{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:19:43Z","timestamp":1788455983700,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870736"],"award-info":[{"award-number":["31870736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870834"],"award-info":[{"award-number":["31870834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071231"],"award-info":[{"award-number":["32071231"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91954119"],"award-info":[{"award-number":["91954119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0504801"],"award-info":[{"award-number":["2017YFA0504801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["035-63201109"],"award-info":[{"award-number":["035-63201109"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["035-63201110"],"award-info":[{"award-number":["035-63201110"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["035-BB042112"],"award-info":[{"award-number":["035-BB042112"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Structural Biology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jsb.2022.107832","type":"journal-article","created":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T18:45:03Z","timestamp":1642272303000},"page":"107832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7"],"prefix":"10.1016","volume":"214","author":[{"given":"Qinqin","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuequan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jsb.2022.107832_b0005","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/hmg\/8.5.743","article-title":"Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA\/A)","volume":"8","author":"Allikmets","year":"1999","journal-title":"Hum. Mol. Genet."},{"issue":"8","key":"10.1016\/j.jsb.2022.107832_b0010","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/01.RES.0000186277.12336.11","article-title":"Cardioprotective role of the mitochondrial ATP-binding cassette protein 1","volume":"97","author":"Ardehali","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.jsb.2022.107832_b0015","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1182\/blood.V96.9.3256","article-title":"Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation","volume":"96","author":"Bekri","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jsb.2022.107832_b0020","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1182\/blood-2006-08-041632","article-title":"RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload","volume":"109","author":"Cavadini","year":"2007","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jsb.2022.107832_b0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-2836(03)00666-1","article-title":"MDL1 is a high copy suppressor of ATM1: evidence for a role in resistance to oxidative stress","volume":"331","author":"Chloupkov\u00e1","year":"2003","journal-title":"J. Mol. Biol."},{"issue":"6","key":"10.1016\/j.jsb.2022.107832_b0030","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.ejpn.2012.02.003","article-title":"X-linked sideroblastic anemia and ataxia: a new family with identification of a fourth ABCB7 gene mutation","volume":"16","author":"D\u2019Hooghe","year":"2012","journal-title":"Eur. J. Paediatr. Neurol."},{"issue":"1","key":"10.1016\/j.jsb.2022.107832_b0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.genom.6.080604.162122","article-title":"Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates","volume":"6","author":"Dean","year":"2005","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"issue":"7","key":"10.1016\/j.jsb.2022.107832_b0040","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1101\/gr.184901","article-title":"The human ATP-binding cassette (ABC) transporter superfamily","volume":"11","author":"Dean","year":"2001","journal-title":"Genome Res."},{"issue":"12","key":"10.1016\/j.jsb.2022.107832_b0045","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"32","key":"10.1016\/j.jsb.2022.107832_b0050","doi-asserted-by":"crossref","first-page":"19228","DOI":"10.1073\/pnas.2006526117","article-title":"A structural framework for unidirectional transport by a bacterial ABC exporter","volume":"117","author":"Fan","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jsb.2022.107832_b0055","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/117693430700300013","article-title":"Structural evolution of the ABC transporter subfamily B","volume":"3","author":"Flanagan","year":"2007","journal-title":"Evol. Bioinform."},{"issue":"10","key":"10.1016\/j.jsb.2022.107832_b0060","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1158\/0008-5472.CAN-04-3327","article-title":"ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma","volume":"65","author":"Frank","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsb.2022.107832_b0065","first-page":"3708","article-title":"Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis","volume":"57","author":"Furuya","year":"1997","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.jsb.2022.107832_b0070","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pro.3235","article-title":"UCSF ChimeraX: Meeting modern challenges in visualization and analysis","volume":"27","author":"Goddard","year":"2018","journal-title":"Protein Sci."},{"issue":"10","key":"10.1016\/j.jsb.2022.107832_b0075","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nsmb836","article-title":"The ATP switch model for ABC transporters","volume":"11","author":"Higgins","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"1","key":"10.1016\/j.jsb.2022.107832_b0080","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0005-2736(76)90160-7","article-title":"A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants","volume":"455","author":"Juliano","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"issue":"7111","key":"10.1016\/j.jsb.2022.107832_b0085","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nature05125","article-title":"Identification of a mammalian mitochondrial porphyrin transporter","volume":"443","author":"Krishnamurthy","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jsb.2022.107832_b0090","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbrc.2021.04.007","article-title":"Cryo-EM structure of human ABCB8 transporter in nucleotide binding state","volume":"557","author":"Li","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.jsb.2022.107832_b0095","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. D Struct. Biol."},{"issue":"7","key":"10.1016\/j.jsb.2022.107832_b0100","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/CIRCULATIONAHA.110.003418","article-title":"Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia\/reperfusion","volume":"124","author":"Liesa","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jsb.2022.107832_b0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-981-13-7647-4_5","article-title":"Transporter-Mediated Drug-Drug Interactions and Their Significance","volume":"1141","author":"Liu","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"6","key":"10.1016\/j.jsb.2022.107832_b0110","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nsmb.3216","article-title":"Mechanistic diversity in ATP-binding cassette (ABC) transporters","volume":"23","author":"Locher","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jsb.2022.107832_b0115","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1046\/j.1365-2141.2001.03015.x","article-title":"X-linked cerebellar ataxia and sideroblastic anaemia associated with a missense mutation in the ABC7 gene predicting V411L","volume":"115","author":"Maguire","year":"2001","journal-title":"Br. J. Haematol."},{"issue":"1","key":"10.1016\/j.jsb.2022.107832_bib236","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jsb.2005.07.007","article-title":"Automated electron microscope tomography using robust prediction of specimen movements","volume":"152","author":"Mastronarde","year":"2005","journal-title":"J. Struct. Biol."},{"issue":"5","key":"10.1016\/j.jsb.2022.107832_b0120","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00424-006-0062-9","article-title":"Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein)","volume":"453","author":"Oude Elferink","year":"2007","journal-title":"Pflugers Arch."},{"issue":"7771","key":"10.1016\/j.jsb.2022.107832_b0125","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41586-019-1498-3","article-title":"Identification of an ATP-sensitive potassium channel in mitochondria","volume":"572","author":"Paggio","year":"2019","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.jsb.2022.107832_b0130","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jsb.2022.107832_b0135","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.jsb.2022.107832_b0140","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1182\/blood-2006-04-015768","article-title":"Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis","volume":"109","author":"Pondarre","year":"2007","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.jsb.2022.107832_b0145","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/ejhg.2015.139","article-title":"Whole-genome sequencing identifies a novel ABCB7 gene mutation for X-linked congenital cerebellar ataxia in a large family of Mongolian ancestry","volume":"24","author":"Protasova","year":"2016","journal-title":"Eur. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.jsb.2022.107832_b0150","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.jsb.2022.107832_b0155","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrm2646","article-title":"ABC transporters: the power to change","volume":"10","author":"Rees","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.jsb.2022.107832_b0160","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsb.2015.08.008","article-title":"CTFFIND4: Fast and accurate defocus estimation from electron micrographs","volume":"192","author":"Rohou","year":"2015","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.jsb.2022.107832_b0165","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1242\/dmm.009019","article-title":"Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease","volume":"5","author":"Rouault","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.jsb.2022.107832_b0170","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1042\/BST20150118","article-title":"Structures and functions of mitochondrial ABC transporters","volume":"43","author":"Schaedler","year":"2015","journal-title":"Biochem. Soc. Trans."},{"issue":"3","key":"10.1016\/j.jsb.2022.107832_b0175","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.bbagen.2014.05.022","article-title":"ABC transporters in adaptive immunity","volume":"1850","author":"Seyffer","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jsb.2022.107832_b0180","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1093\/emboj\/19.11.2492","article-title":"ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation","volume":"19","author":"Shirihai","year":"2000","journal-title":"EMBO J."},{"issue":"6175","key":"10.1016\/j.jsb.2022.107832_b0185","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1246729","article-title":"Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1","volume":"343","author":"Srinivasan","year":"2014","journal-title":"Science"},{"issue":"23","key":"10.1016\/j.jsb.2022.107832_b0190","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1002\/1873-3468.13997","article-title":"The role of the degenerate nucleotide binding site in type I ABC exporters","volume":"594","author":"Stockner","year":"2020","journal-title":"FEBS Lett."},{"issue":"15","key":"10.1016\/j.jsb.2022.107832_b0195","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1093\/bioinformatics\/bti511","article-title":"Resmap: automated representation of macromolecular interfaces as two-dimensional networks","volume":"21","author":"Swint-Kruse","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jsb.2022.107832_b0205","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0006-291X(86)80136-X","article-title":"The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein","volume":"141","author":"Ueda","year":"1986","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.jsb.2022.107832_b0210","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: More and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."},{"issue":"30","key":"10.1016\/j.jsb.2022.107832_b0215","doi-asserted-by":"crossref","first-page":"23287","DOI":"10.1074\/jbc.M001819200","article-title":"Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes","volume":"275","author":"Zhang","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jsb.2022.107832_b0220","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00210-005-0028-z","article-title":"TAP and TAP-like\u2013brothers in arms?","volume":"372","author":"Zhao","year":"2006","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"4","key":"10.1016\/j.jsb.2022.107832_b0225","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth.4193","article-title":"MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy","volume":"14","author":"Zheng","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jsb.2022.107832_b0230","doi-asserted-by":"crossref","first-page":"e42166","DOI":"10.7554\/eLife.42166","article-title":"New tools for automated high-resolution cryo-EM structure determination in RELION-3","volume":"7","author":"Zivanov","year":"2018","journal-title":"Elife"},{"issue":"6","key":"10.1016\/j.jsb.2022.107832_b0235","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.bbabio.2009.02.009","article-title":"Mitochondrial ABC proteins in health and disease","volume":"1787","author":"Zutz","year":"2009","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Journal of Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847722000028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1047847722000028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T03:22:05Z","timestamp":1760930525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1047847722000028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1047847722000028"],"URL":"https:\/\/doi.org\/10.1016\/j.jsb.2022.107832","relation":{},"ISSN":["1047-8477"],"issn-type":[{"value":"1047-8477","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7","name":"articletitle","label":"Article Title"},{"value":"Journal of Structural Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsb.2022.107832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107832"}}