article-title":"Overview of the CCP4 suite and current developments","volume":"D67","author":"Winn","year":"2011","journal-title":"Acta Cryst."},{"key":"10.1016\/j.jsb.2017.12.010_b0115","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nsmb.3245","article-title":"N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A","volume":"23","author":"Yao","year":"2016","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Journal of Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847717302332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847717302332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T06:46:08Z","timestamp":1751179568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047847717302332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S1047847717302332"],"URL":"https:\/\/doi.org\/10.1016\/j.jsb.2017.12.010","relation":{},"ISSN":["1047-8477"],"issn-type":[{"value":"1047-8477","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High resolution crystal structures of Clostridium botulinum neurotoxin A3 and A4 binding domains","name":"articletitle","label":"Article Title"},{"value":"Journal of Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsb.2017.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}