{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:25:53Z","timestamp":1783628753699,"version":"3.55.0"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NIH","award":["R01-CA 044722-22"],"award-info":[{"award-number":["R01-CA 044722-22"]}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"crossref","award":["635\/11"],"award-info":[{"award-number":["635\/11"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.jsbmb.2013.10.002","type":"journal-article","created":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T11:18:13Z","timestamp":1382786293000},"page":"223-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"PA","title":["ERK 5\/MAPK pathway has a major role in 1\u03b1,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells"],"prefix":"10.1016","volume":"144","author":[{"given":"Xuening","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Pesakhov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kafka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Gocek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Danilenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George P.","family":"Studzinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jsbmb.2013.10.002_bib0005","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1073\/pnas.78.8.4990","article-title":"Differentiation of mouse myeloid leukemia cells induced by 1a,25-dihydroxyvitamin D3","volume":"78","author":"Abe","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0010","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3181\/00379727-179-42098","article-title":"A system for monocytic differentiation of leukemic cells HL 60 by a short exposure to 1,25-dihydroxycholecalciferol","volume":"179","author":"Studzinski","year":"1985","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0015","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jm0000160","article-title":"Characterization of a novel analogue of 1\u03b1,25(OH)2-vitamin D3 with two side chains: interaction with its nuclear receptor and cellular actions","volume":"43","author":"Norman","year":"2000","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0020","first-page":"125814","article-title":"Clinical experience using vitamin d and analogs in the treatment of myelodysplasia and acute myeloid leukemia: a review of the literature","volume":"2012","author":"Harrison","year":"2012","journal-title":"Leuk. Res. Treat."},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-8722-3-8","article-title":"From basic research to clinical development of MEK1\/2 inhibitors for cancer therapy","volume":"3","author":"Fremin","year":"2010","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0030","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/j.cellsig.2012.07.007","article-title":"ERK5: structure, regulation and function","volume":"24","author":"Nithianandarajah-Jones","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0035","doi-asserted-by":"crossref","first-page":"e5565","DOI":"10.1371\/journal.pone.0005565","article-title":"Expression of Erk5 in early stage breast cancer and association with disease free survival identifies this kinase as a potential therapeutic target","volume":"4","author":"Montero","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0040","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.4161\/cc.9.22.13790","article-title":"Studzinski, inhibition of Cot1\/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D3","volume":"9","author":"Wang","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0045","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbrc.2008.09.087","article-title":"Identification of pharmacological inhibitors of the MEK5\/ERK5 pathway","volume":"377","author":"Tatake","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0050","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ccr.2010.08.008","article-title":"Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein","volume":"18","author":"Yang","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0055","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1128\/MCB.01246-12","article-title":"Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex","volume":"33","author":"Erazo","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0060","first-page":"264","article-title":"Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells","volume":"56","author":"Wang","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.jsbmb.2013.10.002_bib0065","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/gad.10.2.142","article-title":"Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937","volume":"10","author":"Liu","year":"1996","journal-title":"Genes Dev."}],"container-title":["The Journal of Steroid Biochemistry and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076013001957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960076013001957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T23:43:53Z","timestamp":1760744633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960076013001957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":13,"alternative-id":["S0960076013001957"],"URL":"https:\/\/doi.org\/10.1016\/j.jsbmb.2013.10.002","relation":{},"ISSN":["0960-0760"],"issn-type":[{"value":"0960-0760","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ERK 5\/MAPK pathway has a major role in 1\u03b1,25-(OH)2 vitamin D3-induced terminal differentiation of myeloid leukemia cells","name":"articletitle","label":"Article Title"},{"value":"The Journal of Steroid Biochemistry and Molecular Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jsbmb.2013.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}