{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:05:29Z","timestamp":1791162329435,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.jsbmb.2004.05.005","type":"journal-article","created":{"date-parts":[[2004,10,26]],"date-time":"2004-10-26T11:30:54Z","timestamp":1098790254000},"page":"63-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Cyclin D1 expression is dependent on estrogen receptor function in tamoxifen-resistant breast cancer cells"],"prefix":"10.1016","volume":"92","author":[{"given":"Robin L.","family":"Kilker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina M.","family":"Rutherford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricarmen D.","family":"Planas-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2004.05.005_bib1","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.1038\/sj.onc.1206937","article-title":"Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling","volume":"22","author":"Clarke","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrc721","article-title":"Endocrine-responsive breast cancer and strategies for combating resistance","volume":"2","author":"Ali","year":"2002","journal-title":"Nature Rev. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(95)91156-1","article-title":"Response to a specific antiestrogen (ICI 182,780) in tamoxifen-resistant breast cancer","volume":"345","author":"Howell","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib4","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0960-0760(01)00140-6","article-title":"Where do selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) now fit into breast cancer treatment algorithms?","volume":"79","author":"Howell","year":"2001","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0959-8049(00)00013-7","article-title":"Effective tamoxifen therapy of breast cancer involves both antiproliferative and pro-apoptotic changes","volume":"36","author":"Cameron","year":"2000","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib6","first-page":"3583","article-title":"Effects of tamoxifen on human breast cancer cell cycle kinetics: accumulation of cells in early G1 phase","volume":"43","author":"Osborne","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib7","first-page":"584","article-title":"Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice","volume":"45","author":"Osborne","year":"1985","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00689680","article-title":"Antiestrogen regulation of cell cycle progression and cyclin D1 gene expression in MCF-7 human breast cancer cells","volume":"31","author":"Watts","year":"1994","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib9","doi-asserted-by":"crossref","first-page":"10882","DOI":"10.1074\/jbc.272.16.10882","article-title":"Estrogen-induced activation of cdk4 and cdk2 during G1-phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-cdk2","volume":"272","author":"Prall","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib10","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1128\/MCB.18.8.4499","article-title":"c-Myc or cyclin D1 mimics estrogen effects on cyclin E-cdk2 activation and cell cycle re-entry","volume":"18","author":"Prall","year":"1998","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib11","first-page":"488","article-title":"Estrogen regulates activity of cyclin-dependent kinases and retinoblastoma protein phosphorylation in breast cancer cells","volume":"10","author":"Foster","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib12","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1128\/MCB.17.7.4059","article-title":"Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution","volume":"17","author":"Planas-Silva","year":"1997","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib13","first-page":"2315","article-title":"17\u00df-estradiol induces cyclin D1 gene transcription, p36D\u2212p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G1-arrested human breast cancer cells","volume":"12","author":"Altucci","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib14","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1128\/MCB.16.12.6917","article-title":"Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint","volume":"16","author":"Lukas","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib15","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1128\/MCB.21.3.794-810.2001","article-title":"Multifaceted regulation of cell cycle progression by estrogen: regulation of cdk inhibitors and cdc25A independent of cyclin D1-cdk4 function","volume":"21","author":"Foster","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib16","first-page":"1804","article-title":"Antiestrogen inhibition of cell cycle progression in breast cancer cells is associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation","volume":"9","author":"Watts","year":"1995","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib17","doi-asserted-by":"crossref","first-page":"396s","DOI":"10.1158\/1078-0432.CCR-031205","article-title":"Regulatory nodes that integrate and coordinate signaling as potential targets for breast cancer therapy","volume":"10","author":"Cui","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib18","first-page":"849","article-title":"Inducible overexpression of cyclin D1 in breast cancer cells reverses the growth-inhibitory effects of antiestrogens","volume":"3","author":"Wilcken","year":"1997","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib19","first-page":"6916","article-title":"Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogen in T-47D breast cancer cells","volume":"62","author":"Hui","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib20","doi-asserted-by":"crossref","first-page":"8158","DOI":"10.1038\/sj.onc.1206012","article-title":"Involvement of G1\/S cyclins in estrogen-independent proliferation of estrogen receptor-positive breast cancer cells","volume":"21","author":"Bindels","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1073\/pnas.98.1.142","article-title":"Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF\/granulin precursor)","volume":"98","author":"Lu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib22","first-page":"923","article-title":"Cyclin D1 and estrogen receptor messenger RNA levels are positively correlated in primary breast cancer","volume":"2","author":"Hui","year":"1996","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib23","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/sj.onc.1202023","article-title":"EMS1 gene expression in primary breast cancer: relationship to cyclin D1 and oestrogen receptor expression and patient survival","volume":"17","author":"Hui","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib24","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/jnci\/83.20.1483","article-title":"Her-2\/neu and INT2 proto-oncogene amplification in malignant breast tumors in relation to reproductive factors and exposure to exogenous hormones","volume":"83","author":"Olson","year":"1991","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib25","first-page":"1177","article-title":"cyclin D1 amplification is not associated with reduced overall survival in primary breast cancer but may predict early relapse in patients with features of good prognosis","volume":"2","author":"Seshadri","year":"1996","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib26","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/sj.bjc.6600109","article-title":"Prognostic value of CCNDI gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays","volume":"86","author":"Bieche","year":"2002","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/bjc.1991.28","article-title":"Association of INT2\/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis","volume":"13","author":"Borg","year":"1991","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib28","first-page":"2069","article-title":"Overexpression of cyclin D1 messenger RNA predicts for poor prognosis in estrogen receptor-positive breast cancer","volume":"5","author":"Kenny","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib29","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0959-8049(00)00241-0","article-title":"Faslodex (ICI 182780): an oestrogen receptor downregulator","volume":"36","author":"Howell","year":"2000","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib30","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer-drug screening","volume":"82","author":"Skehan","year":"1990","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib31","first-page":"4007","article-title":"Effects of tamoxifen on cell cycle progression of synchronous MCF-7 human mammary carcinoma cells","volume":"43","author":"Taylor","year":"1983","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib32","doi-asserted-by":"crossref","first-page":"38221","DOI":"10.1074\/jbc.M004424200","article-title":"A pure estrogen antagonist inhibits cyclin E-Cdk2 activity in MCF-7 breast cancer cells and induces accumulation of p130-E2F4 complexes characteristic of quiescence","volume":"275","author":"Carroll","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib33","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1038\/sj.onc.1203827","article-title":"Reversal of an antiestrogen-mediated cell cycle arrest of MCF-7 cells by viral tumor antigens requires the retinoblastoma protein-binding domain","volume":"19","author":"Varma","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib34","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nature00889","article-title":"A naturally ocurring MTA1 variant sequesters oestrogen receptot-\u03b1 in the cytoplasm","volume":"418","author":"Kumar","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib35","first-page":"619","article-title":"Influence of cell proliferation and cell cycle phase on expression of estrogen receptor in MCF-7 breast cancer cells","volume":"44","author":"Jakesz","year":"1984","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib36","first-page":"707","article-title":"Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines","volume":"9","author":"Lukas","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib37","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1210\/mend.13.9.0337","article-title":"Proteasome-mediated proteolysis of estrogen receptor: a novel component in autologous down-regulation","volume":"13","author":"Alarid","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1023\/A:1021804121171","article-title":"Cell proliferation, apoptosis, and expression of cyclin D1 and cyclin E as potential biomarkers in tamoxifen-treated mammary tumors","volume":"77","author":"Christov","year":"2003","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0304-3835(01)00593-6","article-title":"Chemically induced rat mammary tumor treated with tamoxifen showed decreased expression of cyclin D1, cyclin E, and p21Cip1","volume":"170","author":"Jang","year":"2001","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib40","first-page":"4788","article-title":"Functional activity of ectopically expressed estrogen receptor is not sufficient for estrogen-mediated cyclin D1 expression","volume":"59","author":"Planas-Silva","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib41","first-page":"300","article-title":"Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells","volume":"1","author":"Hodges","year":"2003","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0031-6997(24)01479-0","article-title":"Cellular and molecular pharmacology of antiestrogen action and resistance","volume":"53","author":"Clarke","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib43","first-page":"3229","article-title":"MCF7\/LCC2: a 4-hydroxytamoxifen resistant human breast cancer variant that retains sensitivity to the steroidal antiestrogen ICI 182,780","volume":"53","author":"Brunner","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/02841869209088892","article-title":"Effect of estrogen and antiestrogens on cell proliferation and synthesis of secreted proteins in the human breast cancer cell line MCF-7 and a tamoxifen resistant variant subline, AL-1","volume":"31","author":"Lykkesfeldt","year":"1992","journal-title":"Acta Oncol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib45","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1002\/ijc.2910550529","article-title":"Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780","volume":"55","author":"Hu","year":"1993","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1023\/A:1025484908380","article-title":"Oestrogen receptor-mediated modulation of the EGFR\/MAPK pathway in tamoxifen-resistant MCF-7 cells","volume":"81","author":"Hutcheson","year":"2003","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0960-0760(96)00114-8","article-title":"Response-specific antiestrogen resistance in a newly characterized MCF-7 human breast cancer cell line resulting from long-term exposure to trans-hydroxytamoxifen","volume":"59","author":"Herman","year":"1996","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib48","first-page":"1587","article-title":"Altered expression of estrogen-regulated genes in a tamoxifen-resistant and ICI 164,384 and ICI 182,780 sensitive human breast cancer cell line, MCF-7\/TAMR-1","volume":"54","author":"Lykkesfeldt","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib49","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/ijc.2910560225","article-title":"Anti-proliferative and anti-estrogenic effects of ICI 164,384 and ICI 182,780 in 4-OH-tamoxifen-resistant human breast cancer cells","volume":"56","author":"Coopman","year":"1994","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib50","doi-asserted-by":"crossref","first-page":"10030","DOI":"10.1016\/S0021-9258(18)90922-1","article-title":"Effects of antiestrogens on the estrogen-regulated pS2 RNA and the 52- and 160-kilodalton proteins in MCF-7 cells and two tamoxifen-resistant sublines","volume":"259","author":"Westley","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib51","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/0959-8049(93)90218-5","article-title":"Type I IGF receptor and acquired tamoxifen resistance in oestrogen-responsive human breast cancer cells","volume":"29","author":"Wiseman","year":"1993","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib52","first-page":"3331","article-title":"Changes in estrogen receptor, progesterone receptor, and pS2 expression in tamoxifen-resistant human breast cancer","volume":"55","author":"Johnston","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib53","first-page":"141","article-title":"Cyclin D1 expression and patient outcome after tamoxifen therapy in estrogen receptor positive metastatic breast cancer","volume":"10","author":"Han","year":"2003","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib54","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0022-4731(88)90115-X","article-title":"Effect of tamoxifen and tamoxifen derivatives on the conversion of estrone-sulfate to estradiol in the R-27 cells, a tamoxifen-resistant line derived from MCF-7 human breast cancer cells","volume":"30","author":"Gelly","year":"1988","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib55","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1038\/sj.onc.1205420","article-title":"Phosphorylation of human estrogen receptor \u03b1 at serine 118 by two distinct signal transduction patways revealed by phosphorylation-specific antisera","volume":"21","author":"Chen","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib56","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1677\/erc.0.0080191","article-title":"Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer","volume":"8","author":"Dowsett","year":"2001","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib57","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1210\/en.2002-220620","article-title":"Elevated levels of epidermal growth factor receptor\/c-erbB2 heterodimers mediated an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells","volume":"144","author":"Knowlden","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib58","first-page":"5887","article-title":"Inhibition of HER2\/neu (erb B-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells","volume":"60","author":"Kurokawa","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib59","first-page":"4436s","article-title":"Inhibition of erbB receptor (HER) tyrosine kinases as a strategy to abrogate antiestrogen resistance in human breast cancer","volume":"7","author":"Kurokawa","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib60","first-page":"511s","article-title":"ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms","volume":"9","author":"Kurokawa","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib61","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1200\/JCO.2002.20.6.1467","article-title":"Elevated serum HER-2\/neu level predicts decreased response to hormone therapy in metastatic breast cancer","volume":"20","author":"Lipton","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib62","doi-asserted-by":"crossref","first-page":"30458","DOI":"10.1074\/jbc.M305226200","article-title":"Enhanced estrogen receptor (ER) \u03b1, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation","volume":"278","author":"Martin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib63","doi-asserted-by":"crossref","first-page":"346s","DOI":"10.1158\/1078-0432.CCR-031206","article-title":"Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination","volume":"10","author":"Nicholson","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib64","doi-asserted-by":"crossref","first-page":"331s","DOI":"10.1158\/1078-0432.CCR-031212","article-title":"Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance","volume":"10","author":"Schiff","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib65","first-page":"3858","article-title":"AIB1 enhances estrogen-dependent induction of cyclin D1 expression","volume":"61","author":"Planas-Silva","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib66","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/jnci\/95.5.353","article-title":"Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2\/neu in tamoxifen resistance in breast cancer","volume":"95","author":"Osborne","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib67","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1006232830161","article-title":"Acquired antiestrogen resistance in MCF-7 human breast cancer sublines is not accomplished by altered expression of receptors in the ErbB-family","volume":"58","author":"Larsen","year":"1999","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib68","first-page":"1643","article-title":"Expression of epidermal growth factor receptor and c-erbB2 during the development of tamoxifen resistance in human breast cancer","volume":"3","author":"Newby","year":"1997","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib69","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1023\/A:1009523501499","article-title":"Function of the IGF-1 receptor in breast cancer","volume":"5","author":"Surmacz","year":"2000","journal-title":"J. Mam. Gland Biol."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib70","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1074\/jbc.M010840200","article-title":"Phosphatidylinositol 3-kinase\/AKT-mediated activation of estrogen receptor \u03b1","volume":"276","author":"Campbell","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib71","first-page":"707","article-title":"Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells","volume":"1","author":"Clark","year":"2002","journal-title":"Mol. Cancer Therap."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib72","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/sj.bjc.6690112","article-title":"Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line","volume":"79","author":"Parisot","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jsbmb.2004.05.005_bib73","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3835(99)00009-9","article-title":"Changes in the secretion of insulin-like growth factor binding proteins-2 and -4 associated with the development of tamoxifen resistance and estrogen independence in human breast cancer cells lines","volume":"139","author":"Maxwell","year":"1999","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jsbmb.2004.05.005_bib74","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/35082500","article-title":"Specific protection against breast cancers by cyclin D1 ablation","volume":"411","author":"Yu","year":"2001","journal-title":"Nature"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076004003218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076004003218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:48:09Z","timestamp":1760734089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076004003218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":74,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0960076004003218"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2004.05.005","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclin D1 expression is dependent on estrogen receptor function in tamoxifen-resistant breast cancer cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2004.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}