{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:08:30Z","timestamp":1782698910568,"version":"3.54.5"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.jsbmb.2013.02.007","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T18:47:41Z","timestamp":1362077261000},"page":"302-310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh (Cimicifuga or Actaea racemosa)"],"prefix":"10.1016","volume":"139","author":[{"given":"Wolfgang","family":"Wuttke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubertus","family":"Jarry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Haunschild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenter","family":"Stecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Seidlova-Wuttke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0005","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00000441-200210000-00003","article-title":"Hormone replacement therapy and coronary heart disease in women: a review of the evidence","volume":"324","author":"Low","year":"2002","journal-title":"American Journal of the Medical Sciences"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0010","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2217\/WHE.11.87","article-title":"Primary prevention of cardiovascular disease with HRT","volume":"8","author":"Maclaran","year":"2012","journal-title":"Womens Health (Lond, Engl)"},{"issue":"3","key":"10.1016\/j.jsbmb.2013.02.007_bib0015","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"Journal of the American Medical Association"},{"issue":"24","key":"10.1016\/j.jsbmb.2013.02.007_bib0020","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1001\/jama.289.24.3243","article-title":"Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial","volume":"289","author":"Chlebowski","year":"2003","journal-title":"Journal of the American Medical Association"},{"issue":"7","key":"10.1016\/j.jsbmb.2013.02.007_bib0025","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/jnci\/djs014","article-title":"Changing concepts: menopausal hormone therapy and breast cancer","volume":"104","author":"Chlebowski","year":"2012","journal-title":"Journal of the National Cancer Institute"},{"issue":"3","key":"10.1016\/j.jsbmb.2013.02.007_bib0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.amjmed.2010.09.021","article-title":"Timing and duration of menopausal hormone treatment may affect cardiovascular outcomes","volume":"124","author":"Harman","year":"2011","journal-title":"American Journal of Medicine"},{"issue":"6","key":"10.1016\/j.jsbmb.2013.02.007_bib0035","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/humupd\/dmi028","article-title":"Breast cancer risk with postmenopausal hormonal treatment","volume":"11","author":"Collins","year":"2005","journal-title":"Human Reproduction Update"},{"issue":"12","key":"10.1016\/j.jsbmb.2013.02.007_bib0040","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1210\/en.2011-1449","article-title":"Minireview: putting physiology back into estrogens\u2019 mechanism of action","volume":"152","author":"Koos","year":"2011","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jsbmb.2013.02.007_bib0045","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.arr.2007.05.001","article-title":"Isoflavones \u2013 safe food additives or dangerous drugs?","volume":"6","author":"Wuttke","year":"2007","journal-title":"Ageing Research Reviews"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0050","first-page":"16","article-title":"Tackling inequalities in obesity: a protocol for a systematic review of the effectiveness of public health interventions at reducing socioeconomic inequalities in obesity amongst children","volume":"1","author":"Bambra","year":"2012","journal-title":"Systematic Reviews"},{"issue":"82","key":"10.1016\/j.jsbmb.2013.02.007_bib0055","first-page":"1","article-title":"Prevalence of obesity in the United States, 2009\u20132010","author":"Ogden","year":"2012","journal-title":"NCHS Data Brief"},{"issue":"2","key":"10.1016\/j.jsbmb.2013.02.007_bib0060","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2217\/17455057.4.2.183","article-title":"Impact of obesity on female fertility and fertility treatment","volume":"4","author":"Zain","year":"2008","journal-title":"Womens Health (Lond, Engl)"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0065","first-page":"164","article-title":"Adolescent polycystic ovary syndrome","volume":"23","author":"Connor","year":"2012","journal-title":"Adolescent Medicine: State of the Art Reviews"},{"issue":"3","key":"10.1016\/j.jsbmb.2013.02.007_bib0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11892-011-0189-8","article-title":"Adipose tissue dysfunction in polycystic ovary syndrome","volume":"11","author":"Villa","year":"2011","journal-title":"Current Diabetes Reports"},{"issue":"6","key":"10.1016\/j.jsbmb.2013.02.007_bib0075","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/jaoac\/91.6.1257","article-title":"Rapid high-performance thin-layer chromatographic method for detection of 5% adulteration of black cohosh with Cimicifuga foetida, C. heracleifolia, C. dahurica, or C. americana","volume":"91","author":"Ankli","year":"2008","journal-title":"Journal of AOAC International"},{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0080","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/pca.1285","article-title":"Phytochemical fingerprinting to thwart black cohosh adulteration: a 15 Actaea species analysis","volume":"22","author":"Jiang","year":"2011","journal-title":"Phytochemical Analysis"},{"issue":"11","key":"10.1016\/j.jsbmb.2013.02.007_bib0085","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.chroma.2011.01.033","article-title":"Metabolic profiling of Actaea species extracts using high performance liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry","volume":"1218","author":"Ma","year":"2011","journal-title":"Journal of Chromatography A"},{"issue":"Suppl. 1","key":"10.1016\/j.jsbmb.2013.02.007_bib0090","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/S0378-5122(02)00346-8","article-title":"In vitro effects of the Cimicifuga racemosa extract BNO 1055","volume":"44","author":"Jarry","year":"2003","journal-title":"Maturitas"},{"issue":"2\u20133","key":"10.1016\/j.jsbmb.2013.02.007_bib0095","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0960-0760(03)00034-7","article-title":"Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy","volume":"84","author":"Beck","year":"2003","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"6","key":"10.1016\/j.jsbmb.2013.02.007_bib0100","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1055\/s-2005-864148","article-title":"Phenolic esters from the rhizomes of Cimicifuga racemosa do not cause proliferation effects in MCF-7 cells","volume":"71","author":"Stromeier","year":"2005","journal-title":"Planta Medica"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1020241509382","article-title":"Influence of Cimicifuga racemosa on the proliferation of estrogen receptor-positive human breast cancer cells","volume":"76","author":"Bodinet","year":"2002","journal-title":"Breast Cancer Research and Treatment"},{"issue":"6\u20137","key":"10.1016\/j.jsbmb.2013.02.007_bib0110","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.phymed.2007.09.017","article-title":"Growth inhibitory activity of extracts and compounds from Cimicifuga species on human breast cancer cells","volume":"15","author":"Einbond","year":"2008","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2174\/138620708784246022","article-title":"High-content screening and mechanism-based evaluation of estrogenic botanical extracts","volume":"11","author":"Overk","year":"2008","journal-title":"Combinatorial Chemistry and High Throughput Screening"},{"issue":"1\u20132","key":"10.1016\/j.jsbmb.2013.02.007_bib0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.steroids.2011.10.013","article-title":"Tissue physiology and pathology of aromatase","volume":"77","author":"Stocco","year":"2012","journal-title":"Steroids"},{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0125","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.maturitas.2006.10.002","article-title":"Ethanolic extracts of black cohosh (Actaea racemosa) inhibit growth and oestradiol synthesis from oestrone sulphate in breast cancer cells","volume":"56","author":"Rice","year":"2007","journal-title":"Maturitas"},{"issue":"Suppl. 1","key":"10.1016\/j.jsbmb.2013.02.007_bib0130","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.maturitas.2006.06.021","article-title":"Plant extracts for the treatment of menopausal women: safe?","volume":"55","author":"Wuttke","year":"2006","journal-title":"Maturitas"},{"issue":"12","key":"10.1016\/j.jsbmb.2013.02.007_bib0135","first-page":"3448","article-title":"Lack of promotion of estrogen-dependent mammary gland tumors in vivo by an isopropanolic Cimicifuga racemosa extract","volume":"62","author":"Freudenstein","year":"2002","journal-title":"Cancer Research"},{"issue":"2","key":"10.1016\/j.jsbmb.2013.02.007_bib0140","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0378-5122(96)01052-3","article-title":"Cimicifuga and Melbrosia lack oestrogenic effects in mice and rats","volume":"25","author":"Einer-Jensen","year":"1996","journal-title":"Maturitas"},{"issue":"12","key":"10.1016\/j.jsbmb.2013.02.007_bib0145","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1289\/ehp.6413","article-title":"The OECD program to validate the rat uterotrophic bioassay: an overview","volume":"111","author":"Owens","year":"2003","journal-title":"Environmental Health Perspectives"},{"issue":"Suppl. 1","key":"10.1016\/j.jsbmb.2013.02.007_bib0150","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/S0378-5122(02)00347-X","article-title":"Pharmacology of Cimicifuga racemosa extract BNO 1055 in rats: bone, fat and uterus","volume":"44","author":"Seidlova-Wuttke","year":"2003","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.jsbmb.2013.02.007_bib0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jsbmb.2005.05.008","article-title":"No estrogen-like effects of an isopropanolic extract of Rhizoma Cimicifugae racemosae on uterus and vena cava of rats after 17 day treatment","volume":"97","author":"Kretzschmar","year":"2005","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0160","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/jcem-49-1-152","article-title":"FSH and skin temperature during the menopausal hot flash","volume":"49","author":"Tataryn","year":"1979","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"3","key":"10.1016\/j.jsbmb.2013.02.007_bib0165","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00042192-200105000-00005","article-title":"A comparison of oral micronized estradiol with soy phytoestrogen effects on tail skin temperatures of ovariectomized rats","volume":"8","author":"Pan","year":"2001","journal-title":"Menopause"},{"issue":"1-3","key":"10.1016\/j.jsbmb.2013.02.007_bib0170","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ejphar.2003.09.061","article-title":"Oestradiol and mirtazapine restore the disturbed tail-temperature of oestrogen-deficient rats","volume":"482","author":"Berendsen","year":"2003","journal-title":"European Journal of Pharmacology"},{"issue":"11","key":"10.1016\/j.jsbmb.2013.02.007_bib0175","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1210\/en.2010-0630","article-title":"An improved method for recording tail skin temperature in the rat reveals changes during the estrous cycle and effects of ovarian steroids","volume":"151","author":"Williams","year":"2010","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jsbmb.2013.02.007_bib0180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/s-0031-1280317","article-title":"20-OH-ecdysone prevents hot flushes in ovariectomized rats","volume":"78","author":"Puri","year":"2012","journal-title":"Planta Medica"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.maturitas.2011.11.002","article-title":"EMAS position statement: vitamin D and postmenopausal health","volume":"71","author":"Perez-Lopez","year":"2012","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.jsbmb.2013.02.007_bib0190","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bone.2008.04.018","article-title":"Ethanolic extract of Actaea racemosa (black cohosh) potentiates bone nodule formation in MC3T3-E1 preosteoblast cells","volume":"43","author":"Chan","year":"2008","journal-title":"Bone"},{"issue":"5","key":"10.1016\/j.jsbmb.2013.02.007_bib0195","first-page":"424","article-title":"The laboratory rat as an animal model for osteoporosis research","volume":"58","author":"Lelovas","year":"2008","journal-title":"Comparative Medicine"},{"issue":"10","key":"10.1016\/j.jsbmb.2013.02.007_bib0200","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.phymed.2012.05.002","article-title":"Osteoprotective effects of Cimicifuga racemosa and its triterpene-saponins are responsible for reduction of bone marrow fat","volume":"19","author":"Seidlova-Wuttke","year":"2012","journal-title":"Phytomedicine"},{"issue":"8\u20139","key":"10.1016\/j.jsbmb.2013.02.007_bib0205","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.phymed.2012.03.001","article-title":"Cimicifuga racemosa and its triterpene-saponins prevent the Metabolic Syndrome and deterioration of cartilage in the knee joint of ovariectomized rats by similar mechanisms","volume":"19","author":"Seidlova-Wuttke","year":"2012","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.jsbmb.2013.02.007_bib0210","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1055\/s-0029-1185561","article-title":"Effects of estradiol benzoate, raloxifen and an ethanolic extract of Cimicifuga racemosa in nonclassical estrogen regulated organs of ovariectomized rats","volume":"75","author":"Seidlova-Wuttke","year":"2009","journal-title":"Planta Medica"},{"issue":"2","key":"10.1016\/j.jsbmb.2013.02.007_bib0215","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.maturitas.2007.01.002","article-title":"The effects of black cohosh therapies on lipids, fibrinogen, glucose and insulin","volume":"57","author":"Spangler","year":"2007","journal-title":"Maturitas"},{"issue":"11","key":"10.1016\/j.jsbmb.2013.02.007_bib0220","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1139\/Y09-091","article-title":"Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human whole blood","volume":"87","author":"Schmid","year":"2009","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"issue":"21","key":"10.1016\/j.jsbmb.2013.02.007_bib0225","doi-asserted-by":"crossref","first-page":"6707","DOI":"10.1021\/jm9006164","article-title":"Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages","volume":"52","author":"Yang","year":"2009","journal-title":"Journal of Medicinal Chemistry"},{"issue":"3","key":"10.1016\/j.jsbmb.2013.02.007_bib0230","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s10549-011-1929-9","article-title":"Mammographic density, parity and age at first birth, and risk of breast cancer: an analysis of four case\u2013control studies","volume":"132","author":"Woolcott","year":"2012","journal-title":"Breast Cancer Research and Treatment"},{"issue":"2","key":"10.1016\/j.jsbmb.2013.02.007_bib0235","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/01635580701506968","article-title":"Black cohosh does not exert an estrogenic effect on the breast","volume":"59","author":"Ruhlen","year":"2007","journal-title":"Nutrition and Cancer"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0240","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/01.gme.0000230346.20992.34","article-title":"An isopropanolic extract of black cohosh does not increase mammographic breast density or breast cell proliferation in postmenopausal women","volume":"14","author":"Hirschberg","year":"2007","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0245","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.maturitas.2011.08.009","article-title":"Digitized assessment of mammographic breast density \u2013 effects of continuous combined hormone therapy, tibolone and black cohosh compared to placebo","volume":"70","author":"Lundstrom","year":"2011","journal-title":"Maturitas"},{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0250","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/01.gme.0000196813.34247.e2","article-title":"First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055","volume":"13","author":"Raus","year":"2006","journal-title":"Menopause"},{"issue":"7","key":"10.1016\/j.jsbmb.2013.02.007_bib0255","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/ijc.22485","article-title":"A retrospective case\u2013control study of the use of hormone-related supplements and association with breast cancer","volume":"120","author":"Rebbeck","year":"2007","journal-title":"International Journal of Cancer"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0260","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/gme.0b013e318057787f","article-title":"Vaginal, endometrial, and reproductive hormone findings: randomized, placebo-controlled trial of black cohosh, multibotanical herbs, and dietary soy for vasomotor symptoms: the Herbal Alternatives for Menopause (HALT) Study","volume":"15","author":"Reed","year":"2008","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0265","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.maturitas.2008.08.006","article-title":"Effects of Trifolium pratense and Cimicifuga racemosa on the endometrium of Wistar rats","volume":"61","author":"Alves","year":"2008","journal-title":"Maturitas"},{"issue":"Suppl. 1","key":"10.1016\/j.jsbmb.2013.02.007_bib0270","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S0378-5122(02)00350-X","article-title":"The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers","volume":"44","author":"Wuttke","year":"2003","journal-title":"Maturitas"},{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0275","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.maturitas.2004.10.003","article-title":"Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial","volume":"51","author":"Frei-Kleiner","year":"2005","journal-title":"Maturitas"},{"issue":"5 Pt 1","key":"10.1016\/j.jsbmb.2013.02.007_bib0280","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1097\/01.AOG.0000158865.98070.89","article-title":"Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms","volume":"105","author":"Osmers","year":"2005","journal-title":"Obstetrics and Gynecology"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0285","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.maturitas.2007.04.009","article-title":"Efficacy and tolerability of a medicinal product containing an isopropanolic black cohosh extract in Chinese women with menopausal symptoms: a randomized, double blind, parallel-controlled study versus tibolone","volume":"58","author":"Bai","year":"2007","journal-title":"Maturitas"},{"issue":"2","key":"10.1016\/j.jsbmb.2013.02.007_bib0290","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/BF02849914","article-title":"Black cohosh and fluoxetine in the treatment of postmenopausal symptoms: a prospective, randomized trial","volume":"24","author":"Oktem","year":"2007","journal-title":"Advances in Therapy"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0295","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/HNP.0b013e31823d1f67","article-title":"Menopause: a standardized isopropanolic black cohosh extract (remifemin) is found to be safe and effective for menopausal symptoms","volume":"26","author":"Ross","year":"2012","journal-title":"Holistic Nursing Practice"},{"issue":"12","key":"10.1016\/j.jsbmb.2013.02.007_bib0300","doi-asserted-by":"crossref","first-page":"869","DOI":"10.7326\/0003-4819-145-12-200612190-00003","article-title":"Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial","volume":"145","author":"Newton","year":"2006","journal-title":"Annals of Internal Medicine"},{"issue":"6","key":"10.1016\/j.jsbmb.2013.02.007_bib0305","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/gme.0b013e3181ace49b","article-title":"Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial","volume":"16","author":"Geller","year":"2009","journal-title":"Menopause"},{"issue":"18","key":"10.1016\/j.jsbmb.2013.02.007_bib0310","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1200\/JCO.2005.05.4296","article-title":"Phase III double-blind, randomized, placebo-controlled crossover trial of black cohosh in the management of hot flashes: NCCTG Trial N01CC1","volume":"24","author":"Pockaj","year":"2006","journal-title":"Journal of Clinical Oncology"},{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0315","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1055\/s-2007-969500","article-title":"Studies on the endocrine effects of the contents of Cimicifuga racemosa 2. In vitro binding of compounds to estrogen receptors","volume":"51","author":"Jarry","year":"1985","journal-title":"Planta Medica"},{"issue":"7","key":"10.1016\/j.jsbmb.2013.02.007_bib0320","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.phymed.2005.06.007","article-title":"Analysis of formononetin from black cohosh (Actaea racemosa)","volume":"13","author":"Jiang","year":"2006","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jsbmb.2013.02.007_bib0325","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1055\/s-0028-1088384","article-title":"Quantitative determination of triterpenoids and formononetin in rhizomes of black cohosh (Actaea racemosa) and dietary supplements by using UPLC\u2013UV\/ELS detection and identification by UPLC\u2013MS","volume":"75","author":"Avula","year":"2009","journal-title":"Planta Medica"},{"issue":"10","key":"10.1016\/j.jsbmb.2013.02.007_bib0330","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3109\/09513590.2010.538097","article-title":"Black cohosh (Cimicifuga racemosa) in tamoxifen-treated breast cancer patients with climacteric complaints \u2013 a prospective observational study","volume":"27","author":"Rostock","year":"2011","journal-title":"Gynecological Endocrinology"},{"issue":"24","key":"10.1016\/j.jsbmb.2013.02.007_bib0335","doi-asserted-by":"crossref","first-page":"11718","DOI":"10.1021\/jf803298z","article-title":"In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent","volume":"56","author":"Powell","year":"2008","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"10","key":"10.1016\/j.jsbmb.2013.02.007_bib0340","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.6004\/jnccn.2010.0086","article-title":"Nonhormonal management of hot flashes for women on risk reduction therapy","volume":"8","author":"Sideras","year":"2010","journal-title":"Journal of National Comprehensive Cancer Network"},{"issue":"1","key":"10.1016\/j.jsbmb.2013.02.007_bib0355","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/09513590.2012.705380","article-title":"New generation nonhormonal management for hot flashes","volume":"29","author":"Imai","year":"2013","journal-title":"Gynecological Endocrinology"},{"issue":"12","key":"10.1016\/j.jsbmb.2013.02.007_bib0350","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1021\/np100479w","article-title":"Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa","volume":"73","author":"Cicek","year":"2010","journal-title":"Journal of Natural Products"}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076013000381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076013000381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:44:30Z","timestamp":1760744670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076013000381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":70,"alternative-id":["S0960076013000381"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2013.02.007","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh (Cimicifuga or Actaea racemosa)","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2013.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}