{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:26:50Z","timestamp":1791282410548,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.jsbmb.2008.07.004","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T12:47:11Z","timestamp":1217249231000},"page":"20-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Transcriptional analysis of estrogen receptor alpha variant mRNAs in colorectal cancers and their matched normal colorectal tissues"],"prefix":"10.1016","volume":"112","author":[{"given":"Haiping","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyue","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisong","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2008.07.004_bib1","first-page":"632","article-title":"Expression of estrogen receptor (ER) subtypes and ER\u03b2 isoforms in colon cancer","volume":"61","author":"Martha","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib2","first-page":"3","article-title":"Cancer statistics, 2000","volume":"50","author":"Greenlee","year":"2000","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib3","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2398::AID-CNCR26>3.0.CO;2-I","article-title":"The annual report to the nation on the status of cancer, 1973\u20131997","volume":"88","author":"Ries","year":"2000","journal-title":"Cancer (Phila)"},{"key":"10.1016\/j.jsbmb.2008.07.004_bib4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00008469-199303000-00003","article-title":"Gender and colorectal cancer","volume":"2","author":"DeCosse","year":"1993","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/030089169107700313","article-title":"Patterns of large bowel cancer by subsite, age, sex, and marital status","volume":"77","author":"Levi","year":"1991","journal-title":"Tumori"},{"key":"10.1016\/j.jsbmb.2008.07.004_bib6","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1007\/BF02234219","article-title":"Estrogen replacement therapy and colorectal cancer risk in elderly women","volume":"42","author":"Paganini-Hill","year":"1999","journal-title":"Dis. Colon Rectum"},{"key":"10.1016\/j.jsbmb.2008.07.004_bib7","first-page":"880","article-title":"Hormone replacement therapy and the risk of colorectal cancer: a meta-analysis","volume":"93","author":"Nanda","year":"1999","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S0002-9343(99)00063-7","article-title":"Postmenopausal hormone therapy and the risk of colorectal cancer: a review and meta-analysis","volume":"106","author":"Grodstein","year":"1999","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib9","first-page":"653","article-title":"A meta-analysis of hormone replacement therapy and colon cancer in women","volume":"7","author":"Hebert-Croteau","year":"1998","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00008469-199812000-00002","article-title":"Colorectal cancer and hormone replacement therapy: an unexpected finding","volume":"7","author":"Franceschi","year":"1998","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib11","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1093\/emboj\/19.17.4688","article-title":"Identification of a new isoform of the human estrogen receptor-alpha (hER-\u03b1) that is encoded by distinct transcripts and that is able to repress hER-\u03b1 activation function 1","volume":"19","author":"Flouriot","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib12","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1210\/jcem.82.7.4212","article-title":"Expression of estrogen receptor beta in human breast tumors","volume":"82","author":"Dotzlaw","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib13","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1210\/mend-5-11-1571","article-title":"Estrogen receptor variants in clinical breast cancer","volume":"5","author":"McGuire","year":"1991","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib14","first-page":"105","article-title":"Variant human breast tumor estrogen receptor with constitutive activity","volume":"51","author":"Fuqua","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib15","first-page":"593","article-title":"Expression of a constitutionally active estrogen receptor variant in the estrogen receptor negative BT-20 human breast cancer cell line","volume":"53","author":"Castles","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib16","first-page":"4324","article-title":"Prevalence of estrogen receptor variant messenger RNAs in human breast cancer","volume":"56","author":"Leygue","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0960-0760(00)00033-9","article-title":"Identification of twenty alternatively spliced estrogen receptor alpha mRNAs in breast cancer cell lines and tumors using spliced targeted primer approach","volume":"72","author":"Poola","year":"2000","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib18","first-page":"2158","article-title":"Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and MCF-7 cells","volume":"55","author":"Pfeffer","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0303-7207(95)03576-S","article-title":"Human estrogen receptor mRNA variants in both normal and tumor tissues","volume":"112","author":"Gotteland","year":"1995","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib20","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ng0894-536","article-title":"Methylation of the oestrogen receptor CpG island links aging and neoplasia inhuman colon","volume":"7","author":"Issa","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib21","first-page":"5489","article-title":"Aging and DNA methylation in colorectal mucosa and cancer","volume":"58","author":"Nita","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib22","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1158\/0008-5472.CAN-06-3026","article-title":"Estrogen receptors A and B are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min\/+ mice","volume":"67","author":"Nancy","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib23","first-page":"2064","article-title":"ER\u03b1 gene expression in human primary osteoblasts: evidence for the expression of two receptor proteins","volume":"15","author":"Denger","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib24","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1073\/pnas.0831079100","article-title":"Plasma membrane localization and function of the estrogen receptor \u03b1 variant (ER46) in human endothelial cells","volume":"100","author":"Li","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib25","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1073\/pnas.0603339103","article-title":"A variant of estrogen receptor-\u03b1, hER-\u03b136: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling","volume":"103","author":"Wang","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib26","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/cncr.10274","article-title":"Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are distinct from profiles in breast tumors of Caucasian women","volume":"94","author":"Poola","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.jsbmb.2008.07.004_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Kenneth","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jsbmb.2008.07.004_bib28","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1136\/gut.34.5.611","article-title":"Sex differences in the incidence of colorectal cancer: an exploration of oestrogen and progesterone receptors","volume":"34","author":"Singh","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.jsbmb.2008.07.004_bib29","first-page":"3155","article-title":"Estrogen and progesterone receptors in gastric and colorectal cancer","volume":"46","author":"Oshima","year":"1999","journal-title":"Hepato-Gastroenterol."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1309\/5MHB-K6XX-QV50-PCJQ","article-title":"Estrogen and progesterone receptors in colon tumors","volume":"113","author":"Slattery","year":"2000","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-2407-7-56","article-title":"Estrogen receptor alpha (ER\u03b1) mRNA copy numbers in immunohistochemically ER\u03b1-positive-, and negative breast cancer tissues","volume":"7","author":"Poola","year":"2007","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jsbmb.2008.07.004_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1568008013341749","article-title":"Estrogen and colorectal cancer","volume":"1","author":"Di Leo","year":"2001","journal-title":"Curr. Drug Targets Immune Endocr. Metabol. Disord."},{"key":"10.1016\/j.jsbmb.2008.07.004_bib33","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1023\/A:1021053105096","article-title":"Distribution of estrogen receptor subtypes, expression of their variant forms, and clinicopathological characteristics of human colorectal cancer","volume":"47","author":"Cavallini","year":"2002","journal-title":"Dig. Dis. Sci."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007600800201X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096007600800201X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T20:57:19Z","timestamp":1760734639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096007600800201X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":33,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S096007600800201X"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2008.07.004","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional analysis of estrogen receptor alpha variant mRNAs in colorectal cancers and their matched normal colorectal tissues","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2008.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}