{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:58:09Z","timestamp":1790985489523,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2-5","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.jsbmb.2004.12.033","type":"journal-article","created":{"date-parts":[[2005,2,5]],"date-time":"2005-02-05T07:36:29Z","timestamp":1107588989000},"page":"107-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Evaluation of steroid receptor function by gene targeting in mice"],"prefix":"10.1016","volume":"93","author":[{"given":"Tim M.","family":"Wintermantel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich F.","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Sch\u00fctz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2004.12.033_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.0.CO;2-B","article-title":"Cre recombinase: the universal reagent for genome tailoring","volume":"26","author":"Nagy","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.jsbmb.2004.12.033_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.8016642","article-title":"Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting","volume":"265","author":"Gu","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jsbmb.2004.12.033_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/gene.1078","article-title":"A CamKIIalpha iCre BAC allows brain-specific gene inactivation","volume":"31","author":"Casanova","year":"2001","journal-title":"Genesis"},{"key":"10.1016\/j.jsbmb.2004.12.033_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/gene.10097","article-title":"Targeting mammary epithelial cells using a bacterial artificial chromosome","volume":"33","author":"Wintermantel","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.jsbmb.2004.12.033_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng882","article-title":"Disruption of CREB function in brain leads to neurodegeneration","volume":"31","author":"Mantamadiotis","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib6","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1101\/gad.9.13.1608","article-title":"Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation","volume":"9","author":"Cole","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0959-437X(98)80007-5","article-title":"Genetic dissection of glucocorticoid receptor function in mice","volume":"8","author":"Tronche","year":"1998","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib8","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1210\/me.2002-0429","article-title":"Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression","volume":"17","author":"Mittelstadt","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib9","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1101\/gad.13.22.2996","article-title":"The glucocorticoid receptor is required for stress erythropoiesis","volume":"13","author":"Bauer","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib10","doi-asserted-by":"crossref","first-page":"9424","DOI":"10.1073\/pnas.95.16.9424","article-title":"Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism","volume":"95","author":"Berger","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1210\/mend.13.2.0241","article-title":"Effects of mineralocorticoid receptor gene disruption on the components of the renin-angiotensin system in 8-day-old mice","volume":"13","author":"Hubert","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s004240050906","article-title":"Rescue of the mineralocorticoid receptor knock-out mouse","volume":"438","author":"Bleich","year":"1999","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/12703","article-title":"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety","volume":"23","author":"Tronche","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/jmbi.1998.2307","article-title":"Inducible site-specific recombination in the brain","volume":"285","author":"Kellendonk","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib15","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1093\/nar\/27.22.4324","article-title":"Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ERT and Cre-ERT2 recombinases","volume":"27","author":"Indra","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<151::AID-GENE17>3.0.CO;2-E","article-title":"Hepatocyte-specific expression of Cre recombinase","volume":"26","author":"Kellendonk","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.jsbmb.2004.12.033_bib17","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1101\/gad.284704","article-title":"Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth","volume":"18","author":"Tronche","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib18","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1210\/endo.137.7.8770909","article-title":"Growth hormone stimulates tyrosine phosphorylation of JAK2 and STAT5, but not insulin receptor substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo","volume":"137","author":"Chow","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2004.12.033_bib19","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/35016611","article-title":"Gigantism in mice lacking suppressor of cytokine signalling-2","volume":"405","author":"Metcalf","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jsbmb.2004.12.033_bib20","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0092-8674(00)81444-0","article-title":"Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses","volume":"93","author":"Teglund","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2004.12.033_bib21","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1210\/me.2003-0283","article-title":"Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus","volume":"18","author":"Opherk","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib22","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1523\/JNEUROSCI.23-11-04785.2003","article-title":"The glucocorticoid receptor as a potential target to reduce cocaine abuse","volume":"23","author":"Deroche-Gamonet","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib23","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1002\/j.1460-2075.1994.tb06726.x","article-title":"A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1","volume":"13","author":"Heck","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.jsbmb.2004.12.033_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(00)81183-6","article-title":"DNA binding of the glucocorticoid receptor is not essential for survival","volume":"93","author":"Reichardt","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2004.12.033_bib25","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1093\/emboj\/20.24.7168","article-title":"Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor","volume":"20","author":"Reichardt","year":"2001","journal-title":"EMBO J."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076004004261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076004004261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:48:18Z","timestamp":1760734098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076004004261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":25,"journal-issue":{"issue":"2-5","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0960076004004261"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2004.12.033","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of steroid receptor function by gene targeting in mice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2004.12.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}