{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:12:43Z","timestamp":1792152763864,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.jsbmb.2012.05.002","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T06:49:10Z","timestamp":1337064550000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["1,25(OH)2D3 inhibits the deleterious effects induced by high glucose on osteoblasts through undercarboxylated osteocalcin and insulin signaling"],"prefix":"10.1016","volume":"132","author":[{"given":"Ying-ying","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2012.05.002_bib0005","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jnutbio.2010.03.010","article-title":"Vitamin D3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats","volume":"22","author":"Kumar","year":"2011","journal-title":"The Journal of Nutritional Biochemistry"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0010","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/1097-4636(2000)53:6<702::AID-JBM13>3.0.CO;2-V","article-title":"Wound healing around boneanchored percutaneous devices in experimental diabetes mellitus","volume":"53","author":"Gerritsen","year":"2000","journal-title":"Journal of Biomedical Materials Research"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S8756-3282(00)00426-9","article-title":"Glucose-induced inhibition of in vitro bone mineralization","volume":"28","author":"Balint","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0020","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jdiacomp.2009.05.002","article-title":"Metformin reverses the deleterious effects of high glucose on osteoblast function","volume":"24","author":"Zhen","year":"2010","journal-title":"Journal of Diabetes and its Complications"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S8756-3282(97)00220-2","article-title":"Growth-inhibitory effect of a high glucose concentration on osteoblast-like cells","volume":"22","author":"Terada","year":"1998","journal-title":"Bone"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0030","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2010.06.002","article-title":"Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition","volume":"142","author":"Fulzele","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0035","doi-asserted-by":"crossref","first-page":"10973","DOI":"10.1016\/S0021-9258(17)44373-0","article-title":"Characterization of the insulin receptor kinase purified from human placental membranes","volume":"258","author":"Kasuga","year":"1983","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0040","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mehy.2009.02.004","article-title":"Comment on Vitamin D deficiency is the cause of common obesity","volume":"73","author":"Zhang","year":"2009","journal-title":"Medical Hypotheses"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0045","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.mehy.2008.12.031","article-title":"Poor vitamin D status may contribute to high risk for insulin resistance, obesity, and cardiovascular disease in Asian Indians","volume":"72","author":"McCart","year":"2009","journal-title":"Medical Hypotheses"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0050","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00223-002-2139-6","article-title":"Targeted overexpression of Vitamin D receptor in osteoblasts increases calcium concentration without affecting structural properties of bone mineral crystals","volume":"73","author":"Misof","year":"2003","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0055","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/cbf.951","article-title":"Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3","volume":"20","author":"Maestro","year":"2002","journal-title":"Cell Biochemistry and Function"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0060","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1507\/endocrj.47.383","article-title":"Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells","volume":"47","author":"Maestro","year":"2000","journal-title":"Endocrine Journal"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0065","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1096\/fj.02-0424fje","article-title":"Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor","volume":"17","author":"Zeitz","year":"2003","journal-title":"FASEB Journal"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0070","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1017535728844","article-title":"In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue","volume":"33","author":"Bischoff","year":"2001","journal-title":"Histochemical Journal"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0075","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1210\/en.2006-0946","article-title":"Minireview: vitamin D receptor: new assignments for an already busy receptor","volume":"147","author":"Norman","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0080","first-page":"1385","article-title":"Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis","volume":"35","author":"Alvarez","year":"2010","journal-title":"International Journal of Endocrinology"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0085","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.clnu.2010.02.010","article-title":"Relationships between undercarboxylated osteocalcin and vitamin K intakes, bone turnover, and bone mineral density in healthy women","volume":"29","author":"Yamauchi","year":"2010","journal-title":"Clinical Nutrition"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0090","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jcf.2007.11.006","article-title":"Undercarboxylated osteocalcin and bone mass in 8\u201312 year old children with cystic fibrosis","volume":"7","author":"Fewtrell","year":"2008","journal-title":"Journal of Cystic Fibrosis"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0095","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cell.2010.06.003","article-title":"Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism","volume":"142","author":"Ferron","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0100","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1083\/jcb.200809113","article-title":"The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity","volume":"183","author":"Hinoi","year":"2008","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0105","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2007.05.047","article-title":"Endocrine regulation of energy metabolism by the skeleton","volume":"130","author":"Lee","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/BF02555992","article-title":"Morphologic characterization of osteoblast-like cell cultures isolated from newborn rat calvaria","volume":"47","author":"Masquelier","year":"1990","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0115","first-page":"641","article-title":"Effects of serum from children with newly diagnosed Crohn disease on primary cultures of rat osteoblasts","volume":"35","author":"Varghese","year":"2002","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0120","first-page":"2983","article-title":"Culture and identification of SD rat osteoblastsby modified enzymatic digestion in vitro","volume":"12","author":"Wang","year":"2008","journal-title":"Journal of Clinical Rehabilitative Tissue Engineering Research"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0125","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s002239900432","article-title":"Age-related changes in serum undercarboxylated osteocalcin and its relationships with bone density, bone quality, and hip fracture","volume":"62","author":"Liu","year":"1998","journal-title":"Calcified Tissue International"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0130","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nprot.2009.7","article-title":"The role of IFN-gamma Elispot assay in HIV vaccine research","volume":"4","author":"Streeck","year":"2009","journal-title":"Nature Protocols"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1534-5807(02)00199-5","article-title":"Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance","volume":"3","author":"Bl\u00fcher","year":"2002","journal-title":"Developmental Cell"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0140","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0092-8674(00)80546-2","article-title":"Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes","volume":"96","author":"Kulkarni","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0145","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1097-2765(05)00015-8","article-title":"Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction","volume":"6","author":"Michael","year":"2000","journal-title":"Molecular Cell"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0150","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.6250216","article-title":"Vitamin D deficiency inhibits pancreatic secretion of insulin","volume":"209","author":"Norman","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1210\/endo-119-1-84","article-title":"Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo","volume":"119","author":"Cade","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0160","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00774-008-0005-y","article-title":"Analysis of factors affecting increase in bone mineral density at lumbar spine by bisphosphonate treatment in postmenopausal osteoporosis","volume":"27","author":"Kaji","year":"2009","journal-title":"Journal of Bone and Mineral Metabolism"},{"key":"10.1016\/j.jsbmb.2012.05.002_bib0165","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.pbiomolbio.2006.02.016","article-title":"Vitamin D physiology","volume":"92","author":"Lips","year":"2006","journal-title":"Progress in Biophysics and Molecular Biology"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076012000982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076012000982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:40:45Z","timestamp":1760744445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076012000982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0960076012000982"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2012.05.002","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1,25(OH)2D3 inhibits the deleterious effects induced by high glucose on osteoblasts through undercarboxylated osteocalcin and insulin signaling","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2012.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}