{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T03:38:02Z","timestamp":1770521882350,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1-5","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.jsbmb.2007.05.013","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T07:58:18Z","timestamp":1180511898000},"page":"130-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Aromatase inhibitors\u2014Gene discovery"],"prefix":"10.1016","volume":"106","author":[{"given":"William R.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Larionov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorna","family":"Renshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garret","family":"Hampton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Krause","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean B.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Michael","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2007.05.013_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/sj.bjc.6602688","article-title":"Role of aromatase inhibitors in breast cancer","volume":"93","author":"Carpenter","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib2","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/S0959-8049(02)00265-4","article-title":"Neoadjuvant endocrine therapy of breast cancer: a surgical perspective","volume":"38","author":"Dixon","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib3","doi-asserted-by":"crossref","first-page":"355S","DOI":"10.1158\/1078-0432.CCR-031203","article-title":"Data from the arimidex, tamoxifen, alone or in combination (ATAC) trial: implications for use of aromatase inhibitors in 2003","volume":"10","author":"Buzdar","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib4","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1056\/NEJMoa040331","article-title":"A randomised trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer","volume":"350","author":"Coombes","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib5","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1023\/A:1013128213451","article-title":"Preoperative treatment of postmenopausal breast cancer patients with letrozole. A randomised double-blind multicentre study","volume":"12","author":"Eiermann","year":"2001","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib6","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1056\/NEJMoa032312","article-title":"A randomised trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer","volume":"349","author":"Goss","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib7","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMra023246","article-title":"Aromatase inhibitors in breast cancer","volume":"348","author":"Smith","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib8","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1200\/JCO.2003.04.596","article-title":"American Society of Clinical Oncology technology assessment working group update: use of aromatase inhibitors in the adjuvant setting","volume":"21","author":"Winer","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0093-7754(03)00302-6","article-title":"Aromatase inhibitors: mechanism of action and role in the treatment of breast cancer","volume":"30","author":"Miller","year":"2003","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib10","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1200\/JCO.2002.20.3.751","article-title":"Influence of letrozole and anastrozole on total body aromatization and plasma estrogen levels in postmenopausal breast cancer patients evaluated in a randomized, cross-over study","volume":"20","author":"Geisler","year":"2002","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0960-0760(01)00148-0","article-title":"Local endocrine effects of aromatase inhibitors within the breast","volume":"79","author":"Miller","year":"2001","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1521-690X(03)00044-7","article-title":"Biological rationale for endocrine therapy in breast cancer","volume":"18","author":"Miller","year":"2004","journal-title":"Best Practice Res. Clin. Endocr. Metab."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1054\/brst.2002.0408","article-title":"MIB-1 assessments in breast cancers","volume":"11","author":"Iqbal","year":"2002","journal-title":"Breast"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib14","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2144\/03343rr01","article-title":"Optimized protocol for linear RNA amplification and application to gene expression profiling of human renal biopsies","volume":"34","author":"Scherer","year":"2003","journal-title":"BioTechniques"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib15","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data","volume":"31","author":"Irizarry","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib17","unstructured":"R Development Core Team. R: a Language and Environment for Statistical Computing, R Foundation for Statistical Computing, Vienna, 2006."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib18","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib19","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib20","unstructured":"H. Schwender, A. Krause, K. Ickstadt, Identifying interesting genes with siggenes, R-News, in press."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib21","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","article-title":"Open source clustering software","volume":"20","author":"de Hoon","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib22","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1093\/bioinformatics\/bth349","article-title":"Java Treeview\u2014extensible visualization of microarray data","volume":"20","author":"Saldanha","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1677\/erc.0.0030065","article-title":"Aromatase inhibitors","volume":"3","author":"Miller","year":"1996","journal-title":"Endocr. Related Cancer"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib24","doi-asserted-by":"crossref","unstructured":"D.W. Combs, Recent developments in aromatase inhibitors, Expert Opin. Ther. Patients 5 (1995) 529\u2013534.","DOI":"10.1517\/13543776.5.6.529"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib25","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1517\/13543784.9.8.1897","article-title":"Pharmacology and clinical experience with exemestane","volume":"91","author":"Lonning","year":"2000","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib26","first-page":"1511","article-title":"In vitro measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer","volume":"1","author":"Dowsett","year":"1995","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1158\/1541-7786.MCR-04-0122","article-title":"Letrozole-, anastrozole- and tamoxifen-responsive genes in MCF-7aro cells: a microarray approach","volume":"3","author":"Itoh","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib28","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/sj.bjc.6603001","article-title":"Proliferation, steroid receptors and clinical\/pathological response in breast cancer treated with letrozole","volume":"94","author":"Miller","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0959-8049(02)00600-7","article-title":"Pathological features of breast cancer response following neoadjuvant treatment with either letrozole or tamoxifen","volume":"39","author":"Miller","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib30","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1210\/en.2003-0567","article-title":"Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype","volume":"144","author":"Frasor","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib31","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1200\/JCO.2005.03.2755","article-title":"Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers","volume":"24","author":"Oh","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib32","doi-asserted-by":"crossref","first-page":"R66","DOI":"10.1186\/gb-2004-5-9-r66","article-title":"Discovery of estrogen receptor \u03b1 target genes and response elements in breast tumor cells","volume":"5","author":"Lin","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib33","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1158\/0008-5472.CAN-03-3326","article-title":"Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells","volume":"64","author":"Frasor","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib34","first-page":"6367","article-title":"PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer","volume":"60","author":"Gosh","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib35","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1677\/erc.1.00905","article-title":"The anti-oestrogen ICI 182, 780, but not tamoxifen inhibits the growth of MCF-7 breast cancer cells refractory to long-term oestrogen deprivation through down-regulation of oestrogen receptor and IGF signalling","volume":"12","author":"Martin","year":"2005","journal-title":"Endocr. Related Cancer"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib36","first-page":"385","article-title":"Role of estrogen receptor alpha in modulating IGF-1 receptor signalling and function in breast cancer","volume":"23","author":"Surmacz","year":"2004","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib37","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1677\/erc.0.0100579","article-title":"Resistance to different antiestrogens is caused by different multi-factorial changes and is associated with reduced expression of IGF receptor I alpha","volume":"10","author":"Brockdorff","year":"2003","journal-title":"Endocr. Related Cancer"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib38","doi-asserted-by":"crossref","first-page":"12565","DOI":"10.1074\/jbc.275.17.12565","article-title":"Insulin receptor substrate-1 expression is regulated by estrogen in the MCF-7 human breast cancer cell line","volume":"275","author":"Molloy","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib39","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1200\/JCO.2001.19.18.3808","article-title":"Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and\/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial","volume":"19","author":"Ellis","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/sj.tpj.6500022","article-title":"Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies","volume":"1","author":"Dressman","year":"2001","journal-title":"Pharmacogenomics J."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib41","first-page":"1611","article-title":"Effect of estrogens and antiestrogens on growth-regulatory enzymes in human breast cancer cells in tissue culture","volume":"45","author":"Aitken","year":"1985","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib42","first-page":"488","article-title":"Estrogen regulates activity of cyclin-dependent kinases and retinoblastoma protein phosphorylation in breast cancer cells","volume":"10","author":"Foster","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib43","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1677\/jme.1.01677","article-title":"Anti-proliferative effect of estrogen in breast cancer cells that re-express Er\u03b1 is mediated by aberrant regulation of cell cycle genes","volume":"34","author":"Moggs","year":"2005","journal-title":"J. Mol. Endocr."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib44","first-page":"27","article-title":"Aromatase inhibitors and breast cancer","volume":"31","author":"Miller","year":"2006","journal-title":"Minerva Endocrinol."},{"key":"10.1016\/j.jsbmb.2007.05.013_bib45","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1677\/erc.1.00776","article-title":"Mechanisms of tamoxifen resistance","volume":"11","author":"Ring","year":"2004","journal-title":"Endocr. Related Cancer"},{"key":"10.1016\/j.jsbmb.2007.05.013_bib46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrc721","article-title":"Endocrine-responsive breast cancer and strategies for combating resistance","volume":"2","author":"Ali","year":"2002","journal-title":"Nat. Rev. Cancer"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076007001252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076007001252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:54:42Z","timestamp":1760734482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076007001252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":46,"journal-issue":{"issue":"1-5","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0960076007001252"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2007.05.013","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aromatase inhibitors\u2014Gene discovery","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2007.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}