{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:05:21Z","timestamp":1792667121049,"version":"4.5.0"},"reference-count":145,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.jsbmb.2010.12.013","type":"journal-article","created":{"date-parts":[[2010,12,29]],"date-time":"2010-12-29T04:13:35Z","timestamp":1293596015000},"page":"66-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":195,"title":["17\u03b2-Hydroxysteroid dehydrogenases (17\u03b2-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development"],"prefix":"10.1016","volume":"125","author":[{"given":"Sandrine","family":"Marchais-Oberwinkler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Henn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Negri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Oster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Spadaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Werth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Wetzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuiying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Frotscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf W.","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Adamski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jsbmb.2010.12.013_bib0005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/03602530600969440","article-title":"Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase\/reductase superfamily","volume":"39","author":"Hoffmann","year":"2007","journal-title":"Drug Metab. Rev."},{"issue":"1","key":"10.1016\/j.jsbmb.2010.12.013_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2133\/dmpk.21.1","article-title":"Multiplicity of mammalian reductases for xenobiotic carbonyl compounds","volume":"21","author":"Matsunaga","year":"2006","journal-title":"Drug Metab. Pharmacokinet."},{"issue":"4","key":"10.1016\/j.jsbmb.2010.12.013_bib0015","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0006-2952(94)00330-O","article-title":"Xenobiotic carbonyl reduction and physiological steroid oxidoreduction. The pluripotency of several hydroxysteroid dehydrogenases","volume":"49","author":"Maser","year":"1995","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0020","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1210\/endo-123-3-1412","article-title":"Androgenic activity of dehydroepiandrosterone and androstenedione in the rat ventral prostate","volume":"123","author":"Labrie","year":"1988","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0025","doi-asserted-by":"crossref","first-page":"C113","DOI":"10.1016\/0303-7207(91)90116-A","article-title":"Intracrinology","volume":"78","author":"Labrie","year":"1991","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0030","first-page":"281","article-title":"Molecular endocrinology of hydroxysteroid dehydrogenases","volume":"18","author":"Penning","year":"1997","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0035","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0083-6729(00)58023-6","article-title":"Steroid dehydrogenase structures, mechanism of action, and disease","volume":"58","author":"Duax","year":"2000","journal-title":"Vitam. Horm."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2009.04.005","article-title":"Non-genomic signaling by steroids","volume":"308","author":"Prossnitz","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0045","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.1106943","article-title":"A transmembrane intracellular estrogen receptor mediates rapid cell signaling","volume":"307","author":"Revankar","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jsbmb.2010.12.013_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.0.0250001","article-title":"Intracrinology: role of the family of 17beta-hydroxysteroid dehydrogenases in human physiology and disease","volume":"25","author":"Labrie","year":"2000","journal-title":"J. Mol. Endocrinol."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0055","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/humupd\/dmg022","article-title":"Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action","volume":"9","author":"Penning","year":"2003","journal-title":"Hum. Reprod. Update"},{"issue":"15","key":"10.1016\/j.jsbmb.2010.12.013_bib0060","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1021\/jm060186y","article-title":"Lead optimization providing a series of flavone derivatives as potent nonsteroidal inhibitors of the cytochrome P450 aromatase enzyme","volume":"49","author":"Gobbi","year":"2006","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0065","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1021\/ci050237k","article-title":"Pharmacophore modeling and in silico screening for new P450 19 (aromatase) inhibitors","volume":"46","author":"Schuster","year":"2006","journal-title":"J. Chem. Inf. Model."},{"issue":"27","key":"10.1016\/j.jsbmb.2010.12.013_bib0070","doi-asserted-by":"crossref","first-page":"6792","DOI":"10.1021\/jm049535j","article-title":"Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors","volume":"47","author":"Leonetti","year":"2004","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0075","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0960-894X(98)00737-9","article-title":"New selective nonsteroidal aromatase inhibitors: synthesis and inhibitory activity of 2,3 or 5-(alpha-azolylbenzyl)-1H-indoles","volume":"9","author":"Le Borgne","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"5","key":"10.1016\/j.jsbmb.2010.12.013_bib0080","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ardp.19973300506","article-title":"Synthesis and in vitro evaluation of 3-(1-azolylmethyl)-1H-indoles and 3-(1-azolyl-1-phenylmethyl)-1H-indoles as inhibitors of P450 arom","volume":"330","author":"Le Borgne","year":"1997","journal-title":"Arch. Pharm."},{"issue":"11","key":"10.1016\/j.jsbmb.2010.12.013_bib0085","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/S0960-894X(99)00234-6","article-title":"N-substituted 4-(5-indolyl)benzoic acids. Synthesis and evaluation of steroid 5alpha-reductase type I and II inhibitory activity","volume":"9","author":"Baston","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"7","key":"10.1016\/j.jsbmb.2010.12.013_bib0090","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/1521-4184(20007)333:7<201::AID-ARDP201>3.0.CO;2-D","article-title":"5 alpha-reductase in intact DU145 cells: evidence for isozyme I and evaluation of novel inhibitors","volume":"333","author":"Reichert","year":"2000","journal-title":"Arch. Pharm."},{"issue":"6","key":"10.1016\/j.jsbmb.2010.12.013_bib0095","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/S0968-0896(00)00070-5","article-title":"Synthesis of N-substituted piperidine-4-(benzylidene-4-carboxylic acids) and evaluation as inhibitors of steroid-5alpha-reductase type 1 and 2","volume":"8","author":"Picard","year":"2000","journal-title":"Bioorg. Med. Chem."},{"issue":"5","key":"10.1016\/j.jsbmb.2010.12.013_bib0100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/1475636021000059092","article-title":"6-Substituted 3,4-dihydro-naphthalene-2-carboxylic acids: synthesis and structure\u2013activity studies in a novel class of human 5alpha reductase inhibitors","volume":"17","author":"Baston","year":"2002","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.steroids.2009.10.005","article-title":"An overview on 5alpha-reductase inhibitors","volume":"75","author":"Aggarwal","year":"2010","journal-title":"Steroids"},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0110","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0968-0896(01)00293-0","article-title":"5-Phenyl substituted 1-methyl-2-pyridones and 4\u2032-substituted biphenyl-4-carboxylic acids. Synthesis and evaluation as inhibitors of steroid-5alpha-reductase type 1 and 2","volume":"10","author":"Picard","year":"2002","journal-title":"Bioorg. Med. Chem."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0115","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jsbmb.2008.12.024","article-title":"Recent advances in 17beta-hydroxysteroid dehydrogenases","volume":"114","author":"Prehn","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.2009.03700.x","article-title":"Steroid hormone transforming aldo-keto reductases and cancer","volume":"1155","author":"Penning","year":"2009","journal-title":"Ann. N.Y. Acad. Sci."},{"issue":"1\u20133","key":"10.1016\/j.jsbmb.2010.12.013_bib0125","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cbi.2008.10.040","article-title":"The SDR (short-chain dehydrogenase\/reductase and related enzymes) nomenclature initiative","volume":"178","author":"Persson","year":"2009","journal-title":"Chem. Biol. Interact."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0130","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mce.2008.10.040","article-title":"Integrated view on 17beta-hydroxysteroid dehydrogenases","volume":"301","author":"M\u00f6ller","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1\u20135","key":"10.1016\/j.jsbmb.2010.12.013_bib0135","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0960-0760(00)00155-2","article-title":"Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase","volume":"76","author":"Luu-The","year":"2001","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1749-6632.2009.03702.x","article-title":"Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease","volume":"1155","author":"Meier","year":"2009","journal-title":"Ann. N.Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0145","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1042\/BJ20061319","article-title":"Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity","volume":"402","author":"Lukacik","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0150","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jmb.2010.04.002","article-title":"Molecular framework of steroid\/retinoid discrimination in 17beta-hydroxysteroid dehydrogenase type 1 and photoreceptor-associated retinol dehydrogenase","volume":"399","author":"Haller","year":"2010","journal-title":"J. Mol. Biol."},{"issue":"8","key":"10.1016\/j.jsbmb.2010.12.013_bib0155","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1210\/en.2007-0365","article-title":"Transgenic male mice expressing human hydroxysteroid dehydrogenase 2 indicate a role for the enzyme independent of its action on sex steroids","volume":"148","author":"Zhongyi","year":"2007","journal-title":"Endocrinology"},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0160","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mce.2005.12.007","article-title":"Structure and function of human 17beta-hydroxysteroid dehydrogenases","volume":"248","author":"Lukacik","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"issue":"5","key":"10.1016\/j.jsbmb.2010.12.013_bib0165","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/ijc.1525","article-title":"Involvement of up-regulation of 17beta-hydroxysteroid dehydrogenase type 1 in maintenance of intratumoral high estradiol levels in postmenopausal breast cancers","volume":"94","author":"Miyoshi","year":"2001","journal-title":"Int. J. Cancer"},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0170","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jsbmb.2008.12.012","article-title":"17beta-hydroxysteroid dehydrogenase enzymes and breast cancer","volume":"144","author":"Jansson","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"4\u20135","key":"10.1016\/j.jsbmb.2010.12.013_bib0175","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0960-0760(02)00117-6","article-title":"Androgenic and estrogenic 17beta-hydroxysteroid dehydrogenase\/17-ketosteroid reductase in human ovarian epithelial tumors: evidence for the type 1, 2 and 5 isoforms","volume":"81","author":"Blomquist","year":"2002","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0180","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/09513590601152219","article-title":"Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis","volume":"23","author":"\u0160muc","year":"2007","journal-title":"Gynecol. Endocrinol."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0185","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2353\/ajpath.2010.090325","article-title":"Novel hydroxysteroid (17beta) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice","volume":"176","author":"Saloniemi","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.jsbmb.2010.12.013_bib0190","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1210\/jc.2003-032085","article-title":"Increased expression of type I 17beta-hydroxysteroid dehydrogenase enhances in situ production of estradiol in uterine leiomyoma","volume":"89","author":"Kasai","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"16","key":"10.1016\/j.jsbmb.2010.12.013_bib0195","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1056\/NEJM199310143291601","article-title":"The effect of postmenopausal estrogen therapy on bone density in elderly women","volume":"329","author":"Felson","year":"1993","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.jsbmb.2010.12.013_bib0200","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1001\/jama.287.6.734","article-title":"Hormone replacement therapy in relation to breast cancer","volume":"287","author":"Chen","year":"2002","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0205","first-page":"267","article-title":"Effect of 17beta-hydroxysteroid dehydrogenase type 2 inhibitor on bone strength in ovariectomized cynomolgus monkeys","volume":"8","author":"Bagi","year":"2008","journal-title":"J. Musculoskelet. Neuronal. Interact."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0210","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/pros.10139","article-title":"Differential expression of 17beta-hydroxysteroid dehydrogenase isozyme genes in prostate cancer and noncancer tissues","volume":"53","author":"Koh","year":"2002","journal-title":"Prostate"},{"issue":"4","key":"10.1016\/j.jsbmb.2010.12.013_bib0215","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tem.2005.03.006","article-title":"Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase","volume":"16","author":"Yang","year":"2005","journal-title":"Trends Endocrinol. Metab."},{"issue":"6652","key":"10.1016\/j.jsbmb.2010.12.013_bib0220","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/39522","article-title":"An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease","volume":"389","author":"Yan","year":"1997","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0225","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0014-5793(99)00586-4","article-title":"Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease","volume":"451","author":"Oppermann","year":"1999","journal-title":"FEBS Lett."},{"issue":"5669","key":"10.1016\/j.jsbmb.2010.12.013_bib0230","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1091230","article-title":"ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease","volume":"304","author":"Lustbader","year":"2004","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0235","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jmb.2004.07.071","article-title":"Crystal structure of human ABAD\/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics","volume":"342","author":"Kissinger","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0240","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mce.2006.12.021","article-title":"Cofactors, redox state, and directional preferences of hydroxysteroid dehydrogenases","volume":"265\u2013266","author":"Sherbet","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"issue":"11","key":"10.1016\/j.jsbmb.2010.12.013_bib0245","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1073\/pnas.70.11.3052","article-title":"d-Glyceraldehyde-3-phosphate dehydrogenase: three-dimensional structure and evolutionary significance","volume":"70","author":"Buehner","year":"1973","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"11","key":"10.1016\/j.jsbmb.2010.12.013_bib0250","first-page":"2010","article-title":"Critical residues for the specificity of cofactors and substrates in human estrogenic 17beta-hydroxysteroid dehydrogenase 1: variants designed from the three-dimensional structure of the enzyme","volume":"15","author":"Huang","year":"2001","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.jsbmb.2010.12.013_bib0255","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1570-9639(02)00434-X","article-title":"Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation\/reduction kinetics","volume":"1601","author":"McKeever","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.jsbmb.2010.12.013_bib0260","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1210\/en.2008-1817","article-title":"Biochemical factors governing the steady-state estrone\/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells","volume":"150","author":"Sherbet","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0265","doi-asserted-by":"crossref","unstructured":"P. Lukacik, N. Shafqat, K. Kavanagh, J. Bray, F. Von Delft, A. Edwards, C. Arrowsmith, M. Sundstrom, U. Oppermann, Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 4 in complex with NAD (2010), doi:10.2210\/pdb1zbq\/pdb.","DOI":"10.2210\/pdb1zbq\/pdb"},{"issue":"1\u20136","key":"10.1016\/j.jsbmb.2010.12.013_bib0270","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0960-0760(99)00038-2","article-title":"Molecular determinants of steroid recognition and catalysis in aldo-keto reductases. Lessons from 3alpha-hydroxysteroid dehydrogenase","volume":"69","author":"Penning","year":"1999","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0275","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/bj3040289","article-title":"Site-directed mutagenesis of the putative active site of human 17\u03b2-hydroxysteroid dehydrogenase type 1","volume":"304","author":"Puranen","year":"1994","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.jsbmb.2010.12.013_bib0280","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1074\/jbc.M411751200","article-title":"Mechanistic roles of Ser-114, Tyr-155, and Lys-159 in 3alpha-hydroxysteroid dehydrogenase\/carbonyl reductase from Comamonas testosteroni","volume":"280","author":"Hwang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"28","key":"10.1016\/j.jsbmb.2010.12.013_bib0285","doi-asserted-by":"crossref","first-page":"25677","DOI":"10.1074\/jbc.M202160200","article-title":"Critical residues for structure and catalysis in short-chain dehydrogenases\/reductases","volume":"277","author":"Filling","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1\u20133","key":"10.1016\/j.jsbmb.2010.12.013_bib0290","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0009-2797(00)00255-6","article-title":"Molecular mechanisms of estrogen recognition and 17-keto reduction by human 17beta-hydroxysteroid dehydrogenase 1","volume":"130\u2013132","author":"Ghosh","year":"2001","journal-title":"Chem. Biol. Interact."},{"issue":"24","key":"10.1016\/j.jsbmb.2010.12.013_bib0295","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1007\/s00018-008-8588-y","article-title":"The SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes","volume":"65","author":"Kavanagh","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0300","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.mce.2005.12.009","article-title":"Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors","volume":"248","author":"Penning","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.jsbmb.2010.12.013_bib0305","first-page":"77","article-title":"Characterization of structural and functional properties of human 17\u03b2-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis","volume":"11","author":"Puranen","year":"1997","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0310","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1096\/fj.02-0397fje","article-title":"Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17\u03b2-hydroxysteroid dehydrogenase","volume":"17","author":"Gangloff","year":"2003","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0315","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1074\/jbc.275.2.1105","article-title":"Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18\/c-19 steroid discrimination and enzyme-induced strain","volume":"275","author":"Han","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.jsbmb.2010.12.013_bib0320","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nsb0896-665","article-title":"Crystal structure of human estrogenic 17\u03b2-hydroxysteroid dehydrogenase complexed with 17\u03b2-estradiol","volume":"3","author":"Azzi","year":"1996","journal-title":"Nat. Struct. Biol."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0325","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mce.2005.12.004","article-title":"Active site analysis of 17\u03b2-hydroxysteroid dehydrogenase type 1 enzyme complexes with SPROUT","volume":"248","author":"Alho-Richmond","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0330","doi-asserted-by":"crossref","unstructured":"M. Negri, M. Recanatini, R.W. Hartmann, Dynamic motion investigation of 17\u03b2-HSD1 provides insights in its enzyme kinetics and ligand binding, PLoS ONE, 5 (8) (2010): e120026. doi:10.1371\/journal.pone0012026.","DOI":"10.1371\/journal.pone.0012026"},{"issue":"21","key":"10.1016\/j.jsbmb.2010.12.013_bib0335","doi-asserted-by":"crossref","first-page":"6724","DOI":"10.1021\/jm901195w","article-title":"New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity","volume":"52","author":"Bey","year":"2009","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.jsbmb.2010.12.013_bib0340","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1210\/endo.137.5.8612487","article-title":"Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes","volume":"137","author":"Akinola","year":"1996","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0345","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1432-1033.1996.00482.x","article-title":"Molecular cloning of mouse 17\u03b2-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity","volume":"236","author":"Nokelainen","year":"1996","journal-title":"Eur. J. Biochem."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0350","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1677\/jme.1.01853","article-title":"Androgen metabolism via 17\u03b2-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme","volume":"35","author":"Mindnich","year":"2005","journal-title":"J. Mol. Endocrinol."},{"issue":"3\u20135","key":"10.1016\/j.jsbmb.2010.12.013_bib0355","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jsbmb.2009.02.006","article-title":"Selective inhibition of 17\u03b2-hydroxysteroid dehydrogenase type 1 (17\u03b2HSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells","volume":"114","author":"Kruchten","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"6","key":"10.1016\/j.jsbmb.2010.12.013_bib0360","doi-asserted-by":"crossref","first-page":"e10969","DOI":"10.1371\/journal.pone.0010969","article-title":"Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1","volume":"5","author":"M\u00f6ller","year":"2010","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0365","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0960-0760(96)00165-3","article-title":"Sequence of mouse 17beta-hydroxysteroid dehydrogenase type 3 cDNA and tissue distribution of the type 1 and type 3 isoform mRNAs","volume":"60","author":"Sha","year":"1997","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"6","key":"10.1016\/j.jsbmb.2010.12.013_bib0370","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2174\/0929867033368222","article-title":"Inhibitors of 17\u03b2-hydroxysteroid dehydrogenases","volume":"10","author":"Poirier","year":"2003","journal-title":"Curr. Med. Chem."},{"issue":"6","key":"10.1016\/j.jsbmb.2010.12.013_bib0375","doi-asserted-by":"crossref","first-page":"642","DOI":"10.2174\/187152009788680000","article-title":"Advances in development of inhibitors of 17\u03b2-hydroxysteroid dehydrogenases","volume":"9","author":"Poirier","year":"2009","journal-title":"Anticancer Agents Med. Chem."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0380","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2174\/092986708783330629","article-title":"Inhibitors of 17\u03b2-hydroxysteroid dehydrogenase type 1","volume":"15","author":"Bro\u017ei\u010d","year":"2008","journal-title":"Curr. Med. Chem."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0385","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1677\/ERC-08-0042","article-title":"Design and validation of specific inhibitors of 17\u03b2-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis","volume":"15","author":"Day","year":"2008","journal-title":"Endocr. Relat. Cancer"},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0390","first-page":"87","article-title":"17\u03b2-Hydroxysteroid dehydrogenase inhibitors","volume":"35","author":"Day","year":"2010","journal-title":"Minerva Endocrinol."},{"issue":"4\u20135","key":"10.1016\/j.jsbmb.2010.12.013_bib0395","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jsbmb.2009.07.004","article-title":"Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17\u03b2-hydroxysteroid dehydrogenase type 1","volume":"117","author":"Michiels","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"13","key":"10.1016\/j.jsbmb.2010.12.013_bib0400","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1096\/fj.02-0026fje","article-title":"A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity","volume":"16","author":"Qiu","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0405","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1139\/V09-083","article-title":"Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol-adenosine hybrids as inhibitors of 17\u03b2-hydroxysteroid dehydrogenase type 1","volume":"87","author":"Berube","year":"2009","journal-title":"Can. J. Chem."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0410","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3390\/molecules15031590","article-title":"Preparation of 6beta-estradiol derivative libraries as bisubstrate inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 using the multidetachable sulfamate linker","volume":"15","author":"Berube","year":"2010","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0415","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1042\/BJ20091020","article-title":"Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy","volume":"424","author":"Mazumdar","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0420","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1874940200801010061","article-title":"Chemical synthesis, 17\u03b2-hydroxysteroid dehydrogenase type 1 inhibitory activity and assessment of in vitro and in vivo estrogenic activities of estradiol derivatives","volume":"1","author":"Rouillard","year":"2008","journal-title":"Open Enzyme Inhib. J."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0425","unstructured":"J. Messinger, B. Husen, U. Schoen, H. Thole, P. Koskimies, M. Unkila, Substituted estratrien derivatives as 17beta HSD inhibitors, WO2008\/065100 (2008)."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0430","unstructured":"J. Messinger, U. Schoen, B. Husen, H. Thole, P. Koskimies, L. Kallio, Therapeutically active triazoles and their use, WO2008\/034796 (2008)."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0435","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.mce.2008.10.022","article-title":"Estrone C15 derivatives \u2013 a new class of 17beta-hydroxysteroid dehydrogenase type 1 inhibitors","volume":"301","author":"Messinger","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"23","key":"10.1016\/j.jsbmb.2010.12.013_bib0440","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1016\/j.bmcl.2009.09.113","article-title":"Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and d-homo-estrone","volume":"19","author":"M\u00f6ller","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"12","key":"10.1016\/j.jsbmb.2010.12.013_bib0445","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1021\/jm0600794","article-title":"The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening","volume":"49","author":"Schuster","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0450","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2174\/157018007780077417","article-title":"Search for potential non-steroidal inhibitors of 17\u03b2-hydroxysteroid dehydrogenase (17\u03b2-HSD) in the treatment of hormone-dependent cancers","volume":"4","author":"Lota","year":"2007","journal-title":"Lett. Drug Des. Dis."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0455","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2174\/157018008783406705","article-title":"Inhibition of 17\u03b2-hydroxysteroid dehydrogenase (17\u03b2-HSD) by imidazole-based compounds","volume":"5","author":"Olusjano","year":"2008","journal-title":"Lett. Drug Des. Dis."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0460","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2174\/157341310790226397","article-title":"Effect of free and in poly(\u03b7-caprolactone) nanoparticles incorporated new type 1 17beta-hydroxysteroid dehydrogenase inhibitors on cancer cells","volume":"6","author":"Kocbek","year":"2010","journal-title":"Curr. Nanosci."},{"issue":"8","key":"10.1016\/j.jsbmb.2010.12.013_bib0465","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1016\/j.bmc.2008.02.059","article-title":"Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design","volume":"16","author":"Allan","year":"2008","journal-title":"Bioorg. Med. Chem."},{"issue":"21","key":"10.1016\/j.jsbmb.2010.12.013_bib0470","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1021\/jm900928k","article-title":"Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core","volume":"52","author":"Lilienkampf","year":"2009","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0475","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/cmdc.200700271","article-title":"A 3D QSAR model of 17beta-HSD1 inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core applying molecular dynamics simulations and ligand\u2013protein docking","volume":"3","author":"Karkola","year":"2008","journal-title":"ChemMedChem"},{"issue":"7","key":"10.1016\/j.jsbmb.2010.12.013_bib0480","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1021\/jm701447v","article-title":"Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases","volume":"51","author":"Frotscher","year":"2008","journal-title":"J. Med. Chem."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0485","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.mce.2008.09.024","article-title":"Structure\u2013activity study in the class of 6-(3\u2032-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors","volume":"301","author":"Marchais-Oberwinkler","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"15","key":"10.1016\/j.jsbmb.2010.12.013_bib0490","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.1021\/jm800367k","article-title":"Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics","volume":"51","author":"Marchais-Oberwinkler","year":"2008","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.jsbmb.2010.12.013_bib0495","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1016\/j.bmc.2008.04.073","article-title":"Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases","volume":"16","author":"Bey","year":"2008","journal-title":"Bioorg. Med. Chem."},{"issue":"21","key":"10.1016\/j.jsbmb.2010.12.013_bib0500","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.1021\/jm8006917","article-title":"Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1)","volume":"51","author":"Bey","year":"2008","journal-title":"J. Med. Chem."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0505","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mce.2008.09.012","article-title":"The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 1 and type 2","volume":"301","author":"Al-Soud","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0510","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1021\/ja00090a009","article-title":"Representation of molecular electrostatic potentials by topological feature maps","volume":"116","author":"Gasteiger","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0515","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1016\/j.bmc.2010.03.065","article-title":"Novel estrone mimetics with high 17\u03b2-HSD1 inhibitory activity","volume":"18","author":"Oster","year":"2010","journal-title":"Bioorg. Med. Chem."},{"issue":"10\u201311","key":"10.1016\/j.jsbmb.2010.12.013_bib0520","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.crci.2009.05.005","article-title":"Development of biological assays for the identification of selective inhibitors of estradiol formation from estrone in rat liver preparations","volume":"12","author":"Kruchten","year":"2009","journal-title":"C. R. Chim."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0525","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.mce.2008.08.005","article-title":"The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors","volume":"301","author":"Vicker","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.jsbmb.2010.12.013_bib0530","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.bmcl.2009.10.111","article-title":"Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer","volume":"20","author":"Harada","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.jsbmb.2010.12.013_bib0730","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/toxsci\/kfq030","article-title":"Perfluorooctanoic acid effects on steroid hormone and growth factor levels mediate stimulation of peripubertal mammary gland development in C57BL\/6 mice","volume":"115","author":"Zhao","year":"2010","journal-title":"Toxicol. Sci."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0540","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0303-7207(00)00427-5","article-title":"Inhibitors of type II 17beta-hydroxysteroid dehydrogenase","volume":"171","author":"Poirier","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0545","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.ejmech.2008.03.020","article-title":"Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities","volume":"44","author":"Bydal","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0550","unstructured":"A. Kakefuda, Y. Kondoh, M. Hirano, A. Kamikawa, K. Enjo, T. Furutani, Benzimidazole derivatives, WO2009\/014150 (2009)."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0555","unstructured":"T. Niimi, A. Kamikawa, Y. Amano, T. Yamaguchi, K. Suzumura, K. Enjo, T. Furutani, A. Kakefuda, Y. Kondoh, M. Hirano, 17beta-HSD type 5 inhibitor, US2009\/0181960 (2009)."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0560","doi-asserted-by":"crossref","first-page":"7488","DOI":"10.1021\/jm900921c","article-title":"Potent and selective steroidal inhibitors of 17\u03b2-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone","volume":"52","author":"Bellevance","year":"2009","journal-title":"J. Med. Chem."},{"issue":"4","key":"10.1016\/j.jsbmb.2010.12.013_bib0735","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1210\/en.2009-0928","article-title":"Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos","volume":"151","author":"Jokela","year":"2010","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.jsbmb.2010.12.013_bib0740","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1210\/en.2009-0929","article-title":"Hydroxysteroid (17{beta}) dehydrogenase 12 is essential for mouse organogenesis and embryonic survival","volume":"151","author":"Rantakari","year":"2010","journal-title":"Endocrinology"},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0575","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mce.2005.11.042","article-title":"Evaluation of inhibitors for 17beta-hydroxysteroid dehydrogenase type 1 in vivo in immunodeficient mice inoculated with MCF-7 cells stably expressing the recombinant human enzyme","volume":"248","author":"Husen","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"issue":"11","key":"10.1016\/j.jsbmb.2010.12.013_bib0580","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.1210\/en.2006-0778","article-title":"Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts","volume":"147","author":"Husen","year":"2006","journal-title":"Endocrinology"},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0585","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.mce.2005.11.044","article-title":"New inhibitors of 17beta-hydroxysteroid dehydrogenase type 1","volume":"248","author":"Messinger","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"issue":"9","key":"10.1016\/j.jsbmb.2010.12.013_bib0590","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1002\/ijc.23350","article-title":"17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer","volume":"122","author":"Day","year":"2008","journal-title":"Int. J. Cancer"},{"issue":"8","key":"10.1016\/j.jsbmb.2010.12.013_bib0595","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1093\/humrep\/16.8.1736","article-title":"Peritoneal endometriosis: validation of an in-vivo model","volume":"16","author":"Gr\u00fcmmer","year":"2001","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0600","unstructured":"S. Firnhaber, Expression und Regulation von Enzymen des \u00d6strogenmetabolismus in humanen Endometriuml\u00e4sionen kultiviert in der Nacktmaus, PhD-thesis, Universit\u00e4t Duisburg-Essen, Essen Fachbereich Biologie und Geographie, 2006."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0605","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.mce.2008.10.034","article-title":"In vivo mouse model for analysis of hydroxysteroid (17beta) dehydrogenase 1 inhibitors","volume":"301","author":"Lamminen","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"5","key":"10.1016\/j.jsbmb.2010.12.013_bib0610","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/molehr\/gal031","article-title":"Induction of endometriosis in the marmoset monkey (Callithrix jacchus)","volume":"12","author":"Einspanier","year":"2006","journal-title":"Mol. Hum. Reprod."},{"issue":"3","key":"10.1016\/j.jsbmb.2010.12.013_bib0615","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1210\/me.2007-0257","article-title":"Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene","volume":"22","author":"Rantakari","year":"2008","journal-title":"Mol. Endocrinol."},{"issue":"8","key":"10.1016\/j.jsbmb.2010.12.013_bib0620","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1359\/jbmr.080322","article-title":"Overexpression of human hydroxysteroid (17beta) dehydrogenase 2 induces disturbance in skeletal development in young male mice","volume":"23","author":"Shen","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0625","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.mce.2008.08.014","article-title":"Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3","volume":"301","author":"Day","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"35","key":"10.1016\/j.jsbmb.2010.12.013_bib0630","doi-asserted-by":"crossref","first-page":"27100","DOI":"10.1016\/S0021-9258(19)61485-7","article-title":"Amyloid beta-peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stress","volume":"275","author":"Du Yan","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0635","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/nar\/gki198","article-title":"MAFFT version 5: improvement in accuracy of multiple sequence alignment","volume":"33","author":"Katoh","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.jsbmb.2010.12.013_bib0640","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview Version 2 \u2013 a multiple sequence alignment editor and analysis workbench","volume":"25","author":"Waterhouse","year":"2009","journal-title":"Bioinformatics"},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0645","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.mce.2005.12.005","article-title":"Control of cell proliferation by steroids: the role of 17HSDs","volume":"248","author":"Vihko","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2\u20135","key":"10.1016\/j.jsbmb.2010.12.013_bib0650","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jsbmb.2005.01.002","article-title":"Enzymes as modulators in malignant transformation","volume":"93","author":"Vihko","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0655","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ng0594-34","article-title":"Male pseudohermaphroditism caused by mutations of testicular 17\u03b2-hydroxysteroid dehydrogenase 3","volume":"7","author":"Geissler","year":"1994","journal-title":"Nat. Genet."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0660","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2008.11.021","article-title":"HSD17B4 overexpression, an independent biomarker of poor patient outcome in prostate cancer","volume":"301","author":"Rasiah","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jsbmb.2010.12.013_bib0665","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.pharmtox.47.120505.105337","article-title":"Aldo\u2013keto reductases and bioactivation\/detoxication","volume":"47","author":"Jin","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.jsbmb.2010.12.013_bib0670","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1158\/0008-5472.CAN-05-4000","article-title":"Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer","volume":"66","author":"Stanbrough","year":"2006","journal-title":"Cancer Res."},{"issue":"25","key":"10.1016\/j.jsbmb.2010.12.013_bib0675","doi-asserted-by":"crossref","first-page":"15959","DOI":"10.1074\/jbc.272.25.15959","article-title":"Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate","volume":"272","author":"Biswas","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.jsbmb.2010.12.013_bib0745","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1158\/1078-0432.CCR-09-2481","article-title":"Intratumoral estrogen disposition in breast cancer","volume":"16","author":"Haynes","year":"2010","journal-title":"Clin. Cancer Res."},{"issue":"35","key":"10.1016\/j.jsbmb.2010.12.013_bib0685","doi-asserted-by":"crossref","first-page":"22664","DOI":"10.1074\/jbc.273.35.22664","article-title":"Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues","volume":"273","author":"Fomitcheva","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"42","key":"10.1016\/j.jsbmb.2010.12.013_bib0690","doi-asserted-by":"crossref","first-page":"25213","DOI":"10.1074\/jbc.270.42.25213","article-title":"Ke 6 gene. Sequence and organization and aberrant regulation in murine polycystic kidney disease","volume":"270","author":"Maxwell","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.jsbmb.2010.12.013_bib0695","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1210\/endo.140.11.7137","article-title":"Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17beta\/3alpha-hydroxysteroid\/retinoid short chain dehydrogenase\/reductase","volume":"140","author":"Su","year":"1999","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0700","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ajhg.2007.11.002","article-title":"Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation","volume":"82","author":"Froyen","year":"2008","journal-title":"Am. J. Hum. Genet."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0705","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ymgme.2007.06.001","article-title":"HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids","volume":"92","author":"Yang","year":"2007","journal-title":"Mol. Genet. Metab."},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2010.12.013_bib0710","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0303-7207(00)00417-2","article-title":"Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung","volume":"171","author":"Brereton","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0715","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1210\/me.2005-0058","article-title":"Characterization of type 12 17beta-hydroxysteroid dehydrogenase (17beta-HSD12), an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women","volume":"20","author":"Luu-The","year":"2006","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.jsbmb.2010.12.013_bib0720","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbrc.2008.03.063","article-title":"17beta-hydroxysteroid dehydrogenase type 13 is a liver-specific lipid droplet-associated protein","volume":"370","author":"Horiguchi","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"23","key":"10.1016\/j.jsbmb.2010.12.013_bib0725","doi-asserted-by":"crossref","first-page":"11471","DOI":"10.1158\/0008-5472.CAN-06-1448","article-title":"17beta-hydroxysteroid dehydrogenase 14 affects estradiol levels in breast cancer cells and is a prognostic marker in estrogen receptor-positive breast cancer","volume":"66","author":"Jansson","year":"2006","journal-title":"Cancer Res."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076010003973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076010003973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:38:07Z","timestamp":1760744287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076010003973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":145,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0960076010003973"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2010.12.013","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"17\u03b2-Hydroxysteroid dehydrogenases (17\u03b2-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2010.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}