{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:57Z","timestamp":1776384057973,"version":"3.51.2"},"reference-count":21,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.jsbmb.2010.04.008","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T04:58:54Z","timestamp":1271653134000},"page":"84-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Crystal structure of hereditary vitamin D-resistant rickets\u2014Associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand"],"prefix":"10.1016","volume":"121","author":[{"given":"Natacha","family":"Rochel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Hourai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dino","family":"Moras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6 Suppl.","key":"10.1016\/j.jsbmb.2010.04.008_bib1","doi-asserted-by":"crossref","first-page":"1689S","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/sj.ki.5000091","article-title":"New insights into mineral and skeletal regulation by active forms of vitamin D","volume":"69","author":"Hendy","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib3","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1196\/annals.1402.070","article-title":"Vitamin D: molecular mechanism of action","volume":"1116","author":"Christakos","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib4","first-page":"726","article-title":"Vitamin D and human health: lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"Suppl. 3","key":"10.1016\/j.jsbmb.2010.04.008_bib5","first-page":"470","article-title":"Vitamin D receptor defects: the story of hereditary resistance to vitamin D","volume":"3","author":"Koren","year":"2007","journal-title":"Pediatr. Endocrinol. Rev."},{"issue":"Suppl. 2","key":"10.1016\/j.jsbmb.2010.04.008_bib6","doi-asserted-by":"crossref","first-page":"V105","DOI":"10.1359\/jbmr.07s210","article-title":"Vitamin D-resistant diseases","volume":"22","author":"Liberman","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib7","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1359\/jbmr.2004.19.6.1018","article-title":"A unique insertion\/substitution in helix H1 of the vitamin D receptor ligand binding domain in a patient with hereditary 1,25-dihydroxyvitamin D-resistant rickets","volume":"19","author":"Malloy","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI116539","article-title":"Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3","volume":"92","author":"Kristjansson","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib9","first-page":"1617","article-title":"Vitamin D receptors from patients with resistance to 1,25-dihydroxyvitamin D3: point mutations confer reduced transactivation in response to ligand and impaired interaction with the retinoid X receptor heterodimeric partner","volume":"10","author":"Whitfield","year":"1996","journal-title":"Mol. Endocrinol."},{"issue":"September (154 Suppl.)","key":"10.1016\/j.jsbmb.2010.04.008_bib10","first-page":"S57","article-title":"The vitamin D hormone and its nuclear receptor: molecular actions and disease states","author":"Haussler","year":"1997","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib11","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1172\/JCI119158","article-title":"Hereditary vitamin D resistant rickets caused by a novel mutation in the vitamin D receptor that results in decreased affinity for hormone and cellular hyporesponsiveness","volume":"99","author":"Malloy","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/mgme.2001.3181","article-title":"A novel inborn error in the ligand-binding domain of the vitamin D receptor causes hereditary vitamin D-resistant rickets","volume":"73","author":"Malloy","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib13","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1210\/me.2002-0152","article-title":"A novel mutation in helix 12 of the vitamin D receptor impairs coactivator interaction and causes hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia","volume":"16","author":"Malloy","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib14","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1210\/en.2004-0080","article-title":"Hereditary 1,25-dihydroxyvitamin D resistant rickets due to a mutation causing multiple defects in vitamin D receptor function","volume":"145","author":"Malloy","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2010.04.008_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1097-2765(00)80413-X","article-title":"The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand","volume":"5","author":"Rochel","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jsbmb.2010.04.008_bib16","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.2174\/156802606777864926","article-title":"Ligand binding domain of vitamin D receptors","volume":"6","author":"Rochel","year":"2006","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib17","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1021\/jm9014636","article-title":"Structure\u2013function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3","volume":"53","author":"Antony","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","article-title":"Crystallography & NMR system: a new software suite for macromolecular structure determination","volume":"54","author":"Brunger","year":"1998","journal-title":"Acta Crystallogr. D: Biol. Crystallogr."},{"key":"10.1016\/j.jsbmb.2010.04.008_bib20","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for building protein models in electron density maps and the location of errors in these models","volume":"47","author":"Jones","year":"1991","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/j.jsbmb.2010.04.008_bib21","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1046\/j.1432-1327.2001.01953.x","article-title":"Functional and structural characterization of the insertion region in the ligand binding domain of the vitamin D nuclear receptor","volume":"268","author":"Rochel","year":"2001","journal-title":"Eur. J. Biochem."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076010001986?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076010001986?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:41:02Z","timestamp":1760744462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076010001986"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":21,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0960076010001986"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2010.04.008","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crystal structure of hereditary vitamin D-resistant rickets\u2014Associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2010.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}