{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:10:42Z","timestamp":1788999042790,"version":"build-2803163510"},"reference-count":108,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007698","name":"University of Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["S10 OD018142-01"],"award-info":[{"award-number":["S10 OD018142-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/S009302\/1"],"award-info":[{"award-number":["MR\/S009302\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015538","name":"Quillen College of Medicine, East Tennessee State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015538","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006597","name":"Florida State University","doi-asserted-by":"publisher","award":["U24 GM116788"],"award-info":[{"award-number":["U24 GM116788"]}],"id":[{"id":"10.13039\/100006597","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008276","name":"College of Medicine, University of Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Structural Biology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jsb.2021.107795","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T23:31:18Z","timestamp":1631230278000},"page":"107795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2"],"prefix":"10.1016","volume":"213","author":[{"given":"Antonette","family":"Bennett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Jolinon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Tordo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enswert","family":"Binns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mietzsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathleen","family":"Hagemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Michael","family":"Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chipman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Broecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Seeberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Henckaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mavis","family":"Agbandje-McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jsb.2021.107795_b0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"5","key":"10.1016\/j.jsb.2021.107795_b0010","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1128\/jvi.70.5.3235-3241.1996","article-title":"In vivo model of adeno-associated virus vector persistence and rescue","volume":"70","author":"Afione","year":"1996","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.jsb.2021.107795_b0015","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1107\/S0907444913000462","article-title":"Bulk-solvent and overall scaling revisited: faster calculations, improved results","volume":"69","author":"Afonine","year":"2013","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"1","key":"10.1016\/j.jsb.2021.107795_b0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nbt.1599","article-title":"Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle","volume":"28","author":"Asokan","year":"2010","journal-title":"Nat. Biotechnol."},{"issue":"3685","key":"10.1016\/j.jsb.2021.107795_b0025","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1126\/science.149.3685.754","article-title":"Adenovirus-associated defective virus particles","volume":"149","author":"Atchison","year":"1965","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jsb.2021.107795_b0030","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0042-6822(84)90271-X","article-title":"Characterization of the DNA of a defective human parvovirus isolated from a genital site","volume":"134","author":"Bantel-Schaal","year":"1984","journal-title":"Virology"},{"issue":"6","key":"10.1016\/j.jsb.2021.107795_b0035","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/gt.2012.20","article-title":"Directed evolution of novel adeno-associated viruses for therapeutic gene delivery","volume":"19","author":"Bartel","year":"2012","journal-title":"Gene Ther."},{"issue":"6","key":"10.1016\/j.jsb.2021.107795_b0040","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1128\/JVI.74.6.2777-2785.2000","article-title":"Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors","volume":"74","author":"Bartlett","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0045","doi-asserted-by":"crossref","unstructured":"Batty, P., Lillicrap, D., 2019. Advances and Challenges for Hemophilia Gene Therapy. Hum Mol Genet.","DOI":"10.1093\/hmg\/ddz157"},{"issue":"13","key":"10.1016\/j.jsb.2021.107795_b0050","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1128\/JVI.00448-12","article-title":"Identification of the galactose binding domain of the adeno-associated virus serotype 9 capsid","volume":"86","author":"Bell","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0055","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.omtm.2017.07.003","article-title":"Thermal stability as a determinant of AAV serotype identity","volume":"6","author":"Bennett","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"issue":"2","key":"10.1016\/j.jsb.2021.107795_b0060","doi-asserted-by":"crossref","first-page":"107433","DOI":"10.1016\/j.jsb.2019.107433","article-title":"Structure comparison of the chimeric AAV2.7m8 vector with parental AAV2","volume":"209","author":"Bennett","year":"2020","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jsb.2021.107795_b0065","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/oxfordjournals.aje.a120897","article-title":"Epidemiology of adenovirus-associated virus infection in a nursery population","volume":"88","author":"Blacklow","year":"1968","journal-title":"Am. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.jsb.2021.107795_b0070","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1128\/JVI.79.4.2528-2540.2005","article-title":"Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity","volume":"79","author":"Bleker","year":"2005","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.jsb.2021.107795_b0075","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1128\/JVI.00200-16","article-title":"Impact of heparan sulfate binding on transduction of retina by recombinant adeno-associated virus vectors","volume":"90","author":"Boye","year":"2016","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.jsb.2021.107795_b0080","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/humc.2013.087","article-title":"Lessons learned from the clinical development and market authorization of Glybera","volume":"24","author":"Bryant","year":"2013","journal-title":"Hum. Gene Ther. Clin. Dev."},{"issue":"1","key":"10.1016\/j.jsb.2021.107795_b0085","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1128\/jvi.25.1.331-338.1978","article-title":"Characterization of adenovirus-associated virus-induced polypeptides in KB cells","volume":"25","author":"Buller","year":"1978","journal-title":"J. Virol."},{"issue":"560","key":"10.1016\/j.jsb.2021.107795_b0095","doi-asserted-by":"crossref","first-page":"eaba3312","DOI":"10.1126\/scitranslmed.aba3312","article-title":"Restoring the natural tropism of AAV2 vectors for human liver","volume":"12","author":"Cabanes-Creus","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"Database","key":"10.1016\/j.jsb.2021.107795_b0100","doi-asserted-by":"crossref","first-page":"D436","DOI":"10.1093\/nar\/gkn840","article-title":"VIPERdb2: an enhanced and web API enabled relational database for structural virology","volume":"37","author":"Carrillo-Tripp","year":"2009","journal-title":"Nucl. Acids Res."},{"issue":"6","key":"10.1016\/j.jsb.2021.107795_b0105","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ymthe.2004.09.011","article-title":"Adeno-associated virus and the development of adeno-associated virus vectors: a historical perspective","volume":"10","author":"Carter","year":"2004","journal-title":"Mol. Ther."},{"issue":"23","key":"10.1016\/j.jsb.2021.107795_b0110","doi-asserted-by":"crossref","first-page":"14781","DOI":"10.1128\/JVI.79.23.14781-14792.2005","article-title":"Molecular characterization of adeno-associated viruses infecting children","volume":"79","author":"Chen","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0115","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1099\/jgv.0.001212","article-title":"ICTV virus taxonomy profile: parvoviridae","volume":"100","author":"Cotmore","year":"2019","journal-title":"J. Gen. Virol."},{"issue":"4","key":"10.1016\/j.jsb.2021.107795_b0120","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1128\/CMR.00008-08","article-title":"Gene therapy using adeno-associated virus vectors","volume":"21","author":"Daya","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"issue":"11","key":"10.1016\/j.jsb.2021.107795_b0125","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1021\/cb700159m","article-title":"Profiling heparin-chemokine interactions using synthetic tools","volume":"2","author":"de Paz","year":"2007","journal-title":"ACS Chem. Biol."},{"issue":"1","key":"10.1016\/j.jsb.2021.107795_b0130","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0959-440X(02)00283-X","article-title":"Unraveling hot spots in binding interfaces: progress and challenges","volume":"12","author":"DeLano","year":"2002","journal-title":"Curr. Opin. Struct. Biol."},{"issue":"10","key":"10.1016\/j.jsb.2021.107795_b0135","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1107\/S1744309105028514","article-title":"Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5","volume":"61","author":"DiMattia","year":"2005","journal-title":"Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun."},{"issue":"4","key":"10.1016\/j.jsb.2021.107795_b0140","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1128\/JVI.75.4.1824-1833.2001","article-title":"Intracellular trafficking of adeno-associated virus vectors: routing to the late endosomal compartment and proteasome degradation","volume":"75","author":"Douar","year":"2001","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.jsb.2021.107795_b0145","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"12","key":"10.1016\/j.jsb.2021.107795_b0150","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.1128\/JVI.78.12.6381-6388.2004","article-title":"Clades of Adeno-associated viruses are widely disseminated in human tissues","volume":"78","author":"Gao","year":"2004","journal-title":"J. Virol."},{"issue":"18","key":"10.1016\/j.jsb.2021.107795_b0155","doi-asserted-by":"crossref","first-page":"11854","DOI":"10.1073\/pnas.182412299","article-title":"Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy","volume":"99","author":"Gao","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.jsb.2021.107795_b0160","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1073\/pnas.1800853116","article-title":"Microbe-focused glycan array screening platform","volume":"116","author":"Geissner","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.jsb.2021.107795_b0165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0042-6822(84)90272-1","article-title":"Analysis of proteins, helper dependence, and seroepidemiology of a new human parvovirus","volume":"134","author":"Georg-Fries","year":"1984","journal-title":"Virology"},{"issue":"23","key":"10.1016\/j.jsb.2021.107795_b0170","doi-asserted-by":"crossref","first-page":"11556","DOI":"10.1128\/JVI.01536-06","article-title":"Structurally mapping the diverse phenotype of adeno-associated virus serotype 4","volume":"80","author":"Govindasamy","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0175","doi-asserted-by":"crossref","unstructured":"Grant, T., Rohou, A., Grigorieff, N., 2018. cisTEM, user-friendly software for single-particle image processing. Elife 7.","DOI":"10.7554\/eLife.35383"},{"issue":"15","key":"10.1016\/j.jsb.2021.107795_b0180","doi-asserted-by":"crossref","first-page":"7739","DOI":"10.1128\/JVI.00218-12","article-title":"Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8","volume":"86","author":"Gurda","year":"2012","journal-title":"J. Virol."},{"issue":"16","key":"10.1016\/j.jsb.2021.107795_b0185","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.1128\/JVI.00622-13","article-title":"Capsid antibodies to different adeno-associated virus serotypes bind common regions","volume":"87","author":"Gurda","year":"2013","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.jsb.2021.107795_b0190","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.chempr.2016.12.004","article-title":"Automated glycan assembly of oligo-N-acetyllactosamine and keratan sulfate probes to study virus-glycan interactions","volume":"2","author":"Hahm","year":"2017","journal-title":"Chem"},{"issue":"1","key":"10.1016\/j.jsb.2021.107795_b0195","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jsb.2015.08.017","article-title":"Structure of neurotropic adeno-associated virus AAVrh. 8","volume":"192","author":"Halder","year":"2015","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jsb.2021.107795_b0200","first-page":"561","article-title":"Recombinant adeno-associated virus vectors","volume":"1","author":"Hallek","year":"1998","journal-title":"IDrugs"},{"key":"10.1016\/j.jsb.2021.107795_b0205","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1042\/BCJ20180283","article-title":"Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate","volume":"475","author":"Hayes","year":"2018","journal-title":"Biochem. J."},{"key":"10.1016\/j.jsb.2021.107795_b0210","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1073\/pnas.55.6.1467","article-title":"Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics","volume":"55","author":"Hoggan","year":"1966","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsb.2021.107795_b0215","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1038\/s41467-020-17047-1","article-title":"Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties","volume":"11","author":"Hsu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jsb.2021.107795_b0220","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.coviro.2014.05.007","article-title":"Parvovirus glycan interactions","volume":"7","author":"Huang","year":"2014","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0225","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1128\/JVI.00161-16","article-title":"Characterization of the adeno-associated virus 1 and 6 sialic acid binding site","volume":"90","author":"Huang","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0230","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1128\/JVI.00512-08","article-title":"Visualization of the externalized VP2 N termini of infectious human parvovirus B19","volume":"82","author":"Kaufmann","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0235","doi-asserted-by":"crossref","first-page":"11072","DOI":"10.1128\/JVI.77.20.11072-11081.2003","article-title":"Identification of a heparin-binding motif on adeno-associated virus type 2 capsids","volume":"77","author":"Kern","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0240","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1107\/S0907444995014983","article-title":"xdlMAPMAN and xdlDATAMAN \u2013 programs for reformatting, analysis and manipulation of biomacromolecular electron-density maps and reflection data sets","volume":"52","author":"Kleywegt","year":"1996","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jsb.2021.107795_b0245","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/978-1-4939-6588-5_6","article-title":"Production and characterization of vectors based on the cardiotropic AAV serotype 9","volume":"1521","author":"Kohlbrenner","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jsb.2021.107795_b0250","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1089\/hgtb.2012.049","article-title":"Quantification of AAV particle titers by infrared fluorescence scanning of coomassie-stained sodium dodecyl sulfate-polyacrylamide gels","volume":"23","author":"Kohlbrenner","year":"2012","journal-title":"Hum. Gene Ther. Methods"},{"key":"10.1016\/j.jsb.2021.107795_b0255","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.ymthe.2005.08.018","article-title":"Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system","volume":"12","author":"Kohlbrenner","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0260","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1089\/hum.2017.042","article-title":"Manufacturing clinical grade recombinant adeno-associated virus using invertebrate cell lines","volume":"28","author":"Kotin","year":"2017","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0265","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrg3742","article-title":"Engineering adeno-associated viruses for clinical gene therapy","volume":"15","author":"Kotterman","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jsb.2021.107795_b0270","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/bs.ircmb.2016.02.009","article-title":"Heparan sulfate: biosynthesis, structure, and function","volume":"325","author":"Li","year":"2016","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.jsb.2021.107795_b0275","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/mt.2008.261","article-title":"Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro","volume":"17","author":"Limberis","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0280","doi-asserted-by":"crossref","DOI":"10.3390\/v12060668","article-title":"Adeno-Associated Virus (AAV) capsid stability and liposome remodeling during endo\/lysosomal pH trafficking","volume":"12","author":"Lins-Austin","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.jsb.2021.107795_b0285","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1128\/JVI.80.2.821-834.2006","article-title":"Mutations on the external surfaces of adeno-associated virus type 2 capsids that affect transduction and neutralization","volume":"80","author":"Lochrie","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0290","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.virol.2012.05.004","article-title":"Structure of adeno-associated virus-2 in complex with neutralizing monoclonal antibody A20","volume":"431","author":"McCraw","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.jsb.2021.107795_b0295","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1128\/jb.90.1.271-274.1965","article-title":"Association of 20-millimicron particles with adenoviruses","volume":"90","author":"Melnick","year":"1965","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jsb.2021.107795_b0300","first-page":"11","article-title":"Twenty-five years of structural parvovirology","author":"Mietzsch","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.jsb.2021.107795_b0305","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1089\/hum.2013.184","article-title":"OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1\u201312 vectors for gene therapy","volume":"25","author":"Mietzsch","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0310","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00261-17","article-title":"Structural Insights into Human Bocaparvoviruses","volume":"91","author":"Mietzsch","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0315","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1107\/S1744309106048184","article-title":"Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 1","volume":"62","author":"Miller","year":"2006","journal-title":"Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun."},{"key":"10.1016\/j.jsb.2021.107795_b0320","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1107\/S1744309109021460","article-title":"Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9","volume":"65","author":"Mitchell","year":"2009","journal-title":"Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun."},{"key":"10.1016\/j.jsb.2021.107795_b0325","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.virol.2004.10.012","article-title":"Two novel adeno-associated viruses from cynomolgus monkey: pseudotyping characterization of capsid protein","volume":"330","author":"Mori","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.jsb.2021.107795_b0330","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00705-007-1097-8","article-title":"Tissue distribution of cynomolgus adeno-associated viruses AAV10, AAV11, and AAVcy. 7 in naturally infected monkeys","volume":"153","author":"Mori","year":"2008","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0335","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/gt.2008.68","article-title":"Clinical gene therapy using recombinant adeno-associated virus vectors","volume":"15","author":"Mueller","year":"2008","journal-title":"Gene Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0340","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/viro.1996.0367","article-title":"Nucleotide sequencing and generation of an infectious clone of adeno-associated virus 3","volume":"221","author":"Muramatsu","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.jsb.2021.107795_b0345","doi-asserted-by":"crossref","first-page":"11791","DOI":"10.1128\/JVI.05305-11","article-title":"Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking","volume":"85","author":"Nam","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0350","doi-asserted-by":"crossref","first-page":"12260","DOI":"10.1128\/JVI.01304-07","article-title":"Structure of adeno-associated virus serotype 8, a gene therapy vector","volume":"81","author":"Nam","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0355","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/gt.2012.6","article-title":"Intracellular transport of recombinant adeno-associated virus vectors","volume":"19","author":"Nonnenmacher","year":"2012","journal-title":"Gene Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0360","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.aaw2900","article-title":"Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design","volume":"366","author":"Ogden","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jsb.2021.107795_b0365","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1128\/JVI.77.12.6995-7006.2003","article-title":"Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding","volume":"77","author":"Opie","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0370","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41434-019-0085-4","article-title":"AAV9 Vector: a Novel modality in gene therapy for spinal muscular atrophy","volume":"26","author":"Pattali","year":"2019","journal-title":"Gene Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0375","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jsb.2021.107795_b0380","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature16465","article-title":"An essential receptor for adeno-associated virus infection","volume":"530","author":"Pillay","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jsb.2021.107795_b0385","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00391-17","article-title":"Adeno-associated Virus (AAV) Serotypes Have Distinctive Interactions with Domains of the Cellular AAV Receptor","volume":"91","author":"Pillay","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0390","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/mt.2011.22","article-title":"Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer","volume":"19","author":"Pulicherla","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0395","doi-asserted-by":"crossref","first-page":"9396","DOI":"10.1128\/JVI.00209-12","article-title":"The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing","volume":"86","author":"Raupp","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0400","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(17)31868-8","article-title":"Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial","volume":"390","author":"Russell","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jsb.2021.107795_b0405","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/JVI.72.1.309-319.1998","article-title":"Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2","volume":"72","author":"Rutledge","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0410","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1128\/JVI.02093-13","article-title":"Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes","volume":"88","author":"Salganik","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0415","doi-asserted-by":"crossref","first-page":"8911","DOI":"10.1128\/JVI.00672-08","article-title":"Molecular characterization of the heparin-dependent transduction domain on the capsid of a novel adeno-associated virus isolate, AAV(VR-942)","volume":"82","author":"Schmidt","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0420","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1128\/JVI.02012-07","article-title":"Adeno-associated virus type 12 (AAV12): a novel AAV serotype with sialic acid- and heparan sulfate proteoglycan-independent transduction activity","volume":"82","author":"Schmidt","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0425","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1128\/JVI.01686-08","article-title":"Infectious molecular clones of adeno-associated virus isolated directly from human tissues","volume":"83","author":"Schnepp","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0430","doi-asserted-by":"crossref","unstructured":"Serio, A., Bilican, B., Barmada, S.J., Ando, D.M., Zhao, C., Siller, R., Burr, K., Haghi, G., Story, D., Nishimura, A.L., Carrasco, M.A., Phatnani, H.P., Shum, C., Wilmut, I., Maniatis, T., Shaw, C.E., Finkbeiner, S., Chandran, S., 2013. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.","DOI":"10.1073\/pnas.1300398110"},{"key":"10.1016\/j.jsb.2021.107795_b0435","doi-asserted-by":"crossref","first-page":"28814","DOI":"10.1074\/jbc.M113.482380","article-title":"Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency","volume":"288","author":"Shen","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsb.2021.107795_b0440","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0076-6879(10)80033-3","article-title":"Use of glycan microarrays to explore specificity of glycan-binding proteins","volume":"480","author":"Smith","year":"2010","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jsb.2021.107795_b0445","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1038\/mt.2009.128","article-title":"A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells","volume":"17","author":"Smith","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0450","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1021\/ja502616y","article-title":"Defining the stoichiometry and cargo load of viral and bacterial nanoparticles by Orbitrap mass spectrometry","volume":"136","author":"Snijder","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jsb.2021.107795_b0455","doi-asserted-by":"crossref","first-page":"10220","DOI":"10.1073\/pnas.1001673107","article-title":"A viral assembly factor promotes AAV2 capsid formation in the nucleolus","volume":"107","author":"Sonntag","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsb.2021.107795_b0460","doi-asserted-by":"crossref","first-page":"12686","DOI":"10.1128\/JVI.05359-11","article-title":"The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes","volume":"85","author":"Sonntag","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0465","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1128\/JVI.72.2.1438-1445.1998","article-title":"Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions","volume":"72","author":"Summerford","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0470","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/mt.2016.49","article-title":"AAVR: A Multi-Serotype Receptor for AAV","volume":"24","author":"Summerford","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0475","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jsb.2006.05.009","article-title":"EMAN2: an extensible image processing suite for electron microscopy","volume":"157","author":"Tang","year":"2007","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jsb.2021.107795_b0480","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1093\/brain\/awy126","article-title":"A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency","volume":"141","author":"Tordo","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.jsb.2021.107795_b0485","doi-asserted-by":"crossref","first-page":"E4812","DOI":"10.1073\/pnas.1704766114","article-title":"Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion","volume":"114","author":"Tse","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jsb.2021.107795_b0490","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jviromet.2016.07.009","article-title":"Generation and characterization of anti-adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies","volume":"236","author":"Tseng","year":"2016","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.jsb.2021.107795_b0495","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1128\/JVI.02524-12","article-title":"Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking","volume":"87","author":"Venkatakrishnan","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0500","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jsb.2021.107795_b0505","doi-asserted-by":"crossref","first-page":"9281","DOI":"10.1128\/JVI.74.19.9281-9293.2000","article-title":"Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection","volume":"74","author":"Wobus","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0510","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.1128\/JVI.74.18.8635-8647.2000","article-title":"Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism","volume":"74","author":"Wu","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0515","doi-asserted-by":"crossref","first-page":"11393","DOI":"10.1128\/JVI.01288-06","article-title":"Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes","volume":"80","author":"Wu","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jsb.2021.107795_b0520","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/s41467-021-21935-5","article-title":"Adeno-associated virus capsid assembly is divergent and stochastic","volume":"12","author":"W\u00f6rner","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jsb.2021.107795_b0525","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jsb.2011.09.006","article-title":"UCSF Chimera, MODELLER, and IMP: an integrated modeling system","volume":"179","author":"Yang","year":"2012","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jsb.2021.107795_b0530","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/gt.2010.27","article-title":"Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors","volume":"17","author":"Zeltner","year":"2010","journal-title":"Gene Ther."},{"key":"10.1016\/j.jsb.2021.107795_b0535","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth.4193","article-title":"MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy","volume":"14","author":"Zheng","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jsb.2021.107795_b0540","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.celrep.2015.07.019","article-title":"In silico reconstruction of the viral evolutionary lineage yields a potent gene therapy vector","volume":"12","author":"Zinn","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jsb.2021.107795_b0545","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S1046-2023(02)00220-7","article-title":"Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors","volume":"28","author":"Zolotukhin","year":"2002","journal-title":"Methods"}],"container-title":["Journal of Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847721001003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847721001003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:02:50Z","timestamp":1778583770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047847721001003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":108,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1047847721001003"],"URL":"https:\/\/doi.org\/10.1016\/j.jsb.2021.107795","relation":{},"ISSN":["1047-8477"],"issn-type":[{"value":"1047-8477","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2","name":"articletitle","label":"Article Title"},{"value":"Journal of Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsb.2021.107795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107795"}}