{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:22:52Z","timestamp":1790839372755,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.jsbmb.2006.06.009","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T12:46:58Z","timestamp":1155041218000},"page":"118-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Actions of gonadotropin-releasing hormone analogues in pituitary gonadotrophs and their modulation by ovarian steroids"],"prefix":"10.1016","volume":"101","author":[{"given":"Juergen M.","family":"Weiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J.","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Polack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Emons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Dieter","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Diedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Ortmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2006.06.009_bib1","first-page":"161","article-title":"Expression and signal transduction pathways of gonadotropin-releasing hormone receptors","volume":"50","author":"Stojilkovic","year":"1995","journal-title":"Recent Prog. Horm. Res."},{"issue":"2","key":"10.1016\/j.jsbmb.2006.06.009_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1056\/NEJM199101103240205","article-title":"Gonadotropin-releasing hormone and its analogues","volume":"324","author":"Conn","year":"1991","journal-title":"N. Engl. J. Med."},{"issue":"4535","key":"10.1016\/j.jsbmb.2006.06.009_bib3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.6296998","article-title":"Homologous regulation of gonadotropin-releasing hormone receptors in cultured pituitary cells","volume":"215","author":"Loumaye","year":"1982","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.jsbmb.2006.06.009_bib4","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1021\/jm00160a008","article-title":"New effective gonadotropin releasing hormone antagonists with minimal potency for histamine release in vitro","volume":"29","author":"Rivier","year":"1986","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.jsbmb.2006.06.009_bib5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0015-0282(97)81407-0","article-title":"Comparison of different doses of gonadotropin-releasing hormone antagonist Cetrorelix during controlled ovarian hyperstimulation","volume":"67","author":"Albano","year":"1997","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.jsbmb.2006.06.009_bib6","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/oxfordjournals.humrep.a138597","article-title":"Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation","volume":"9","author":"Diedrich","year":"1994","journal-title":"Hum. Reprod."},{"issue":"2","key":"10.1016\/j.jsbmb.2006.06.009_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0301-2115(95)02138-W","article-title":"Preserved pituitary response under ovarian stimulation with HMG and GnRH antagonists (Cetrorelix) in women with tubal infertility","volume":"61","author":"Felberbaum","year":"1995","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"3","key":"10.1016\/j.jsbmb.2006.06.009_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0015-0282(97)80071-4","article-title":"Dose-related suppression of serum luteinizing hormone in women by a potent new gonadotropin-releasing hormone antagonist (Ganirelix) administered by intranasal spray","volume":"67","author":"Fujimoto","year":"1997","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.jsbmb.2006.06.009_bib9","first-page":"1220","article-title":"Endocrine effects and pharmacokinetic characteristics of a potent new gonadotropin-releasing hormone antagonist (Ganirelix) with minimal histamine-releasing properties: studies in postmenopausal women","volume":"75","author":"Rabinovici","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.jsbmb.2006.06.009_bib10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/oxfordjournals.humrep.a138593","article-title":"Introduction of LHRH-antagonists into the treatment of gynaecological disorders","volume":"9","author":"Reissmann","year":"1994","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.jsbmb.2006.06.009_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1472-6483(11)60210-1","article-title":"Gonadotrophin-releasing hormone (GnRH) and GnRH agonists: mechanisms of action","volume":"5","author":"Ortmann","year":"2002","journal-title":"Reprod. Biomed. Online"},{"issue":"6","key":"10.1016\/j.jsbmb.2006.06.009_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3109\/09513599909167587","article-title":"LH-RH analogues. I. Their impact on reproductive medicine","volume":"13","author":"Schally","year":"1999","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2006.06.009_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2165\/00024677-200201050-00002","article-title":"Gonadotropin-releasing hormone antagonists: pharmacology and clinical use in women","volume":"1","author":"Weiss","year":"2002","journal-title":"Treat. Endocrinol."},{"issue":"4","key":"10.1016\/j.jsbmb.2006.06.009_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1471-0528.1985.tb01113.x","article-title":"Reduced in-vitro fertilization of human oocytes from patients with raised basal luteinizing hormone levels during the follicular phase","volume":"92","author":"Stanger","year":"1985","journal-title":"Br. J. Obstet. Gynaecol."},{"issue":"6","key":"10.1016\/j.jsbmb.2006.06.009_bib15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1472-6483(10)61113-3","article-title":"GnRH antagonists in IVF","volume":"10","author":"Kolibianakis","year":"2005","journal-title":"Reprod. Biomed. Online"},{"issue":"7","key":"10.1016\/j.jsbmb.2006.06.009_bib16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1080\/07853890310001302","article-title":"GnRH antagonists in the treatment of infertility","volume":"35","author":"Weiss","year":"2003","journal-title":"Ann. Med."},{"issue":"4","key":"10.1016\/j.jsbmb.2006.06.009_bib17","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/humrep\/17.4.874","article-title":"GnRH antagonist in assisted reproduction: a Cochrane review","volume":"17","author":"Al Inany","year":"2002","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.jsbmb.2006.06.009_bib18","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/humrep\/15.3.526","article-title":"Ovarian stimulation with HMG: results of a prospective randomized phase III European study comparing the luteinizing hormone-releasing hormone (LHRH)-antagonist cetrorelix and the LHRH-agonist buserelin. European Cetrorelix Study group","volume":"15","author":"Albano","year":"2000","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.jsbmb.2006.06.009_bib19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00404-001-0267-2","article-title":"Use of GnRH antagonists in ovarian stimulation for assisted reproductive technologies compared to the long protocol","volume":"265","author":"Ludwig","year":"2001","journal-title":"Meta-anal. Arch. Gynecol. Obstet."},{"issue":"2","key":"10.1016\/j.jsbmb.2006.06.009_bib20","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0015-0282(99)00524-5","article-title":"Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin)","volume":"73","author":"Olivennes","year":"2000","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jsbmb.2006.06.009_bib21","first-page":"165","article-title":"Regulation of gonadotropin secretion by steroid hormones","volume":"12","author":"Brann","year":"1991","journal-title":"Front Neuroendocrinol."},{"issue":"1","key":"10.1016\/j.jsbmb.2006.06.009_bib22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0960-0760(94)90249-6","article-title":"Modulation of calcium signaling and LH secretion by progesterone in pituitary gonadotrophs and clonal pituitary cells","volume":"48","author":"Ortmann","year":"1994","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/j.jsbmb.2006.06.009_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/oxfordjournals.humrep.a136732","article-title":"Mechanism of GnRH action in gonadotrophs","volume":"3","author":"Clayton","year":"1988","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.jsbmb.2006.06.009_bib24","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1210\/endo-108-3-887","article-title":"Regulation of pituitary gonadotropin-releasing hormone receptors by gonadal hormones","volume":"108","author":"Clayton","year":"1981","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.jsbmb.2006.06.009_bib25","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1095\/biolreprod44.4.725","article-title":"Regulation of gonadotropin secretion and number of gonadotropin-releasing hormone receptors by inhibin, activin-A, and estradiol","volume":"44","author":"Gregg","year":"1991","journal-title":"Biol. Reprod."},{"issue":"7","key":"10.1016\/j.jsbmb.2006.06.009_bib26","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1093\/humrep\/deh272","article-title":"Elevated progesterone at initiation of stimulation is associated with a lower ongoing pregnancy rate after IVF using GnRH antagonists","volume":"19","author":"Kolibianakis","year":"2004","journal-title":"Hum. Reprod."},{"issue":"1","key":"10.1016\/j.jsbmb.2006.06.009_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0022-4731(90)90139-J","article-title":"Weak estrogenic activity of phenol red in the pituitary gonadotroph: re-evaluation of estrogen and antiestrogen effects","volume":"35","author":"Ortmann","year":"1990","journal-title":"J. Steroid Biochem."},{"issue":"3\u20134","key":"10.1016\/j.jsbmb.2006.06.009_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0960-0760(95)00121-F","article-title":"Ovarian steroids modulate gonadotropin-releasing hormone-induced biphasic luteinizing hormone secretory responses and inositol phosphate accumulation in rat anterior pituitary cells and alpha T3-1 gonadotrophs","volume":"54","author":"Ortmann","year":"1995","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"6171","key":"10.1016\/j.jsbmb.2006.06.009_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/333370a0","article-title":"Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization","volume":"333","author":"Bouvier","year":"1988","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jsbmb.2006.06.009_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0163-7258(97)00053-3","article-title":"Phosphorylation of phospholipase C-coupled receptors","volume":"75","author":"Tobin","year":"1997","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.jsbmb.2006.06.009_bib31","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1210\/edrv.18.2.0295","article-title":"Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor","volume":"18","author":"Sealfon","year":"1997","journal-title":"Endocr. Rev."},{"issue":"4","key":"10.1016\/j.jsbmb.2006.06.009_bib32","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1210\/edrv-15-4-462","article-title":"Gonadotropin-releasing hormone receptors: structure and signal transduction pathways","volume":"15","author":"Stojilkovic","year":"1994","journal-title":"Endocr. Rev."},{"issue":"42","key":"10.1016\/j.jsbmb.2006.06.009_bib33","doi-asserted-by":"crossref","first-page":"30146","DOI":"10.1074\/jbc.274.42.30146","article-title":"Lack of a C-terminal tail in the mammalian gonadotropin-releasing hormone receptor confers resistance to agonist-dependent phosphorylation and rapid desensitization","volume":"274","author":"Willars","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.jsbmb.2006.06.009_bib34","doi-asserted-by":"crossref","first-page":"11472","DOI":"10.1074\/jbc.273.19.11472","article-title":"Gonadotropin-releasing hormone receptors with intracellular carboxyl-terminal tails undergo acute desensitization of total inositol phosphate production and exhibit accelerated internalization kinetics","volume":"273","author":"Heding","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jsbmb.2006.06.009_bib35","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1006\/bbrc.1997.7331","article-title":"Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptors","volume":"238","author":"Blomenrohr","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.jsbmb.2006.06.009_bib36","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1210\/endo.136.11.7588262","article-title":"Rapid desensitization of GnRH-stimulated intracellular signalling events in alpha T3-1 and HEK-293 cells expressing the GnRH receptor","volume":"136","author":"Anderson","year":"1995","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.jsbmb.2006.06.009_bib37","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1074\/jbc.M008916200","article-title":"Rapid down-regulation of the type I inositol 1,4,5-trisphosphate receptor and desensitization of gonadotropin-releasing hormone-mediated Ca2+ responses in alpha T3-1 gonadotropes","volume":"276","author":"Willars","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.jsbmb.2006.06.009_bib38","first-page":"46","article-title":"Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines","volume":"18","author":"Kaiser","year":"1997","journal-title":"Endocr. Rev."},{"issue":"4","key":"10.1016\/j.jsbmb.2006.06.009_bib39","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1210\/endo-122-4-1689","article-title":"Gonadotropin-releasing hormone desensitization preferentially inhibits expression of the luteinizing hormone beta-subunit gene in vivo","volume":"122","author":"Lalloz","year":"1988","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.jsbmb.2006.06.009_bib40","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1210\/endo.136.7.7789305","article-title":"Expression of gonadotropin-releasing hormone (GnRH) receptor gene is altered by GnRH agonist desensitization in a manner similar to that of gonadotropin beta-subunit genes in normal and castrated rat pituitary","volume":"136","author":"Lerrant","year":"1995","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jsbmb.2006.06.009_bib41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000126527","article-title":"Inhibitory effect of a highly potent antagonist of LH releasing hormone (SB-75) on the pituitary gonadal axis in the intact and castrated rat","volume":"58","author":"Ayalon","year":"1993","journal-title":"Neuroendocrinology"},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2006.06.009_bib42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0303-7207(93)90263-J","article-title":"Effects of antiandrogens and ethane dimethane sulphonate (EDS) on gene expression, free subunits, bioactivity and secretion of pituitary gonadotrophins in male rats","volume":"91","author":"Gromoll","year":"1993","journal-title":"Mol. Cell Endocrinol."},{"issue":"1","key":"10.1016\/j.jsbmb.2006.06.009_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1507\/endocrj.52.131","article-title":"GnRH antagonist-induced down-regulation of the mRNA expression of pituitary receptors: comparisons with GnRH agonist effects","volume":"52","author":"Murase","year":"2005","journal-title":"Endocr. J."},{"issue":"32","key":"10.1016\/j.jsbmb.2006.06.009_bib44","doi-asserted-by":"crossref","first-page":"18853","DOI":"10.1074\/jbc.270.32.18853","article-title":"A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites","volume":"270","author":"Zhou","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.jsbmb.2006.06.009_bib45","doi-asserted-by":"crossref","first-page":"12663","DOI":"10.1016\/S0021-9258(18)90797-0","article-title":"Receptor-binding properties of gonadotropin-releasing hormone derivatives. Prolonged receptor occupancy and cell-surface localization of a potent antagonist analog","volume":"259","author":"Loumaye","year":"1984","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.jsbmb.2006.06.009_bib46","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1073\/pnas.0400605101","article-title":"Effect of long-term treatment with low doses of the LHRH antagonist Cetrorelix on pituitary receptors for LHRH and gonadal axis in male and female rats","volume":"101","author":"Horvath","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.jsbmb.2006.06.009_bib47","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1210\/endo.137.8.8754771","article-title":"Chronic administration of the luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix decreases gonadotrope responsiveness and pituitary LHRH receptor messenger ribonucleic acid levels in rats","volume":"137","author":"Pinski","year":"1996","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.jsbmb.2006.06.009_bib48","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1073\/pnas.93.6.2398","article-title":"Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix","volume":"93","author":"Halmos","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.jsbmb.2006.06.009_bib49","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1073\/pnas.98.4.1829","article-title":"Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH","volume":"98","author":"Kovacs","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"21","key":"10.1016\/j.jsbmb.2006.06.009_bib50","doi-asserted-by":"crossref","first-page":"12197","DOI":"10.1073\/pnas.211442598","article-title":"Comparison of mechanisms of action of luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats","volume":"98","author":"Kovacs","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.jsbmb.2006.06.009_bib51","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1210\/endo.138.2.5034","article-title":"Potential role for a regulator of G protein signaling (RGS3) in gonadotropin-releasing hormone (GnRH) stimulated desensitization","volume":"138","author":"Neill","year":"1997","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.jsbmb.2006.06.009_bib52","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1210\/endo-108-3-752","article-title":"Desensitization to gonadotropin-releasing hormone observed in superfused pituitary cells on Cytodex beads","volume":"108","author":"Smith","year":"1981","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.jsbmb.2006.06.009_bib53","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0960-0760(92)90091-V","article-title":"Effects of progesterone on gonadotropin-releasing hormone receptor concentration in cultured estrogen-primed female rat pituitary cells","volume":"42","author":"Emons","year":"1992","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.jsbmb.2006.06.009_bib54","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1677\/joe.0.1320251","article-title":"Acute effects of oestradiol and progesterone on melittin- and gonadotrophin-releasing hormone-induced LH secretion","volume":"132","author":"Ortmann","year":"1992","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.jsbmb.2006.06.009_bib55","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1210\/jcem-60-3-590","article-title":"Reduction in pituitary desensitization and prolongation of gonadotropin release by estrogen during continuous administration of gonadotropin-releasing hormone in women: its antagonism by progesterone","volume":"60","author":"Araki","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.jsbmb.2006.06.009_bib56","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1210\/mend-2-9-775","article-title":"Modulation by sex steroids and [D-Trp6, Des-Gly-NH2(10)]luteinizing hormone (LH)-releasing hormone ethylamide of alpha-subunit and LH beta messenger ribonucleic acid levels in the rat anterior pituitary gland","volume":"2","author":"Simard","year":"1988","journal-title":"Mol. Endocrinol."},{"issue":"3","key":"10.1016\/j.jsbmb.2006.06.009_bib57","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/09513599209015549","article-title":"Pituitary and ovarian suppression after early follicular and mid-luteal administration of a LHRH agonist in a depot formulation: decapeptyl CR","volume":"6","author":"Broekmans","year":"1992","journal-title":"Gynecol. Endocrinol."},{"issue":"6","key":"10.1016\/j.jsbmb.2006.06.009_bib58","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1159\/000126308","article-title":"Alterations in gonadotropin secretion in middle-aged persistent-estrous rats following LHRH agonist treatment","volume":"56","author":"Matt","year":"1992","journal-title":"Neuroendocrinology"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076006001580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076006001580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:53:06Z","timestamp":1760734386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076006001580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":58,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0960076006001580"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2006.06.009","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Actions of gonadotropin-releasing hormone analogues in pituitary gonadotrophs and their modulation by ovarian steroids","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2006.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}